WO2008092466A1 - Antiviral combination for treatment of hcv & hbv - Google Patents
Antiviral combination for treatment of hcv & hbv Download PDFInfo
- Publication number
- WO2008092466A1 WO2008092466A1 PCT/EG2007/000002 EG2007000002W WO2008092466A1 WO 2008092466 A1 WO2008092466 A1 WO 2008092466A1 EG 2007000002 W EG2007000002 W EG 2007000002W WO 2008092466 A1 WO2008092466 A1 WO 2008092466A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hcv
- hbv
- abs
- antibodies
- need
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
Definitions
- Oligonucleotides which act by destruction or incapacitation of HCV RNA in the cytoplasm to prevent or to reduce attachment of RNA to the ER and impair translation of large ORE that produce the HCV polyprotein , Protease inhibitors VX-950 and SCH 503034 have recently entered phase II clinical trails, Interleukins -2 and interleukins -12 ,Immune modulators (Thymos ⁇ n- levamisole), Herbal Therapy Phyllantus amaurus, Nucleoside analogs (Lamuvidine-Famcyclovir) , Therapeutic vaccines, we filled an application about using of antistreptolysine antibodies as clonal antibodies with tranexamic acid as synthetic amino acids in patent office of Egypt in3/9/2003 no.
- Fibrin is made from its zymogene fibrinogen, a soluble plasma glycoprotein That is synthesized by the liver. Processes in the coagulation cascade activate The zymogene prothrombin to the serine protease thrombin, which is responsible For converting fibrinogen into fibrin. Fibrin is then cross linked by factor XIII To form a clot.
- Fibrinogen is a 340 kDa glycoprotein synthesized in the liver hepatocytes and megakaryocyte, which normally has a concentration between 1.5 - 4.0 g/L
- fibrinogen is useful in forming bridges between platelets, by binding to Their GpIIb/IIIa surface membrane proteins; though fibrinogen's major use is As a precursor to fibrin in the normal liver, sinusoids are formed.
- Endothelial space within the sub endothelial space lie hepatic satellite cells
- a mixture formed of 2 components (100 mg/ ml) under complete aseptic Conditions the following were done 1 Vol. Of first component were mixed With 1 Vol.
- the resulting preparation was tested for; HIV,HIV2,HCV and HBV
- the resulting mixing solution was sterilized by filtration and carefully put in sterilized ampoule sealed after this.
- the ampoule containing mixture should be brought to room temperature
- the chemical part is easily absorbed via GIT with peak plasma concentration Occurring after 2 hours with very low protein binding. It is excreted in the urine Mainly as unchanged drug. For Abs. Renal absorption were occur as any protein Particular molecules .It is excreted in the bile, urine and saliva.
- Component of the mixture is injected separately in -1 st ' and -2 nd ' group while the -3 rd group injected by the mixture of the two components for about 15 days for all group
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EG2007/000002 WO2008092466A1 (en) | 2007-01-31 | 2007-01-31 | Antiviral combination for treatment of hcv & hbv |
AU2007345420A AU2007345420A1 (en) | 2007-01-31 | 2007-01-31 | Antiviral combination for treatment of HCV & HBV |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EG2007/000002 WO2008092466A1 (en) | 2007-01-31 | 2007-01-31 | Antiviral combination for treatment of hcv & hbv |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008092466A1 true WO2008092466A1 (en) | 2008-08-07 |
Family
ID=39673681
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EG2007/000002 WO2008092466A1 (en) | 2007-01-31 | 2007-01-31 | Antiviral combination for treatment of hcv & hbv |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2007345420A1 (en) |
WO (1) | WO2008092466A1 (en) |
-
2007
- 2007-01-31 AU AU2007345420A patent/AU2007345420A1/en not_active Abandoned
- 2007-01-31 WO PCT/EG2007/000002 patent/WO2008092466A1/en active Application Filing
Non-Patent Citations (11)
Title |
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ARCHIV. FÜR HYGIENE UND BAKTERIOLOGIE, GERMANY, WEST, vol. 154, no. 1, 1970, pages 52 - 57 * |
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 117, no. 3, 1983, pages 908 - 915 * |
DATABASE MEDLINE [online] CHEDID L. ET AL.: "Antibody responses elicited by a polyvalent vaccine containing synthesis diphtheric, streptococcal and hepatitis peptides coupled to the same carrier", Database accession no. (NLM6421289) * |
DATABASE MEDLINE [online] ELIAS A. ET AL.: "Serum inhibitors of streptolysin "O" in acute epidemic hepatitis", Database accession no. (NLM4097644) * |
DATABASE MEDLINE [online] LENDVAI B. ET AL.: "Antistreptokinase reaction in the presence of O-streptolysin pseudoantibody", Database accession no. (NLM5779961) * |
DATABASE MEDLINE [online] POLKEY M. ET AL.: "Hepatic dysfunction induced by streptokinase", Database accession no. (NLM1642215) * |
DATABASE MEDLINE [online] ZHITAR V.D. ET AL.: "Mathematical method of determining the indicators of blood coagulation and fibrinolysis in the diagnosis of acute liver necrosis in hepatitis B", Database accession no. (NLM6513438) * |
DE JONGE J. ET AL.: "Fibrinolysis During Liver Transplantation Is Enhanced by Using Solvent/Detergent Virus-Inactivated Plasma (ESDEP)", ANESTH. ANALOG., vol. 94, 2000, pages 1127 - 1131 * |
KLINICHESKAIA MEDITSINA, USSR, vol. 62, no. 10, 1984, pages 102 - 106 * |
ORVOSI HETILAP, HUNGARY, vol. 110, no. 9, 1969, pages 471 - 474 * |
THE AMERICAN JOURNAL OF GASTROENTEROLOGY, vol. 87, no. 8, 1992, pages 1062 * |
Also Published As
Publication number | Publication date |
---|---|
AU2007345420A1 (en) | 2008-08-07 |
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