WO2008099805A1 - Central circulation-improving agent - Google Patents

Central circulation-improving agent Download PDF

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Publication number
WO2008099805A1
WO2008099805A1 PCT/JP2008/052242 JP2008052242W WO2008099805A1 WO 2008099805 A1 WO2008099805 A1 WO 2008099805A1 JP 2008052242 W JP2008052242 W JP 2008052242W WO 2008099805 A1 WO2008099805 A1 WO 2008099805A1
Authority
WO
WIPO (PCT)
Prior art keywords
improving agent
central circulation
circulation
central
disclosed
Prior art date
Application number
PCT/JP2008/052242
Other languages
French (fr)
Japanese (ja)
Inventor
Tsutomu Nakahara
Kunio Ishii
Original Assignee
School Juridical Person Kitasato Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by School Juridical Person Kitasato Institute filed Critical School Juridical Person Kitasato Institute
Publication of WO2008099805A1 publication Critical patent/WO2008099805A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed is a vasodilator which can specifically improve the central circulation including retinal circulation. Specifically disclosed is a central circulation-improving agent comprising an EP2 receptor agonist as an active ingredient.
PCT/JP2008/052242 2007-02-14 2008-02-12 Central circulation-improving agent WO2008099805A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-033163 2007-02-14
JP2007033163A JP2008195660A (en) 2007-02-14 2007-02-14 Agent for ameliorating central circulation

Publications (1)

Publication Number Publication Date
WO2008099805A1 true WO2008099805A1 (en) 2008-08-21

Family

ID=39690034

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/052242 WO2008099805A1 (en) 2007-02-14 2008-02-12 Central circulation-improving agent

Country Status (2)

Country Link
JP (1) JP2008195660A (en)
WO (1) WO2008099805A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010168301A (en) * 2009-01-22 2010-08-05 Kitasato Institute Agent for ameliorating central circulation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000128858A (en) * 1997-02-04 2000-05-09 Ono Pharmaceut Co Ltd Omega-cycloalkyl-prostaglandin e2 derivative
WO2004032965A1 (en) * 2002-10-10 2004-04-22 Ono Pharmaceutical Co., Ltd. Endogenous repair factor production promoters
WO2005061492A1 (en) * 2003-12-22 2005-07-07 Ono Pharmaceutical Co., Ltd. Nitrogen-containing heterocyclic compounds and drugs comprising the same as the active ingredient

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000128858A (en) * 1997-02-04 2000-05-09 Ono Pharmaceut Co Ltd Omega-cycloalkyl-prostaglandin e2 derivative
WO2004032965A1 (en) * 2002-10-10 2004-04-22 Ono Pharmaceutical Co., Ltd. Endogenous repair factor production promoters
WO2005061492A1 (en) * 2003-12-22 2005-07-07 Ono Pharmaceutical Co., Ltd. Nitrogen-containing heterocyclic compounds and drugs comprising the same as the active ingredient

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
CAMPOCHIARO P.A. ET AL.: "Adenosine and its agonists cause retinal vasodilation and hemorrhages", ARCHIVES OF OPHTHALMOLOGY, vol. 107, March 1989 (1989-03-01), pages 412 - 416 *
CAO J. ET AL.: "In vitro pharmacological characterization of the prostanoid receptor population in the non-pregnant porcine myometrium", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 442, 2002, pages 115 - 123 *
DREJANCEVIC-PERIC I. ET AL.: "Restoration of normal vascular relaxation mechanisms in cerebral arteries by chromosomal substitution in consomic SS.13BN rats", AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY, vol. 289, 18 March 2005 (2005-03-18), pages H188 - H195 *
HOTTA H. ET AL.: "Cilostazol, a selective cAMP phosphodiesterase inhibitor, dilates retinal arterioles and increases retinal and choroidal blood flow in rats", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 344, 1998, pages 49 - 52, XP002497732, DOI: doi:10.1016/S0014-2999(98)00015-6 *
KUBO S. ET AL.: "E-Prostanoid (EP)2/EP4 receptor-dependent maturation of human monocyte-derived dendritic cells and induction of helper T2 polarization", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 309, no. 3, 2004, pages 1213 - 1220, XP002659216, DOI: doi:10.1124/JPET.103.062646 *
MARUYAMA T.: "Prostaglandin E2 Juyotai no Subtype Sentakuteki Sadoyaku/Kikkoyaku no Kaihatsu -Sentakuteki Kagobutsu o Mochiita Kento kara Akirakani Nattakoto-", BESSATSU IGAKU NO AYUMI, 7 KAI MAKUKANTSUGATA JUYOTAI KENKYU NO SHIN TENKAI - POST GENOME JIDAI NO JUYOTAI KENKYU NO YUKUE, 15 March 2001 (2001-03-15), pages 187 - 193 *
MORI A. ET AL.: "Intravenously administered vasodilatory prostaglandins increase retinal and choroidal blood flow in rats", JOURNAL OF PHARMACOLOGICAL SCIENCES, vol. 103, 16 January 2007 (2007-01-16), pages 103 - 112 *
NEGISHI M. ET AL.: "Prostaglandin Juyotai", PHARMACIA, vol. 29, no. 7, 1 July 1993 (1993-07-01), pages 758 - 763 *
STJERNSCHANTZ J. ET AL.: "Microvascular effects of selective prostaglandin analogues in the eye with special reference to latanoprost and glaucoma treatment", PROGRESS IN RETINAL AND EYE RESEARCH, vol. 19, no. 4, 2000, pages 459 - 496, XP001126960, DOI: doi:10.1016/S1350-9462(00)00003-3 *
TAKAHASHI K. ET AL.: "Differential effect of prostaglandins E1 and E2 on lipopolysaccharide-induced adhesion molecule expression on human monocytes", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 512, 2005, pages 223 - 230, XP004850152, DOI: doi:10.1016/j.ejphar.2005.01.046 *
YOKOTANI K. ET AL.: "Prostanoid EP3 and TP receptors-mediated inhibition of noradrenaline release from the isolated rat stomach", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 459, 2003, pages 187 - 193 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010168301A (en) * 2009-01-22 2010-08-05 Kitasato Institute Agent for ameliorating central circulation

Also Published As

Publication number Publication date
JP2008195660A (en) 2008-08-28

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