WO2008116330A2

WO2008116330A2 - Multifunctional layer on textile fibres and sheet material for active ingredient absorption and release

Info

Publication number: WO2008116330A2
Application number: PCT/CH2008/000107
Authority: WO
Inventors: Oliver Marte; Martin Meyer
Original assignee: Tex-A-Tec Ag
Priority date: 2007-03-27
Filing date: 2008-03-15
Publication date: 2008-10-02
Also published as: WO2008116330A3

Abstract

The invention relates to a multifunctional layer on textile fibres and sheet materials for active ingredient absorption and release, comprising a first phase (I), made from at least one lipophilic water-insoluble compound. At least one active ingredient (S) is included in said first phase (I), the phase forming a storage medium therefor. The first phase (I) is surrounded by a first membrane (M1), the membrane (M1) being permeable to lipophilic and non-dissociated hydrophilic materials. The multifunctional layer further comprises at least one second phase (II), in the form of a further hydrophilic membrane (M2) and which absorbs water, wherein the release speed of the included active ingredients may be controlled by the make up of the second phase (II). At least one further third phase (III), made up of ampiphilic components with fatty groups and/or perfluorinated hydrocarbon groups, forms a barrier layer to the air. Methods for producing composites using the multifunctional layer are disclosed, permitting a recharging of the multifunctional layer with essentially lipophilic active substances. The release of the active substances to the skin with textiles worn near the skin provided with the above can thus be controlled.

Description

Multifunctional layer on textile fibers and fabrics for the absorption and release of active substances

The invention relates to a multifunctional layer on textile fibers and fabrics for the active ingredient in and dispensing according to claim 1, as well as processes for their preparation and processes using the same according to claims 23 to 34.

The trend towards multifunctional coatings on textile fibers and fabrics, which has been going on for several years, is leading to high expectations on the part of consumers, as a result of which new and improved functional coatings are coming onto the market. Additional pressure for improving existing as well as developing new functional layers comes from consumer protection and environmental legislation, in particular through the newly enacted Chemicals Regulation (REACH: Registration, Evaluation, Authorization and Restriction of Chemicals). This signifies a significant limitation of the chemicals available for obtaining new equipment effects. This directly affects the development of new processes to replace existing ones, but with different chemicals and changing reaction conditions. Another factor influencing the framework of a new process is market requirements in response to recent developments, which in turn become non-overlooked trendsetters (for example, taking into account the potential dangers of nanoparticles).

A highly topical subject in this regard are functional layers on textiles worn close to the body, which make it possible to transfer cosmetic and therapeutic active substances to the skin or transdermally, after these active substances were previously incorporated into the functional layer.

The range of active ingredients used in this regard is very broad, ranging from simple molecules such as vitamin E to complex natural products with a Variety of species that lead to interactions and synergisms of the various mechanisms of action that can not be used in the oral administration of such preparations.

Due to the disadvantages of the functional coatings (so-called drug delivery layers) which are already introduced and sometimes also introduced into the market with active substances, new demands arise as a consequence of the consumers' unfulfilled expectations.

The drug delivery layers known today in the textile industry consist essentially of a polymer layer sorbing the active substance and / or of particulate "cage molecules" such as cyclodextrins or dendrimers (HJ Buschmann et al., Textiles as depot for fragrances, Fragrances - SÖFW Citernesi, P. Cappellori, Cosmetic Clothes - Fabrics with Protective Functions, Fragrances - SÖfW Journal, 127 (2001), pp. 64-71, HJ. Buschmann, E. Schollmeyer, textiles with cyclodextrins as passive protection against mosquitoes, Melliand Textilberichte 10 (2004), pp. 790-792). In most cases, these layers are loaded directly during their production and are therefore so-called "one-way" layers.

An essential improvement of the "one-way" concept is the steeply loadable coatings described in WO 2006/007753. Therein, a chemical coating matrix is described, which is able to form so-called nanotags, whose size adapts itself dynamically to the active substances to be sorbed. During wearing of the corresponding garments, the active substances desorb and diffuse due to the concentration gradient on or into the skin. The factors that trigger desorption are temperature and humidity. The garment is washed after use and can be loaded again.

Other known drug delivery functional layers show major disadvantages with respect to the various objectives associated with the use of such layers.

Three very significant drawbacks to all the drug delivery layers propagated today are common, are the very limited controllable kinetics for delivery of the active substance, the washing resistance of the active substance stored in the layer and the unwanted foreign substance uptake (eg surfactants) through the layer during the washing process. The washing resistance of the active substance incorporated in the layer is not present in this layer according to the concept.

The kinetics for the release of the active substance is in all first or pseudo-first order D rrug delivery functional layers realized today. This means that the temporal substance release decreases exponentially. On the one hand, the freshly loaded layer thus leads to a significant excess of the active substance on the skin and, on the other hand, to a rapid depletion of the active substance in the functional layer.

The requirement for a certain washing resistance of the stored active substance in the drug delivery layer seems to be superficially contradictory, since in the case of use their release is required. However, if the physiological and / or medical combined with the economic benefits, it should be noted that due to the sometimes very high cost of the active substances, a longer functional life of the loaded layers makes sense. This despite spite of interim washing processes. A practical example of this are stockings that are worn close to the skin and thus predestined for a drug delivery application. During the use phase, however, the socks are subjected to two to three hand washes before being cleaned by a machine washing process. However, in order to achieve the goal of a certain washing resistance to a large extent exclusion of a simultaneous collection of foreign substances, new solutions that deviate completely from the previous drug delivery layer concepts can be found.

The object of the invention is to provide a multifunctional layer on textile fibers and fabrics for active ingredient absorption and Abgab, and provide methods for their preparation and methods using the same, both a controllable kinetics for delivery of the active substance and a certain washing resistance in the layer ensure stored active substance.

The task becomes by the realization of a novel layer concept, or a inventive multi-functional layer solved what the textile industry novel chemicals and Hersteflverfahren are necessary.

The following objectives are achieved with the multi-functional layer according to the invention or the layer structure according to the invention:

Reloading of the multifunctional layer with predominantly lipophilic active substances and their delivery to the skin in connection with textiles which are equipped and worn close to the body;

A washing resistance of the active substances stored in the multifunctional layer limited to a few washing cycles, in order to save on active substance costs and to simplify the use of such textiles or garments;

Controllability of the kinetics for delivery of the active substance, in order to adapt the kinetics of the absorption rate through the skin and thereby to avoid undesirable side effects due to excess concentrations of the active substance on the skin (fat feeling, wetness, etc.);

Establishing a barrier function to both a stain rejection or prevent a foreign substance intake during the washing process to achieve as well as to avoid a loss of active substance during the washing process.

The realization of the various objectives is carried out with a multi-phase layer concept, which has a clear target-oriented layer structure and has an active substance absorption by the skin adapted transport mechanism of the substance stored in the layer.

In the following, the structure of the multifunctional layer will be explained in more detail first with reference to FIG. 1:

An innermost phase (Phase I) of the multifunctional layer forms a storage medium later. applied or to be introduced active substances S ₁ -. The phase I can be both particulate and flat, the fiber enveloping formed and located on the fiber surface F of a textile fibers or fabrics. The ingredients incorporated in this phase I cause a polarity, which results in a very high affinity for lipophilic substances (active substances S ₁ ). Thus, Phase I is able to absorb up to 200% of its own mass of lipophilic substances. The phase I has a first shell with membrane character, or a membrane M1 similar to one Vacuole of eukaryotic cells. Due to the chemical properties of the M1 membrane, it is especially permeable to non-ionic lipophilic substances and non-dissociated hydrophilic substances. The permeability for amphiphilic cationic or anionic compounds is determined by the prevailing in the membrane M1 pH. This is the case in particular when it is a dipolar membrane M1, ie the layer enveloping the phase I has a betaine structure.

The particulate or film phase I forms a storage medium, or a storage phase for the active substance S. Phase I consists of at least one lipophilic, water-insoluble, non-reactive and / or amino and / or OH-functional Compound used as a monomolecular, oligomeric and / or polymeric compound. Phase I is chemically fixed in the presence of reactive compounds with suitable crosslinker systems, which preferably takes place after application to the textile substrate. This results in a non-water-soluble gel or a gel body.

As unploused amino- and hydroxyl-containing compounds derivatized polysaccharides, polysiloxanes, polyurethanes, polyesters and polyamides, ester and acid waxes are used. Polymers which are terminated as preferred lipophilic amino- and OH-groups are silicone compounds which are preferably crosslinked with di- or polyisocyanates.

Another variant for the preparation of phase I as the active substance storage phase is the use of predominantly nanoscale polymeric silicic acids. These are coated with at least one lipophilic .Amino and / or OH-functional compound with the addition of suitable crosslinkers and at least one amphiphilic polymeric compound and crosslinked as described above. The advantage of using coated nanoparticles lies in their higher mechanical strength, which may be of importance depending on the textile material or its intended use. Both the pure gel bodies and the gel bodies solidified with polysilicic acids have in the particulate state a size of 200-1000 nm, preferably of 500-800 nm. Other ingredients for the formation of the membrane M1 are monomeric and polymeric lipophilic-hydrophilic (amphiphilic) acting substances that show an orientation (hydrophobic / hydrophilic) due to these properties in the boundary phase 'gel body / water'. The orientation takes place on its own momentum when the gel phase is stirred into an aqueous solution containing the crosslinking chemical. The crosslinking of the amphiphilic substance forming the boundary phase results in a membrane M1, or a membrane layer which encloses the active substance reservoir.

As typical lipophilic / hydrophilic or amphiphilic compounds for forming the boundary phase 'gel body / water' (membrane M1) non-ionic, cationic and anionic surfactants may be mentioned whose fatty residues from a C ₃ -C ₂₄ -Fettkohlenwasserstoff- chain (preferably C ₁₂ -C ₁₈ ) such as sorbitan laurate, laurylamine or dilaurylamine, quaternary compounds such as dimethyllaurylbenzylammonium chloride or dialkyldimethylammonium chloride and anionic compounds such as phospholipids, alkyl and Alkyllaurylsulfonate.

Another very suitable class of compounds are amphiphilic polymers such as fat-modified polysaccharides and acrylates having a fatty hydrocarbon chain of C ₃ -C ₂₄ , preferably C ₁₂ -C ₁₈ , or alcohol ethoxylate maleate / α-olefin copolymers. Preferably used compounds are amphiphilic compounds such as ethylene oxide derivatives (EO ₂ - EO ₂₀ ) and lipophilic radicals (C ₃ -C ₂₄ ) carrying polyelectrolytes, which are also crosslinkable, eg Pemulen (Noveon, Germany). The crosslinking of the membrane M1 forming compounds is made in contrast to the Geivemetzung with a reaction technically different cross-linking system. A typical example is the use of an amino group-terminated silicone wax and a diisocyanate forming the active substance-receiving gel bodies (Phase I) and an alcohol ethoxylate maleate / α-olefin copolymer with an aziridine crosslinker, which form the first membrane layer M1 around the gel body ,

The choice of the crosslinker system is based on the reaction groups present in the particular system to be crosslinked. Nucleophilic reaction groups such as OH-R, H ₂ NR are preferably crosslinked in phase I and phase II with isocyanates, dialdehydes and α-Arninoalkylierungsprodukten. R-CONH ₂ or R ₁ -CONH-R ₂ are preferably used in the membrane M1 with α-aminoalkylation products or dialdehydes (eg glutaric acid). aldehyde) and carboxyl-bearing compounds with aziridines. R is representative of an aliphatic, aromatic or heterocyclic radical. Among the isocyanates, it is above all the polyfunctional isocyanates which are used (R (N = C = O) _n ; n = 2 to 4). Examples of typical crosslinkers are: 1,6-diisocyanatohexane (Bayer, Germany), 3-isocyanatomethyl-3,5,5-trimethylcyclohexylisocyanate (Hüls, Germany) or uretdione of 2,4-diisocyanatotoluene (Bayer , Germany).

The use of α-aminoalkylation today focuses mainly on Ethyienhamstoff- and melamine derivatives, which are both as methyl and as etherified compounds in the trade. Examples are Knittex FEL and Lyofix CHN (Huntsman, Germany).

The aziridines used are divided into aliphatic and aromatic. Typical representatives of aliphatic propylenimine derivatives are: 1,1'-azelaoyl-bis (2-methyiaziridine) and N, N ', N ", N'" - tetrapropylene-1,2,3,4-butanetetracarboxamide. Typical representatives of aromatic propylenimine derivatives are: toluene-2,6-dipropyleneurea (TPH) or diphenylmethane-bis-4,4'-N, N'-dipropyleneurea.

The phase I (innermost phase) with the membrane M1 is surrounded or enveloped by a second phase II, which also has a membrane character. Phase II shows, according to the concept, a markedly reduced absorption capacity for lipophilic active substances in comparison to phase I. It can consist of several layers that differ physically and chemically, but always have membrane character and thus the kinetics for delivery of the active substance compared to conventional drug delivery layers essential changes. Due to the ingredients used to prepare the phase II (membrane phase), this layer tends to be hydrophilic and capable of adsorbing water. The possibility of water sorption is of essential importance to the inventive concept. The water absorption and the resulting swelling of the phase II or of the membrane matrix produces an aqueous barrier layer which largely prevents both the washout process of the active substance and the access of wash liquor ingredients.

Phase II, which forms the outer membrane phase, encloses the gel bodies or the gel layer with its membrane M1, which represents the active substance reservoir (phase I). The preparation of the phase II is carried out by the use of various differently polar, in water. Partial swelling and crosslinkable polymers. Examples of the polymers to be used are polyacrylates, polyurethanes, derivatized polyvinyl alcohols and acetates, polysaccharides and their derivatives, gelatin, etc. In order to achieve a more or less pronounced membrane character of the phase, the layered polymers should be chosen such that the hydrophilic character dominates ( HLB values> 12). On the one hand results in only limited solubility of the active substance S and on the other hand, an increased water absorption.

Known drug delivery layers show a first-order delivery kinetics while, according to the coating concept according to the invention for the first 2/3 of the active substance mass, a delivery kinetics of quasi-zeroth or pseudo-zero order is realized. The solubility of the active substance in phase II largely determines the delivery rate. The release rate is thus controlled by the chemical nature of the phase II, or via the components which form the phase II as a membrane layer.

A third phase III forms the boundary layer, or the boundary phase 'phase M / air' or 'phase II / Hauf. While the phase II is hydrophilic dominated, the phase III in the formed layer again shows a predominantly hydrophobic character. Due to the intrinsically amphiphilic structure of the compounds forming the phase III, a thermodynamically favored orientation of the apolar, aprotic molecule radicals to the air results. Thus, this boundary phase has at least the dimension of a molecular layer. The formation of phase III is inherently dynamic by the use of suitable amphiphilic substances. These can be monomolecular as well as used as polymers, for example in the form of a fluorocarbon resin (Softgard M3, soft Chemicals, Italy). As a result of the directed orientation resulting from the acting interface forces, the polar backbone of the fluorocarbon resin points in the direction of phase II, while the fluorinated carbon chains of the polymer form the interface with the air. This phase III serves on the one hand the soil repellency while wearing the garment and on the other hand, the rejection of polar but also non-polar washing liquor ingredients. The phase III can also be constructed in several phases, but each of the sub-phases performs the same function. The third phase Mi, which is likewise emulsified in the second phase II, preferably consists of a crosslinkable polymer of a fluorinated fatty hydrocarbon (C ₂ -C _121, preferably C ₄ -C ₈ ). The phase III forms the dirt-repellent boundary layer by self-organization during the layer drying.

For chemical fixation, the Phase II crosslinker is added. These are preferably isocyanates or α-aminoalkylation products in combination with corresponding catalyst systems. As typical catalysts for isocyanates dibutyltin laurate or 1, 4-diazabicyclo [2.2.2] octane are used. To catalyze α-aminoalkylation products metal-set catalysts, organic and inorganic acids and their mixtures of metal salt catalysts and acids such as MgCl ₂ - used 6 H ₂ O and citric acid.

A fourth phase IV to be introduced optionally represent bactericidal and / or fungicidal components or compounds which are incorporated into phase II. These serve exclusively to protect the multifunctional layer and the active substances stored therein from bacterial and / or fungicidal infestation. The coating concept according to the invention largely avoids contamination of the skin with bactericidal and / or fungicidal compounds and thus minimizes or eliminates the risk of transdermal absorption of these compounds. The optionally used fourth phase IV, which consists of bactericidal and / or fungicidal compounds, is also admixed with the formulation of phase II (membrane phase). These are inorganic compounds, in particular metal particles, ceramic particles with metal layers of copper and silver and their salts. Preference is given to nanoscale silver, silicon dioxide silver particles and / or silicon dioxide copper particles. In the following, organic compounds or quaternary ammonium compounds carrying reactive groups, such as e.g. Dimethyltetradecyl (3-trimethoxysilyl) propylammonium chloride, dimethyloctadecyltrimethoxysilylpropylammonium chloride or aldehyde and peroxide releasing compounds.

Phase IV can also consist of several subphases, all of which serve the same function. multiphase drug delivery layer.

The active substance in the nano-container or in phase I with a concentration A is in equilibrium with the active substance S in the matrix, or in phase II with a concentration B. The corresponding transport constants are designated κ _Λ and r , The concentration B of the active substance in the matrix is transferred to the skin with a transport constant r ₂ on which a concentration C of the active substance S is built up and sorbed by the skin with a transport constant r ₃ , the concentration D of which in the Skin dissolved active substance concentration corresponds.

~ Fig. 3 shows the time course of a transdermal active substance transfer. Plotted is a normalized active substance concentration as a function of time. The following transport constants are given: ^ = 0.30; r. ₁ = 0.05; r ₂ = 0.10; r ₃ = 0.10. Recognizable are:

- Concentration A: markedly slowed or delayed decrease of the active substance in the nano-container;

- Concentration B: build-up and delayed release of the active substance in the matrix (phase II);

- Concentration C: According to the invention slowed down structure of the active substance on the skin and delivery with simultaneous sorption through the skin.

In the following, various methods are described in more detail. A further great advantage of the coating concept according to the invention is the production of composites, which, on the one hand, enormously facilitates the formulation technology of the textile supplier and, on the other hand, substantially increases process safety. For the inventive layer concept, this means that, for example, two composites are to be produced, one phase being phase I (gel body having a first membrane M1) and the other being phase II (membrane phase) containing the optionally used ingredients ,

Production method of phase I with the membrane M1.

One or more water-insoluble compounds such as silicone waxes and oils, micronized ester and amide waxes which may also carry reactive groups, are mixed and dissolved or dispersed in a solvent adapted to the waxes or oils. The solvents to be used are in an M number range of 8-20, preferably 12-15. Subsequently, a polyfunctional crosslinking reagent having at least two crosslinking groups per molecule is added and the solution L1 is heated to 25-50.degree. Preferably used crosslinking reagents are free and blocked polyisocyanates, α-aminoalkylation products and dialdehydes.

This, the phase I forming polymer solution or suspension is emulsified to form Mikrocontainem in a second solution L2 by means of a Hochdruckhomogenisiergerätes. The second solution contains a water-soluble electrolyte to adjust an ionic strength of 0.005 - 0.1, preferably 0.01 - 0.05, and an amphiphilic crosslinkable substance and a crosslinking component. During the emulsification of phase I, droplets or particles are formed whose diameters are 200-1000 nm, preferably 500-800 nm, which are enveloped by the amphiphilic substance and thus form a membrane M1 in combination with the crosslinker present. In special cases, the emulsifier system consists of a combination of a carboxyl-bearing and an amino-terminated surfactant, this combination leading to a betaine structure of the membrane M1.

While highly elastic microcontainers are formed in the manner described, pressure-resistant microcontainers can be produced by adding highly porous organic and / or inorganic particles to phase I.

The microcontainers produced in this way represent the composite K1, which is later processed with the composite K2 into a finishing formulation.

Phase II manufacturing process.

The phase II, which envelops the phase I and membrane M1 in the multifunctional layer, is hydrophilic dominated and also has membrane character, or it provides a

Membrane M2

To prepare the phase II, at least one polymer which is water-soluble or in the form of an emulsion in water-insoluble form is used. When using water-soluble it is imperative to use an adequate crosslinking agent. In addition, the aqueous phase II, an amphiphilic substance is added, preferably a fluorocarbon resin emuted in water. Optionally, bactericidal and / or fungicidal substances are added in this phase. The thus completed phase, since it is present as an emulsion, conveniently emulsified again by means of a high pressure homogenizer and is now available as a composite K2 for the preparation of a finishing formulation.

As an alternative to the preparation of two composites, only a single composite can be produced using analogous formulation technology, which contains all phases, as will be described later in Example 1.

Application methods.

According to the objectives of the drug delivery layer, x g of the composite K2 are metered into a water reservoir and, after intensive mixing, mixed with y g of the composite K1. The mixing ratio is dependent on the goals that the multifunctional layer has to meet. Typical mixing ratios of composite K1 to composite K2 range from 90/10 to 20/80%, preferably 60/40 to 30/70%.

Any further ingredients serve to adjust the pH and to ensure wettability of the textile material by the finish formulation.

Application of the finish formulation to the textile substrate is by a padding, coating or spraying process. The liquor order is based on the fiber material of the textile material and is 30 - 80% based on the dry weight of the textile material.

Very important is the drying process, which usually takes place immediately after the fleet application. The drying conditions (temperature, ventilation, relative humidity, etc.) should be selected so that the cooling limit temperature on the fabric is between 25 and 50 ^° C. Under these conditions, the boundary layer, or the boundary phase 'phase H / air' can form, which has a barrier function to prevent the ingress of dirt and Waschflotteningredienzien in membrane M2 (membrane phase). Example 1: Production of a Repeatable Multifunctional Layer to be Loaded. 10 g of a hydrophobic silicone wax Wacker 50550 / 8VP (Wacker Chemie AG, Germany) and 5 g of an amino-functional silicone oil Wacker Finish WR 1300 (Wacker Chemie AG, Germany) are dissolved in 20 g of isopropanol at 40 - 50 ⁰ C and with IPDI trimer Desmodur 24470 BA (Bayer MaterialScience, Germany).

This polymer solution is emulsified in 64.9 g of a 0.05 molar sodium chloride solution containing 4.5 g of an alcohol ethoxylate maleate / α-olefin copolymer. Subsequently the emulsion are 7 (Fievo Chemie, Netherlands) were added and stirred for 15 minutes at about 30 ⁰ C 00:11 g Aziridinvernetzer XAMA. The emulsion thus prepared contains the phase I coated with a membrane M1 in a droplet size of 700-800 nm.

In the solution to be applied, 60 g / l of the emulsion produced and 10 g / l Methocel K100 (Dow Deutschland GmbH & Co, Germany), 70 g / l acrylate resin mixture consisting of 50% Tubicoat A19 and 50% Tubicoat HS64 new ( Bezema, Switzerland) and an isocyanate crosslinker Tubicoat Fixer H24 (Bezema, Switzerland).

The formulation thus prepared is applied to the textile material by means of an impregnation process.

The fleet order is 70% based on the dry weight of the textile material. Immediately after the impregnation, the drying is performed at a cooling limit temperature 25-70 ° C, preferably at 40 - 50 ⁰ C. The layer fixing is carried out at 120-170 ⁰ C, preferably at 140-160 ⁰ C for 1 - 5 minutes, preferably 2 - 3 minutes.

Example 2 Production of a Repeatable Multifunctional Layer Having a Bactericidal Activity.

a) Preparation of the composite K1:

300g / kg of an amino functional silicone oil (Wacker Finish WR 1300 Wacker Chemie AG, Germany) in 552 g / kg Isopropano) at 40 - 50 ⁰ C and treated with 30 g / kg of a polyisocyanate (IPDI trimer, Bayer Material Science, Germany). 118 g / kg of polysilicic acid (Sipernat D10, Degussa, Germany) was added and mixed homogeneously. The mixing is done in a ball mill for 30 minutes.

The particulate suspension is poured into an aqueous 0.03 molar sodium sulfate solution

50 g / kg of a Alkohoi-ethoxylatmaleat / α-olefin copolymer contains, dispersed.

The dispensed 1.5 g / kg XAMA 7 (Flevo Chemie, The Netherlands) are then added and stirred for 15 minutes at 30 ⁰ C.

The composite K1 thus produced contains the phase enveloped by a membrane M1

I in a particle size of 700 - 900 nm.

b) Preparation of the composite K2:

500 g / kg of an acrylate resin mixture (10% binder VSO, 90% binder ASM, soft Chemicals, Italy) are stirred into 260 g / kg of water and 80 g / kg of a fluorocarbon resin (Softgard M3, soft chemicals, Italy) and 80 g / kg IPDI trimer (Bayer Material Science, Germany) and 80 g / kg Dorafresh AG (silver salt suspension, Dohmen GmbH, Germany) and homogenized. The composite K2 thus produced is used in combination with composite K1 by the customer for the preparation of the application liquor formulation.

Fleet formulation and application:

600 g / l of water serve as a template into which 80 g / l of the composite K1 and 120 g / l of the

Komposits K2 be stirred. In addition, the solution becomes 200 g / L of a 5%

Methocel solution (Methocel K100, Dow Germany GmbH & Co.) added and homogenized.

The fleet application to the textile substrate is carried out by a padding process with a liquor order of 70 - 72% based on the substrate dry weight. The subsequent drying takes place at a cooling limit temperature on the fabric of

40 - 50 ⁰ C, while the fixation of the functional layer at 150 - 160 ° C during 1.5

Minutes.

Claims

claims

1. Multifunctional layer on textile fibers and fabrics for drug absorption and -abgäbe, characterized in that it comprises a first phase (I), which consists of at least one lipophilic, water-insoluble compound that in the first phase (I) at least one active substance (S) is introduced, for which the phase (I) forms a storage medium, that the first phase (I) with the stored active substances form a gel body, that the first phase (I) by a first membrane (M1) is surrounded, said Membrane (M1) is permeable to lipophilic and non-dissociated hydrophilic substances in that the multifunctional layer has at least one second phase (II), which is hydrophilic as a further membrane (M2) and adsorbs water and that on the structure of the second phase (II ) the delivery rate of the active substance is controllable.

2. Multifunctional layer according to claim 1, characterized in that the water-insoluble compound of the first phase I is a non-reactive or an amino and / or OH-functional compound.

3. Multifunctional layer according to claim 2, characterized in that the amino- and hydroxyl-containing compound is a derivatized polysaccharide, polysiloxane, polyurethane, polyester, polyamide, an ester or an acid wax.

4. Multifunctional layer according to one of claims 1 - 3, characterized in that the first phase (I) contains nanoscale polymeric silicas.

5. Multifunctional layer according to one of claims 1 - 4, characterized in that the pure gel body and the gel body formed with polymeric silicic acids in the particulate state have a size of 200-1000 nm, preferably of 500-800 nm.

6. Multifunctional layer according to one of claims 1-5, characterized in that as typical lipophilic / hydrophilic or amphiphilic compounds for the formation of first membrane (M1) non-ionic, cationic and anionic surfactants are provided, whose fat residues from a C ₃ -C ₂₄ -Fettkohlenwasserstoffkette, preferably C ₁₂ -C ₁₈ , consist.

7. Mυltifunktionsschicht according to claim 6, characterized in that as surfactants sorbitan laurate, laurylamine, dilaurylamine or anionic compounds, preferably phospholipids, alkyl and Alkyllaurylsulfonate are provided.

8. Multifunctional layer according to claim 6, characterized in that as surfactants quaternary compounds, preferably dimethyllaurylbenzylammonium chloride or dialkyldimethylammonium chloride are provided.

9. multifunctional layer according to claim 6, characterized in that are provided as amphiphilic compounds fat-modified, ethoxylated polymeric acrylic and / or maleic acid derivatives.

10. Multifunctional layer according to one of claims 1-9, characterized in that the first membrane (M1) has a betaine structure.

11. Multi-functional layer according to any one of claims 1-10, characterized in that the second phase (II) consists of various differently polar, partially swelling and crosslinkable polymers in water.

12. Multifunctional layer according to claim 11, characterized in that the second phase (II) has a membrane character and is capable of water sorption, whereby it forms an aqueous barrier layer.

13. Multifunctional layer according to claim 11 or 12, characterized in that the second phase (II) has a hydrophilic character with HLB values> 12.

14. Multifunctional layer according to one of claims 11-13, characterized in that the crosslinkable polymers are polyacrylates, polyurethanes, derivatized polyvinyl alcohols and acetates, polysaccharides and their derivatives or gelatin.

15. Multifunctional layer according to one of claims 1-14, characterized in that it comprises at least one further third phase (IJJ), which consists of feitresia and / or perfluorohydrocarbon residues, amphiphilic components and forms a boundary layer to the air.

16. Multifunctional layer according to claim 15, characterized in that the amphiphilic component is a fluorocarbon resin.

17. Multifunctional layer according to claim 15, characterized in that the amphiphilic components for forming the third phase (III) are monomolecular or present as polymers.

18. Multifunctional layer according to one of claims 1-17, characterized in that it comprises at least one further fourth phase (IV), which has bactericidal and / or fungicidal components.

19. Multifunctional layer according to claim 18, characterized in that the bactericidal and / or fungicidal components are organic compounds, in particular quaternary compounds, aldehyde and peroxide-releasing compounds.

20. Multi-functional layer according to claim 18, characterized in that the bactericidal and fungicidal components are inorganic compounds, in particular metal particles, ceramic particles with metal layers of copper and silver and their salts.

21. Multifunctional layer according to one of claims 1-20, characterized in that the first phase (I), the first membrane (M1) and / or the second phase (II) has at least one crosslinking component.

22. Multifunctional layer according to claim 21, characterized in that the crosslinking components are isocyanates, aziridines, dialdehydes and Aminoalkylierungs- products.

23. Method for producing a first composite (K1) or the first phase (I) with the membrane (M1) according to one of claims 1 - 22, characterized in that at least one water-insoluble compound is dissolved or dispersed in a suitable solvent, that a polyfunctional crosslinking reagent is added and a resulting first solution (L1) to 25 - 50 ⁰ C. is heated, that the first solution (L1) is emulsified in a second solution (L2) containing a water-soluble electrolyte, an amphiphilic crosslinkable substance and a crosslinking component, wherein droplets and / or particles are formed, that the droplets and / or particles are enveloped by the amphiphilic substance and form a first membrane (M1) with the crosslinker component and thus that the first composite (K1) is formed.

24. The method according to claim 23, characterized in that a silicone wax, a silicone oil, a micronized ester or an amide wax is used as the water-insoluble compound.

25. The method according to claim 23 or 24, characterized in that a compound having at least two crosslinking groups per molecule is used as the polyfunctional crosslinking reagent.

26. The method according to any one of claims 23 - 25, characterized in that aziridines are used as the polyfunctional crosslinking reagent.

27. The method according to any one of claims 23 - 25, characterized in that free and blocked polyisocyanates, α-Aminoalkylierungsprödukte and dialdehydes are used as crosslinking reagent.

28. A process for producing a second composite (K2), or the second phase (II) according to any one of claims 1 - 22, characterized in that at least one water-soluble or present as an emulsion in water-insoluble polymer polymer is added to an amphiphilic substance, that emulsifying the resulting emulsion to form the second composite (K2).

29. The method according to claim 28, characterized in that the amphiphilic substance is a surfactant, a resin emulsified in water fluorocarbon resin or a fat-modified fected polymer is used.

30. A method for producing a single composite according to any one of claims 23 - 29, characterized in that it contains all the components of the first composite (K1) and the second composite (K2).

31. Method using the multifunctional layer according to one of claims 1 - 30, characterized in that the second composite (K2) is placed in a water mask and mixed thoroughly, that it is mixed with the first composite (K1) and that the first to second composite is used in a mixing ratio, which is derived from the requirements of the multifunctional layer.

32. The method according to claim 31, characterized in that a mixing ratio of the first composite (K1) to the second composite (K2) of 90/10% up to 20/80%, preferably 60/40% up to 30/70% is used ,

33. The method of claim 31 or 32, characterized in that the drying of the multi-functional layer at a Kühlgreπztemperatur of 30 - 10 ⁰ C, preferably at 40 - 50 ⁰ C is performed.

34. The method according to any one of claims 31 - 33, characterized in that the fixing of the multi-functional layer at 120 - 170 ⁰ C, preferably at 140 - 160 ⁰ C and for 1 - 5 minutes, preferably 2-3 minutes takes place.