WO2008110351A3 - Use of (r) and (s)-2-aryl-propionic acid derivatives as antiseptic agents - Google Patents

Use of (r) and (s)-2-aryl-propionic acid derivatives as antiseptic agents Download PDF

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Publication number
WO2008110351A3
WO2008110351A3 PCT/EP2008/001965 EP2008001965W WO2008110351A3 WO 2008110351 A3 WO2008110351 A3 WO 2008110351A3 EP 2008001965 W EP2008001965 W EP 2008001965W WO 2008110351 A3 WO2008110351 A3 WO 2008110351A3
Authority
WO
WIPO (PCT)
Prior art keywords
epidermal
present
aryl
infections
antiseptic
Prior art date
Application number
PCT/EP2008/001965
Other languages
French (fr)
Other versions
WO2008110351A2 (en
Inventor
Marco Cantarini
Marco Gentile
Original Assignee
Dompe Pha R Ma Spa Res & Mfg
Marco Cantarini
Marco Gentile
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dompe Pha R Ma Spa Res & Mfg, Marco Cantarini, Marco Gentile filed Critical Dompe Pha R Ma Spa Res & Mfg
Publication of WO2008110351A2 publication Critical patent/WO2008110351A2/en
Publication of WO2008110351A3 publication Critical patent/WO2008110351A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

The present invention relates to the use of amides of (R) and (S)-2-aryl- propionic acids as antiseptic agents. The present invention also provides a pharmaceutical preparation including compounds of formula (I), having antiseptic properties for the treatment of gastrointestinal, muco-epidermal and epidermal infections. The present invention is related to pharmaceutical compositions containing an antiseptic agent carried in a suitable vehicle to provide mouthwashes, tablets, solutions, gels, creams and others. The formulations are applied topically to sites of gastrointestinal, muco-epidermal or epidermal infections. Compounds of present invention can be useful in the treatment of nausea, vomiting, bloating, diarrhea, constipation and oropharyngeal, esophageal, vaginal, rectal, nasal and other mucosal infections.
PCT/EP2008/001965 2007-03-15 2008-03-12 Use of (r) and (s)-2-aryl-propionic acid derivatives as antiseptic agents WO2008110351A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07104237.8 2007-03-15
EP07104237 2007-03-15

Publications (2)

Publication Number Publication Date
WO2008110351A2 WO2008110351A2 (en) 2008-09-18
WO2008110351A3 true WO2008110351A3 (en) 2009-04-30

Family

ID=39760135

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/001965 WO2008110351A2 (en) 2007-03-15 2008-03-12 Use of (r) and (s)-2-aryl-propionic acid derivatives as antiseptic agents

Country Status (1)

Country Link
WO (1) WO2008110351A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230085223A (en) * 2008-12-04 2023-06-13 충시 위 High Penetration Compositions and Their Applications
CN103030574B (en) * 2013-01-04 2014-10-01 中国农业大学 Cyano acidamide compound, and synthetic method and application of compound

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5942600A (en) * 1995-05-25 1999-08-24 G. D. Searle & Co. Seryl-lysyl-based peptide and peptidomimetic inhibitors of N-myristoyl transferase as anti-infective agents
WO2001062709A2 (en) * 2000-02-24 2001-08-30 Jomaa Pharmaka Gmbh Use of 2-phenylene diamine derivatives for the treatment of infections
WO2001087838A1 (en) * 2000-05-19 2001-11-22 Merck Sharp & Dohme Limited Cyclohexane derivatives and their use as therapeutic agents
WO2002059081A2 (en) * 2001-01-26 2002-08-01 Kirin Beer Kabushiki Kaisha Urea derivatives as inhibitors of ccr-3 receptor
WO2002065977A2 (en) * 2001-02-20 2002-08-29 Israel Institute For Biological Research Compounds co-inducing cholinergic up-regulation and inflammation down-regulation and uses thereof
WO2002068377A1 (en) * 2001-02-27 2002-09-06 Dompé S.p.A. Omega-aminoalkylamides of r-2-aryl-propionic acids as inhibitors of the chemotaxis of polymorphonucleate and mononucleate cells
WO2004037784A2 (en) * 2002-10-21 2004-05-06 Irm Llc Pyrrolidones with anti-hiv activity
WO2005110970A1 (en) * 2004-05-10 2005-11-24 Grünenthal GmbH Oxo-substituted cyclohexyl-1,4-diamine derivatives
WO2007045462A2 (en) * 2005-10-19 2007-04-26 Grünenthal GmbH Novel vanilloid receptor ligands and their use for producing medicaments
WO2008010025A1 (en) * 2006-07-18 2008-01-24 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of ibuprofen with very fast skin penetration rate
WO2008012605A1 (en) * 2006-07-27 2008-01-31 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of ketoprofen and related compounds with very fast skin penetration rate
WO2008125337A2 (en) * 2007-04-16 2008-10-23 Grünenthal GmbH Novel vanilloid receptor ligands and the use thereof for the production of pharmaceuticals

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5942600A (en) * 1995-05-25 1999-08-24 G. D. Searle & Co. Seryl-lysyl-based peptide and peptidomimetic inhibitors of N-myristoyl transferase as anti-infective agents
WO2001062709A2 (en) * 2000-02-24 2001-08-30 Jomaa Pharmaka Gmbh Use of 2-phenylene diamine derivatives for the treatment of infections
WO2001087838A1 (en) * 2000-05-19 2001-11-22 Merck Sharp & Dohme Limited Cyclohexane derivatives and their use as therapeutic agents
WO2002059081A2 (en) * 2001-01-26 2002-08-01 Kirin Beer Kabushiki Kaisha Urea derivatives as inhibitors of ccr-3 receptor
WO2002065977A2 (en) * 2001-02-20 2002-08-29 Israel Institute For Biological Research Compounds co-inducing cholinergic up-regulation and inflammation down-regulation and uses thereof
WO2002068377A1 (en) * 2001-02-27 2002-09-06 Dompé S.p.A. Omega-aminoalkylamides of r-2-aryl-propionic acids as inhibitors of the chemotaxis of polymorphonucleate and mononucleate cells
WO2004037784A2 (en) * 2002-10-21 2004-05-06 Irm Llc Pyrrolidones with anti-hiv activity
WO2005110970A1 (en) * 2004-05-10 2005-11-24 Grünenthal GmbH Oxo-substituted cyclohexyl-1,4-diamine derivatives
WO2007045462A2 (en) * 2005-10-19 2007-04-26 Grünenthal GmbH Novel vanilloid receptor ligands and their use for producing medicaments
WO2008010025A1 (en) * 2006-07-18 2008-01-24 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of ibuprofen with very fast skin penetration rate
WO2008012605A1 (en) * 2006-07-27 2008-01-31 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of ketoprofen and related compounds with very fast skin penetration rate
WO2008125337A2 (en) * 2007-04-16 2008-10-23 Grünenthal GmbH Novel vanilloid receptor ligands and the use thereof for the production of pharmaceuticals

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ALLEGRETTI M ET AL: "2-Arylpropionic CXC Chemokine Receptor 1 (CXCR1) Ligands as Novel Noncompetitive CXCL8 Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON.; US, vol. 48, no. 13, 30 June 2005 (2005-06-30), pages 4312 - 4331, XP008102465, ISSN: 0022-2623, [retrieved on 20050527] *
AURELI L ET AL: "Predicting human serum albumin affinity of Interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON.; US, vol. 48, 8 March 2005 (2005-03-08), pages 2469 - 2479, XP002380701, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
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