WO2008126430A1 - 組織保存液の評価方法 - Google Patents

組織保存液の評価方法 Download PDF

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Publication number
WO2008126430A1
WO2008126430A1 PCT/JP2008/050599 JP2008050599W WO2008126430A1 WO 2008126430 A1 WO2008126430 A1 WO 2008126430A1 JP 2008050599 W JP2008050599 W JP 2008050599W WO 2008126430 A1 WO2008126430 A1 WO 2008126430A1
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
preservation solution
evaluation
tissue preservation
luminescence
Prior art date
Application number
PCT/JP2008/050599
Other languages
English (en)
French (fr)
Inventor
Eiji Kobayashi
Original Assignee
Otsuka Pharmaceutical Factory, Inc.
Jichi Medical University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Factory, Inc., Jichi Medical University filed Critical Otsuka Pharmaceutical Factory, Inc.
Priority to EP08703449A priority Critical patent/EP2135958A4/en
Priority to CA2680739A priority patent/CA2680739C/en
Priority to JP2009508930A priority patent/JP5198433B2/ja
Priority to US12/450,116 priority patent/US8871440B2/en
Priority to CN200880007925.1A priority patent/CN101778948B/zh
Priority to AU2008238756A priority patent/AU2008238756B2/en
Publication of WO2008126430A1 publication Critical patent/WO2008126430A1/ja
Priority to IL200826A priority patent/IL200826A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements

Abstract

　本発明は、発光又は蛍光標識遺伝子が導入された哺乳動物組織を組織保存液に浸漬すること、浸漬後の該組織中の該標識遺伝子による発光又は蛍光レベルを測定すること、及び発光又は蛍光レベルに基づき組織保存液の保存効果を判定することを含む、組織保存液の保存効果の評価方法を提供する。
PCT/JP2008/050599 2007-03-13 2008-01-18 組織保存液の評価方法 WO2008126430A1 (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP08703449A EP2135958A4 (en) 2007-03-13 2008-01-18 METHOD FOR EVALUATING A TISSUE CONSERVATION SOLUTION
CA2680739A CA2680739C (en) 2007-03-13 2008-01-18 Method for evaluation of tissue preservation solution
JP2009508930A JP5198433B2 (ja) 2007-03-13 2008-01-18 組織保存液の評価方法
US12/450,116 US8871440B2 (en) 2007-03-13 2008-01-18 Method for evaluation of tissue preservation solution
CN200880007925.1A CN101778948B (zh) 2007-03-13 2008-01-18 评价组织保存溶液的方法
AU2008238756A AU2008238756B2 (en) 2007-03-13 2008-01-18 Method for evaluation of tissue preservation solution
IL200826A IL200826A (en) 2007-03-13 2009-09-08 A method for evaluating a tissue preservation solution

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007064171 2007-03-13
JP2007-064171 2007-03-13

Publications (1)

Publication Number Publication Date
WO2008126430A1 true WO2008126430A1 (ja) 2008-10-23

Family

ID=39863589

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/050599 WO2008126430A1 (ja) 2007-03-13 2008-01-18 組織保存液の評価方法

Country Status (10)

Country Link
US (1) US8871440B2 (ja)
EP (1) EP2135958A4 (ja)
JP (1) JP5198433B2 (ja)
KR (1) KR20090130184A (ja)
CN (1) CN101778948B (ja)
AU (1) AU2008238756B2 (ja)
CA (1) CA2680739C (ja)
IL (1) IL200826A (ja)
TW (1) TW200836625A (ja)
WO (1) WO2008126430A1 (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014004907A2 (pt) 2011-08-30 2017-03-28 Watlow Electric Mfg método e sistema para controlar uma matriz térmica
EP3015545B1 (en) * 2013-06-28 2018-12-26 Otsuka Pharmaceutical Factory, Inc. Trehalose and dextran-containing solution for transplanting mammalian cells

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0640801A (ja) * 1992-07-24 1994-02-15 Morishita Roussel Kk 移植臓器用溶液
JPH08325101A (ja) * 1995-05-31 1996-12-10 Seitai Kagaku Kenkyusho:Kk 動物組織保存方法
WO2005115141A1 (ja) * 2004-05-26 2005-12-08 National University Corporation Kagawa University 希少糖を利用した細胞・組織・臓器保存液及び該液を用いる保存方法
JP2007064171A (ja) 2005-09-02 2007-03-15 Toyota Motor Corp 火花点火内燃機関

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976796A (en) 1996-10-04 1999-11-02 Loma Linda University Construction and expression of renilla luciferase and green fluorescent protein fusion genes
US6045990A (en) * 1998-07-09 2000-04-04 Baust; John M. Inclusion of apoptotic regulators in solutions for cell storage at low temperature
US6365338B1 (en) * 1999-04-27 2002-04-02 David A. Bull Organ preservative solution containing trehalose, anti-oxidant, cations and an energy source
US6790636B1 (en) 2000-06-14 2004-09-14 The United States Of America As Represented By The Department Of Health And Human Services Rapid fluorescent labeling of tissue for microdissection using fluorescent specific binding agents
US7179658B2 (en) * 2001-09-06 2007-02-20 Beckman Coulter, Inc. Particle based homogeneous assays using capillary electrophoresis with laser-induced fluorescence detection
US6989891B2 (en) * 2001-11-08 2006-01-24 Optiscan Biomedical Corporation Device and method for in vitro determination of analyte concentrations within body fluids
US6921633B2 (en) 2002-11-18 2005-07-26 Biolife Solutions Incorporated Methods and compositions for the preservation of cells, tissues or organs in the vitreous state
WO2005007192A2 (en) * 2003-06-06 2005-01-27 Fibrogen, Inc. Cytoprotection through the use of hif hydroxylase inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0640801A (ja) * 1992-07-24 1994-02-15 Morishita Roussel Kk 移植臓器用溶液
JPH08325101A (ja) * 1995-05-31 1996-12-10 Seitai Kagaku Kenkyusho:Kk 動物組織保存方法
WO2005115141A1 (ja) * 2004-05-26 2005-12-08 National University Corporation Kagawa University 希少糖を利用した細胞・組織・臓器保存液及び該液を用いる保存方法
JP2007064171A (ja) 2005-09-02 2007-03-15 Toyota Motor Corp 火花点火内燃機関

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
ANNU. REV. BIOMED. ENG., vol. 4, 2002, pages 235
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 329, no. 1, 2005, pages 288
CONTAG P.R. ET AL.: "Bioluminescent indicators in living mammals", NAT. MED., vol. 4, no. 2, 1998, pages 245 - 247, XP000914588 *
INOUE H. ET AL.: "Development of new inbred transgenic strains of rats with LacZ or GFP", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 329, no. 1, 2005, pages 288 - 295, XP004757029 *
J. BIOMED. OPT., vol. 10, no. 4, 2005, pages 41204
LIPPINCOTT-SCHWARTZ J. ET AL.: "Development and use of fluorescent protein markers in living cells", SCIENCE, vol. 300, no. 5616, 2003, pages 87 - 91, XP009053701 *
MURAKAMI T. ET AL.: "Genetic modification in organ transplantation and in vivo luciferase imagin", PROC. SPIE INT. SOC. OPT. ENG., vol. 5704, 2005, pages 169 - 176, XP008137512 *
NAT. MED., vol. 4, no. 2, 1998, pages 245
SCIENCE, vol. 300, no. 5616, 2003, pages 87
See also references of EP2135958A4
TRANSPLANTATION, vol. 81, no. 8, 2006
TRANSPLANTATION, vol. 81, no. 8, 2006, pages 1179 - 1184

Also Published As

Publication number Publication date
CN101778948B (zh) 2014-03-19
EP2135958A4 (en) 2010-05-26
AU2008238756B2 (en) 2013-09-19
IL200826A (en) 2013-03-24
JPWO2008126430A1 (ja) 2010-07-22
AU2008238756A1 (en) 2008-10-23
US20100028883A1 (en) 2010-02-04
TW200836625A (en) 2008-09-16
CA2680739A1 (en) 2008-10-23
US8871440B2 (en) 2014-10-28
CN101778948A (zh) 2010-07-14
KR20090130184A (ko) 2009-12-18
EP2135958A1 (en) 2009-12-23
JP5198433B2 (ja) 2013-05-15
CA2680739C (en) 2013-04-09
IL200826A0 (en) 2010-05-17

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