WO2008127524A3 - Biomarkers of very rapid antidepressant response and of mechanism of very rapid antidepressant response - Google Patents

Biomarkers of very rapid antidepressant response and of mechanism of very rapid antidepressant response Download PDF

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Publication number
WO2008127524A3
WO2008127524A3 PCT/US2008/003201 US2008003201W WO2008127524A3 WO 2008127524 A3 WO2008127524 A3 WO 2008127524A3 US 2008003201 W US2008003201 W US 2008003201W WO 2008127524 A3 WO2008127524 A3 WO 2008127524A3
Authority
WO
WIPO (PCT)
Prior art keywords
antidepressant response
rapid antidepressant
biomarkers
rapid
response
Prior art date
Application number
PCT/US2008/003201
Other languages
French (fr)
Other versions
WO2008127524A2 (en
Inventor
Marquis P Vawter
Jr William E Bunney
Joseph Wu
Original Assignee
Univ Californina
Marquis P Vawter
Jr William E Bunney
Joseph Wu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Californina, Marquis P Vawter, Jr William E Bunney, Joseph Wu filed Critical Univ Californina
Publication of WO2008127524A2 publication Critical patent/WO2008127524A2/en
Publication of WO2008127524A3 publication Critical patent/WO2008127524A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

This invention provides molecular markers that are indicators of subjects that are likely to respond to sleep deprivation as a treatment for a psychiatric disorder. In particular, genes are identified whose expression is altered in responders to sleep deprivation for the treatment of a psychiatric disorder (e.g., depression, mania, etc.).
PCT/US2008/003201 2007-03-07 2008-03-07 Biomarkers of very rapid antidepressant response and of mechanism of very rapid antidepressant response WO2008127524A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89359007P 2007-03-07 2007-03-07
US60/893,590 2007-03-07

Publications (2)

Publication Number Publication Date
WO2008127524A2 WO2008127524A2 (en) 2008-10-23
WO2008127524A3 true WO2008127524A3 (en) 2009-03-26

Family

ID=39864575

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/003201 WO2008127524A2 (en) 2007-03-07 2008-03-07 Biomarkers of very rapid antidepressant response and of mechanism of very rapid antidepressant response

Country Status (1)

Country Link
WO (1) WO2008127524A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10731216B2 (en) 2014-09-10 2020-08-04 Northernlight Diagnostics Ab Methods and compositions for biomarkers of depression and pharmacoresponse
CN111453831A (en) * 2020-05-11 2020-07-28 浙江养生堂天然药物研究所有限公司 Drinking water for improving sleep quality

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050186138A1 (en) * 2003-10-16 2005-08-25 Irm, Llc Methods and compositions for modulating circadian rhythm

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050186138A1 (en) * 2003-10-16 2005-08-25 Irm, Llc Methods and compositions for modulating circadian rhythm

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BUNNEY ET AL.: "Microarray Technology: A Review of New Strategies to Discover Candidate Vulnerability Genes in Psychiatric Disorders", AM J PSYCHIATRY, vol. 160, 2003, pages 657 - 666 *
BUNNEY ET AL.: "Molecular Clock Genes in Man and Lower Animals: Possible Implications for Circadian Abnormalities in Depression", NEUROPSYCHOPHARMACOLOGY, vol. 22, 2000, pages 335 - 345 *
CONTI ET AL.: "Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine", MOLECULAR PSYCHIATRY, vol. 12, February 2007 (2007-02-01), pages 167 - 189 *
D'HAENEN ET AL.: "Biological Psychiatry", vol. II, 2002, JOHN WILEY AND SONS, ISBN: 0471491985 *
VAWTER: "NIH Grant 1R21MH074307-01", NIH GRANT 1R21MH074307-01, 2005, Retrieved from the Internet <URL:http://crisp.cit.nih.gov> [retrieved on 20081218] *

Also Published As

Publication number Publication date
WO2008127524A2 (en) 2008-10-23

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