WO2008093756A1 - 生物学的製剤 - Google Patents

生物学的製剤 Download PDF

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Publication number
WO2008093756A1
WO2008093756A1 PCT/JP2008/051457 JP2008051457W WO2008093756A1 WO 2008093756 A1 WO2008093756 A1 WO 2008093756A1 JP 2008051457 W JP2008051457 W JP 2008051457W WO 2008093756 A1 WO2008093756 A1 WO 2008093756A1
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WO
WIPO (PCT)
Prior art keywords
seq
amino acid
acid sequence
sequence represented
subunit
Prior art date
Application number
PCT/JP2008/051457
Other languages
English (en)
French (fr)
Inventor
Haruo Hanawa
Original Assignee
Niigata University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Niigata University filed Critical Niigata University
Priority to JP2008556159A priority Critical patent/JP5272735B2/ja
Publication of WO2008093756A1 publication Critical patent/WO2008093756A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

異なる分子種の受容体及び／又はリガンド結合蛋白と、リガンドとの複合体が形成できるようなヘテロダイマーを開発すること。 本発明は、ＩＬ－１受容体タイプＩＩの細胞外ドメインと第１化学的部分とを含む第１サブユニットと、ＩＬ－１受容体アクセソリープロテインの細胞外ドメインと第２化学的部分とを含む第２サブユニットとからなり、第１化学的部分と第２化学的部分とは、第１サブユニットと第２サブユニットとを会合させて、ＩＬ－１リガンドに結合可能な複合体を形成させる、ヘテロダイマーを提供する。本発明のヘテロダイマーは、配列番号３４又は３７に列挙されるアミノ酸配列のポリペプチド等と、配列番号４３ないし４７のいずれかに列挙されるアミノ酸配列のポリペプチド等とを含み、前記ＩＬ－受容体アクセソリープロテインＩｇ融合蛋白は、配列番号３５又は３８に列挙されるアミノ酸配列のポリペプチド等と、配列番号４３ないし４７のいずれかに列挙されるアミノ酸配列のポリペプチド等とを含むことを特徴とする場合がある。
PCT/JP2008/051457 2007-01-30 2008-01-30 生物学的製剤 WO2008093756A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008556159A JP5272735B2 (ja) 2007-01-30 2008-01-30 生物学的製剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-018681 2007-01-30
JP2007018681 2007-01-30

Publications (1)

Publication Number Publication Date
WO2008093756A1 true WO2008093756A1 (ja) 2008-08-07

Family

ID=39674063

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/051457 WO2008093756A1 (ja) 2007-01-30 2008-01-30 生物学的製剤

Country Status (2)

Country Link
JP (1) JP5272735B2 (ja)
WO (1) WO2008093756A1 (ja)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000018932A2 (en) * 1998-09-25 2000-04-06 Regeneron Pharmaceuticals, Inc. Receptor based antagonists and methods of making and using
US20050197293A1 (en) * 2002-10-28 2005-09-08 Scott Mellis Use of an IL-1 antagonist for treating arthritis
WO2005117945A1 (en) * 2004-06-04 2005-12-15 Regeneron Pharmaceuticals, Inc. Methods of using il-1 antagonists to treat autoinflammatory disease
WO2006076673A2 (en) * 2005-01-14 2006-07-20 Regeneron Pharmaceuticals, Inc. Use of il-i antagonists to treat polymyalgia rheumatica and giant cell arteritis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000018932A2 (en) * 1998-09-25 2000-04-06 Regeneron Pharmaceuticals, Inc. Receptor based antagonists and methods of making and using
US20050197293A1 (en) * 2002-10-28 2005-09-08 Scott Mellis Use of an IL-1 antagonist for treating arthritis
WO2005117945A1 (en) * 2004-06-04 2005-12-15 Regeneron Pharmaceuticals, Inc. Methods of using il-1 antagonists to treat autoinflammatory disease
WO2006076673A2 (en) * 2005-01-14 2006-07-20 Regeneron Pharmaceuticals, Inc. Use of il-i antagonists to treat polymyalgia rheumatica and giant cell arteritis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHANGLU LIU ET AL.: "Rat homolog of mouse interleukin-1 receptor accessory protein: cloning, localization and modulation studies", JOURNAL OF NEUROIMMUNOLOGY, vol. 66, no. 1-2, 1996, pages 41 - 48, XP002940631 *
CHARLES A.: "Dinarello, Setting the cytokine trap for autoimmunity", NATURE MEDICINE, vol. 9, no. 1, 2003, pages 20 - 22 *
DATABASE GENBANK [online] 1 November 1995 (1995-11-01), BRISTULF J. ET AL., Database accession no. (P43303) *

Also Published As

Publication number Publication date
JPWO2008093756A1 (ja) 2010-05-20
JP5272735B2 (ja) 2013-08-28

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