WO2008102584A1 - Novel flavanol compound and method for production thereof - Google Patents

Novel flavanol compound and method for production thereof Download PDF

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Publication number
WO2008102584A1
WO2008102584A1 PCT/JP2008/050616 JP2008050616W WO2008102584A1 WO 2008102584 A1 WO2008102584 A1 WO 2008102584A1 JP 2008050616 W JP2008050616 W JP 2008050616W WO 2008102584 A1 WO2008102584 A1 WO 2008102584A1
Authority
WO
WIPO (PCT)
Prior art keywords
novel
production
flavanol compound
flavanol
compound
Prior art date
Application number
PCT/JP2008/050616
Other languages
French (fr)
Japanese (ja)
Inventor
Ping Zhao
Toshihiko Shoji
Tomomasa Kanda
Original Assignee
Asahi Breweries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Breweries, Ltd. filed Critical Asahi Breweries, Ltd.
Publication of WO2008102584A1 publication Critical patent/WO2008102584A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

Abstract

Disclosed is a novel compound which can be used as a pharmaceutical agent, a cosmetic, a health food, a food additive or the like. Specifically disclosed is a flavanol compound shown by the formula (1). (1)
PCT/JP2008/050616 2007-02-21 2008-01-18 Novel flavanol compound and method for production thereof WO2008102584A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-041250 2007-02-21
JP2007041250A JP2008201745A (en) 2007-02-21 2007-02-21 New flavanol compound and method for producing the same

Publications (1)

Publication Number Publication Date
WO2008102584A1 true WO2008102584A1 (en) 2008-08-28

Family

ID=39709863

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/050616 WO2008102584A1 (en) 2007-02-21 2008-01-18 Novel flavanol compound and method for production thereof

Country Status (2)

Country Link
JP (1) JP2008201745A (en)
WO (1) WO2008102584A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003024951A1 (en) * 2001-09-17 2003-03-27 Consejo Superior Investigaciones Científicas Flavonol and cysteine conjugates
WO2006032572A1 (en) * 2004-08-10 2006-03-30 Consejo Superior De Investigaciones Científicas Use of flavanol derivatives for the cryopreservation of living cells
JP2006328025A (en) * 2005-05-30 2006-12-07 Asahi Breweries Ltd Nitric oxide regulator, food and beverage containing the same, food additive, medicine and cosmetic

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003024951A1 (en) * 2001-09-17 2003-03-27 Consejo Superior Investigaciones Científicas Flavonol and cysteine conjugates
WO2006032572A1 (en) * 2004-08-10 2006-03-30 Consejo Superior De Investigaciones Científicas Use of flavanol derivatives for the cryopreservation of living cells
JP2006328025A (en) * 2005-05-30 2006-12-07 Asahi Breweries Ltd Nitric oxide regulator, food and beverage containing the same, food additive, medicine and cosmetic

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TORRES J.L. ET AL.: "Cysteinyl-flavan-3-ol Conjugates from Grape Procyanidins. Antioxidant and Antiproliferative Properties", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 10, no. 8, 2002, pages 2497 - 2509, XP002980981 *

Also Published As

Publication number Publication date
JP2008201745A (en) 2008-09-04

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