WO2008096842A1 - Method for screening of substance for prevention or treatment of degenerative disease - Google Patents

Method for screening of substance for prevention or treatment of degenerative disease Download PDF

Info

Publication number
WO2008096842A1
WO2008096842A1 PCT/JP2008/052099 JP2008052099W WO2008096842A1 WO 2008096842 A1 WO2008096842 A1 WO 2008096842A1 JP 2008052099 W JP2008052099 W JP 2008052099W WO 2008096842 A1 WO2008096842 A1 WO 2008096842A1
Authority
WO
WIPO (PCT)
Prior art keywords
substance
prevention
treatment
degenerative disease
screening
Prior art date
Application number
PCT/JP2008/052099
Other languages
French (fr)
Japanese (ja)
Inventor
Ken Nakata
Kunihiko Hosotani
Original Assignee
Osaka University
Technoview, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osaka University, Technoview, Inc. filed Critical Osaka University
Priority to JP2008557160A priority Critical patent/JP5548972B2/en
Publication of WO2008096842A1 publication Critical patent/WO2008096842A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Disclosed is a method for the screening of a substance for the prevention or treatment of a degenerative disease, which enables to screen a substance useful for the prevention or treatment of a degenerative disease while observing a biological reaction in a cell tissue induced by a mechanical load in vitro. Specifically disclosed is a method for the screening of a substance for the prevention or treatment of a degenerative disease, which comprises adding a candidate substance to a cell tissue placed in a culture container and determining the change in the cell tissue which is caused by applying a mechanical load to the cell tissue, thereby evaluating the substance.
PCT/JP2008/052099 2007-02-09 2008-02-08 Method for screening of substance for prevention or treatment of degenerative disease WO2008096842A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008557160A JP5548972B2 (en) 2007-02-09 2008-02-08 Method for screening drug for prevention or treatment of degenerative disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-029957 2007-02-09
JP2007029957 2007-02-09

Publications (1)

Publication Number Publication Date
WO2008096842A1 true WO2008096842A1 (en) 2008-08-14

Family

ID=39681743

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/052099 WO2008096842A1 (en) 2007-02-09 2008-02-08 Method for screening of substance for prevention or treatment of degenerative disease

Country Status (2)

Country Link
JP (1) JP5548972B2 (en)
WO (1) WO2008096842A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005123905A1 (en) * 2004-06-17 2005-12-29 Ken Nakata Cell culturing method by biomechanical stimulus load and its device

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10304874A (en) * 1997-03-07 1998-11-17 Chugai Pharmaceut Co Ltd New cell strain and screening using the same cell strain
JP2003033199A (en) * 2001-04-25 2003-02-04 Takeda Chem Ind Ltd Screening method
JP2003125787A (en) * 2001-06-26 2003-05-07 Takeda Chem Ind Ltd Method for differentiation culture of cartilage
IL162132A0 (en) * 2001-12-07 2005-11-20 Geron Corp Chondrocyte precursors derived from human embryonic stem cells
AU2003223416A1 (en) * 2002-03-25 2003-10-13 Condros, Inc. Tissue analogs for in vitro testing and method of use therefor
US20060003311A1 (en) * 2002-06-13 2006-01-05 Fulde Fabienne A In vitro screening of cellular events using 3d cell culture systems
BRPI0411020A (en) * 2003-06-06 2006-07-18 Wyeth Corp gene expression profile, methods of identifying wnt pathway modular agents, preparing a gene expression profile, screening a remodeling agent associated with bone loading, and reagents that bind to proteins that modulate bone remodeling and / or bone mineralization, treating a bone mineralization disease or disorder, modulating bone mineralization in a cell and bone mineralization and / or bone remodeling in a patient, and determining whether a compound or composition enhances the loading effect. activity in bone cell activity / function and / or mineralization, candidate agent for treating a low bone mass condition and composition
EP1690932A4 (en) * 2003-10-20 2008-03-05 Teijin Pharma Ltd Bone and/or joint disease-associated gene
JP2006212017A (en) * 2005-02-03 2006-08-17 Otake:Kk Apparatus for carrying out rotational culture under loading and pressure

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005123905A1 (en) * 2004-06-17 2005-12-29 Ken Nakata Cell culturing method by biomechanical stimulus load and its device

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MUROI Y. ET AL.: "Hito Katsumaku Yurai Kansaibo o Mochiita Sanjigen Baiyo Soshiki no Kurikaeshi Asshuku Rikigaku Shigeki (Mechanical Stress) to Hyaluronic Acid Shigeki ni yoru Nankotsu Bunka", THE JOURNAL OF THE JAPANESE ORTHOPAEDIC ASSOCIATION, vol. 80, no. 8, 2006, pages S973 *

Also Published As

Publication number Publication date
JPWO2008096842A1 (en) 2010-05-27
JP5548972B2 (en) 2014-07-16

Similar Documents

Publication Publication Date Title
WO2008070865A3 (en) Materials and methods for efficient and accurate detection of analytes
EP2383575A4 (en) Method for pretreating specimen and method for assaying biological substance
WO2011002850A8 (en) Methods of determining the presence and/or concentration of an analyte in a sample
WO2008058683A3 (en) Arrangement and method for the analysis of biological samples
WO2007114986A3 (en) Cooperative probes and methods of using them
WO2006122295A8 (en) Methods of monitoring functional status of transplants using gene panels
HK1129340A1 (en) Vials and apparatus for obtaining an aliquot of a sample
WO2010092164A3 (en) Bacterial dna as markers of cardiovascular and/or metabolic disease
IN2012DN00866A (en)
WO2010090471A3 (en) Novel diagnostic marker for type 1 diabetes mellitus
WO2008115419A3 (en) Gene expression markers for prediction of patient response to chemotherapy
EP3061808A3 (en) Culture medium for epithelial stem cells and organoids comprising said stem cells
WO2010141075A8 (en) Specific analysis of ketone and aldehyde analytes using reagent compounds, labeling strategies, and mass spectrometry workflow
WO2007106545A3 (en) Propagation of primary cells
UA116618C2 (en) CONSTITUTION-BASED CYSTEINE ANTIBODY AGAINST CD79b
AU2013207599A1 (en) Process for determining one or more analytes in samples of biological origin having complex composition, and use thereof
GB0503629D0 (en) Method and apparatus for automated analysis of biological specimen
WO2010047779A3 (en) Integrated bioanalyzer
EP2370111A4 (en) Probe for a biological specimen and labelling method and screening method using the probe
GB0814035D0 (en) Apparatus and method for biological sample culture or testing
WO2011071364A3 (en) A specimen collecting and testing apparatus
WO2011014485A3 (en) Methods to characterize cell reprogramming and uses thereof
WO2011143575A3 (en) smFRET WITH MEMBRANE PROTEINS
GB0525591D0 (en) An improved method of preparing a biological specimen for examination
BRPI0916111A2 (en) cuvette for storing a biological sample [to be analyzed by means of a predefined detection technique, method of making a cuvette, method for authenticating a cuvette, method for analyzing a biological sample and system for analyzing a biological sample

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08710978

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2008557160

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08710978

Country of ref document: EP

Kind code of ref document: A1