WO2008133789A3 - Methods and compositions for targeting afap - Google Patents
Methods and compositions for targeting afap Download PDFInfo
- Publication number
- WO2008133789A3 WO2008133789A3 PCT/US2008/003686 US2008003686W WO2008133789A3 WO 2008133789 A3 WO2008133789 A3 WO 2008133789A3 US 2008003686 W US2008003686 W US 2008003686W WO 2008133789 A3 WO2008133789 A3 WO 2008133789A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- compositions
- cancer
- afap
- targeting
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000008685 targeting Effects 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 108050000056 Actin-filament associated proteins Proteins 0.000 abstract 1
- 102000009185 Actin-filament associated proteins Human genes 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 abstract 1
- 101000928226 Homo sapiens Actin filament-associated protein 1 Proteins 0.000 abstract 1
- 206010033128 Ovarian cancer Diseases 0.000 abstract 1
- 206010061535 Ovarian neoplasm Diseases 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 102000049204 human AFAP1 Human genes 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
Embodiments of the invention are directed to methods and compositions for inhibiting activation of cSrc by human actin filament associated protein (AFAP). Libraries and methods of screening compositions for inhibitive activity are also provided. Also provided are methods of treating cancer. Cancer may be, for example, but is not limited to ovarian cancer, breast cancer, and gastrointestinal cancer. Also provided are methods of decreasing resistance to chemotherapy.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08779575A EP2136620A2 (en) | 2007-03-20 | 2008-03-20 | Methods and compositions for targeting afap |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91908607P | 2007-03-20 | 2007-03-20 | |
US60/919,086 | 2007-03-20 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2008133789A2 WO2008133789A2 (en) | 2008-11-06 |
WO2008133789A3 true WO2008133789A3 (en) | 2008-12-24 |
WO2008133789A4 WO2008133789A4 (en) | 2009-02-19 |
Family
ID=39775374
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/003686 WO2008133789A2 (en) | 2007-03-20 | 2008-03-20 | Methods and compositions for targeting afap |
Country Status (3)
Country | Link |
---|---|
US (1) | US20080234232A1 (en) |
EP (1) | EP2136620A2 (en) |
WO (1) | WO2008133789A2 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030104443A1 (en) * | 2001-09-21 | 2003-06-05 | University Of West Virginia | AFAP sequences, polypeptides, antibodies and methods |
US7153843B2 (en) * | 1998-06-26 | 2006-12-26 | Georgetown University | Inhibitors of phosphatidyl myo-inositol cycle |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4612370A (en) * | 1982-04-02 | 1986-09-16 | The Regents Of The University Of California | Lipid-saccharide reaction products |
JPH0683633B2 (en) * | 1987-04-08 | 1994-10-26 | 花王株式会社 | Release oil composition for food |
US5149794A (en) * | 1990-11-01 | 1992-09-22 | State Of Oregon | Covalent lipid-drug conjugates for drug targeting |
US5660858A (en) * | 1996-04-03 | 1997-08-26 | Research Triangle Pharmaceuticals | Cyclosporin emulsions |
-
2008
- 2008-03-20 US US12/077,653 patent/US20080234232A1/en not_active Abandoned
- 2008-03-20 EP EP08779575A patent/EP2136620A2/en not_active Withdrawn
- 2008-03-20 WO PCT/US2008/003686 patent/WO2008133789A2/en active Search and Examination
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7153843B2 (en) * | 1998-06-26 | 2006-12-26 | Georgetown University | Inhibitors of phosphatidyl myo-inositol cycle |
US20030104443A1 (en) * | 2001-09-21 | 2003-06-05 | University Of West Virginia | AFAP sequences, polypeptides, antibodies and methods |
Non-Patent Citations (2)
Title |
---|
BAISDEN ET AL.: "The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity", ONCOGENE, vol. 20, 2001, pages 6435, XP008122478 * |
RUCCI ET AL.: "Inhibition of protein kinase c-Src reduces the incidence of breast cancer metastases and increases survival in mice: implications for therapy", J. PHARM. EXPT. THERAP., vol. 318, 2006, pages 161 - 172, XP008122477 * |
Also Published As
Publication number | Publication date |
---|---|
EP2136620A2 (en) | 2009-12-30 |
WO2008133789A4 (en) | 2009-02-19 |
WO2008133789A2 (en) | 2008-11-06 |
US20080234232A1 (en) | 2008-09-25 |
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