WO2008125616A3 - Method for the purification of bio-molecules - Google Patents

Method for the purification of bio-molecules Download PDF

Info

Publication number
WO2008125616A3
WO2008125616A3 PCT/EP2008/054407 EP2008054407W WO2008125616A3 WO 2008125616 A3 WO2008125616 A3 WO 2008125616A3 EP 2008054407 W EP2008054407 W EP 2008054407W WO 2008125616 A3 WO2008125616 A3 WO 2008125616A3
Authority
WO
WIPO (PCT)
Prior art keywords
interest
compound
present
slurry
mixture
Prior art date
Application number
PCT/EP2008/054407
Other languages
French (fr)
Other versions
WO2008125616A2 (en
Inventor
Van De Emilius Johannes Albertus Xaverius Sandt
Aad Johannes Bouman
Burchart De Erik Vos
Original Assignee
Dsm Ip Assets Bv
Van De Emilius Johannes Albertus Xaverius Sandt
Aad Johannes Bouman
Burchart De Erik Vos
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv, Van De Emilius Johannes Albertus Xaverius Sandt, Aad Johannes Bouman, Burchart De Erik Vos filed Critical Dsm Ip Assets Bv
Publication of WO2008125616A2 publication Critical patent/WO2008125616A2/en
Publication of WO2008125616A3 publication Critical patent/WO2008125616A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Abstract

The present invention provides a method for purifying a compound of interest comprising the steps of: i.) Adjusting the pH of an aqueous mixture comprising biomass and said compound of interest to a value at which the amount of dissolved compound of interest is less than 10% of the total amount of said compound of interest present in said mixture; ii.) Isolating a slurry from the mixture obtained in step i.) by removing at least 40% of the water present in the mixture obtained in step L); iii.) Adjusting the pH of the slurry obtained in step ii.) to a value at which the amount of dissolved compound of interest is more than 90% of the total amount of said compound of interest present in said slurry; iv.) Removing solids from the mixture obtained in step iii.) to give a solution comprising said compound of interest, wherein said removing in steps ii.) and iv.) is carried out with the same means.
PCT/EP2008/054407 2007-04-12 2008-04-11 Method for the purification of bio-molecules WO2008125616A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07106017 2007-04-12
EP07106017.2 2007-04-12

Publications (2)

Publication Number Publication Date
WO2008125616A2 WO2008125616A2 (en) 2008-10-23
WO2008125616A3 true WO2008125616A3 (en) 2009-01-22

Family

ID=38266720

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/054407 WO2008125616A2 (en) 2007-04-12 2008-04-11 Method for the purification of bio-molecules

Country Status (1)

Country Link
WO (1) WO2008125616A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102127572B (en) * 2010-12-17 2013-04-10 华东理工大学 Method for producing mycophenolic acid from penicillium brevicompactum by high-efficiency accumulation
CN102391224A (en) * 2011-10-15 2012-03-28 福建和泉生物科技有限公司 Method for preparing crude mycophenolic acid by adopting ultra-nanofiltration membrane separation technology
CN112125794A (en) * 2019-06-24 2020-12-25 阜新达得利化工股份有限公司 Improved preparation method of trifluoro-chloro-chrysanthemic acid

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1158387A (en) * 1967-06-13 1969-07-16 Ici Ltd Procedure for Isolation of Mycophenolic Acid
US4452891A (en) * 1980-09-08 1984-06-05 Ajinomoto Company Incorporated Method for production of mycophenolic acid by fermentation
WO2001064931A1 (en) * 2000-02-29 2001-09-07 Biocon India Limited Manufacture and purification of mycophenolic acid
WO2005105768A2 (en) * 2004-04-26 2005-11-10 Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg Process for preparation of mycophenolic acid and ester derivatives thereof
WO2005105771A1 (en) * 2004-04-27 2005-11-10 Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid
EP1624070A1 (en) * 2004-08-05 2006-02-08 Tecnimede-Sociedade Tecnico-Medicinal, S.A. Process for the production of mycophenolic acid
WO2006031665A1 (en) * 2004-09-10 2006-03-23 Ivax Pharmaceuticals S.R.O. Process for isolation of mycophenolic acid

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1158387A (en) * 1967-06-13 1969-07-16 Ici Ltd Procedure for Isolation of Mycophenolic Acid
US4452891A (en) * 1980-09-08 1984-06-05 Ajinomoto Company Incorporated Method for production of mycophenolic acid by fermentation
WO2001064931A1 (en) * 2000-02-29 2001-09-07 Biocon India Limited Manufacture and purification of mycophenolic acid
WO2005105768A2 (en) * 2004-04-26 2005-11-10 Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg Process for preparation of mycophenolic acid and ester derivatives thereof
WO2005105771A1 (en) * 2004-04-27 2005-11-10 Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid
EP1624070A1 (en) * 2004-08-05 2006-02-08 Tecnimede-Sociedade Tecnico-Medicinal, S.A. Process for the production of mycophenolic acid
WO2006031665A1 (en) * 2004-09-10 2006-03-23 Ivax Pharmaceuticals S.R.O. Process for isolation of mycophenolic acid

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WILLIAMS R H ET AL: "FERMENTATION, ISOLATION, AND BIOLOGICAL PROPERTIES OF MYCOPHENOLIC ACID", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 8, 1968, pages 229 - 233, XP000956424, ISSN: 0066-4804 *

Also Published As

Publication number Publication date
WO2008125616A2 (en) 2008-10-23

Similar Documents

Publication Publication Date Title
WO2008091740A3 (en) Polyelectrolyte precipitation and purification of antibodies
WO2010048355A3 (en) Process for enhanced total organic carbon removal while maintaining optimum membrane filter performance
WO2006074331A3 (en) Distillation process
WO2007008630A3 (en) Floating sequencing batch reactor and method for wastewater treatment
WO2008006038A3 (en) Methods and compositions for butanol production
WO2009099485A8 (en) Methods and systems for processing waste water
WO2008127305A3 (en) Method of isolating biomacromolecules using low ph and divalent cations
MD20070214A (en) Process for producing wine and wine obtained by said process
WO2011073335A3 (en) Method for producing potable water and/or purifying water including the elimination of a target compound and filtration within a filter drum
WO2011131532A3 (en) Method for the manufacture of an ammonium sulfate composition
WO2009071428A3 (en) Method for producing biogas from a fermentation substrate having an adjusted ammonia-nitrogen concentration
WO2009027200A3 (en) Method for purifying polycrystalline silicon
WO2008125616A3 (en) Method for the purification of bio-molecules
WO2007076943A3 (en) System and method for the renovation of process water
MX2010009950A (en) Method for purifying methacrylic acid.
WO2008027570A9 (en) Method of isolating shikimic acid from a plant
WO2012094286A3 (en) Phosphoric acid production gypsum filtration flocculant pre-dilution (make down) with post-filtration phosphoric acid
WO2007041994A3 (en) Method for initiating microbiological processes in artificial waters
WO2006108663A8 (en) Method for recovering a basic amino acid from a fermentation liquor
TW200611901A (en) Method for producing 1, 3-dioxolan-4, 6-dione compound
WO2008101000A3 (en) Composition and method for agglomerating solids in solid-liquid separation processes
WO2009062601A3 (en) Method for the fermentative production of butanol from a mash from which non-fermentable substances and solids were separated prior to fermentation
TW200640378A (en) A process for recycling and reusing waste medium for mushroom culture
WO2007055771A3 (en) Dual injection of two polymeric filtration aids for gypsum removal from phosphoric acid/gypsum slurry
PL1786974T3 (en) Device and method for production of cellulose-based products

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08736120

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08736120

Country of ref document: EP

Kind code of ref document: A2