WO2008120661A1 - 新規な縮合ピロール誘導体 - Google Patents

新規な縮合ピロール誘導体 Download PDF

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WO2008120661A1
WO2008120661A1 PCT/JP2008/055856 JP2008055856W WO2008120661A1 WO 2008120661 A1 WO2008120661 A1 WO 2008120661A1 JP 2008055856 W JP2008055856 W JP 2008055856W WO 2008120661 A1 WO2008120661 A1 WO 2008120661A1
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Prior art keywords
pyrrole derivative
hydrogen atom
novel fused
fused pyrrole
formula
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PCT/JP2008/055856
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English (en)
French (fr)
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Toshihiko Sone
Norie Tsuboya
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Dainippon Sumitomo Pharma Co., Ltd.
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Application filed by Dainippon Sumitomo Pharma Co., Ltd. filed Critical Dainippon Sumitomo Pharma Co., Ltd.
Publication of WO2008120661A1 publication Critical patent/WO2008120661A1/ja

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    • C07D209/04—Indoles; Hydrogenated indoles
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Abstract

　本発明は、医薬として、式（１）： ［式中、Ｒ1は置換アルキル基等を表し、Ｒ2は水素原子等を表し、－Ｗ4＝Ｗ5－Ｗ6＝Ｗ7－は式：－ＣＲ4＝ＣＲ5－ＣＲ6＝ＣＲ7－（式中、Ｒ4、Ｒ5、Ｒ6及びＲ7は各々独立して式：－Ｅ－Ａ等を表し、式中Ｅは単結合等を表し、Ａは水素原子等を表）等を表し、Ｒ8は水素原子等を表し、Ｒ9はハロゲン原子で置換されたアルキル基等を表し、Ｒ10は水素原子等を表す）]で表される化合物もしくはプロドラッグ、又はそれらの薬学上許容される塩からなる有用な新規な縮合ピロール誘導体を提供する。
PCT/JP2008/055856 2007-03-29 2008-03-27 新規な縮合ピロール誘導体 WO2008120661A1 (ja)

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Cited By (4)

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EP2567959A1 (en) 2011-09-12 2013-03-13 Sanofi 6-(4-Hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2021263278A1 (en) * 2020-06-23 2021-12-30 The Scripps Research Institute Rev-erb agonists for the treatment of th17-mediated inflammatory disorders
US11471455B2 (en) 2018-10-05 2022-10-18 Annapurna Bio, Inc. Compounds and compositions for treating conditions associated with APJ receptor activity
WO2023122093A1 (en) * 2021-12-20 2023-06-29 University Of Florida Research Foundation, Incorporated Rev-erb agonists for th17-mediated inflammatory disorders

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2567959A1 (en) 2011-09-12 2013-03-13 Sanofi 6-(4-Hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US11471455B2 (en) 2018-10-05 2022-10-18 Annapurna Bio, Inc. Compounds and compositions for treating conditions associated with APJ receptor activity
US11944622B2 (en) 2018-10-05 2024-04-02 Annapurna Bio, Inc. Compounds and compositions for treating conditions associated with APJ receptor activity
WO2021263278A1 (en) * 2020-06-23 2021-12-30 The Scripps Research Institute Rev-erb agonists for the treatment of th17-mediated inflammatory disorders
WO2023122093A1 (en) * 2021-12-20 2023-06-29 University Of Florida Research Foundation, Incorporated Rev-erb agonists for th17-mediated inflammatory disorders

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