WO2008120765A1 - Analgesic composition - Google Patents

Analgesic composition Download PDF

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Publication number
WO2008120765A1
WO2008120765A1 PCT/JP2008/056239 JP2008056239W WO2008120765A1 WO 2008120765 A1 WO2008120765 A1 WO 2008120765A1 JP 2008056239 W JP2008056239 W JP 2008056239W WO 2008120765 A1 WO2008120765 A1 WO 2008120765A1
Authority
WO
WIPO (PCT)
Prior art keywords
acid
propionic
vitamin
analgesic
components
Prior art date
Application number
PCT/JP2008/056239
Other languages
French (fr)
Japanese (ja)
Inventor
Manabu Nozaki
Shigeki Sawamura
Original Assignee
Kobayashi Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kobayashi Pharmaceutical Co., Ltd. filed Critical Kobayashi Pharmaceutical Co., Ltd.
Publication of WO2008120765A1 publication Critical patent/WO2008120765A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A61K31/51—Thiamines, e.g. vitamin B1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

[PROBLEMS] To provide an analgesic composition which can enhances the analgesic effect of a propionic-acid-type analgesic agent such as ibuprofen contained therein and has excellent safety. [MEANS FOR SOLVING PROBLEMS] The composition comprises a propionic-acid-type analgesic agents and two or more vitamin B components. The total amount of the vitamin B components is preferably 0.001 to 100 parts by weight relative to 1 part by weight of the propionic-acid-type analgesic agent. The propionic-acid-type analgesic agent is preferably ibuprofen. The vitamin B components preferably comprise at least vitamin B12 or folic acid.
PCT/JP2008/056239 2007-03-30 2008-03-28 Analgesic composition WO2008120765A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007091793A JP5161472B2 (en) 2007-03-30 2007-03-30 Analgesic composition
JP2007-091793 2007-03-30

Publications (1)

Publication Number Publication Date
WO2008120765A1 true WO2008120765A1 (en) 2008-10-09

Family

ID=39808345

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/056239 WO2008120765A1 (en) 2007-03-30 2008-03-28 Analgesic composition

Country Status (2)

Country Link
JP (1) JP5161472B2 (en)
WO (1) WO2008120765A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018076305A (en) * 2016-10-31 2018-05-17 エスエス製薬株式会社 Pharmaceutical composition
WO2021037874A1 (en) * 2019-08-26 2021-03-04 Dsm Ip Assets B.V. Solid oral dosage form comprising naproxen and vitamin b12
WO2021037871A1 (en) * 2019-08-26 2021-03-04 Dsm Ip Assets B.V. Solid oral dosage form comprising naproxen and vitamin b6

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011168580A (en) * 2010-01-19 2011-09-01 Daiichi Sankyo Healthcare Co Ltd Pharmaceutical composition
JP6106359B2 (en) * 2010-12-13 2017-03-29 第一三共ヘルスケア株式会社 Solid formulation containing loxoprofen sodium and vitamin B1
JP7026457B2 (en) * 2016-07-07 2022-02-28 第一三共ヘルスケア株式会社 Oral pharmaceutical composition containing loxoprofen or a salt thereof and vitamins B12

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000050028A1 (en) * 1999-02-24 2000-08-31 Andrew Peter Worsley Compositions for the treatment of pain
WO2000056404A1 (en) * 1999-03-24 2000-09-28 Kilgowan Limited Formulations for treatment of pain comprising vitamin b12 and phenylanine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000050028A1 (en) * 1999-02-24 2000-08-31 Andrew Peter Worsley Compositions for the treatment of pain
WO2000056404A1 (en) * 1999-03-24 2000-09-28 Kilgowan Limited Formulations for treatment of pain comprising vitamin b12 and phenylanine

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BRUGGEMAN G. ET AL.: "Results of a double-blind study of diclofenac + vitamin B1, B6, B12 versus diclofenac in patients with acute pain of the lumbar vertebrae", KLIN. WOCHENSCHR., vol. 68, no. 2, 1990, pages 116 - 120 *
GLUECK C.J. ET AL.: "Stromelysin-1 5A/6A and eNOS T-786C polymorphisms, MTHFR C677T and A1298C mutations, and cigarette-cannabis smoking: a pilot, hypothesis-generating study of gene-environment pathophysiological associations with Buerger's disease", CLIN. APPL. THROMB. HEMOST., vol. 12, no. 4, 2006, pages 427 - 439 *
O'SHAUGHNESSY J.A. ET AL.: "Phase II study of pemetrexed in patients pretreated with an anthracycline, a taxane, and capecitabine for advanced breast cancer", CLIN. BREAST CANCER, vol. 6, no. 2, 2005, pages 143 - 149 *
TANAKA C.: "New Pharmacology, (4th revised edition)", 2002, NANKODO CO., LTD., pages: 484 - 485 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018076305A (en) * 2016-10-31 2018-05-17 エスエス製薬株式会社 Pharmaceutical composition
WO2021037874A1 (en) * 2019-08-26 2021-03-04 Dsm Ip Assets B.V. Solid oral dosage form comprising naproxen and vitamin b12
WO2021037871A1 (en) * 2019-08-26 2021-03-04 Dsm Ip Assets B.V. Solid oral dosage form comprising naproxen and vitamin b6
CN114302713A (en) * 2019-08-26 2022-04-08 帝斯曼知识产权资产管理有限公司 Solid oral dosage form comprising naproxen and vitamin B6

Also Published As

Publication number Publication date
JP5161472B2 (en) 2013-03-13
JP2008247822A (en) 2008-10-16

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