WO2008107663A3 - Inhibitory product removal - Google Patents

Inhibitory product removal Download PDF

Info

Publication number
WO2008107663A3
WO2008107663A3 PCT/GB2008/000726 GB2008000726W WO2008107663A3 WO 2008107663 A3 WO2008107663 A3 WO 2008107663A3 GB 2008000726 W GB2008000726 W GB 2008000726W WO 2008107663 A3 WO2008107663 A3 WO 2008107663A3
Authority
WO
WIPO (PCT)
Prior art keywords
compartment
electrodes
culture medium
product removal
ionic component
Prior art date
Application number
PCT/GB2008/000726
Other languages
French (fr)
Other versions
WO2008107663A2 (en
Inventor
Steven Doig
Michael Wright
Christopher John Knowles
Original Assignee
Ekb Technology Ltd
Steven Doig
Michael Wright
Christopher John Knowles
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ekb Technology Ltd, Steven Doig, Michael Wright, Christopher John Knowles filed Critical Ekb Technology Ltd
Priority to EP08709586A priority Critical patent/EP2129769A2/en
Publication of WO2008107663A2 publication Critical patent/WO2008107663A2/en
Publication of WO2008107663A3 publication Critical patent/WO2008107663A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/34—Internal compartments or partitions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

A process for the removal of an ionic component from a cell culture medium includes the provision of the culture medium in a first compartment of a compartmentalised electrokinetic cell in which the electrodes are isolated from the culture medium. A second compartment is located between the first compartment and one of the electrodes and is separated from the first component by means allowing transfer of the ionic component between the compartments. A DC electric field is applied between the electrodes to cause the ionic component to pass from the first compartment into the second compartment. Apparatus for cultivation of animal cells, using the process of the invention, is also provided.
PCT/GB2008/000726 2007-03-02 2008-03-03 Inhibitory product removal WO2008107663A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08709586A EP2129769A2 (en) 2007-03-02 2008-03-03 Inhibitory product removal

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0704025.6 2007-03-02
GBGB0704025.6A GB0704025D0 (en) 2007-03-02 2007-03-02 Inhibitory product removal

Publications (2)

Publication Number Publication Date
WO2008107663A2 WO2008107663A2 (en) 2008-09-12
WO2008107663A3 true WO2008107663A3 (en) 2008-10-30

Family

ID=37965776

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/000726 WO2008107663A2 (en) 2007-03-02 2008-03-03 Inhibitory product removal

Country Status (3)

Country Link
EP (1) EP2129769A2 (en)
GB (1) GB0704025D0 (en)
WO (1) WO2008107663A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2976421B1 (en) * 2013-03-22 2016-11-09 Danmarks Tekniske Universitet A bio-electrochemical system for removing inhibitors of anaerobic digestion processes from anaerobic reactors

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007133A2 (en) * 1978-07-19 1980-01-23 Chemap AG Fermenter
DD211579A1 (en) * 1982-11-19 1984-07-18 Adw Ddr METHOD AND DEVICE FOR REMOVING AND OBTAINING IONOGENIC METABOLIC PRODUCTS
EP0219791A2 (en) * 1985-10-14 1987-04-29 Hitachi, Ltd. Process for culturing recombinant cells
EP0385613A1 (en) * 1989-02-24 1990-09-05 Bend Research, Inc. Ammonia removal from mammalian cell cultures
EP0657542A1 (en) * 1993-12-08 1995-06-14 MUSASHINO CHEMICAL LABORATORY Ltd. Method for fermentative production of lactic acid
GB2395481A (en) * 2002-11-19 2004-05-26 C Tech Innovation Ltd Electric Field control of biocatalysis reactions

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007133A2 (en) * 1978-07-19 1980-01-23 Chemap AG Fermenter
DD211579A1 (en) * 1982-11-19 1984-07-18 Adw Ddr METHOD AND DEVICE FOR REMOVING AND OBTAINING IONOGENIC METABOLIC PRODUCTS
EP0219791A2 (en) * 1985-10-14 1987-04-29 Hitachi, Ltd. Process for culturing recombinant cells
EP0385613A1 (en) * 1989-02-24 1990-09-05 Bend Research, Inc. Ammonia removal from mammalian cell cultures
EP0657542A1 (en) * 1993-12-08 1995-06-14 MUSASHINO CHEMICAL LABORATORY Ltd. Method for fermentative production of lactic acid
GB2395481A (en) * 2002-11-19 2004-05-26 C Tech Innovation Ltd Electric Field control of biocatalysis reactions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HONG LI ET AL: "An electrokinetic bioreactor: using direct electric current for enhanced lactic acid fermentation and product recovery", TETRAHEDRON, vol. 60, 2004, pages 655 - 661, XP002491541 *

Also Published As

Publication number Publication date
GB0704025D0 (en) 2007-04-11
EP2129769A2 (en) 2009-12-09
WO2008107663A2 (en) 2008-09-12

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