WO2008121813A3 - Modulation of cytokine production - Google Patents

Modulation of cytokine production Download PDF

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Publication number
WO2008121813A3
WO2008121813A3 PCT/US2008/058648 US2008058648W WO2008121813A3 WO 2008121813 A3 WO2008121813 A3 WO 2008121813A3 US 2008058648 W US2008058648 W US 2008058648W WO 2008121813 A3 WO2008121813 A3 WO 2008121813A3
Authority
WO
WIPO (PCT)
Prior art keywords
cytokine production
modulation
duba
polypeptides
methods
Prior art date
Application number
PCT/US2008/058648
Other languages
French (fr)
Other versions
WO2008121813A2 (en
Inventor
Vishva Dixit
Nobuhiko Kayagaki
Original Assignee
Genentech Inc
Vishva Dixit
Nobuhiko Kayagaki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc, Vishva Dixit, Nobuhiko Kayagaki filed Critical Genentech Inc
Publication of WO2008121813A2 publication Critical patent/WO2008121813A2/en
Publication of WO2008121813A3 publication Critical patent/WO2008121813A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/19—Omega peptidases (3.4.19)
    • C12Y304/19012—Ubiquitinyl hydrolase 1 (3.4.19.12)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Methods of using DUBA polypeptides and nucleic acids in modulating cytokine production and in modulating immune response are provided. Methods of diagnosing and treating certain pathophysiological conditions using the DUBA polypeptides and nucleic acids of the invention are also provided.
PCT/US2008/058648 2007-03-30 2008-03-28 Modulation of cytokine production WO2008121813A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92090307P 2007-03-30 2007-03-30
US60/920,903 2007-03-30

Publications (2)

Publication Number Publication Date
WO2008121813A2 WO2008121813A2 (en) 2008-10-09
WO2008121813A3 true WO2008121813A3 (en) 2009-02-05

Family

ID=39808870

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/058648 WO2008121813A2 (en) 2007-03-30 2008-03-28 Modulation of cytokine production

Country Status (1)

Country Link
WO (1) WO2008121813A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007120334A2 (en) 2005-12-15 2007-10-25 Genentech, Inc. Methods and compositions for targeting polyubiquitin
ES2414804T3 (en) 2008-01-18 2013-07-22 Genentech, Inc. Methods and compositions that target polyubiquitin
EP2558496B1 (en) * 2010-04-15 2018-07-25 Genentech, Inc. Anti-polyubiquitin antibodies and methods of use
EP2739651B1 (en) 2011-08-05 2019-02-20 Genentech, Inc. Anti-polyubiquitin antibodies and methods of use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005046452A2 (en) * 2003-11-10 2005-05-26 The Board Of Trustees Of The Leland Stanford Junior University A polypeptide complex that regulates cell cycle and anergy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005046452A2 (en) * 2003-11-10 2005-05-26 The Board Of Trustees Of The Leland Stanford Junior University A polypeptide complex that regulates cell cycle and anergy

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BALAKIREV MY ET AL: "Otubains: a new family of cysteine proteases in the ubiquitin pathway", EMBO REPORTS, XX, XX, vol. 4, no. 5, 18 April 2003 (2003-04-18), pages 517 - 522, XP002993680 *
KAYAGAKI NOBUHIKO ET AL: "DUBA: a deubiquitinase that regulates type I interferon production.", SCIENCE (NEW YORK, N.Y.) 7 DEC 2007, vol. 318, no. 5856, 7 December 2007 (2007-12-07), pages 1628 - 1632, XP002504119, ISSN: 1095-9203 *
KAYAGAKI NOBUHIKO ET AL: "DUBA: a deubiquitinase that regulates type I interferon production.", SCIENCE EXPRESS, vol. 318, 8 November 2007 (2007-11-08), XP002504186, Retrieved from the Internet <URL:www.sciencemag.org/cgi/content/full/1145918/DC1> [retrieved on 20081115] *
NIJMAN SEBASTIAN M B ET AL: "A genomic and functional inventory of deubiquitinating enzymes.", CELL 2 DEC 2005, vol. 123, no. 5, 2 December 2005 (2005-12-02), pages 773 - 786, XP002504120, ISSN: 0092-8674 *

Also Published As

Publication number Publication date
WO2008121813A2 (en) 2008-10-09

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