WO2008119882A3 - Procédés de criblage - Google Patents

Procédés de criblage Download PDF

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Publication number
WO2008119882A3
WO2008119882A3 PCT/FI2008/050146 FI2008050146W WO2008119882A3 WO 2008119882 A3 WO2008119882 A3 WO 2008119882A3 FI 2008050146 W FI2008050146 W FI 2008050146W WO 2008119882 A3 WO2008119882 A3 WO 2008119882A3
Authority
WO
WIPO (PCT)
Prior art keywords
binding agents
screening methods
methods based
human adam12
human
Prior art date
Application number
PCT/FI2008/050146
Other languages
English (en)
Other versions
WO2008119882A8 (fr
WO2008119882A2 (fr
Inventor
Mikko Suonpaeae
Paeivi Aronkytoe
Pertti Hurskainen
Outi Mulari
Jarkko Karvinen
Original Assignee
Wallac Oy
Mikko Suonpaeae
Paeivi Aronkytoe
Pertti Hurskainen
Outi Mulari
Jarkko Karvinen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wallac Oy, Mikko Suonpaeae, Paeivi Aronkytoe, Pertti Hurskainen, Outi Mulari, Jarkko Karvinen filed Critical Wallac Oy
Publication of WO2008119882A2 publication Critical patent/WO2008119882A2/fr
Publication of WO2008119882A3 publication Critical patent/WO2008119882A3/fr
Publication of WO2008119882A8 publication Critical patent/WO2008119882A8/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention porte sur un nouvel épitope d'ADAM12 humain et sur des agents de liaison, de préférence des fragments Fab, se liant spécifiquement audit épitope. L'invention porte également sur un procédé pour détecter l'ADAM 12 dans un échantillon biologique à l'aide desdits agents de liaison, et sur des procédés de criblage prénatal et des procédés de diagnostic prénatal utilisant lesdits agents de liaison.
PCT/FI2008/050146 2007-03-30 2008-03-28 Procédés de criblage WO2008119882A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FI20075209 2007-03-30
FI20075209 2007-03-30
US90748507P 2007-04-04 2007-04-04
US60/907,485 2007-04-04

Publications (3)

Publication Number Publication Date
WO2008119882A2 WO2008119882A2 (fr) 2008-10-09
WO2008119882A3 true WO2008119882A3 (fr) 2008-11-20
WO2008119882A8 WO2008119882A8 (fr) 2009-07-30

Family

ID=39720517

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FI2008/050146 WO2008119882A2 (fr) 2007-03-30 2008-03-28 Procédés de criblage

Country Status (1)

Country Link
WO (1) WO2008119882A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114008079A (zh) * 2019-03-20 2022-02-01 贾夫林肿瘤学公司 抗adam12抗体和嵌合抗原受体以及包含其的组合物和方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997009430A2 (fr) * 1995-09-05 1997-03-13 Celltech Therapeutics Limited Metalloproteinase humaine, ses variants et sequences d'adn codantes qui lui sont destinees
US20020147132A1 (en) * 1996-02-23 2002-10-10 Mochida Pharmaceutical Co., Ltd. Meltrins
EP1524523A1 (fr) * 2003-10-17 2005-04-20 Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts Utilisation de ADAM 12 pour le diagnostic et le traitement de pré-éclampsie
WO2005071387A1 (fr) * 2004-01-09 2005-08-04 Children's Medical Center Coporation Methodes de diagnostic et de pronostic de cancers d'origine epitheliale
US20060134654A1 (en) * 2004-05-19 2006-06-22 Wewer Ulla M ADAM12, a novel marker for abnormal cell function

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997009430A2 (fr) * 1995-09-05 1997-03-13 Celltech Therapeutics Limited Metalloproteinase humaine, ses variants et sequences d'adn codantes qui lui sont destinees
US20020147132A1 (en) * 1996-02-23 2002-10-10 Mochida Pharmaceutical Co., Ltd. Meltrins
EP1524523A1 (fr) * 2003-10-17 2005-04-20 Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts Utilisation de ADAM 12 pour le diagnostic et le traitement de pré-éclampsie
WO2005071387A1 (fr) * 2004-01-09 2005-08-04 Children's Medical Center Coporation Methodes de diagnostic et de pronostic de cancers d'origine epitheliale
US20060134654A1 (en) * 2004-05-19 2006-06-22 Wewer Ulla M ADAM12, a novel marker for abnormal cell function

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CARL-MCGRATH STACY ET AL: "The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer", INTERNATIONAL JOURNAL OF ONCOLOGY, DEMETRIOS A. SPANDIDOS ED. & PUB, GR, vol. 26, no. 1, 1 January 2005 (2005-01-01), pages 17 - 24, XP009105604, ISSN: 1019-6439 *
IGARASHI ET AL: "Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 581, no. 13, 29 May 2007 (2007-05-29), pages 2416 - 2422, XP022086940, ISSN: 0014-5793 *
SEALS DARREN F ET AL: "The ADAMs family of metalloproteases: Multidomain proteins with multiple functions", GENES AND DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, PLAINVIEW, NY, US, vol. 17, no. 1, 1 January 2003 (2003-01-01), pages 7 - 30, XP002459610, ISSN: 0890-9369 *
YAMAMOTO S ET AL: "ADAM family proteins in the immune system", IMMUNOLOGY TODAY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 20, no. 6, 1 June 1999 (1999-06-01), pages 278 - 284, XP004169720, ISSN: 0167-5699 *

Also Published As

Publication number Publication date
WO2008119882A8 (fr) 2009-07-30
WO2008119882A2 (fr) 2008-10-09

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