WO2008101160A3 - Htra1-pdz and htra3-pdz modulators - Google Patents
Htra1-pdz and htra3-pdz modulators Download PDFInfo
- Publication number
- WO2008101160A3 WO2008101160A3 PCT/US2008/054081 US2008054081W WO2008101160A3 WO 2008101160 A3 WO2008101160 A3 WO 2008101160A3 US 2008054081 W US2008054081 W US 2008054081W WO 2008101160 A3 WO2008101160 A3 WO 2008101160A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pdz
- htra3
- htra1
- modulators
- pdz domain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
Abstract
The invention provides optimized HtrA1 PDZ domain and HtrA3 PDZ domain ligands. The invention further provides modulators of HtrA1 PDZ domain-ligand interaction and HtrA3 PDZ domain-ligand interaction, and methods of identifying and using these modulators.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08729968A EP2111413A2 (en) | 2007-02-16 | 2008-02-15 | Htra1-pdz and htra3-pdz modulators |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89042807P | 2007-02-16 | 2007-02-16 | |
US60/890,428 | 2007-02-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008101160A2 WO2008101160A2 (en) | 2008-08-21 |
WO2008101160A3 true WO2008101160A3 (en) | 2009-02-19 |
Family
ID=39590928
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/054081 WO2008101160A2 (en) | 2007-02-16 | 2008-02-15 | Htra1-pdz and htra3-pdz modulators |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP2111413A2 (en) |
AR (1) | AR065370A1 (en) |
CL (1) | CL2008000493A1 (en) |
PE (1) | PE20081795A1 (en) |
TW (1) | TW200846358A (en) |
WO (1) | WO2008101160A2 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8168181B2 (en) | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
US7989160B2 (en) | 2006-02-13 | 2011-08-02 | Alethia Biotherapeutics Inc. | Polynucleotides and polypeptide sequences involved in the process of bone remodeling |
PT2766393T (en) | 2011-10-14 | 2018-10-15 | Hoffmann La Roche | Anti-htra1 antibodies and methods of use |
EP2875051B1 (en) | 2012-07-19 | 2019-02-20 | Daiichi Sankyo Company, Limited | Anti-siglec-15 antibodies |
MX2018004509A (en) | 2015-10-30 | 2018-08-01 | Genentech Inc | Anti-htra1 antibodies and methods of use thereof. |
JP2019507176A (en) | 2016-03-04 | 2019-03-14 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Novel difluoroketamide derivatives as HTRA1 inhibitors |
JP2019513698A (en) | 2016-03-04 | 2019-05-30 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Novel trifluoromethylpropanamide derivatives as HTRA1 inhibitors |
CN109415330A (en) | 2016-07-18 | 2019-03-01 | 豪夫迈·罗氏有限公司 | Novel difluoro keto acyl amine derivative as HTRA1 inhibitor |
WO2018036957A1 (en) | 2016-08-23 | 2018-03-01 | F. Hoffmann-La Roche Ag | New trifluoromethylpropanamide derivatives as htra1 inhibitors |
JP2019526563A (en) | 2016-08-23 | 2019-09-19 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Novel difluoroketamide derivatives as HTRA1 inhibitors |
WO2018206816A1 (en) * | 2017-05-12 | 2018-11-15 | Universität Duisburg-Essen | Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors |
WO2020083916A1 (en) * | 2018-10-22 | 2020-04-30 | University Of Copenhagen | Virally expressed inhibitors of pdz domains, such as pick1 and uses thereof |
AU2021232645A1 (en) * | 2020-03-06 | 2022-09-15 | University Of Copenhagen | Lipid conjugated peptide inhibitors of PICK1 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040214272A1 (en) * | 1999-05-06 | 2004-10-28 | La Rosa Thomas J | Nucleic acid molecules and other molecules associated with plants |
-
2008
- 2008-02-15 AR ARP080100656A patent/AR065370A1/en unknown
- 2008-02-15 WO PCT/US2008/054081 patent/WO2008101160A2/en active Application Filing
- 2008-02-15 TW TW097105456A patent/TW200846358A/en unknown
- 2008-02-15 EP EP08729968A patent/EP2111413A2/en not_active Withdrawn
- 2008-02-15 PE PE2008000341A patent/PE20081795A1/en not_active Application Discontinuation
- 2008-02-15 CL CL200800493A patent/CL2008000493A1/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040214272A1 (en) * | 1999-05-06 | 2004-10-28 | La Rosa Thomas J | Nucleic acid molecules and other molecules associated with plants |
Non-Patent Citations (10)
Title |
---|
DATABASE UniProt 2004, XP002501527, Database accession no. Q6UK25 * |
FACCIO L, ET AL.: "TISSUE-SPECIFIC SPLICING OF OMI STRESS-REGULATED ENDOPROTEASE LEADS TO AN INACTIVE PROTEASE WITH A MODIFIED PDZ MOTIF", GENOMICS, vol. 68, 2000, pages 343 - 347, XP004437838 * |
GUPTA S, ET AL.: "THE C-TERMINAL TAIL OF PRESENILIN REGULATES OMI/HTRA2 PROTEASE ACTIVITY", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 44, 2004, pages 45844 - 45854, XP002488179 * |
JUNQUEIRA D, ET AL.: "RANDOM MUTAGENESIS OF PDZOMI DOMAIN AND SELECTION OF MUTANTS THAT SPECIFICALLY BIND THE MYC PROTO-ONCOGENE AND INDUCE APOPTOSIS", ONCOGENE, vol. 22, 2003, pages 2772 - 2781, XP002501627 * |
LI W, ET AL.: "STRUCTURAL INSIGHTS INTO THE PRO-APOPTOTIC FUNCTION OF MITOCHONDRIAL SERINE PROTEASE HTRA2/OMI", NATURE STRUCTURAL BIOLOGY, vol. 9, no. 6, 2002, pages 436 - 441, XP002501628 * |
MARTINS L MIGUEL ET AL: "Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,; US, vol. 278, no. 49, 5 December 2003 (2003-12-05), pages 49417 - 49427, XP002366468, ISSN: 0021-9258 * |
MURWANTOKO ET AL: "Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease", BIOCHEMICAL JOURNAL, THE BIOCHEMICAL SOCIETY, LONDON, vol. 381, no. 3, 1 August 2002 (2002-08-01), pages 895 - 904, XP009103026, ISSN: 0264-6021 * |
NIE G-Y ET AL: "IDENTIFICATION AND CLONING OF TWO ISOFORMS OF HUMAN HIGH-TEMPERATURE REQUIREMENT FACTOR A3 (HTRA3), CHARACTERIZATION OF ITS GENOMIC STRUCTURE AND COMPARISON OF ITS TISSUE DISTRIBUTION WITH HTRA1 AND HTRA2", BIOCHEMICAL JOURNAL, THE BIOCHEMICAL SOCIETY, LONDON, vol. 371, no. PRT 1, 1 April 2003 (2003-04-01), pages 39 - 48, XP002976438, ISSN: 0264-6021 * |
RUNYON STEVEN T ET AL: "Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3", PROTEIN SCIENCE, CAMBRIDGE UNIVERSITY PRESS, CAMBRIDGE, GB, vol. 16, no. 11, 1 November 2007 (2007-11-01), pages 2454 - 2471, XP009103036, ISSN: 0961-8368 * |
ZHANG Y, ET AL.: "CONVERGENT AND DIVERGENT LIGAND SPECIFICITY AMONG PDZ DOMAINS OF THE LAP AND ZONULA OCCLUDENS (ZO) FAMILIES", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 281, no. 31, 2006, pages 22299 - 22311, XP002488178 * |
Also Published As
Publication number | Publication date |
---|---|
EP2111413A2 (en) | 2009-10-28 |
TW200846358A (en) | 2008-12-01 |
CL2008000493A1 (en) | 2008-06-27 |
WO2008101160A2 (en) | 2008-08-21 |
AR065370A1 (en) | 2009-06-03 |
PE20081795A1 (en) | 2009-01-08 |
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