WO2008115043A1 - Ensemble spéculum vaginal standard et système d'excitation de fluorescence variable à large spectre pour le diagnostic de maladies de l'appareil génital féminin - Google Patents

Ensemble spéculum vaginal standard et système d'excitation de fluorescence variable à large spectre pour le diagnostic de maladies de l'appareil génital féminin Download PDF

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Publication number
WO2008115043A1
WO2008115043A1 PCT/MX2007/000042 MX2007000042W WO2008115043A1 WO 2008115043 A1 WO2008115043 A1 WO 2008115043A1 MX 2007000042 W MX2007000042 W MX 2007000042W WO 2008115043 A1 WO2008115043 A1 WO 2008115043A1
Authority
WO
WIPO (PCT)
Prior art keywords
diagnosis
diagnostic
diseases
new
genital tract
Prior art date
Application number
PCT/MX2007/000042
Other languages
English (en)
Spanish (es)
Inventor
Joel Gerardo Diaz Sánchez
Jose Gerardo Zertuche Zuani
Cala Hegde
Original Assignee
Diaz Sanchez Joel Gerardo
Jose Gerardo Zertuche Zuani
Cala Hegde
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diaz Sanchez Joel Gerardo, Jose Gerardo Zertuche Zuani, Cala Hegde filed Critical Diaz Sanchez Joel Gerardo
Priority to PCT/MX2007/000042 priority Critical patent/WO2008115043A1/fr
Publication of WO2008115043A1 publication Critical patent/WO2008115043A1/fr
Priority to MX2009009987A priority patent/MX2009009987A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064—Constructional details of the endoscope body
    • A61B1/00105—Constructional details of the endoscope body characterised by modular construction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00186—Optical arrangements with imaging filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0661—Endoscope light sources
    • A61B1/0669—Endoscope light sources at proximal end of an endoscope
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/303—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the vagina, i.e. vaginoscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/30—Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
    • A61B2090/306—Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure using optical fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/20—Surgical microscopes characterised by non-optical aspects

Definitions

  • Vaginal speculum This was invented many centuries ago, in the Talmud and in ancient documents from India dated around the year 1000 B.C. There are already descriptions of this one. It was the Hebrews who introduced the use of the speculum to vaginally examine women suffering from female genital tract problems. Such an apparatus consisted of a mobile cylinder contained in a lead tube.
  • vaginal speculums The most commonly used vaginal speculums are Graves and Pederson's, disposable or sterilizable.
  • speculacopy The technique used for observation through the correct handling of the speculum is called speculacopy, which consists of its introduction into the vagina to observe the vaginal wall and the cervix. Speculoscopy is considered within gynecology as a direct visualization inspection method.
  • the cervix or Portio is the horizon of the examination with the speculum and that is where the signs of infections can be found by: Trichomona vaginalis, Neisseria, Chlamydia, Herpex, and dysplasia caused by the papillomavirus, among others.
  • Trichomona vaginalis Neisseria, Chlamydia, Herpex, and dysplasia caused by the papillomavirus, among others.
  • These Infections are nowadays called sexually transmitted diseases, which have been increasing in the population during the last 15 years, which is why they are called emerging diseases.
  • speculoscopy refers to the method of visual inspection of the cervix using the acetic acid test and illuminating with white-blue light by chemiluminescent light. This technique is only considered for research purposes and is not attached to massive cervical cancer or sexually transmitted disease screening programs.
  • the standard Vaginal speculum Graves or Pederson etc., disposable or sterilizable and its broad spectrum variable fluorescence excitation system for the diagnosis of diseases of the female genital tract presented in the present invention aims, in addition to the above described, to reduce the medical costs in patient management.
  • the chosen filter of linear variable spectrum interference allows us to select the wavelength range from 400 nm to 1000 nm in which you want work at intervals between the separation of bands from 50 to 50 nm exceptionally easy, providing high quality light.
  • the chosen fiber optic cable is universal, which is hermetically sealed allowing sterilization.
  • the light source box contains connection adapters for Halogen lamps, so that with its emission peaks it covers the entire required spectrum.
  • the invention relates to a combination of a standard vaginal speculum (Serious or Pederson, etc., sterilizable or disposable) (Figure 1) with an excitation system for fluorescence by means of a high power illuminator ( Figure 1-A), with a filter variable linear interference that has a frequency spectrum between 400 nm to 1000 nm
  • luminescence is the optical radiation of a physical system produced during transfer of an excited condition to a basic condition.
  • the light (or photonic energy) emitted is triggered by frequency energy in the x-ray, ultraviolet, infrared or visible spectrum.
  • the luminescence can be divided into 2 phenomena: phosphorescence and fluorescence. In phosphorescence the body continues to emit light after being excited.
  • Fluorescence is the basis of many modern methods within the Life Sciences that at this time has its greatest objective in molecular and cellular biology, immunology, virology and oncology.
  • the standard vaginal speculum consists of two leaflets or leaves in the form of a "duck's beak" ( Figure 1-B) that are insertable in the vagina and that when opened with smooth movements the vaginal walls can be visualized.
  • the speculum also has a handle ( Figure 1-C) with which it allows us to perform the location of the uterine cervix with different movements, positioning the speculum in a way that does not produce a feeling of discomfort in the patient. Once in correct position, this can be fixed with its respective adjustment knob (Figure 1-D), as well as with the leaflet locks (Figure 1-E).
  • the speculum has two entries of remove and put, the one that is located in the handle allows us to fix the source of illumination that comes from the optical fiber (Figure 1-F) and the second one located in the upper leaflet allows us to put the holder Barrier filters (Figure 1- G).
  • optical fiber conducts the light from the box of the illumination source to the speculum, this fiber is characterized by its brilliance in the transmission of light and by being Hepnetics sealed hospital grade, which allows us to sterilize ( Figures 1-H, 5-A).
  • the barrier filter holder ( Figures 1-K and 3) is inserted into the posterior lip of the upper leaflet of the speculum by means of a pressure clip ( Figures 1-G and 3-A).
  • the filter holder is annular with 2 rings that allow the change of the barrier filters in a simple way ( Figures 3-B and 3-C), the filter is housed between these two rings ( Figure 3-D).
  • the illuminator is easily installed in the speculum handle by means of the "H" adapter that is fixed in the speculum handle screw knob ( Figures 1-1 and 5-B). In the same way as the filter holder, it is inserted into the illuminator of the "H” adapter by means of a clamping clip ( Figure 5-C).
  • a small condensing lens mounted with a system that allows the light rays to converge on the cervix giving with this light cone the greatest power and luminosity to be able to excite the fluorochromes of each of our tests Diagnostics to examine the cervix ( Figures 1-J and 5-D).

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

L'objectif de l'invention proposant un ensemble spéculum vaginal standard combiné à un système d'excitation de fluorescence variable à large spectre pour le diagnostic de maladies de l'appareil génital féminin est de présenter un système de fluorescence qui comprend des filtres d'excitation et des filtres barrières à l'intérieur de systèmes de visualisation directe, notamment de spéculoscopie, facile à utiliser pour le diagnostic des maladies de l'appareil génital féminin. Parmi les avantages essentiels présentés par ledit système, on notera que ce dernier peut notamment être combiné à des systèmes de loupes permettant d'agrandir une image ou à tout type de coloscope pour que le médecin qui l'utilise puisse observer les détails d'un quelconque changement pathologique en haute définition. De manière avantageuse, la technique de l'invention fait intervenir un fluorochrome (seul ou combinés à d'autres fluorochromes) particulièrement conçu pour réagir avec différents réactifs spécifiques, chacun pour une maladie de l'appareil génital, et qui, après réaction et production de fluorescence, peut être observé à l'aide des filtres barrières sur un fond obscur avec des couleurs et des contrastes qui permettent d'établir un diagnostic correct.
PCT/MX2007/000042 2007-03-22 2007-03-22 Ensemble spéculum vaginal standard et système d'excitation de fluorescence variable à large spectre pour le diagnostic de maladies de l'appareil génital féminin WO2008115043A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/MX2007/000042 WO2008115043A1 (fr) 2007-03-22 2007-03-22 Ensemble spéculum vaginal standard et système d'excitation de fluorescence variable à large spectre pour le diagnostic de maladies de l'appareil génital féminin
MX2009009987A MX2009009987A (es) 2007-03-22 2009-09-18 Combinacion de especulo vaginal estandar con un sistema de excitacion para fluorescencia variable de amplio espectro para el diagnostico de enfermedades del tracto genital femenino.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/MX2007/000042 WO2008115043A1 (fr) 2007-03-22 2007-03-22 Ensemble spéculum vaginal standard et système d'excitation de fluorescence variable à large spectre pour le diagnostic de maladies de l'appareil génital féminin

Publications (1)

Publication Number Publication Date
WO2008115043A1 true WO2008115043A1 (fr) 2008-09-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MX2007/000042 WO2008115043A1 (fr) 2007-03-22 2007-03-22 Ensemble spéculum vaginal standard et système d'excitation de fluorescence variable à large spectre pour le diagnostic de maladies de l'appareil génital féminin

Country Status (1)

Country Link
WO (1) WO2008115043A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5251613A (en) * 1991-05-06 1993-10-12 Adair Edwin Lloyd Method of cervical videoscope with detachable camera
WO1996029926A1 (fr) * 1995-03-31 1996-10-03 The Board Of Regents, The University Of Texas System Sonde destinee a la detection des neoplasies cervicales au moyen de la spectroscopie a fluorescence
WO1998005253A1 (fr) * 1996-08-02 1998-02-12 The Board Of Regents, The University Of Texas System Procede et appareil permettant de caracteriser les tissus de visceres epitheliales tapissees
WO2001072216A2 (fr) * 2000-03-28 2001-10-04 Board Of Regents, The University Of Texas System Procedes et dispositifs d'imagerie numerique diagnostique multispectrale
WO2006105654A1 (fr) * 2005-04-08 2006-10-12 Led Medical Diagnostics, Inc. Speculums substantiellement non fluorescents et méthodes qui s’y rattachent
US20070038120A1 (en) * 2005-07-05 2007-02-15 The Board Of Regents Of The University Of Texas Depth-Resolved Spectroscopy Method and Apparatus

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5251613A (en) * 1991-05-06 1993-10-12 Adair Edwin Lloyd Method of cervical videoscope with detachable camera
WO1996029926A1 (fr) * 1995-03-31 1996-10-03 The Board Of Regents, The University Of Texas System Sonde destinee a la detection des neoplasies cervicales au moyen de la spectroscopie a fluorescence
WO1998005253A1 (fr) * 1996-08-02 1998-02-12 The Board Of Regents, The University Of Texas System Procede et appareil permettant de caracteriser les tissus de visceres epitheliales tapissees
WO2001072216A2 (fr) * 2000-03-28 2001-10-04 Board Of Regents, The University Of Texas System Procedes et dispositifs d'imagerie numerique diagnostique multispectrale
WO2006105654A1 (fr) * 2005-04-08 2006-10-12 Led Medical Diagnostics, Inc. Speculums substantiellement non fluorescents et méthodes qui s’y rattachent
US20070038120A1 (en) * 2005-07-05 2007-02-15 The Board Of Regents Of The University Of Texas Depth-Resolved Spectroscopy Method and Apparatus

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