WO2008129928A1 - Réactif de marquage d'une biomolécule et système de détection d'une biomolécule les utilisant - Google Patents

Réactif de marquage d'une biomolécule et système de détection d'une biomolécule les utilisant Download PDF

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Publication number
WO2008129928A1
WO2008129928A1 PCT/JP2008/056573 JP2008056573W WO2008129928A1 WO 2008129928 A1 WO2008129928 A1 WO 2008129928A1 JP 2008056573 W JP2008056573 W JP 2008056573W WO 2008129928 A1 WO2008129928 A1 WO 2008129928A1
Authority
WO
WIPO (PCT)
Prior art keywords
biomolecule
labeling reagent
detection system
same
disclosed
Prior art date
Application number
PCT/JP2008/056573
Other languages
English (en)
Japanese (ja)
Inventor
Kazuya Tsukada
Hisatake Okada
Original Assignee
Konica Minolta Medical & Graphic, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Konica Minolta Medical & Graphic, Inc. filed Critical Konica Minolta Medical & Graphic, Inc.
Publication of WO2008129928A1 publication Critical patent/WO2008129928A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0065—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle
    • A61K49/0067—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle quantum dots, fluorescent nanocrystals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6489—Photoluminescence of semiconductors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

L'invention concerne un réactif de marquage d'une biomolécule qui est sûr pour un composant de corps vivant, tel qu'une cellule vivante ou un tissu vivant, et qui présente une performance électroluminescente élevée et pouvant être détecté avec une sensibilité élevée. Un système de détection d'une biomolécule utilisant le réactif est également décrit. Un réactif de marquage d'une biomolécule est spécifiquement décrit et comprend un point quantique fluorescent qui donne un résultat négatif dans le test d'Ames et une valeur de PII (une valeur d'irritation de peau) de 1,0 ou moins.
PCT/JP2008/056573 2007-04-18 2008-04-02 Réactif de marquage d'une biomolécule et système de détection d'une biomolécule les utilisant WO2008129928A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007109155 2007-04-18
JP2007-109155 2007-04-18

Publications (1)

Publication Number Publication Date
WO2008129928A1 true WO2008129928A1 (fr) 2008-10-30

Family

ID=39875456

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/056573 WO2008129928A1 (fr) 2007-04-18 2008-04-02 Réactif de marquage d'une biomolécule et système de détection d'une biomolécule les utilisant

Country Status (1)

Country Link
WO (1) WO2008129928A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2009072441A1 (ja) * 2007-12-05 2011-04-21 コニカミノルタエムジー株式会社 検出方法および検出キット

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JAISWAL J.K. ET AL.: "Use of fluorescent quantum dots for studying live cells and organisms", PROCEEDINGS. SPIE - THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING, vol. 5705, 2005, pages 210 - 216 *
SHIOHARA A. ET AL.: "Ryoshi-dot no Hyomen Kako to Anzensei Hyoka", BIOIMAGING, vol. 14, no. 3, 26 September 2005 (2005-09-26), pages 191 - 192 *
VOURA E.B. ET AL.: "Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy", NATURE MEDICINE, vol. 10, no. 9, September 2004 (2004-09-01), pages 993 - 998, XP002490537 *
YAMAMOTO K. ET AL.: "Handotai nado Nano-ryushi ni yoru Seibutsu . Iryo Oyo, Handotai nado-Nano-ryushi ni yoru DDS", HEISEI 15 NENDO SOKATSU . BUNTAN KENKYU HOKOKUSHO, 2004, pages 11 - 16 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2009072441A1 (ja) * 2007-12-05 2011-04-21 コニカミノルタエムジー株式会社 検出方法および検出キット

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