WO2008106984A3 - Pig model for breast cancer, mitochondria related protein folding disorders and/or epidermolysis bullosa simplex - Google Patents
Pig model for breast cancer, mitochondria related protein folding disorders and/or epidermolysis bullosa simplex Download PDFInfo
- Publication number
- WO2008106984A3 WO2008106984A3 PCT/DK2008/050057 DK2008050057W WO2008106984A3 WO 2008106984 A3 WO2008106984 A3 WO 2008106984A3 DK 2008050057 W DK2008050057 W DK 2008050057W WO 2008106984 A3 WO2008106984 A3 WO 2008106984A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- breast cancer
- related protein
- protein folding
- epidermolysis bullosa
- modified
- Prior art date
Links
- 206010006187 Breast cancer Diseases 0.000 title abstract 4
- 208000026310 Breast neoplasm Diseases 0.000 title abstract 4
- 208000007150 epidermolysis bullosa simplex Diseases 0.000 title abstract 4
- 210000003470 mitochondria Anatomy 0.000 title abstract 4
- 208000007153 proteostasis deficiencies Diseases 0.000 title abstract 4
- 238000013310 pig model Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 4
- 101150028074 2 gene Proteins 0.000 abstract 1
- 102000036365 BRCA1 Human genes 0.000 abstract 1
- 108700020463 BRCA1 Proteins 0.000 abstract 1
- 101150072950 BRCA1 gene Proteins 0.000 abstract 1
- 108010066321 Keratin-14 Proteins 0.000 abstract 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical class NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 1
- 101710198224 Ornithine carbamoyltransferase, mitochondrial Proteins 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000002103 transcriptional effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
- C12N15/877—Techniques for producing new mammalian cloned embryos
- C12N15/8778—Swine embryos
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/90—Vectors containing a transposable element
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Environmental Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2717251A CA2717251A1 (en) | 2007-03-07 | 2008-03-06 | Pig model for breast cancer, mitochondria related protein folding disorders and/or epidermolysis bullosa simplex |
US12/529,816 US20100115636A1 (en) | 2007-03-07 | 2008-03-06 | Pig model for breast cancer, mitochondria related protein folding disorders and/or epidermolysis bullosa simplex |
EP08715611A EP2134848A2 (en) | 2007-03-07 | 2008-03-06 | Pig model for breast cancer, mitochondria related protein folding disorders and/or epidermolysis bullosa simplex |
US13/592,045 US20130150465A1 (en) | 2007-03-07 | 2012-08-22 | Pig model for breast cancer, mitochondria related protein folding disorders and/or epidermolysis bullosa simplex |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200700342 | 2007-03-07 | ||
DKPA200700342 | 2007-03-07 | ||
DKPA200700344 | 2007-03-07 | ||
DKPA200700344 | 2007-03-07 | ||
DKPA200700341 | 2007-03-07 | ||
DKPA200700341 | 2007-03-07 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/592,045 Continuation US20130150465A1 (en) | 2007-03-07 | 2012-08-22 | Pig model for breast cancer, mitochondria related protein folding disorders and/or epidermolysis bullosa simplex |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008106984A2 WO2008106984A2 (en) | 2008-09-12 |
WO2008106984A3 true WO2008106984A3 (en) | 2008-12-31 |
Family
ID=39592108
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DK2008/050057 WO2008106984A2 (en) | 2007-03-07 | 2008-03-06 | Pig model for breast cancer, mitochondria related protein folding disorders and/or epidermolysis bullosa simplex |
Country Status (4)
Country | Link |
---|---|
US (2) | US20100115636A1 (en) |
EP (1) | EP2134848A2 (en) |
CA (1) | CA2717251A1 (en) |
WO (1) | WO2008106984A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8912386B2 (en) | 2007-03-28 | 2014-12-16 | University Of Iowa Research Foundation | Transgenic pig model of cystic fibrosis |
US8618352B2 (en) | 2007-03-28 | 2013-12-31 | University Of Iowa Research Foundation | Transgenic porcine models of cystic fibrosis |
WO2008121199A2 (en) * | 2007-03-28 | 2008-10-09 | University Of Iowa Research Foundation | Transgenic animal models of disease |
US10172333B2 (en) | 2013-03-15 | 2019-01-08 | Exemplar Genetics, Llc | Animal models of cancer |
WO2016140353A1 (en) * | 2015-03-04 | 2016-09-09 | 株式会社 医療実験用大動物供給事業準備会社 | Disease model pig exhibiting stable phenotype, and production method thereof |
GB201504124D0 (en) | 2015-03-11 | 2015-04-22 | Proqr Therapeutics B V | Oligonucleotides |
US10697014B2 (en) | 2015-12-03 | 2020-06-30 | The Penn State Research Foundation | Genomic regions with epigenetic variation that contribute to phenotypic differences in livestock |
EP4314260A1 (en) * | 2021-03-24 | 2024-02-07 | Modernatx, Inc. | Lipid nanoparticles and polynucleotides encoding ornithine transcarbamylase for the treatment of ornithine transcarbamylase deficiency |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999060108A2 (en) * | 1998-05-15 | 1999-11-25 | Sri International | Transgenic animals produced by homologous sequence targeting |
US20020035736A1 (en) * | 2000-03-16 | 2002-03-21 | Sharon Erickson | HER2-transgenic non-human tumor model |
WO2002077027A1 (en) * | 2000-03-23 | 2002-10-03 | Curagen Corporation | Human stra6-like protein and nucleic acids encoding the same |
WO2003064633A1 (en) * | 2002-01-11 | 2003-08-07 | Gtc Biotherapeutics, Inc. | Method and system for fusion and activation following nuclear transfer in reconstructed embryos |
GB2388114A (en) * | 2002-04-10 | 2003-11-05 | Peter Maccallum Cancer Inst | Methods of diagnosis or prognosis of a BRCA associated disorder |
WO2004064768A2 (en) * | 2003-01-23 | 2004-08-05 | Agy Therapeutics, Inc. | Animal model for alzheimer's disease |
WO2007028396A2 (en) * | 2005-09-08 | 2007-03-15 | Aarhus Universitet | Cell nuclear transfer |
WO2007124751A2 (en) * | 2006-05-01 | 2007-11-08 | Aarhus Universitet | An animal model and a method for producing an animal model |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001019181A1 (en) * | 1999-09-13 | 2001-03-22 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusets, As Represented By Its Amherst Campus | Cloning pigs using donor cells or nuclei from differentiated cells and production of pluripotent porcine. |
-
2008
- 2008-03-06 WO PCT/DK2008/050057 patent/WO2008106984A2/en active Application Filing
- 2008-03-06 US US12/529,816 patent/US20100115636A1/en not_active Abandoned
- 2008-03-06 EP EP08715611A patent/EP2134848A2/en not_active Withdrawn
- 2008-03-06 CA CA2717251A patent/CA2717251A1/en not_active Abandoned
-
2012
- 2012-08-22 US US13/592,045 patent/US20130150465A1/en not_active Abandoned
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999060108A2 (en) * | 1998-05-15 | 1999-11-25 | Sri International | Transgenic animals produced by homologous sequence targeting |
US20020035736A1 (en) * | 2000-03-16 | 2002-03-21 | Sharon Erickson | HER2-transgenic non-human tumor model |
WO2002077027A1 (en) * | 2000-03-23 | 2002-10-03 | Curagen Corporation | Human stra6-like protein and nucleic acids encoding the same |
WO2003064633A1 (en) * | 2002-01-11 | 2003-08-07 | Gtc Biotherapeutics, Inc. | Method and system for fusion and activation following nuclear transfer in reconstructed embryos |
GB2388114A (en) * | 2002-04-10 | 2003-11-05 | Peter Maccallum Cancer Inst | Methods of diagnosis or prognosis of a BRCA associated disorder |
WO2004064768A2 (en) * | 2003-01-23 | 2004-08-05 | Agy Therapeutics, Inc. | Animal model for alzheimer's disease |
WO2007028396A2 (en) * | 2005-09-08 | 2007-03-15 | Aarhus Universitet | Cell nuclear transfer |
WO2007124751A2 (en) * | 2006-05-01 | 2007-11-08 | Aarhus Universitet | An animal model and a method for producing an animal model |
Non-Patent Citations (5)
Title |
---|
CAO T, ET AL.: "AN INDUCIBLE MOUSE MODEL FOR EPIDERMOLYSIS BULLOSA SIMPLEX: IMPLICATION FOR GENE THERAPY", THE JOURNAL OF CELL BIOLOGY, vol. 152, no. 3, 2001, pages 651 - 656, XP002500577 * |
DATABASE EMBL 1 September 1996 (1996-09-01), XP002488550, Database accession no. Z75667 * |
LLOYDS ET AL, ET AL.: "THE BASAL KERATIN NETWORK OF STRATIFIED SQUAMOUS EPITHELIA: DEFINING K15 FUNCTION IN THE ABSENCE OF K14", THE JOURNAL OF CELL BIOLOGY, vol. 129, no. 5, 1995, pages 1329 - 1344, XP002500576 * |
PETERS B, ET AL.: "COMPLETE CYTOLYSIS AND NEONATAL LETHALITY IN KERATIN 5 KNOCKOUT MICE REVEALS ITS FUNDAMENTAL ROLE IN SKIN INTEGRITY AND IN EPIDERMOLYSIS BULLOSA SIMPLEX", MOLECULAR BIOLOGY, vol. 12, 2001, pages 1775 - 1789, XP002500578 * |
VODICKA PETR ET AL: "The miniature pig as an animal model in biomedical research", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, NEW YORK, NY, US, vol. 1049, 1 May 2005 (2005-05-01), pages 161 - 171, XP009090232, ISSN: 0077-8923 * |
Also Published As
Publication number | Publication date |
---|---|
EP2134848A2 (en) | 2009-12-23 |
CA2717251A1 (en) | 2008-09-12 |
WO2008106984A2 (en) | 2008-09-12 |
US20130150465A1 (en) | 2013-06-13 |
US20100115636A1 (en) | 2010-05-06 |
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