WO2008104777A3 - Peptide - Google Patents

Peptide Download PDF

Info

Publication number
WO2008104777A3
WO2008104777A3 PCT/GB2008/000668 GB2008000668W WO2008104777A3 WO 2008104777 A3 WO2008104777 A3 WO 2008104777A3 GB 2008000668 W GB2008000668 W GB 2008000668W WO 2008104777 A3 WO2008104777 A3 WO 2008104777A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptide
seq
antimicrobial
domain
rpafrkaafrvmracv
Prior art date
Application number
PCT/GB2008/000668
Other languages
French (fr)
Other versions
WO2008104777A2 (en
Inventor
Timothy Rutland Walsh
Robin Anthony Howe
Christopher Dempsey
Ayman Hawrani
Original Assignee
Univ Bristol
Timothy Rutland Walsh
Robin Anthony Howe
Christopher Dempsey
Ayman Hawrani
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Bristol, Timothy Rutland Walsh, Robin Anthony Howe, Christopher Dempsey, Ayman Hawrani filed Critical Univ Bristol
Publication of WO2008104777A2 publication Critical patent/WO2008104777A2/en
Publication of WO2008104777A3 publication Critical patent/WO2008104777A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention encompasses a novel peptide with antimicrobial activity, particularly but not only against Gram-negative bacteria, and uses thereof. The peptide is non-cyclic and comprises or consists of an antimicrobial domain that adopts an alpha-helix conformation upon interaction with a negatively- charged membrane. The antimicrobial domain has a sequence shown by formula (IV) : X1- X2 -X3 - X4- X5 - X6- X7 - X8-X9 X10-X11-X12-X13-X14-X15-X16 (SEQ ID NO: 7), in which X1, X5, X10 and X13 are each independently K or R; X15 is C; and the remaining residues are as specified herein. An examplar peptide is RPAFRKAAFRVMRACV ('RTA3'; SEQ ID NO: 9).
PCT/GB2008/000668 2007-03-01 2008-02-29 Peptide WO2008104777A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0703945.6 2007-03-01
GB0703945A GB0703945D0 (en) 2007-03-01 2007-03-01 Peptide

Publications (2)

Publication Number Publication Date
WO2008104777A2 WO2008104777A2 (en) 2008-09-04
WO2008104777A3 true WO2008104777A3 (en) 2009-03-19

Family

ID=37965714

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/000668 WO2008104777A2 (en) 2007-03-01 2008-02-29 Peptide

Country Status (2)

Country Link
GB (1) GB0703945D0 (en)
WO (1) WO2008104777A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110262508A1 (en) * 2007-11-07 2011-10-27 Paul Michael Watt Antimicrobial compositions, formulations and uses thereof
GB201505393D0 (en) * 2015-03-30 2015-05-13 Secr Defence Antimicrobal peptide formulations
CN109097298B (en) * 2018-08-08 2021-09-28 福建九为生物技术有限公司 Method for preparing bdellovibrio bacteriovorus preparation by enrichment culture method

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004072093A2 (en) * 2003-02-14 2004-08-26 The University Of Bristol Antimicrobial agents from streptococcus mitis and streptococcus oralis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004072093A2 (en) * 2003-02-14 2004-08-26 The University Of Bristol Antimicrobial agents from streptococcus mitis and streptococcus oralis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
APELGREN L D ET AL: "PURIFICATION OF A STREPTOCOCCAL BACTERIOCIN (VIRIDIN B9 AND ITS SEPARATION FROM ALPHA-HEMOLYSIN", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 15, no. 3, 1 March 1979 (1979-03-01), pages 436 - 439, XP009034498, ISSN: 0066-4804 *
TOKE ORSOLYA: "Antimicrobial peptides: New candidates in the fight against bacterial infections", BIOPOLYMERS, vol. 80, no. 6, 2005, pages 717 - 735, XP002495275, ISSN: 0006-3525 *

Also Published As

Publication number Publication date
WO2008104777A2 (en) 2008-09-04
GB0703945D0 (en) 2007-04-11

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