WO2008097854A3 - Procédé et substances pour traiter une infection par le vph - Google Patents

Procédé et substances pour traiter une infection par le vph Download PDF

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Publication number
WO2008097854A3
WO2008097854A3 PCT/US2008/052819 US2008052819W WO2008097854A3 WO 2008097854 A3 WO2008097854 A3 WO 2008097854A3 US 2008052819 W US2008052819 W US 2008052819W WO 2008097854 A3 WO2008097854 A3 WO 2008097854A3
Authority
WO
WIPO (PCT)
Prior art keywords
hpv infection
substances
treating hpv
directed
polypeptides
Prior art date
Application number
PCT/US2008/052819
Other languages
English (en)
Other versions
WO2008097854A2 (fr
WO2008097854A4 (fr
Inventor
Penelope J Duerksen-Hughes
Maria Filippova
Sandy S Tungteakkhun
Jonathan W Neidigh
Original Assignee
Univ Loma Linda
Penelope J Duerksen-Hughes
Maria Filippova
Sandy S Tungteakkhun
Jonathan W Neidigh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Loma Linda, Penelope J Duerksen-Hughes, Maria Filippova, Sandy S Tungteakkhun, Jonathan W Neidigh filed Critical Univ Loma Linda
Publication of WO2008097854A2 publication Critical patent/WO2008097854A2/fr
Publication of WO2008097854A3 publication Critical patent/WO2008097854A3/fr
Publication of WO2008097854A4 publication Critical patent/WO2008097854A4/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne de nouveaux polypeptides et compositions capables de se lier à l'oncoprotéine E6 du papillomavirus humain (VPH) et des procédés d'emploi des nouveaux polypeptides et compositions de l'invention pour traiter une infection par le VPH. Sous un aspect, l'invention concerne des vecteurs d'expression codant les polypeptides, qui contiennent un domaine de liaison E6 dérivé d'un fragment FADD, et des cellules hôtes contenant les vecteurs.
PCT/US2008/052819 2007-02-02 2008-02-01 Procédé et substances pour traiter une infection par le vph WO2008097854A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88795107P 2007-02-02 2007-02-02
US60/887,951 2007-02-02

Publications (3)

Publication Number Publication Date
WO2008097854A2 WO2008097854A2 (fr) 2008-08-14
WO2008097854A3 true WO2008097854A3 (fr) 2008-11-20
WO2008097854A4 WO2008097854A4 (fr) 2009-01-15

Family

ID=39682348

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/052819 WO2008097854A2 (fr) 2007-02-02 2008-02-01 Procédé et substances pour traiter une infection par le vph

Country Status (1)

Country Link
WO (1) WO2008097854A2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6558950B1 (en) * 1997-03-03 2003-05-06 Mcgill University Methods and reagents for modulating apoptosis
US20070197444A1 (en) * 2006-02-17 2007-08-23 Nastech Pharmaceutical Company Inc. Phage displayed cell binding peptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6558950B1 (en) * 1997-03-03 2003-05-06 Mcgill University Methods and reagents for modulating apoptosis
US20070197444A1 (en) * 2006-02-17 2007-08-23 Nastech Pharmaceutical Company Inc. Phage displayed cell binding peptides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FILIPPOVA ET AL.: "The human papillomavirus 16 E6 protein binds to Fas-associated death domain and protects cells from Fas-triggered apoptosis.", J. BIOL. CHEM., vol. 279, no. 24, 11 June 2004 (2004-06-11), pages 25729 - 25744, XP055354902 *
FILIPPOVA ET AL.: "The large and small isoforms ofhuman papillomavirus type 16 E6 bind to and differentially affect procaspase 8 stability and activity.", J. VIROL., vol. 81, no. 8, 31 January 2007 (2007-01-31), pages 4116 - 4129, XP055354906 *
GARNETT ET AL.: "Modulation of apoptosis in human papillomavirus (HPV) oncoproteins.", ARCH. VIROL., vol. 151, 27 July 2006 (2006-07-27), pages 2321 - 2335, XP019461754 *

Also Published As

Publication number Publication date
WO2008097854A2 (fr) 2008-08-14
WO2008097854A4 (fr) 2009-01-15

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