WO2008121385A3 - Compositions and methods useful for modulating spondyloarthropathies - Google Patents

Compositions and methods useful for modulating spondyloarthropathies Download PDF

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Publication number
WO2008121385A3
WO2008121385A3 PCT/US2008/004165 US2008004165W WO2008121385A3 WO 2008121385 A3 WO2008121385 A3 WO 2008121385A3 US 2008004165 W US2008004165 W US 2008004165W WO 2008121385 A3 WO2008121385 A3 WO 2008121385A3
Authority
WO
WIPO (PCT)
Prior art keywords
spondyloarthropathies
modulating
upr
tlr
hla
Prior art date
Application number
PCT/US2008/004165
Other languages
French (fr)
Other versions
WO2008121385A2 (en
Inventor
Robert A Colbert
Matthew Turner
Judith A Smith
Original Assignee
Childrens Hosp Medical Center
Robert A Colbert
Matthew Turner
Judith A Smith
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Hosp Medical Center, Robert A Colbert, Matthew Turner, Judith A Smith filed Critical Childrens Hosp Medical Center
Publication of WO2008121385A2 publication Critical patent/WO2008121385A2/en
Publication of WO2008121385A3 publication Critical patent/WO2008121385A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed

Abstract

The invention relates to the discovery that HLA-B27 stimulates the unfolded protein response and that the unfolded protein response (UPR) and toll-like receptor (TLR) activation exhibit a synergistic effect. The UPR-TLR synergy results in among other things significantly increased expression of a set of genes. HLA-B27 activation of the UPR and the UPR-TLR synergy contributes to the development of various disorders including spondyloarthropathies. Thus the invention provides methods of modulating an HLA-B27 pathway and modulating various disorders including spondyloarthropathies.
PCT/US2008/004165 2007-03-30 2008-03-31 Compositions and methods useful for modulating spondyloarthropathies WO2008121385A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92090107P 2007-03-30 2007-03-30
US60/920,901 2007-03-30

Publications (2)

Publication Number Publication Date
WO2008121385A2 WO2008121385A2 (en) 2008-10-09
WO2008121385A3 true WO2008121385A3 (en) 2008-12-18

Family

ID=39808835

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/004165 WO2008121385A2 (en) 2007-03-30 2008-03-31 Compositions and methods useful for modulating spondyloarthropathies

Country Status (1)

Country Link
WO (1) WO2008121385A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9884087B1 (en) 2013-05-03 2018-02-06 Chan Soon-Shiong Nanthealth Foundation Compositions and methods of improved wound healing
WO2021138568A1 (en) * 2020-01-03 2021-07-08 Sanford Burnham Prebys Medical Discovery Institute Methods and compositions for binding immunoglobulin protein targeting

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004046098A2 (en) * 2002-05-16 2004-06-03 Vanderbilt University Method for predicting autoimmune diseases
US20040176239A1 (en) * 2003-03-03 2004-09-09 Tomoyuki Nakamura Dielectric ceramic, manufacturing method thereof, and multilayer ceramic capacitor
WO2005083125A2 (en) * 2004-02-20 2005-09-09 Biogen Idec Ma Inc. Surrogate markers of neuropathic pain
US20050221432A1 (en) * 2004-03-31 2005-10-06 Michael Rycyzyn Methods for altering protein production rates
US20060063187A1 (en) * 2004-09-15 2006-03-23 Hotamisligil Gokhan S Modulation of XBP-1 activity for treatment of metabolic disorders
US20060193869A1 (en) * 2004-12-17 2006-08-31 Franck Barrat Methods and compositions for induction or promotion of immune tolerance
US20060270003A1 (en) * 2003-07-08 2006-11-30 Genentech, Inc. IL-17A/F heterologous polypeptides and therapeutic uses thereof

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004046098A2 (en) * 2002-05-16 2004-06-03 Vanderbilt University Method for predicting autoimmune diseases
US20040176239A1 (en) * 2003-03-03 2004-09-09 Tomoyuki Nakamura Dielectric ceramic, manufacturing method thereof, and multilayer ceramic capacitor
US20060270003A1 (en) * 2003-07-08 2006-11-30 Genentech, Inc. IL-17A/F heterologous polypeptides and therapeutic uses thereof
WO2005083125A2 (en) * 2004-02-20 2005-09-09 Biogen Idec Ma Inc. Surrogate markers of neuropathic pain
US20050221432A1 (en) * 2004-03-31 2005-10-06 Michael Rycyzyn Methods for altering protein production rates
US20060063187A1 (en) * 2004-09-15 2006-03-23 Hotamisligil Gokhan S Modulation of XBP-1 activity for treatment of metabolic disorders
US20060193869A1 (en) * 2004-12-17 2006-08-31 Franck Barrat Methods and compositions for induction or promotion of immune tolerance

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KJER S. ET AL.: "Intrinsic susceptibility to misfolding of a hot-spot for Hirschsprung disease mutations in the ectodomain of RET", HUMAN GENETICS, vol. 12, no. 17, 2003, pages 2133 - 2144, XP003024217 *
MURPHY C.A. ET AL.: "Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation", J. EXP. MED., vol. 198, no. 12, 2003, pages 1951 - 1957, XP002294202 *
TAN ET AL.: "HLA-B27 in transgenic rats forms disulfide-linked heavy chain oligomers and multimers that bind to the chaperone BiP", J. IMMUNOL., vol. 172, no. 8, 2004, pages 5110 - 5119 *

Also Published As

Publication number Publication date
WO2008121385A2 (en) 2008-10-09

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