WO2008130553A1 - Novel opiate reduction utilizing catalytic hydrogen transfer reaction - Google Patents
Novel opiate reduction utilizing catalytic hydrogen transfer reaction Download PDFInfo
- Publication number
- WO2008130553A1 WO2008130553A1 PCT/US2008/004869 US2008004869W WO2008130553A1 WO 2008130553 A1 WO2008130553 A1 WO 2008130553A1 US 2008004869 W US2008004869 W US 2008004869W WO 2008130553 A1 WO2008130553 A1 WO 2008130553A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- formula
- compound according
- hco
- Prior art date
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- 0 Oc1c2OC3C(N=O)=CC=C(C(C4)*CC5)C35c2c4cc1 Chemical compound Oc1c2OC3C(N=O)=CC=C(C(C4)*CC5)C35c2c4cc1 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2009010931A MX2009010931A (en) | 2007-04-16 | 2008-04-15 | Novel opiate reduction utilizing catalytic hydrogen transfer reaction. |
ES08742920T ES2423180T3 (en) | 2007-04-16 | 2008-04-15 | New opioid reduction by catalytic hydrogen transfer reaction |
US12/595,519 US8309727B2 (en) | 2007-04-16 | 2008-04-15 | Opiate reduction utilizing catalytic hydrogen transfer reaction |
EP08742920.5A EP2137190B1 (en) | 2007-04-16 | 2008-04-15 | Novel opiate reduction utilizing catalytic hydrogen transfer reaction |
CA002684458A CA2684458A1 (en) | 2007-04-16 | 2008-04-15 | Novel opiate reduction utilizing catalytic hydrogen transfer reaction |
JP2010504070A JP5373764B2 (en) | 2007-04-16 | 2008-04-15 | Novel opiate reduction using catalytic hydrogen transfer reaction |
AU2008241528A AU2008241528B2 (en) | 2007-04-16 | 2008-04-15 | Novel opiate reduction utilizing catalytic hydrogen transfer reaction |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91195007P | 2007-04-16 | 2007-04-16 | |
US60/911,950 | 2007-04-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008130553A1 true WO2008130553A1 (en) | 2008-10-30 |
Family
ID=39560869
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/004869 WO2008130553A1 (en) | 2007-04-16 | 2008-04-15 | Novel opiate reduction utilizing catalytic hydrogen transfer reaction |
Country Status (8)
Country | Link |
---|---|
US (1) | US8309727B2 (en) |
EP (1) | EP2137190B1 (en) |
JP (2) | JP5373764B2 (en) |
AU (1) | AU2008241528B2 (en) |
CA (1) | CA2684458A1 (en) |
ES (1) | ES2423180T3 (en) |
MX (1) | MX2009010931A (en) |
WO (1) | WO2008130553A1 (en) |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011117172A1 (en) | 2010-03-23 | 2011-09-29 | Siegfried Ltd. | Preparation of low impurity opiates in a continuous flow reactor |
WO2012013671A1 (en) * | 2010-07-27 | 2012-02-02 | Universität Innsbruck | Processes for the production of 14 - oxygenated morphinan - 6 - ones |
WO2014013313A1 (en) | 2012-07-16 | 2014-01-23 | Rhodes Technologies | Process for improved opioid synthesis |
WO2014013311A1 (en) | 2012-07-16 | 2014-01-23 | Rhodes Technologies | Process for improved opioid synthesis |
US8846923B1 (en) | 2013-12-18 | 2014-09-30 | Cody Laboratories, Inc. | Preparation of 14-hydroxycodeinone sulfate |
US9012468B2 (en) | 2012-02-08 | 2015-04-21 | Mallinckrodt Llc | One pot process for producing 6-hydroxyl nal-opiate |
US9062062B1 (en) | 2013-12-18 | 2015-06-23 | Cody Laboratories, Inc. | Synthesis of oxycodone hydrochloride |
WO2015107472A1 (en) | 2014-01-15 | 2015-07-23 | Rhodes Technologies | Process for improved oxymorphone synthesis |
WO2015107471A1 (en) | 2014-01-15 | 2015-07-23 | Rhodes Technologies | Process for improved oxycodone synthesis |
WO2016032505A1 (en) * | 2014-08-25 | 2016-03-03 | Johnson Matthey Public Limited Company | Improved processes for making opioids including 14-hydroxycodeinone and 14-hydroxymorphinone |
US20160168089A1 (en) * | 2014-12-12 | 2016-06-16 | H. Lundbeck A/S | Process for the manufacture of idalopirdine |
EP3252055A1 (en) | 2016-05-31 | 2017-12-06 | Alcaliber Investigacion Desarrollo e Innovacion, S.L. | Process for obtaining 3,14-diacetyloxymorphone from oripavine |
US10227354B2 (en) | 2013-12-18 | 2019-03-12 | Cody Laboratories, Inc. | Conversion of oxycodone base to oxycodone hydrochloride |
EP3495371A1 (en) * | 2017-12-05 | 2019-06-12 | Siegfried AG | Synthesis of noroxymorphone |
CN111205296A (en) * | 2018-11-22 | 2020-05-29 | 中国科学院上海有机化学研究所 | Oxycodone compound and intermediate and preparation method thereof |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5923827B2 (en) * | 1981-12-16 | 1984-06-05 | フエザ−安全剃刀株式会社 | safety razor blade |
EP2580218B1 (en) | 2010-06-11 | 2015-02-25 | Rhodes Technologies | Process for n-dealkylation of tertiary amines |
AU2011263417B2 (en) | 2010-06-11 | 2014-03-27 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof |
GB2495062A (en) | 2010-07-02 | 2013-03-27 | Johnson Matthey Plc | Process for the synthesis and purification of oxycodone |
US9657029B2 (en) * | 2012-06-11 | 2017-05-23 | Siegfried Generics International Ag | Method of preparing oxymorphone |
BR112016008459B1 (en) | 2013-11-07 | 2023-02-07 | SpecGx LLC | PRODUCTION OF 6-HYDROXY MORPHINANS WITHOUT ISOLATING INTERMEDIATES |
US20160340362A1 (en) * | 2015-05-20 | 2016-11-24 | Noramco, Inc. | Process For The Preparation Of Oxymorphone Freebase |
CN114573508A (en) * | 2020-12-01 | 2022-06-03 | 中国科学院上海有机化学研究所 | Oxycodone compounds, intermediates and preparation method thereof |
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GB939287A (en) | 1961-03-14 | 1963-10-09 | Sankyo Co | New morphinone and codeinone derivatives and process for preparing the same |
US6177567B1 (en) | 1999-10-15 | 2001-01-23 | Boehringer Ingelheim Chemicals, Inc. | Method for preparing oxycodone |
US6365742B1 (en) | 1997-06-30 | 2002-04-02 | Johnson Matthey Public Limited Company | Preparation of opiates, intermediates and uses of salts |
US20040017891A1 (en) | 2002-06-19 | 2004-01-29 | Tadao Endo | Radiological imaging apparatus and method |
WO2004108090A2 (en) | 2003-06-05 | 2004-12-16 | Halsey Drug Company | Process for manufacturing oxycodone |
WO2005097801A1 (en) | 2004-03-30 | 2005-10-20 | Euro-Celtique S.A. | Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone |
WO2006094672A1 (en) | 2005-03-04 | 2006-09-14 | Euro-Celtique S.A. | Method of reducing alpha, beta unsaturated ketones in opioid compositions |
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US3905981A (en) | 1973-10-12 | 1975-09-16 | Research Corp | N-dealkylation of tertiary amines |
US4277604A (en) | 1980-01-25 | 1981-07-07 | The United States Of America As Represented By The Department Of Health And Human Services | Facile synthesis of codeine precursors from thebaine |
US4472253A (en) | 1981-08-17 | 1984-09-18 | The Florida Board Of Regents On Behalf Of The Florida State University | Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative |
US4795813A (en) | 1981-08-17 | 1989-01-03 | The Florida Board Of Regents On Behalf Of The Florida State University | Synthesis of derivatives of codeine and other 3-O-alkylmorphines |
US5112975A (en) | 1984-03-27 | 1992-05-12 | Mallinckrodt Specialty Chemicals Company | Preparation of noroxymorphone from morphine |
US4639520A (en) | 1984-03-27 | 1987-01-27 | Mallinckrodt, Inc. | Preparation of 14-hydroxy-N-ethoxy-carbonyl-norcodeinone |
US5668285A (en) * | 1986-10-31 | 1997-09-16 | The United States Of America As Represented By The Department Of Health And Human Services | Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates |
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-
2008
- 2008-04-15 WO PCT/US2008/004869 patent/WO2008130553A1/en active Application Filing
- 2008-04-15 MX MX2009010931A patent/MX2009010931A/en unknown
- 2008-04-15 AU AU2008241528A patent/AU2008241528B2/en not_active Ceased
- 2008-04-15 CA CA002684458A patent/CA2684458A1/en not_active Abandoned
- 2008-04-15 JP JP2010504070A patent/JP5373764B2/en not_active Expired - Fee Related
- 2008-04-15 ES ES08742920T patent/ES2423180T3/en active Active
- 2008-04-15 EP EP08742920.5A patent/EP2137190B1/en not_active Not-in-force
- 2008-04-15 US US12/595,519 patent/US8309727B2/en active Active
-
2013
- 2013-07-26 JP JP2013155260A patent/JP2013216696A/en active Pending
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GB939287A (en) | 1961-03-14 | 1963-10-09 | Sankyo Co | New morphinone and codeinone derivatives and process for preparing the same |
US6365742B1 (en) | 1997-06-30 | 2002-04-02 | Johnson Matthey Public Limited Company | Preparation of opiates, intermediates and uses of salts |
US6177567B1 (en) | 1999-10-15 | 2001-01-23 | Boehringer Ingelheim Chemicals, Inc. | Method for preparing oxycodone |
US20040017891A1 (en) | 2002-06-19 | 2004-01-29 | Tadao Endo | Radiological imaging apparatus and method |
WO2004108090A2 (en) | 2003-06-05 | 2004-12-16 | Halsey Drug Company | Process for manufacturing oxycodone |
WO2005097801A1 (en) | 2004-03-30 | 2005-10-20 | Euro-Celtique S.A. | Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone |
WO2006094672A1 (en) | 2005-03-04 | 2006-09-14 | Euro-Celtique S.A. | Method of reducing alpha, beta unsaturated ketones in opioid compositions |
Cited By (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8921557B2 (en) | 2010-03-23 | 2014-12-30 | Siegfried Ag | Preparation of low impurity opiates in a continuous flow reactor |
EP2377866A1 (en) | 2010-03-23 | 2011-10-19 | Siegfried Ltd. | Preparation of low impurity opiates in a continuous flow reactor |
AU2011231748B2 (en) * | 2010-03-23 | 2013-11-14 | Siegfried Ag | Preparation of low impurity opiates in a continuous flow reactor |
WO2011117172A1 (en) | 2010-03-23 | 2011-09-29 | Siegfried Ltd. | Preparation of low impurity opiates in a continuous flow reactor |
WO2012013671A1 (en) * | 2010-07-27 | 2012-02-02 | Universität Innsbruck | Processes for the production of 14 - oxygenated morphinan - 6 - ones |
US9012468B2 (en) | 2012-02-08 | 2015-04-21 | Mallinckrodt Llc | One pot process for producing 6-hydroxyl nal-opiate |
US10316042B2 (en) | 2012-07-16 | 2019-06-11 | Rhodes Technologies | Process for improved opioid synthesis |
TWI588147B (en) * | 2012-07-16 | 2017-06-21 | 羅德科技公司 | Process for improved opioid synthesis |
CN104470928A (en) * | 2012-07-16 | 2015-03-25 | 罗德科技公司 | Process For Improved Opioid Synthesis |
CN104507947A (en) * | 2012-07-16 | 2015-04-08 | 罗德科技公司 | Process for improved opioid synthesis |
WO2014013311A1 (en) | 2012-07-16 | 2014-01-23 | Rhodes Technologies | Process for improved opioid synthesis |
US11390627B2 (en) | 2012-07-16 | 2022-07-19 | Rhodes Technologies | Process for improved opioid synthesis |
WO2014013313A1 (en) | 2012-07-16 | 2014-01-23 | Rhodes Technologies | Process for improved opioid synthesis |
US10202396B2 (en) | 2012-07-16 | 2019-02-12 | Rhodes Technologies | Process for improved opioid synthesis |
KR101946104B1 (en) * | 2012-07-16 | 2019-02-08 | 로드스 테크놀로지즈 | Process for improved opioid synthesis |
KR101946103B1 (en) * | 2012-07-16 | 2019-02-08 | 로드스 테크놀로지즈 | Process for improved opioid synthesis |
TWI643859B (en) * | 2012-07-16 | 2018-12-11 | 羅德科技公司 | Process for improved opioid synthesis |
TWI643860B (en) * | 2012-07-16 | 2018-12-11 | 羅德科技公司 | Process for improved opioid synthesis |
EA029925B1 (en) * | 2012-07-16 | 2018-05-31 | Родс Текнолоджис | Process for improved opioid synthesis |
EA028092B1 (en) * | 2012-07-16 | 2017-10-31 | Родс Текнолоджис | Process for improved opioid synthesis |
AU2013291725B2 (en) * | 2012-07-16 | 2016-07-28 | Rhodes Technologies | Process for improved opioid synthesis |
AU2013291723B2 (en) * | 2012-07-16 | 2016-07-28 | Rhodes Technologies | Process for improved opioid synthesis |
CN104507947B (en) * | 2012-07-16 | 2017-06-27 | 罗德科技公司 | For the method for improved opioid synthesis |
US9309257B2 (en) | 2013-12-18 | 2016-04-12 | Cody Laboratories, Inc. | Preparation of oxycodone base form 14-hydroxycodeinone sulfate |
US8846923B1 (en) | 2013-12-18 | 2014-09-30 | Cody Laboratories, Inc. | Preparation of 14-hydroxycodeinone sulfate |
US9062062B1 (en) | 2013-12-18 | 2015-06-23 | Cody Laboratories, Inc. | Synthesis of oxycodone hydrochloride |
US10227354B2 (en) | 2013-12-18 | 2019-03-12 | Cody Laboratories, Inc. | Conversion of oxycodone base to oxycodone hydrochloride |
US9090620B2 (en) | 2013-12-18 | 2015-07-28 | Cody Laboratories, Inc. | Preparation of 14-hydroxycodeinone sulfate |
US9108976B2 (en) | 2013-12-18 | 2015-08-18 | Cody Laboratories, Inc. | Preparation of 14-hydroxycodeinone sulfate |
US9233972B2 (en) | 2013-12-18 | 2016-01-12 | Cody Laboratories, Inc. | Preparation of 14-hydroxycodeinone sulfate |
WO2015107471A1 (en) | 2014-01-15 | 2015-07-23 | Rhodes Technologies | Process for improved oxycodone synthesis |
US10844072B2 (en) | 2014-01-15 | 2020-11-24 | Rhodes Technologies | Process for improved oxycodone synthesis |
US9932348B2 (en) | 2014-01-15 | 2018-04-03 | Rhodes Technologies | Process for improved oxycodone synthesis |
US10428079B2 (en) | 2014-01-15 | 2019-10-01 | Rhodes Technologies | Process for improved oxycodone synthesis |
CN106029669A (en) * | 2014-01-15 | 2016-10-12 | 罗德科技公司 | Process for improved oxymorphone synthesis |
US10189852B2 (en) | 2014-01-15 | 2019-01-29 | Rhodes Technologies | Process for improved oxymorphone synthesis |
US9938285B2 (en) | 2014-01-15 | 2018-04-10 | Rhodes Technologies | Process for improved oxymorphone synthesis |
WO2015107472A1 (en) | 2014-01-15 | 2015-07-23 | Rhodes Technologies | Process for improved oxymorphone synthesis |
AU2015207734B2 (en) * | 2014-01-15 | 2017-02-23 | Rhodes Technologies | Process for improved oxymorphone synthesis |
EP3186256A1 (en) * | 2014-08-25 | 2017-07-05 | Johnson Matthey Public Limited Company | Improved processes for making opioids including 14-hydroxycodeinone and 14-hydroxymorphinone |
EP4112622A1 (en) * | 2014-08-25 | 2023-01-04 | Macfarlan Smith Limited | Improved processes for making opioids including 14-hydroxycodeinone and 14-hydroxymorphinone |
EP3186256B1 (en) * | 2014-08-25 | 2023-02-22 | Macfarlan Smith Limited | Improved process for making 14-hydroxycodeinone |
US10324632B2 (en) | 2014-08-25 | 2019-06-18 | Johnson Matthey Public Limited Company | Processes for making opioids including 14-hydroxycodeinone and 14-hydroxymorphinone |
AU2014404332B2 (en) * | 2014-08-25 | 2019-07-11 | Macfarlan Smith Limited | Improved processes for making opioids including 14-hydroxycodeinone and 14-hydroxymorphinone |
WO2016032505A1 (en) * | 2014-08-25 | 2016-03-03 | Johnson Matthey Public Limited Company | Improved processes for making opioids including 14-hydroxycodeinone and 14-hydroxymorphinone |
US10649669B2 (en) | 2014-08-25 | 2020-05-12 | Johson Matthey Public Limited Company | Processes for making opioids including 14-hydroxycodeinone and 14-hydroxymorphinone |
US20160168089A1 (en) * | 2014-12-12 | 2016-06-16 | H. Lundbeck A/S | Process for the manufacture of idalopirdine |
EP3252055A1 (en) | 2016-05-31 | 2017-12-06 | Alcaliber Investigacion Desarrollo e Innovacion, S.L. | Process for obtaining 3,14-diacetyloxymorphone from oripavine |
WO2017207519A1 (en) | 2016-05-31 | 2017-12-07 | Alcaliber Investigación Desarrollo E Innovación, S.L. | Process for obtaining 3,14-diacetyloxymorphone from oripavine |
US10927122B2 (en) | 2017-12-05 | 2021-02-23 | Siegfried Ag | Synthesis of noroxymorphone |
WO2019110413A1 (en) * | 2017-12-05 | 2019-06-13 | Siegfried Ag | Synthesis of noroxymorphone |
EP3495371A1 (en) * | 2017-12-05 | 2019-06-12 | Siegfried AG | Synthesis of noroxymorphone |
CN111205296A (en) * | 2018-11-22 | 2020-05-29 | 中国科学院上海有机化学研究所 | Oxycodone compound and intermediate and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
US8309727B2 (en) | 2012-11-13 |
MX2009010931A (en) | 2009-10-29 |
JP2013216696A (en) | 2013-10-24 |
EP2137190B1 (en) | 2013-06-12 |
AU2008241528A1 (en) | 2008-10-30 |
JP5373764B2 (en) | 2013-12-18 |
EP2137190A1 (en) | 2009-12-30 |
AU2008241528B2 (en) | 2013-07-04 |
JP2010524938A (en) | 2010-07-22 |
ES2423180T3 (en) | 2013-09-18 |
US20100048905A1 (en) | 2010-02-25 |
CA2684458A1 (en) | 2008-10-30 |
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