WO2008110351A3 - Use of (r) and (s)-2-aryl-propionic acid derivatives as antiseptic agents - Google Patents
Use of (r) and (s)-2-aryl-propionic acid derivatives as antiseptic agents Download PDFInfo
- Publication number
- WO2008110351A3 WO2008110351A3 PCT/EP2008/001965 EP2008001965W WO2008110351A3 WO 2008110351 A3 WO2008110351 A3 WO 2008110351A3 EP 2008001965 W EP2008001965 W EP 2008001965W WO 2008110351 A3 WO2008110351 A3 WO 2008110351A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- epidermal
- present
- aryl
- infections
- antiseptic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
The present invention relates to the use of amides of (R) and (S)-2-aryl- propionic acids as antiseptic agents. The present invention also provides a pharmaceutical preparation including compounds of formula (I), having antiseptic properties for the treatment of gastrointestinal, muco-epidermal and epidermal infections. The present invention is related to pharmaceutical compositions containing an antiseptic agent carried in a suitable vehicle to provide mouthwashes, tablets, solutions, gels, creams and others. The formulations are applied topically to sites of gastrointestinal, muco-epidermal or epidermal infections. Compounds of present invention can be useful in the treatment of nausea, vomiting, bloating, diarrhea, constipation and oropharyngeal, esophageal, vaginal, rectal, nasal and other mucosal infections.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07104237.8 | 2007-03-15 | ||
EP07104237 | 2007-03-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008110351A2 WO2008110351A2 (en) | 2008-09-18 |
WO2008110351A3 true WO2008110351A3 (en) | 2009-04-30 |
Family
ID=39760135
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2008/001965 WO2008110351A2 (en) | 2007-03-15 | 2008-03-12 | Use of (r) and (s)-2-aryl-propionic acid derivatives as antiseptic agents |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008110351A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20210123406A (en) | 2008-12-04 | 2021-10-13 | 충시 위 | High Penetration Compositions and Their Applications |
CN103030574B (en) * | 2013-01-04 | 2014-10-01 | 中国农业大学 | Cyano acidamide compound, and synthetic method and application of compound |
Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5942600A (en) * | 1995-05-25 | 1999-08-24 | G. D. Searle & Co. | Seryl-lysyl-based peptide and peptidomimetic inhibitors of N-myristoyl transferase as anti-infective agents |
WO2001062709A2 (en) * | 2000-02-24 | 2001-08-30 | Jomaa Pharmaka Gmbh | Use of 2-phenylene diamine derivatives for the treatment of infections |
WO2001087838A1 (en) * | 2000-05-19 | 2001-11-22 | Merck Sharp & Dohme Limited | Cyclohexane derivatives and their use as therapeutic agents |
WO2002059081A2 (en) * | 2001-01-26 | 2002-08-01 | Kirin Beer Kabushiki Kaisha | Urea derivatives as inhibitors of ccr-3 receptor |
WO2002065977A2 (en) * | 2001-02-20 | 2002-08-29 | Israel Institute For Biological Research | Compounds co-inducing cholinergic up-regulation and inflammation down-regulation and uses thereof |
WO2002068377A1 (en) * | 2001-02-27 | 2002-09-06 | Dompé S.p.A. | Omega-aminoalkylamides of r-2-aryl-propionic acids as inhibitors of the chemotaxis of polymorphonucleate and mononucleate cells |
WO2004037784A2 (en) * | 2002-10-21 | 2004-05-06 | Irm Llc | Pyrrolidones with anti-hiv activity |
WO2005110970A1 (en) * | 2004-05-10 | 2005-11-24 | Grünenthal GmbH | Oxo-substituted cyclohexyl-1,4-diamine derivatives |
WO2007045462A2 (en) * | 2005-10-19 | 2007-04-26 | Grünenthal GmbH | Novel vanilloid receptor ligands and their use for producing medicaments |
WO2008010025A1 (en) * | 2006-07-18 | 2008-01-24 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of ibuprofen with very fast skin penetration rate |
WO2008012605A1 (en) * | 2006-07-27 | 2008-01-31 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of ketoprofen and related compounds with very fast skin penetration rate |
WO2008125337A2 (en) * | 2007-04-16 | 2008-10-23 | Grünenthal GmbH | Novel vanilloid receptor ligands and the use thereof for the production of pharmaceuticals |
-
2008
- 2008-03-12 WO PCT/EP2008/001965 patent/WO2008110351A2/en active Application Filing
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5942600A (en) * | 1995-05-25 | 1999-08-24 | G. D. Searle & Co. | Seryl-lysyl-based peptide and peptidomimetic inhibitors of N-myristoyl transferase as anti-infective agents |
WO2001062709A2 (en) * | 2000-02-24 | 2001-08-30 | Jomaa Pharmaka Gmbh | Use of 2-phenylene diamine derivatives for the treatment of infections |
WO2001087838A1 (en) * | 2000-05-19 | 2001-11-22 | Merck Sharp & Dohme Limited | Cyclohexane derivatives and their use as therapeutic agents |
WO2002059081A2 (en) * | 2001-01-26 | 2002-08-01 | Kirin Beer Kabushiki Kaisha | Urea derivatives as inhibitors of ccr-3 receptor |
WO2002065977A2 (en) * | 2001-02-20 | 2002-08-29 | Israel Institute For Biological Research | Compounds co-inducing cholinergic up-regulation and inflammation down-regulation and uses thereof |
WO2002068377A1 (en) * | 2001-02-27 | 2002-09-06 | Dompé S.p.A. | Omega-aminoalkylamides of r-2-aryl-propionic acids as inhibitors of the chemotaxis of polymorphonucleate and mononucleate cells |
WO2004037784A2 (en) * | 2002-10-21 | 2004-05-06 | Irm Llc | Pyrrolidones with anti-hiv activity |
WO2005110970A1 (en) * | 2004-05-10 | 2005-11-24 | Grünenthal GmbH | Oxo-substituted cyclohexyl-1,4-diamine derivatives |
WO2007045462A2 (en) * | 2005-10-19 | 2007-04-26 | Grünenthal GmbH | Novel vanilloid receptor ligands and their use for producing medicaments |
WO2008010025A1 (en) * | 2006-07-18 | 2008-01-24 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of ibuprofen with very fast skin penetration rate |
WO2008012605A1 (en) * | 2006-07-27 | 2008-01-31 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of ketoprofen and related compounds with very fast skin penetration rate |
WO2008125337A2 (en) * | 2007-04-16 | 2008-10-23 | Grünenthal GmbH | Novel vanilloid receptor ligands and the use thereof for the production of pharmaceuticals |
Non-Patent Citations (2)
Title |
---|
ALLEGRETTI M ET AL: "2-Arylpropionic CXC Chemokine Receptor 1 (CXCR1) Ligands as Novel Noncompetitive CXCL8 Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON.; US, vol. 48, no. 13, 30 June 2005 (2005-06-30), pages 4312 - 4331, XP008102465, ISSN: 0022-2623, [retrieved on 20050527] * |
AURELI L ET AL: "Predicting human serum albumin affinity of Interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON.; US, vol. 48, 8 March 2005 (2005-03-08), pages 2469 - 2479, XP002380701, ISSN: 0022-2623 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008110351A2 (en) | 2008-09-18 |
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