WO2008102333A2 - Bone fixation surfaces for intervertebral implants - Google Patents
Bone fixation surfaces for intervertebral implants Download PDFInfo
- Publication number
- WO2008102333A2 WO2008102333A2 PCT/IL2007/001052 IL2007001052W WO2008102333A2 WO 2008102333 A2 WO2008102333 A2 WO 2008102333A2 IL 2007001052 W IL2007001052 W IL 2007001052W WO 2008102333 A2 WO2008102333 A2 WO 2008102333A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- implant
- intervertebral implant
- intervertebral
- fixation
- fixation surface
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
- A61F2/4425—Intervertebral or spinal discs, e.g. resilient made of articulated components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2/4611—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof of spinal prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/3011—Cross-sections or two-dimensional shapes
- A61F2002/30138—Convex polygonal shapes
- A61F2002/30153—Convex polygonal shapes rectangular
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/3011—Cross-sections or two-dimensional shapes
- A61F2002/30159—Concave polygonal shapes
- A61F2002/30179—X-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/30199—Three-dimensional shapes
- A61F2002/30252—Three-dimensional shapes quadric-shaped
- A61F2002/30253—Three-dimensional shapes quadric-shaped ellipsoidal or ovoid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30621—Features concerning the anatomical functioning or articulation of the prosthetic joint
- A61F2002/30639—Features concerning the anatomical functioning or articulation of the prosthetic joint having rolling elements between both articulating surfaces
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/3082—Grooves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30878—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30878—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
- A61F2002/30884—Fins or wings, e.g. longitudinal wings for preventing rotation within the bone cavity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2002/30934—Special articulating surfaces
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
- A61F2/4425—Intervertebral or spinal discs, e.g. resilient made of articulated components
- A61F2002/443—Intervertebral or spinal discs, e.g. resilient made of articulated components having two transversal endplates and at least one intermediate component
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0017—Angular shapes
- A61F2230/0019—Angular shapes rectangular
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0028—Shapes in the form of latin or greek characters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0073—Quadric-shaped
- A61F2230/0076—Quadric-shaped ellipsoidal or ovoid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00574—Coating or prosthesis-covering structure made of carbon, e.g. of pyrocarbon
- A61F2310/0058—Coating made of diamond or of diamond-like carbon DLC
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
- A61F2310/00856—Coating or prosthesis-covering structure made of compounds based on metal nitrides
- A61F2310/0088—Coating made of titanium nitride
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
- A61F2310/00856—Coating or prosthesis-covering structure made of compounds based on metal nitrides
- A61F2310/00886—Coating made of chromium nitride
Definitions
- the present invention relates to fixation of intervertebral implants and, in particular, it concerns intervertebral disc replacements or spacers which have stepped endplate surfaces to provide stable load support via cortical and endplate tissues combined with prompt fixation to promote the desired osteointegration.
- Intervertebral implants such as total disc replacements ("TDR") and intervertebral spacers (or “cages”) must be firmly fixed to the vertebral endplates immediately after implantation.
- Post-operative migration of intervertebral implants is a serious complication. Such migration may occur into cancellous bone core of the vertebral body ("subsidence"), and/or to any direction outside to the intervertebral space, damaging the vertebral body and disrupting the vertebral alignment.
- Implant migration also carries with it a high risk of both functional failure and damage to the nervous and/or visceral structures. Migration of an artificial disc may require either removal of the disc or disc maintenance, both followed by fusion, or re-implantation or repositioning of a TDR.
- an intervertebral implant should provide an angle of inclination between the upper and lower fixation surfaces.
- an angle of inclination generates a wedge-like overall profile which, when combined with normal axial loading of the vertebral column, may contribute to migration of the
- intervertebral implants illustrating various approaches to fixation may be found in the following US patents and published applications nos.: 5425773; 6989032; 6994727; 7048766; 2004/0073311; and 2004/0225364.
- intervertebral implant with a tiered endplate surface to provide stable load support via cortical tissue combined with a desired degree of lordosis. It would also be advantageous to provide an intervertebral implant which would employ a combination of non-sharp features to provide prompt fixation to promote osteointegration and to provide structural support primarily through the structurally strong cortical bone tissue of the vertebrae.
- the present invention is an intervertebral implant with a stepped endplate surface to provide stable load support via cortical and endplate tissues combined with prompt fixation to promote the desired osteointegration.
- an intervertebral implant for deployment between an inferior endplate of a superior vertebral body and a superior endplate of an inferior vertebral body of a spinal column, the implant comprising an implant structure including at least one implant element, the implant structure providing a first fixation surface for fixation to one of the vertebral endplates, the first fixation surface including a first bone contact region and a second bone contact region, the second bone contact region being higher in an axial direction than the first bone contact region, wherein a transition from the first bone contact region to the second bone contact region has a stepped form including at least two steps.
- adjacent steps of the at least two steps are spaced apart by between 5 percent and 40 percent, and preferably between 7 percent and 15 percent, of a posterior-anterior dimension of the first fixation surface.
- a height of each of the at least two steps is less than a width of contact surfaces on both sides of the step.
- the stepped form further includes at least one projecting ridge extending along, and adjacent to, at least part of a length of one of the steps.
- the at least one projecting ridge has a flank surface which runs into one of the steps.
- the at least one projecting ridge terminates at end surfaces deployed to inhibit migration of the implant parallel to the steps.
- the stepped form is located at least in part in a primary load-bearing region extending at least around a major part of a periphery of the first fixation surface.
- the primary load- bearing region exhibits: (a) a generally concave form in a lateral-lateral direction; and (b) the stepped form in an anterior-posterior direction, wherein upper contact surfaces of each of the steps are arranged to provide non-migratory support against loading in a primary load-bearing direction, the stepped form defining an effective lordosis plane inclined relative to the primary load-bearing direction.
- the primary load- bearing region extends inwards at least about 2 millimeters from the periphery of the first fixation surface.
- the primary load- bearing region extends over substantially the entirety of the first fixation surface.
- the first fixation surface further features at least one press-fit anchoring projection, the press-fit anchoring projection having an axial dimension smaller than both its anterior- posterior and its lateral-lateral dimensions, and being formed with at least two opposing faces inclined to provide a wedge angle of between 1 degree and 30 degrees.
- the press-fit anchoring projection is formed with corner regions deployed to provide anchoring against axial rotational migration of the intervertebral implant.
- the first fixation surface further includes a convex central region.
- At least part of the convex central region has a stepped form.
- the convex central region further includes a plurality of non-sharp ridges extending along edges of steps of the stepped form.
- the implant structure further provides a second fixation surface for fixation to the other of the vertebral endplates, at least part of the second fixation surface including a stepped form.
- the implant structure is a rigid spacer providing a second fixation surface for fixation to the other of the vertebral endplates, the second fixation surface being in fixed spatial relation to the first fixation surface.
- the implant structure is a total disc replacement including at least two of the implant elements interconnected by a joint arrangement.
- the joint arrangement includes a ball-and-socket joint.
- the joint arrangement includes a flexible cushion. According to a further feature of the present invention, the joint arrangement is configured to generate distraction of an intervertebral spacing between the superior and inferior vertebral bodies as a smooth function of angular displacement from a neutral position over at least part of a range of motion in each of at least two independent directions of angular displacement.
- FIG. IA is a ventral isometric view of an intervertebral implant, in this case a intervertebral disc replacement, constructed and operative according to the teachings of the present invention, showing a superior fixation surface;
- FIG. IB is an inverted isometric view of the intervertebral implant of Figure IA showing an inferior fixation surface;
- FIG. 1C is a dorsal view of the intervertebral implant of Figure IA;
- FIG. ID is a coronal cross-section taken through the intervertebral implant of
- FIG. 2A is a sagittal cross-section taken through the intervertebral implant of Figure IA;
- FIG. 2B is a dorsal isometric view of the intervertebral implant of Figure IA;
- FIG. 2C is an inverted dorsal isometric view of the intervertebral implant of
- FIG. 3 A is a plan view of a cervical vertebral body showing the positioning of the intervertebral implant of Figure IA;
- FIG. 3B is a sagittal cross-sectional view taken through two adjacent cervical vertebral bodies between which the intervertebral implant of Figure IA has been implanted;
- FIG. 4A is a ventral view of the vertebral segment of Figure 3B showing the deployment of the intervertebral implant of Figure IA;
- FIG. 4B is a ventral view similar to Figure 4A showing for comparison the deployment of a commercially available ball-and-socket type intervertebral disc replacement;
- FIGS. 5A-5E are ventral, lateral, dorsal, isometric and inverted isometric views, respectively, of an alternative embodiment of an intervertebral implant, in this case an intervertebral disc replacement including a flexible cushion, constructed and operative according to the teachings of the present invention;
- FIGS. 6A-6E are ventral, lateral, dorsal, isometric and inverted isometric views, respectively, of a further alternative embodiment of an intervertebral implant, in this case an intervertebral disc replacement including a ball-and-socket joint, constructed and operative according to the teachings of the present invention;
- FIGS. 7A-7E are isometric, inverted isometric, ventral, lateral and dorsal views, respectively, of an alternative embodiment of an intervertebral implant, in this case an intervertebral spacer, constructed and operative according to the teachings of the present invention
- FIGS. 8A-8E are isometric, inverted isometric, ventral, lateral and dorsal views, respectively, of an intervertebral spacer similar to that of Figures 7A-7E, illustrating an alternative configuration of press-fit anchoring projections;
- FIGS. 9A-9E are dorsal, lateral, ventral, ventral isometric and dorsal isometric views, respectively, of an alternative embodiment of an intervertebral implant, in this case an intervertebral lumbar disc replacement conceptually similar to that of Figures 1A-4A, constructed and operative according to the teachings of the present invention;
- FIGS. 1 OA- 1OE are dorsal, lateral, ventral, ventral isometric and dorsal isometric views, respectively, of a further alternative embodiment of an intervertebral implant, in this case an intervertebral lumbar disc replacement including a flexible cushion, constructed and operative according to the teachings of the present invention;
- FIGS. 1 IA-I IE are dorsal, lateral, ventral, ventral isometric and dorsal isometric views, respectively, of a still further alternative embodiment of an intervertebral implant, in this case an intervertebral lumbar disc replacement including a ball-and-socket joint, constructed and operative according to the teachings of the present invention; and
- FIGS. 12A-12E are dorsal, lateral, ventral, lateral isometric and dorsal isometric views, respectively, of a further alternative embodiment of an intervertebral implant, in this case a lumbar intervertebral spacer, constructed and operative according to the teachings of the present invention.
- the present invention is an intervertebral implant with stepped or tiered fixation surfaces to provide stable load support via cortical bone and endplate tissues combined with effective short-term and long-term locking against implant migration.
- intervertebral implants according to the present invention may be better understood with reference to the drawings and the accompanying description.
- the present invention provides various combinations of features for use in bone fixation surfaces for intervertebral implants. These features are applicable to all types of intervertebral implants, including articulated intervertebral disc replacements of all types and rigid intervertebral spacers of all types.
- the invention is implemented with an intervertebral disc replacement according to the teachings of co-pending international patent application no.
- FIGS 1A-4A illustrate a first embodiment of an intervertebral implant 10, constructed and operative according to the teachings of the present invention, for deployment as shown in Figure 3B between an inferior endplate of a superior vertebral body 12 and a superior endplate of an inferior vertebral body 14 of a spinal column.
- implant 10 corresponds to the first embodiment of an intervertebral disc replacement described in the aforementioned co-pending international patent application no. PCT/IL07/000239, which is hereby incorporated in its entirety.
- the articulation surfaces of implant 10, which are not directly relevant to the invention as claimed herein, are described in detail in the above-referenced document, and for brevity will not be addressed extensively here.
- implant 10 has a structure including at least one, and in this case two, implant elements: an upper element 16 and a lower element 18.
- Upper element 16 provides a first fixation surface 20 for fixation to the inferior endplate of the superior vertebral body.
- fixation surface 20 includes a primary load-bearing region extending at least around a major part of a periphery of the first fixation surface, and in this case, over substantially the entirety of fixation surface 20.
- This primary load-bearing region exhibits a generally concave form in a lateral- lateral direction, as best seen in Figures 1C, ID and 4A, and a generally stepped or tiered form in an anterior-posterior direction, as best seen in Figures 2A and 3B. More specifically, referring to Figure 2A, the generally tiered form includes a plurality of load-bearing surfaces 22 separated by step surfaces 24, together forming a series of steps which provide a transition from a relatively higher anterior (or medial) region of the surface and a relatively lower posterior region.
- fixation surface 20 provides a highly advantageous combination of features. Specifically, the use of steps to achieve variation in axial height of the bone contact surfaces in at least one direction rather than the more intuitive sloped surfaces provides immediate purchase of the non-sharp edges of the steps by press-fitting against the bone. As the surface becomes more settled into the bone under applied loading and osteo- integration occurs, the resulting stepped interlocking bone-implant interface provides highly effective resistance to linear and rotary migration of the implant.
- the load-bearing region is referred to as "extending at least around a major part of a periphery of the first fixation surface.” This language is used to define a minimum extent of the load-bearing region, namely, extending inwards from the outer periphery of the fixation surface around the majority, and typically substantially the entirety, of the periphery.
- the peripheral extent of the load-bearing region is preferably only interrupted by the presence of one or more anchoring projection, as will be described below.
- the inward extent of the load- bearing region is chosen to be sufficient to cooperate effectively with the cortical bone tissue so as to transfer most of the load via the structurally strong cortical bone, as illustrated in Figure 3B, and is typically at least about 2 millimeters.
- stepped form and “tiered form” are used herein interchangeably in the description and claims to refer to a form in which, when viewed in cross-section in at least one direction, horizontal surfaces, or shallowly inclined surfaces, located at different levels are connected by more steeply inclined or vertical surfaces.
- the horizontal spacing between adjacent steps is greater than the height of the steps.
- the shallowly inclined surfaces are inclined at no more than about 20 degrees to an axial plane, and more preferably no more than 10 degrees thereto.
- the more steeply inclined surfaces are preferably inclines at no less than 45 degrees, and more preferably, at least about 60 degrees, to an axial plane.
- An edge angle formed between the surfaces is preferably no less than 90 degrees.
- the invention is not limited to such an example, and any direction, or a combination of different directions of the steps may be used.
- the steps need not be straight.
- the stepped form may be in a region which has a gradient or otherwise complex form in the direction parallel to the steps. Any reference to the steps being "parallel", or a spacing between the steps, refers to the geometry as viewed in plan (axial) view. Similarly, the steps may be curved as viewed in plan view.
- the load-bearing surfaces 22 are described herein as arranged to provide non- migratory support.
- non-migratory support is used herein in the description and claims to refer to surfaces deployed so as to oppose axial loading without generating a significant shear effect which would tend to generate migration of the intervertebral insert in an axial plane. More specifically, the load-bearing surfaces 22 are preferably deployed without significant inclination in an anterior- posterior direction. In the lateral-lateral direction, the support surfaces are preferably formed with symmetrical inclination (which may vary along their length) so as to provide centering of the vertebral body endplate while still avoiding generating migratory forces. The details of various exemplary embodiments will be described more fully below.
- an "effective lordosis plane” which corresponds to the overall orientation imparted to the vertebral body endplate against which fixation surface 20 is engaged.
- the effective lordosis plane may be regarded as the "best-fit plane” approximating to the anterior-posterior profile of the fixation surface, and neglecting any localized anchoring projections or other features for which counter-sunk recesses are to be cut.
- the "best-fit” may be defined according to any suitable best-fit criteria including, but not limited to, a "least squares" approximation, as is well known in the art.
- the effective lordosis plane is referred to as "inclined" relative to the primary load-bearing direction.
- the term “inclined” is used to refer to two lines, a line and a plane, or two planes which are non-parallel and non-perpendicular.
- non-sharp Various projecting features of the fixation surfaces of the present invention are referred to as “non-sharp.”
- the phrase “non-sharp” is used herein in the description and claims to refer to features which do not exhibit points or edges presenting angles less than 30 degrees, and preferably for which all edges present angles of at least 45 degrees.
- Such non-sharp projections are believed to offer more stable long-term osteo-integration than is achieved by sharp projections.
- the relative orientations should be understood to refer to a "neutral position" of the intervertebral disc replacement. This neutral a position is taken to be the normal un- flexed state of the apparatus when implanted within a spinal column.
- the neutral position preferably corresponds to a substantially parallel state of the flat regions.
- the apparatus is self-biasing under axial loading so as to return towards the neutral position.
- recesses or “projections”.
- projection or “protuberance” from a surface, or a convex surface, is defined as a part of a body which could be severed from the underlying surface by cutting along a single plane, independent of whether the surface of the projection or protuberance includes localized recesses or concavely curved features.
- concavely curved or convexly curved in a given direction
- the intention is that a cross-section taken in through the surface parallel to the given direction exhibits the described curvature.
- the terminology used when describing the geometry of the apparatus of the present invention is the medical terminology, although this terminology may be used interchangeably with alternative mechanical terminology at times.
- the medical terminology is to be interpreted according to the context of the intended location and orientation in which the device is to be deployed in the body, although the terminology is used to refer to the device when standing alone.
- a central vertical plane passing front-to-back through the device is termed “sagittal” while a cross-ways vertical plane passing side-to-side is termed “coronal” and a horizontal plane is termed “axial”.
- a front view is termed “ventral”, a rear view “dorsal”, a side view "lateral” and a top view "axial”.
- bending forward is “(anterior) flexion”
- bending backwards is “(posterior) extension”
- bending sideways is “lateral bending”
- twisting to the sides is “axial rotation”.
- axes of deflection or rotation, which are side-to-side for flexion and extension, front-to-back for lateral bending and vertical for axial rotation. It should be noted however that, depending upon the type of disc replacement used, these motions may not be pure rotations about a fixed axis, but rather more complex motions in which the effective center of rotation shifts during the course of the motion.
- a linear directions front-to-back is referred to as “anterior- posterior”
- side-to-side is “lateral-lateral.”
- first and second members When reference is made to “first” and “second” members, unless otherwise stated, it should be assumed that the features described may be applied interchangeably to the superior (upper) and inferior (lower) members.
- the terras "first” and “second” are used herein in the description and claims as non-specific labels to refer to any pair of adjacent vertebral bodies between which the apparatus of the present invention is to be inserted.
- the present invention may be employed to advantage at one location or multiple locations throughout the cervical, thoracic and lumbar regions of the spinal column, from the joint of cervical vertebrae C2/C3 through to the bottom lumbar joint of L5/S1.
- intervertebral spacing varying as a "smooth function" of angular displacement from the neutral position.
- smooth function is used herein to refer to any function which can be differentiated at all points within the relevant range.
- the variation of intervertebral spacing with angular displacement is “smooth” in that it does not have any abrupt changes in gradient.
- the restoring moment acting as a result of axial loading corresponding to the derivative of the intervertebral spacing with respect to angle, does not have any sudden steps, and the motion attenuation is therefore non-impact attenuation.
- Load-bearing surfaces 22 are preferably arranged to provide non-migratory support against loading in a primary load-bearing direction (arrow 27), while the generally tiered form preferably defines an effective lordosis plane 28 inclined relative to the primary load-bearing direction 27.
- the tiered structure provides a correctly oriented effective lordosis plane 28 while at the same time ensuring that load- bearing surfaces 22 are correctly oriented to provide support against applied axial loads without generating secondary lateral forces.
- the combination of load-bearing surfaces 22 and step surfaces 24 provides an anti -migration bone engaging configuration which is believed to be highly advantageous, even if used at different angles.
- surfaces 22 and 24 serve as pairs of elongated surfaces converging to a crest. Unlike conventional keels or sharp ridges which are either countersunk or cut into the bone surface, these angular crests lodge against the surface of the bone and become press-fit against the bone under subsequent loading. The result is a bone-implant interface which takes on an intimately inter-engaged pattern of crests and troughs, thereby providing highly effective anchoring against migration.
- the width dimensions of the pairs of surfaces measured perpendicular to the length of the crest, corresponding to the distance between the steps is preferably at least about 5 percent, and more preferably at least about 7 percent, of a posterior-anterior dimension of the first fixation surface.
- the width dimensions of the pairs of surfaces measured perpendicular to the length of the crest, corresponding to the distance between the steps, is preferably no more than 40 percent, and more preferably no more than about 15 percent, of a posterior-anterior dimension of the first fixation surface.
- the interface geometry preserves an overall profile matched to the natural bone surface form and does not typically require significant preparation or reshaping of the bone surface (except for minor press-fit anchoring projections where present, such as will be described below).
- a preferred width of the pairs of elongated surfaces is typically in the range from about 2 to about 4 millimeters, and a maximum depth of the troughs between crests is preferably between about 0.5 and about 2 millimeters.
- the crests are preferably non-sharp crests, and are preferably modified by the presence of ridges, as will be described below.
- the crests are substantially parallel so as to form the generally stepped or tiered form described above.
- other forms of deployment of the surfaces, and the resulting crests are also possible. Examples include, but are not limited to, crests extending radially outwards from a central region, patterns with various directions of crests such as in concentric polygons, and various curved patterns of crests.
- surfaces 22 are preferably arranged to provide non-migratory support against loading in a primary load-bearing direction, while the generally tiered form defines an effective lordosis plane inclined relative to the primary load-bearing direction.
- surfaces 22 and 24 define what is referred to here as a tiered or stepped form.
- the primary load-bearing region preferably further includes a plurality of non-sharp projecting ridges 26 extending substantially parallel, and adjacent, to the steps or crests formed between surfaces 22 and 24.
- each projecting ridge 26 has a flank surface which runs into one of step surfaces 24.
- one flank of the ridge is either coplanar with step surface 24, or intersects therewith at a change of gradient.
- ridges 26 are formed with an upper edge angle of about 60 degrees, and each step surface 24 is angled at about 60 degrees to the load- bearing surfaces 22, with step surface 24 and one face of ridges 26 forming a continuous planar surface.
- Projecting ridges 26 preferably do not all extend across the entirety of the implant, but rather terminate at end surfaces 28 (see Figure 2B) deployed to inhibit lateral migration of the implant.
- two projecting ridges 26 are provided along the edge of each step, each providing two opposite-facing end surfaces 28.
- the ridge nearest the posterior extreme of fixation surface 20 may also have interruptions to form end surfaces, in the particularly preferred case illustrated here, the posterior ridge is continuous across the width of fixation surface 20 in order to maximize the surface for osteointegration with the hard cortical bone of the vertebral body.
- Additional fixation against linear and rotational migration is preferably formed by providing fixation surface 20 with at least one press-fit anchoring projection 30.
- Press-fit anchoring projection 30 has an axial (height) dimension smaller than both its anterior-posterior and its lateral-lateral dimensions, and is preferably formed with at least two opposing faces inclined to provide a wedge angle of between 1 degree and 30 degrees, and typically between about 5 and 15 degrees.
- anchoring projection 30 is formed with corner regions deployed to provide anchoring against axial rotational migration of the intervertebral implant.
- a rectangular shape in axial view is typically preferred.
- a complementary recess in the vertebral body is typically formed by use of standard tools, such as a Kerrison punch.
- anchoring projection 30 is preferably located on the anterior periphery of the device, either in the form of a single projection as shown, or a pair of spaced apart projections (see Figures 8A-8E, below).
- the primary load-bearing region preferably exhibits upward-turned edges towards the lateral periphery of the fixation surface, which give a generally concave outer profile as seen in dorsal view.
- This concave outer profile has a centering effect on the superior vertebral body and helps to provide for stable and effective transfer of loading between the implant and the cortical bone of the superior vertebral body.
- the central part of the fixation surface is formed to play only a minor or even negligible part in the transfer of loading, and yet to follow closely the shape of the adjacent vertebral body endplate in order to accelerate osteo-integration over a large surface and to provide better fixation and anti-migration qualities for the entire device.
- a continuous roughly arcuate concave form in the lateral- lateral direction is believed to provide both the peripheral support and the central proximity to the vertebral endplate.
- the fixation surface 20 may here be considered to be a single continuous surface in which the structural features of the primary load-bearing region extend over substantially the entirety of the fixation surface.
- the concave shape in the lateral-lateral direction helps to provide migration resistance to the device in the lateral direction.
- the generally concave geometry of the upper fixation surface 20 enhances its fixation and reduces the chance of lateral slippage.
- the arcuate shape provides a niche in which the entire vertebral endplate is received, and encourages attachment in a balanced self-centering manner under the influence of the natural spinal column alignment and predominantly axial natural loading force applied on the spinal column.
- a radius of curvature of between about 6 and about 10 centimeters, and most preferably about 8 centimeters is typically suitable, and an angular deflection of between about 10 degrees and about 15 degrees, and most preferably about 12 degrees, from side to side.
- Figure 4B this shows for comparison the geometry of the bone contact surfaces for an exemplary commercially available ball- and-socket intervertebral disc replacement 36. Comparing this drawing with Figure 4A, it is apparent that the relatively smaller and flat bone contact surface of the prior device lacks the self-centering properties of the peripherally concave profile of fixation surface 20, and fails to concentrate the load on the cortical bone tissue.
- second member 18 provides a second fixation surface 32 for fixation to the superior endplate of the inferior vertebral body 14.
- a preferred form for second fixation surface 32 in the case of a cervical intervertebral implant is illustrated in Figures IB, 2A, 2C, 3B and 4A.
- second fixation surface 32 preferably includes a plurality of non-sharp ridges 34 extending in a lateral-lateral direction to oppose anterior or posterior migration.
- a generally convexly curved form in a lateral-lateral direction is preferably used, and at least the anterior part of the device is seated between the uncinate processes, as is known in the art, thereby anchoring the implant against lateral migration.
- fixation features of the present invention are applicable to a wide range of intervertebral implants.
- the invention has been illustrated thus far with reference to Figures 1A-4A in the context of an intervertebral disc replacement with a joint arrangement configured to generate distraction of an intervertebral spacing between the superior and inferior vertebral bodies as a smooth function of angular displacement from a neutral position over at least part of a range of motion in each of at least two and preferably three independent directions of angular displacement.
- joint arrangements which provide this functionality are not per se part of the present invention, and may be found in the aforementioned co-pending international patent application no. PCT/EL07/000239. For conciseness, they will not be reproduced here.
- FIGS 5A-5E show an embodiment of an intervertebral implant 40, constructed and operative according to the teachings of the present invention, which employs first and second fixation surfaces 20 and 32 as described above in the context of implant 10.
- implant 40 is an intervertebral disc replacement with a joint arrangement implemented as a flexible cushion 42.
- the flexible cushion referred to here may be any conventional cushion- type replacement disc joint arrangement, typically employing a solid, filled or hollow polymeric structure which may have an accordion-type structure or any other structure known for this purpose.
- Figures 6A-6E show an embodiment of an intervertebral implant 50, constructed and operative according to the teachings of the present invention, which employs first and second fixation surfaces 20 and 32 as described above in the context of implant 10.
- implant 50 is an intervertebral disc replacement with a joint arrangement implemented as a ball-and- socket joint 52.
- the ball-and-socket joint may be any type of commercially available ball-and-socket joint, with or without an additional polymeric envelope.
- FIGS 7A-7E show an embodiment of an intervertebral implant 60, constructed and operative according to the teachings of the present invention, which employs first and second fixation surfaces 20 and 32 as described above in the context of implant 10.
- implant 60 is a rigid intervertebral spacer in which second fixation surface 32 is in fixed spatial relation to first fixation surface 20.
- the intervertebral spacer may be a solid structure as shown, or may be formed as a partially or fully hollow "cage.” Referring briefly to Figures 8A-8E, this shows a variant of intervertebral spacer 60, equally applicable to other embodiments, in which first fixation surface 20 is formed with two anchoring projections 30.
- FIG. 9A-12E the principles of the present invention are equally applicable to intervertebral implants for use throughout the spinal column. While the general principles of the invention indeed remain the same, the specific forms of the implants vary considerably according to the anatomical and mechanical needs of the different regions. The invention will now be illustrated with reference to a number of embodiments of lumber intervertebral implants. A first of these implants, an intervertebral disc replacement generally designated 100, constructed and operative according to the teachings of the present invention, is illustrated in Figures 9A-9E.
- intervertebral implant 100 is similar to intervertebral implant 10 described above. For conciseness of description, analogous features are labeled here with the corresponding reference numerals incremented by 100, and will not be described again in detail.
- intervertebral implant 100 features upper and lower members 116 and 118, and an upper fixation surface 120 with a tiered peripheral primary load-bearing region formed with load-bearing surfaces 122, steps 124 and ridges 126.
- the tiered profile provides effective short and long term fixation against migration
- a generally concave lateral- lateral profile provides centering and support for the adjacent cortical tissue of the vertebral body endplate.
- the tiered profile also preferably provides non-migratory support for axial loading combined with a required degree of lordosis.
- the most striking distinctive features of the required geometry of a lumbar intervertebral implant compared to a cervical implant are that both the upper and the lower vertebral bodies in the lumbar region present endplates with significant concavities, and that these concavities are roughly symmetrical. Accordingly, the upper and lower fixation surfaces of implant 100 are formed with convex central regions 70 in order to maintain the desired proximity between the fixation surface and the vertebral body endplate.
- the convex central region also features a tiered form in an anterior-posterior direction, i.e., with surfaces for opposing axial loading and steps reducing the thickness of the central region towards the posterior side to contribute to the effective lordosis angle of the implant.
- a plurality of non- sharp ridges 72 preferably extend along edges of steps of the tiered form.
- convex central region 70 may have any form suited to achieve the desired proximity and osteo-integration geometry desired for a given vertebral body endplate shape.
- the projection may be warped to an asymmetrical shape, with the highest point significantly off center, or the form may include two or more superimposed roughly spherical portions of different radii of curvature.
- the lumbar vertebrae also present a recessed endplate structure at the superior endplate of the inferior vertebral body.
- Preferred implementations of the present invention therefore provide a second fixation surface 74, for fixation to the superior endplate of the inferior vertebral body, which is similar or even identical to the surface 120.
- the lordosis correction may be achieved exclusively through the geometry of either one of the upper and lower members, or may be divided between the two members.
- the structure of second fixation surface 74 may be fully understood by reference to the description of surface 120 and its analogous predecessor 20 described above.
- FIGS 10A- 1OE illustrate an alternative embodiment of an intervertebral implant, in this case an intervertebral lumbar disc replacement, designated 140, constructed and operative according to the teachings of the present invention.
- Implant 140 includes a flexible cushion.
- FIGS 11 A-I IE illustrate a still further alternative embodiment of an intervertebral implant, in this case an intervertebral lumbar disc replacement, designated 150, constructed and operative according to the teachings of the present invention.
- Implant 150 includes a ball-and-socket joint.
- Figures 12A-12E illustrate a further alternative embodiment of an intervertebral implant, in this case a lumbar intervertebral spacer, designated 160, constructed and operative according to the teachings of the present invention.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0721029 BRPI0721029A2 (en) | 2006-02-23 | 2007-08-23 | SUBSTITUTE INVERTEBRAL DISC |
US12/526,782 US8518119B2 (en) | 2006-02-23 | 2007-08-23 | Bone fixation surfaces for intervertebral implants |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ILPCT/IL2007/000239 | 2007-02-22 | ||
PCT/IL2007/000239 WO2007096879A2 (en) | 2006-02-23 | 2007-02-22 | Intervertebral disc replacement |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008102333A2 true WO2008102333A2 (en) | 2008-08-28 |
WO2008102333A3 WO2008102333A3 (en) | 2009-05-07 |
Family
ID=38437769
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IL2007/001052 WO2008102333A2 (en) | 2006-02-23 | 2007-08-23 | Bone fixation surfaces for intervertebral implants |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008102333A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8142505B2 (en) | 2006-02-23 | 2012-03-27 | Faneuil Innovations Investment Ltd. | Intervertebral disc replacement |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7083649B2 (en) * | 2002-10-29 | 2006-08-01 | St. Francis Medical Technologies, Inc. | Artificial vertebral disk replacement implant with translating pivot point |
-
2007
- 2007-08-23 WO PCT/IL2007/001052 patent/WO2008102333A2/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7083649B2 (en) * | 2002-10-29 | 2006-08-01 | St. Francis Medical Technologies, Inc. | Artificial vertebral disk replacement implant with translating pivot point |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8142505B2 (en) | 2006-02-23 | 2012-03-27 | Faneuil Innovations Investment Ltd. | Intervertebral disc replacement |
Also Published As
Publication number | Publication date |
---|---|
WO2008102333A3 (en) | 2009-05-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US8518119B2 (en) | Bone fixation surfaces for intervertebral implants | |
US11419734B2 (en) | Intervertebral implant | |
US10105233B2 (en) | Anterior prosthetic spinal disc replacement | |
US9125755B2 (en) | Transforaminal prosthetic spinal disc replacement | |
EP2349116B1 (en) | Articulating intervertebral disc prosthesis | |
EP1983945B1 (en) | Modular intervertebral disc replacements | |
US8673009B2 (en) | Spinal prosthesis and facet joint prosthesis | |
EP1647243A2 (en) | Disc prostheses and facet joint prosthesis | |
US20070198093A1 (en) | Spinal implant with offset keels | |
CN102014803A (en) | Artificial intervertebral spacer | |
WO2008102333A2 (en) | Bone fixation surfaces for intervertebral implants | |
EP3763301B1 (en) | Augmented glenoid design | |
TWI402055B (en) | Intervertebral prosthesis |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 07805512 Country of ref document: EP Kind code of ref document: A2 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 12526782 Country of ref document: US |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2009/06465 Country of ref document: TR |
|
NENP | Non-entry into the national phase in: |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 07805512 Country of ref document: EP Kind code of ref document: A2 |
|
ENP | Entry into the national phase in: |
Ref document number: PI0721029 Country of ref document: BR Kind code of ref document: A2 Effective date: 20090821 |