WO2008120998A3 - Acoustically sensitive drug delivery particles - Google Patents

Acoustically sensitive drug delivery particles Download PDF

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Publication number
WO2008120998A3
WO2008120998A3 PCT/NO2008/000115 NO2008000115W WO2008120998A3 WO 2008120998 A3 WO2008120998 A3 WO 2008120998A3 NO 2008000115 W NO2008000115 W NO 2008000115W WO 2008120998 A3 WO2008120998 A3 WO 2008120998A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug delivery
sensitive drug
delivery particles
acoustically sensitive
carrying particles
Prior art date
Application number
PCT/NO2008/000115
Other languages
French (fr)
Other versions
WO2008120998A2 (en
Inventor
Sigrid L Fossheim
Cecilia Leal Lauten
Petras Juzenas
Karen Sibylla Rognavaldsson
Esben A Nilssen
Original Assignee
Epitarget As
Sigrid L Fossheim
Cecilia Leal Lauten
Petras Juzenas
Karen Sibylla Rognavaldsson
Esben A Nilssen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NO20071688A external-priority patent/NO328851B1/en
Priority claimed from NO20072822A external-priority patent/NO20072822L/en
Application filed by Epitarget As, Sigrid L Fossheim, Cecilia Leal Lauten, Petras Juzenas, Karen Sibylla Rognavaldsson, Esben A Nilssen filed Critical Epitarget As
Priority to EP08741712A priority Critical patent/EP2142167A2/en
Priority to US12/285,120 priority patent/US20090098212A1/en
Publication of WO2008120998A2 publication Critical patent/WO2008120998A2/en
Publication of WO2008120998A3 publication Critical patent/WO2008120998A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

Novel ultrasound sensitive drug carrying particles are disclosed, as well as uses and methods thereof. The drug carrying particles accumulate in the diseased target tissue and efficiently release their payload upon ultrasound exposure.
PCT/NO2008/000115 2007-03-30 2008-03-28 Acoustically sensitive drug delivery particles WO2008120998A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP08741712A EP2142167A2 (en) 2007-03-30 2008-03-28 Acoustically sensitive drug delivery particles
US12/285,120 US20090098212A1 (en) 2007-03-30 2008-09-29 Acoustically sensitive drug delivery particle

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
NO20071688A NO328851B1 (en) 2007-03-30 2007-03-30 Ultrasound sensitive particulate material and use of said material for the manufacture of a medicament for the treatment of localized disease, the drug being released by ultrasound
NO20071688 2007-03-30
NO20072822 2007-06-04
NO20072822A NO20072822L (en) 2007-06-04 2007-06-04 Acoustically sensitive drug delivery particles

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/285,120 Continuation-In-Part US20090098212A1 (en) 2007-03-30 2008-09-29 Acoustically sensitive drug delivery particle

Publications (2)

Publication Number Publication Date
WO2008120998A2 WO2008120998A2 (en) 2008-10-09
WO2008120998A3 true WO2008120998A3 (en) 2009-02-05

Family

ID=39651341

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NO2008/000115 WO2008120998A2 (en) 2007-03-30 2008-03-28 Acoustically sensitive drug delivery particles

Country Status (3)

Country Link
US (1) US20090098212A1 (en)
EP (1) EP2142167A2 (en)
WO (1) WO2008120998A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009075582A2 (en) * 2007-12-10 2009-06-18 Epitarget As Acoustically sensitive drug delivery particles comprising non-lamellar forming lipids
US20110020429A1 (en) * 2007-12-10 2011-01-27 Epitarget As Use of particles comprising an alcohol
US20120130288A1 (en) * 2009-03-20 2012-05-24 University Of Cincinnati Ultrasound-mediated inducement, detection, and enhancement of stable cavitation
EP2253308A1 (en) * 2009-05-22 2010-11-24 Ludwig-Maximilians-Universität München Pharmaceutical composition comprising microbubbles for targeted tumor therapy
JP2012529502A (en) * 2009-06-08 2012-11-22 エピターゲット・アーエス Acoustically sensitive drug delivery particles containing non-lamellar-forming phosphatidylcholine
EP2440181A2 (en) 2009-06-08 2012-04-18 Epitarget AS Acoustically sensitive drug delivery particles comprising phosphatidylethanolamine
WO2010143972A2 (en) 2009-06-08 2010-12-16 Epitarget As Acoustically sensitive drug delivery particles comprising non-lamellar forming lipids
US20120148663A1 (en) 2009-06-08 2012-06-14 Epitarget As Lipophilic drug carrier
WO2011078695A2 (en) 2009-12-22 2011-06-30 Epitarget As Acoustically sensitive drug delivery particles comprising low concentrations of phosphatidylethanolamine
TW201208706A (en) 2010-08-17 2012-03-01 Univ Nat Yang Ming Ultrasonically-triggered drug vehicle with magnetic resonance imaging function
JP2014509311A (en) * 2011-01-05 2014-04-17 ザ レジェンツ オブ ザ ユニヴァーシティー オブ カリフォルニア Acoustically responsive particles with low cavitation threshold
KR20150034517A (en) 2013-09-26 2015-04-03 삼성전자주식회사 Liposome comprising a complex of a hydrophobic active ingredient and a polypeptide, and use thereof
KR20150047336A (en) 2013-10-24 2015-05-04 삼성전자주식회사 Nanoparticles, method for the preparation thereof, and use thereof
KR20150062652A (en) 2013-11-29 2015-06-08 삼성전자주식회사 Sonosensitive liposome, a pharmaceutical composition comprising the same and a method of delivering an active agent into a subject using the same
WO2016109892A1 (en) * 2015-01-05 2016-07-14 Crasto Gazelle Ultrasound triggered delivery of growth factors from liposomes for tissue regeneration
CN107530283A (en) 2015-03-03 2018-01-02 奎尔波特股份有限公司 Combine liposomal pharmaceutical preparation
CA2977397A1 (en) * 2015-03-03 2016-09-09 Cureport, Inc. Dual loaded liposomal pharmaceutical formulations
US20230263905A1 (en) * 2020-04-29 2023-08-24 Imgt Co, Ltd. Sonosensitive liposome and method for preparing same

Citations (8)

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Publication number Priority date Publication date Assignee Title
WO1999030620A1 (en) * 1997-12-18 1999-06-24 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
WO2005016141A1 (en) * 2003-07-09 2005-02-24 California Pacific Medical Center Remote detection of substance delivery to cells
US20050260260A1 (en) * 2004-05-19 2005-11-24 Edward Kisak Liposome compositions for the delivery of macromolecules
US20060002994A1 (en) * 2004-03-23 2006-01-05 Thomas James L Responsive liposomes for ultrasonic drug delivery
WO2006042270A1 (en) * 2004-10-08 2006-04-20 Alza Corporation Method of inserion of a lipid-linked moiety into a pre-formed lipid assembly using microwaves
WO2006065432A2 (en) * 2004-12-14 2006-06-22 Watkin, Kenneth L. Nanoparticles for delivery of therapeutic agents using ultrasound and associated methods
WO2008033031A2 (en) * 2006-09-12 2008-03-20 Epitarget As Mri trackable drug delivery particles, uses and methods thereof
WO2008035985A2 (en) * 2006-09-22 2008-03-27 Epitarget As T1 mri trackable drug delivery particles, uses and methods thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776429A (en) * 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US6726925B1 (en) * 1998-06-18 2004-04-27 Duke University Temperature-sensitive liposomal formulation

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999030620A1 (en) * 1997-12-18 1999-06-24 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
WO2005016141A1 (en) * 2003-07-09 2005-02-24 California Pacific Medical Center Remote detection of substance delivery to cells
US20060002994A1 (en) * 2004-03-23 2006-01-05 Thomas James L Responsive liposomes for ultrasonic drug delivery
US20050260260A1 (en) * 2004-05-19 2005-11-24 Edward Kisak Liposome compositions for the delivery of macromolecules
WO2006042270A1 (en) * 2004-10-08 2006-04-20 Alza Corporation Method of inserion of a lipid-linked moiety into a pre-formed lipid assembly using microwaves
WO2006065432A2 (en) * 2004-12-14 2006-06-22 Watkin, Kenneth L. Nanoparticles for delivery of therapeutic agents using ultrasound and associated methods
WO2008033031A2 (en) * 2006-09-12 2008-03-20 Epitarget As Mri trackable drug delivery particles, uses and methods thereof
WO2008035985A2 (en) * 2006-09-22 2008-03-27 Epitarget As T1 mri trackable drug delivery particles, uses and methods thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CALVAGNO MARIA GRAZIA ET AL: "Effects of lipid composition and preparation conditions on physical-chemical properties, technological parameters and in vitro biological activity of gemcitabine-loaded liposomes", CURRENT DRUG DELIVERY, vol. 4, no. 1, January 2007 (2007-01-01), pages 89 - 101, XP002505686, ISSN: 1567-2018 *
LIN HUNG-YIN ET AL: "Factors affecting responsivity of unilamellar liposomes to 20 kHz ultrasound.", LANGMUIR : THE ACS JOURNAL OF SURFACES AND COLLOIDS 20 JUL 2004, vol. 20, no. 15, 20 July 2004 (2004-07-20), pages 6100 - 6106, XP002505685, ISSN: 0743-7463 *
MYHR ET AL: "Synergistic and tumour selective effects of chemotherapy and ultrasound treatment", CANCER LETTERS, NEW YORK, NY, US, vol. 232, no. 2, 8 February 2006 (2006-02-08), pages 206 - 213, XP005273209, ISSN: 0304-3835 *

Also Published As

Publication number Publication date
US20090098212A1 (en) 2009-04-16
EP2142167A2 (en) 2010-01-13
WO2008120998A2 (en) 2008-10-09

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