WO2008125989A3 - Polyketide based proteasome inhibitor - Google Patents

Polyketide based proteasome inhibitor Download PDF

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Publication number
WO2008125989A3
WO2008125989A3 PCT/IB2008/001890 IB2008001890W WO2008125989A3 WO 2008125989 A3 WO2008125989 A3 WO 2008125989A3 IB 2008001890 W IB2008001890 W IB 2008001890W WO 2008125989 A3 WO2008125989 A3 WO 2008125989A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteasome inhibitor
polyketide
based proteasome
polyketide based
proteasome
Prior art date
Application number
PCT/IB2008/001890
Other languages
French (fr)
Other versions
WO2008125989A2 (en
Inventor
Rolf Mueller
Helge Bjoern Bode
Silke Christine Wenzel
Yasser Abbas Elnakady
Original Assignee
Saarland University
Rolf Mueller
Helge Bjoern Bode
Silke Christine Wenzel
Yasser Abbas Elnakady
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Saarland University, Rolf Mueller, Helge Bjoern Bode, Silke Christine Wenzel, Yasser Abbas Elnakady filed Critical Saarland University
Publication of WO2008125989A2 publication Critical patent/WO2008125989A2/en
Publication of WO2008125989A3 publication Critical patent/WO2008125989A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)

Abstract

A method of inhibiting the proteasome comprising contacting the proteasome with a polyketide.
PCT/IB2008/001890 2007-04-16 2008-04-16 Polyketide based proteasome inhibitor WO2008125989A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0707315A GB0707315D0 (en) 2007-04-16 2007-04-16 Novel proteasome inhibitor
GB0707315.8 2007-04-16

Publications (2)

Publication Number Publication Date
WO2008125989A2 WO2008125989A2 (en) 2008-10-23
WO2008125989A3 true WO2008125989A3 (en) 2009-05-22

Family

ID=38116810

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/001890 WO2008125989A2 (en) 2007-04-16 2008-04-16 Polyketide based proteasome inhibitor

Country Status (2)

Country Link
GB (1) GB0707315D0 (en)
WO (1) WO2008125989A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111650898B (en) * 2020-05-13 2023-10-20 大唐七台河发电有限责任公司 Distributed control system and method with high fault tolerance performance

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004012732A2 (en) * 2002-07-31 2004-02-12 Charité-Universitätsmedizin Berlin Use of a proteasome inhibitor in the treatment of endothelial dysfunction and/or in a low-dose proteasome inhibitor therapy
WO2006081371A2 (en) * 2005-01-27 2006-08-03 Research Development Foundation Combination therapy with triterpenoid compounds and proteasome inhibitors
US20070191917A1 (en) * 2006-02-16 2007-08-16 Vassiliki Poulaki Methods and compositions for treating conditions of the eye
US20070249540A1 (en) * 2004-05-24 2007-10-25 Adonia Papathanassiu Methods for Inhibiting Proteasome and Heat Shock Protein 90

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004012732A2 (en) * 2002-07-31 2004-02-12 Charité-Universitätsmedizin Berlin Use of a proteasome inhibitor in the treatment of endothelial dysfunction and/or in a low-dose proteasome inhibitor therapy
US20070249540A1 (en) * 2004-05-24 2007-10-25 Adonia Papathanassiu Methods for Inhibiting Proteasome and Heat Shock Protein 90
WO2006081371A2 (en) * 2005-01-27 2006-08-03 Research Development Foundation Combination therapy with triterpenoid compounds and proteasome inhibitors
US20070191917A1 (en) * 2006-02-16 2007-08-16 Vassiliki Poulaki Methods and compositions for treating conditions of the eye

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CRAWFORD LISA J A ET AL: "Comparative selectivity and specificity of the proteasome inhibitors BzLLLCOCHO, PS-341, and MG-132", CANCER RESEARCH, vol. 66, no. 12, June 2006 (2006-06-01), pages 6379 - 6386, XP002519458, ISSN: 0008-5472 *
ELNAKADY YASSER A ET AL: "Evidence for the mode of action of the highly cytotoxic streptomyces polyketide kendomycin", CHEMBIOCHEM - A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY, WILEY VCH, WEINHEIM, DE, vol. 8, no. 11, 1 July 2007 (2007-07-01), pages 1261 - 1271, XP009111157, ISSN: 1439-4227 *
FEKETE MIRELA R ET AL: "Anthracyclines, proteasome activity and multi-drug-resistance", BMC CANCER, BIOMED CENTRAL, LONDON, GB, vol. 5, no. 1, 13 September 2005 (2005-09-13), pages 114, XP021004719, ISSN: 1471-2407 *
GROLL MICHAEL, ROBERT HUBER: "Inhibitors of the eukariotic proteasome core particle: a structural approach", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1695, 2004, pages 33 - 44, XP004663734 *
HYUN A. KIM ET AL.: "Facilitation of Fas mediated Aptosis of Human Chondrocytes by Proteasome Inhibitor an Actinomycin D", J. RHEUMATOLOGY, vol. 30, no. 3, 2003, pages 550 - 558, XP009113364 *
KOHNO J ET AL: "Structures of TMC-95A-D: novel proteasome inhibitors from Apiospora montagnei sacc. TC 1093.", THE JOURNAL OF ORGANIC CHEMISTRY 25 FEB 2000, vol. 65, no. 4, 25 February 2000 (2000-02-25), pages 990 - 995, XP002518171, ISSN: 0022-3263 *
MOORE B S ET AL: "Advances in and applications of proteasome inhibitors", CURRENT OPINION IN CHEMICAL BIOLOGY, CURRENT BIOLOGY LTD, LONDON, GB, vol. 12, no. 4, 1 August 2008 (2008-08-01), pages 434 - 440, XP024528063, ISSN: 1367-5931, [retrieved on 20080724] *
YUAN YU ET AL: "Total synthesis of kendomycin: a macro-C-glycosidation approach.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 17 NOV 2004, vol. 126, no. 45, 17 November 2004 (2004-11-17), pages 14720 - 14721, XP002518170, ISSN: 0002-7863 *

Also Published As

Publication number Publication date
GB0707315D0 (en) 2007-05-23
WO2008125989A2 (en) 2008-10-23

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