WO2008129465A3 - Stable pharmaceutical compositions of bupropion - Google Patents

Stable pharmaceutical compositions of bupropion Download PDF

Info

Publication number
WO2008129465A3
WO2008129465A3 PCT/IB2008/051453 IB2008051453W WO2008129465A3 WO 2008129465 A3 WO2008129465 A3 WO 2008129465A3 IB 2008051453 W IB2008051453 W IB 2008051453W WO 2008129465 A3 WO2008129465 A3 WO 2008129465A3
Authority
WO
WIPO (PCT)
Prior art keywords
bupropion
pharmaceutical compositions
stable pharmaceutical
relates
stabilizing agent
Prior art date
Application number
PCT/IB2008/051453
Other languages
French (fr)
Other versions
WO2008129465A2 (en
WO2008129465A9 (en
Inventor
Venkatesh Joshi
Prashant Mandaogade
Mahavir Chaugule
Girish Kumar Jain
Original Assignee
Wockhardt Research Center
Venkatesh Joshi
Prashant Mandaogade
Mahavir Chaugule
Girish Kumar Jain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wockhardt Research Center, Venkatesh Joshi, Prashant Mandaogade, Mahavir Chaugule, Girish Kumar Jain filed Critical Wockhardt Research Center
Publication of WO2008129465A2 publication Critical patent/WO2008129465A2/en
Publication of WO2008129465A3 publication Critical patent/WO2008129465A3/en
Publication of WO2008129465A9 publication Critical patent/WO2008129465A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds

Abstract

The present invention relates to stable pharmaceutical compositions comprising bupropion or salts thereof and a basic stabilizing agent, wherein the stabilizing agent is capable of maintaining a pH of less than 6 around bupropion particles. The invention also relates to processes for the preparation of such compositions.
PCT/IB2008/051453 2007-04-20 2008-04-16 Stable pharmaceutical compositions of bupropion WO2008129465A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN771/MUM/2007 2007-04-20
IN769MU2007 2007-04-20
IN771MU2007 2007-04-20
IN769/MUM/2007 2007-04-20

Publications (3)

Publication Number Publication Date
WO2008129465A2 WO2008129465A2 (en) 2008-10-30
WO2008129465A3 true WO2008129465A3 (en) 2009-08-20
WO2008129465A9 WO2008129465A9 (en) 2009-10-15

Family

ID=39876034

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/051453 WO2008129465A2 (en) 2007-04-20 2008-04-16 Stable pharmaceutical compositions of bupropion

Country Status (1)

Country Link
WO (1) WO2008129465A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5358970A (en) * 1993-08-12 1994-10-25 Burroughs Wellcome Co. Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
US6238697B1 (en) * 1998-12-21 2001-05-29 Pharmalogix, Inc. Methods and formulations for making bupropion hydrochloride tablets using direct compression
US6333332B1 (en) * 2000-08-25 2001-12-25 Impax Laboratories, Inc. Stabilized pharmaceutical compositions containing bupropion hydrochloride
US20050112198A1 (en) * 2003-10-27 2005-05-26 Challapalli Prasad V. Bupropion formulation for sustained delivery

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5358970A (en) * 1993-08-12 1994-10-25 Burroughs Wellcome Co. Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
US6238697B1 (en) * 1998-12-21 2001-05-29 Pharmalogix, Inc. Methods and formulations for making bupropion hydrochloride tablets using direct compression
US6333332B1 (en) * 2000-08-25 2001-12-25 Impax Laboratories, Inc. Stabilized pharmaceutical compositions containing bupropion hydrochloride
US20050112198A1 (en) * 2003-10-27 2005-05-26 Challapalli Prasad V. Bupropion formulation for sustained delivery

Also Published As

Publication number Publication date
WO2008129465A2 (en) 2008-10-30
WO2008129465A9 (en) 2009-10-15

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