WO2008114976A8 - Spinorphin derivatives as potent and selective human p2x3 receptor antagonist - Google Patents

Spinorphin derivatives as potent and selective human p2x3 receptor antagonist Download PDF

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Publication number
WO2008114976A8
WO2008114976A8 PCT/KR2008/001476 KR2008001476W WO2008114976A8 WO 2008114976 A8 WO2008114976 A8 WO 2008114976A8 KR 2008001476 W KR2008001476 W KR 2008001476W WO 2008114976 A8 WO2008114976 A8 WO 2008114976A8
Authority
WO
WIPO (PCT)
Prior art keywords
peptide
spinorphin
receptor antagonist
potent
human
Prior art date
Application number
PCT/KR2008/001476
Other languages
French (fr)
Other versions
WO2008114976A1 (en
Inventor
Yong-Chul Kim
Kwan-Young Jeong
Original Assignee
Anygen Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anygen Co., Ltd. filed Critical Anygen Co., Ltd.
Publication of WO2008114976A1 publication Critical patent/WO2008114976A1/en
Publication of WO2008114976A8 publication Critical patent/WO2008114976A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a spinorphin derivative useful as a potent and selective human P2X3 receptor antagonist. More particularly, the present invention provides a spinorphin derivative useful as a potent and selective human P2X3 receptor antagonist selected from peptide AVVYPWT, peptide LAVYPWT, peptide LVAYPWT, peptide LVVAPWT and/ or cyclic peptide LWYPWT. Human P2X3 receptor antagonist has been developed on the electrophysiological evaluation of spinorphin peptide derivatives, truncated peptide analogues, cyclic peptides and a retroinverso peptide at human P2X3 receptors to determine the channel blocking activity.
PCT/KR2008/001476 2007-03-19 2008-03-17 Spinorphin derivatives as potent and selective human p2x3 receptor antagonist WO2008114976A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020070026408A KR100880370B1 (en) 2007-03-19 2007-03-19 Spinorphin derivatives as potent and selective human P2X3 receptor antagonist
KR10-2007-0026408 2007-03-19

Publications (2)

Publication Number Publication Date
WO2008114976A1 WO2008114976A1 (en) 2008-09-25
WO2008114976A8 true WO2008114976A8 (en) 2009-11-05

Family

ID=39766051

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2008/001476 WO2008114976A1 (en) 2007-03-19 2008-03-17 Spinorphin derivatives as potent and selective human p2x3 receptor antagonist

Country Status (2)

Country Link
KR (1) KR100880370B1 (en)
WO (1) WO2008114976A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110201642A1 (en) * 2008-11-03 2011-08-18 John Blunt Bioactive Compounds
CN115327000B (en) * 2022-10-12 2022-12-27 深圳市海滨制药有限公司 Method for detecting 4-methylenepiperidine in efinaconazole

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5367053A (en) * 1993-05-19 1994-11-22 Houghten Pharmaceuticals, Inc. Opioid peptide inhibitors
EP1453849A4 (en) 2001-11-09 2006-03-01 Algos Therapeutics Inc Antisense modulation of purinoreceptor p2x3

Also Published As

Publication number Publication date
WO2008114976A1 (en) 2008-09-25
KR20080085245A (en) 2008-09-24
KR100880370B1 (en) 2009-02-03

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