WO2008132925A1 - Method for producing 3-aminothiophene - Google Patents

Method for producing 3-aminothiophene Download PDF

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Publication number
WO2008132925A1
WO2008132925A1 PCT/JP2008/056024 JP2008056024W WO2008132925A1 WO 2008132925 A1 WO2008132925 A1 WO 2008132925A1 JP 2008056024 W JP2008056024 W JP 2008056024W WO 2008132925 A1 WO2008132925 A1 WO 2008132925A1
Authority
WO
WIPO (PCT)
Prior art keywords
aminothiophene
producing
represented
general formula
formula
Prior art date
Application number
PCT/JP2008/056024
Other languages
French (fr)
Japanese (ja)
Inventor
Takeshi Kakimoto
Tomotaka Miyashita
Miki Enomoto
Daisuke Ura
Yoji Aoki
Toshio Kitashima
Original Assignee
Mitsui Chemicals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Chemicals, Inc. filed Critical Mitsui Chemicals, Inc.
Publication of WO2008132925A1 publication Critical patent/WO2008132925A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

Disclosed is a method for producing 3-aminothiophene represented by the formula (4) below, which comprises a step for producing a metal carboxylate salt represented by the general formula (2) below by hydrolyzing a 3-aminothiophene-2-carboxylate derivative represented by the general formula (1) below, a step for producing a salt represented by the general formula (3) below, which is composed of 3-aminothiophene and an acid, by performing a decarboxylation reaction of the metal carboxylate salt under acidic conditions, and a step for neutralizing the salt represented by the general formula (3) below. This method for producing 3-aminothiophene which is useful as an intermediate for agrochemicals, is characterized in that the decarboxylation reaction is performed without isolating a 3-aminothiophene-2-carboxylic acid represented by the formula (5) below. [chemical formula 1] (1) (2) (5) (3) (4) (In the formulae, R represents an alkyl group having 1-12 carbon atoms or a phenyl group; M represents an alkali metal or an alkaline earth metal; and HX represents an acid.)
PCT/JP2008/056024 2007-04-12 2008-03-28 Method for producing 3-aminothiophene WO2008132925A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007104715A JP2010143826A (en) 2007-04-12 2007-04-12 Method for producing 3-aminothiophene derivative
JP2007-104715 2007-04-12

Publications (1)

Publication Number Publication Date
WO2008132925A1 true WO2008132925A1 (en) 2008-11-06

Family

ID=39925385

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/056024 WO2008132925A1 (en) 2007-04-12 2008-03-28 Method for producing 3-aminothiophene

Country Status (3)

Country Link
JP (1) JP2010143826A (en)
TW (1) TW200906816A (en)
WO (1) WO2008132925A1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH072836A (en) * 1993-06-16 1995-01-06 Mitsubishi Chem Corp Method for producing n-thienylaminomethyleneacetic acid derivative
WO2005040110A1 (en) * 2003-10-08 2005-05-06 Eli Lilly And Company Pyrrole and pyrazole derivatives as potentiators of glutamate receptors
WO2005070916A1 (en) * 2004-01-09 2005-08-04 Eli Lilly And Company Thiophene and furan compounds
WO2007122806A1 (en) * 2006-04-17 2007-11-01 Mitsui Chemicals, Inc. 2-alkenyl-3-aminothiophene derivative and method for producing the same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH072836A (en) * 1993-06-16 1995-01-06 Mitsubishi Chem Corp Method for producing n-thienylaminomethyleneacetic acid derivative
WO2005040110A1 (en) * 2003-10-08 2005-05-06 Eli Lilly And Company Pyrrole and pyrazole derivatives as potentiators of glutamate receptors
WO2005070916A1 (en) * 2004-01-09 2005-08-04 Eli Lilly And Company Thiophene and furan compounds
WO2007122806A1 (en) * 2006-04-17 2007-11-01 Mitsui Chemicals, Inc. 2-alkenyl-3-aminothiophene derivative and method for producing the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BARKER J.M. ET AL.: "An easy synthesis of 3-amino- and 3-nitrothiophene", SYNTH. COMMUN., vol. 25, no. 23, 1995, pages 3729 - 3734 *

Also Published As

Publication number Publication date
TW200906816A (en) 2009-02-16
JP2010143826A (en) 2010-07-01

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