WO2008111474A1 - Process for production of indole compound - Google Patents

Process for production of indole compound Download PDF

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Publication number
WO2008111474A1
WO2008111474A1 PCT/JP2008/054016 JP2008054016W WO2008111474A1 WO 2008111474 A1 WO2008111474 A1 WO 2008111474A1 JP 2008054016 W JP2008054016 W JP 2008054016W WO 2008111474 A1 WO2008111474 A1 WO 2008111474A1
Authority
WO
WIPO (PCT)
Prior art keywords
indole compound
oco
amount
active carbon
compound
Prior art date
Application number
PCT/JP2008/054016
Other languages
French (fr)
Japanese (ja)
Inventor
Masahiko Hayashi
Yukiko Nomura
Juichi Yanagi
Tatsuo Fujii
Original Assignee
Japan Envirochemicals, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Envirochemicals, Ltd. filed Critical Japan Envirochemicals, Ltd.
Publication of WO2008111474A1 publication Critical patent/WO2008111474A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J21/00—Catalysts comprising the elements, oxides, or hydroxides of magnesium, boron, aluminium, carbon, silicon, titanium, zirconium, or hafnium
    • B01J21/18—Carbon
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J35/00—Catalysts, in general, characterised by their form or physical properties
    • B01J35/30—Catalysts, in general, characterised by their form or physical properties characterised by their physical properties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Indole Compounds (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Catalysts (AREA)

Abstract

Disclosed is a process for producing an indole compound by contacting an indoline compound with oxygen in the presence of a catalyst comprising active carbon which satisfies the requirement represented by the formula (I). 4000<S×(Oco) (I) [wherein S represents a BET specific surface area (m2/g); and Oco represents an amount (expressed by wt%) of the surface oxygen released in the form of carbon monoxide by heating relative to the amount of active carbon.] The process enables to produce an indole compound which is useful as the skeletal component for a pharmaceutical agent (e.g., indomethacin) or a dye at low cost and in a safe and efficient manner.
PCT/JP2008/054016 2007-03-09 2008-03-06 Process for production of indole compound WO2008111474A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-059414 2007-03-09
JP2007059414A JP2008222576A (en) 2007-03-09 2007-03-09 Method for producing indole compound

Publications (1)

Publication Number Publication Date
WO2008111474A1 true WO2008111474A1 (en) 2008-09-18

Family

ID=39759416

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/054016 WO2008111474A1 (en) 2007-03-09 2008-03-06 Process for production of indole compound

Country Status (2)

Country Link
JP (1) JP2008222576A (en)
WO (1) WO2008111474A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
US9394285B2 (en) 2013-03-15 2016-07-19 Pfizer Inc. Indole and indazole compounds that activate AMPK
CN106432040A (en) * 2016-08-09 2017-02-22 中钢集团鞍山热能研究院有限公司 Environment-friendly synthesis method for medicine intermediate 5-bromoindole
CN106966950A (en) * 2017-04-17 2017-07-21 兰州大学 A kind of preparation method of the bromo indole of pharmaceutical intermediate 5

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51110561A (en) * 1975-03-25 1976-09-30 Mitsui Toatsu Chemicals INDOOR USEIZOHO
JP2005145859A (en) * 2003-11-13 2005-06-09 Nippon Steel Chem Co Ltd Dehydrogenation method and method for producing aromatic heterocyclic compound
WO2006028035A1 (en) * 2004-09-06 2006-03-16 Japan Envirochemicals, Ltd. Oxidation reaction catalyst and process for producing compound using the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51110561A (en) * 1975-03-25 1976-09-30 Mitsui Toatsu Chemicals INDOOR USEIZOHO
JP2005145859A (en) * 2003-11-13 2005-06-09 Nippon Steel Chem Co Ltd Dehydrogenation method and method for producing aromatic heterocyclic compound
WO2006028035A1 (en) * 2004-09-06 2006-03-16 Japan Envirochemicals, Ltd. Oxidation reaction catalyst and process for producing compound using the same

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
US9394285B2 (en) 2013-03-15 2016-07-19 Pfizer Inc. Indole and indazole compounds that activate AMPK
CN106432040A (en) * 2016-08-09 2017-02-22 中钢集团鞍山热能研究院有限公司 Environment-friendly synthesis method for medicine intermediate 5-bromoindole
CN106432040B (en) * 2016-08-09 2019-02-19 中钢集团鞍山热能研究院有限公司 A kind of green synthesis method of medicine intermediate 5- bromo indole
CN106966950A (en) * 2017-04-17 2017-07-21 兰州大学 A kind of preparation method of the bromo indole of pharmaceutical intermediate 5

Also Published As

Publication number Publication date
JP2008222576A (en) 2008-09-25

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