WO2008091364A3 - Nanoparticles as tags for bioanalyte detection by nuclear magnetic resonance or electron spin resonance - Google Patents
Nanoparticles as tags for bioanalyte detection by nuclear magnetic resonance or electron spin resonance Download PDFInfo
- Publication number
- WO2008091364A3 WO2008091364A3 PCT/US2007/072297 US2007072297W WO2008091364A3 WO 2008091364 A3 WO2008091364 A3 WO 2008091364A3 US 2007072297 W US2007072297 W US 2007072297W WO 2008091364 A3 WO2008091364 A3 WO 2008091364A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tags
- nanoparticles
- nuclear magnetic
- resonance
- magnetic resonance
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
- G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
- G01N24/10—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using electron paramagnetic resonance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
- G01N33/587—Nanoparticles
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/30—Sample handling arrangements, e.g. sample cells, spinning mechanisms
- G01R33/302—Miniaturized sample handling arrangements for sampling small quantities, e.g. flow-through microfluidic NMR chips
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
- G01R33/34—Constructional details, e.g. resonators, specially adapted to MR
- G01R33/341—Constructional details, e.g. resonators, specially adapted to MR comprising surface coils
- G01R33/3415—Constructional details, e.g. resonators, specially adapted to MR comprising surface coils comprising arrays of sub-coils, i.e. phased-array coils with flexible receiver channels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/46—NMR spectroscopy
- G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- High Energy & Nuclear Physics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Dispersion Chemistry (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Biotechnology (AREA)
- Nanotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Abstract
Embodiments of the invention relate to detecting biological molecules with ultra-sensitivity and convenience. The embodiments are especially directed to utilizing nanoparticles as tags and identifying the tags using a nuclear magnetic resonance device. The probes containing the nanoparticles can be used in solution or attached to a substrate.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47769606A | 2006-06-30 | 2006-06-30 | |
US11/477,696 | 2006-06-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008091364A2 WO2008091364A2 (en) | 2008-07-31 |
WO2008091364A3 true WO2008091364A3 (en) | 2008-12-11 |
Family
ID=39645010
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/072297 WO2008091364A2 (en) | 2006-06-30 | 2007-06-27 | Nanoparticles as tags for bioanalyte detection by nuclear magnetic resonance or electron spin resonance |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008091364A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104535601A (en) * | 2014-12-19 | 2015-04-22 | 上海师范大学 | Dual-mode sensor for detecting Cd<2+> based on magnetic nanoparticles and preparation method of dual-mode sensor |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102269758B (en) * | 2010-06-04 | 2013-11-20 | 国家纳米科学中心 | Method for visual detection of antigen-antibody reaction, kit and application thereof |
DE202011051402U1 (en) * | 2010-09-27 | 2011-11-25 | Aspect Magnet Technologies Ltd. | Microwells MRI readable markers |
WO2014078775A1 (en) * | 2012-11-16 | 2014-05-22 | Lightstat, Llc | Multiplexed bioassay techniques |
AU2016270823B2 (en) | 2015-06-01 | 2020-09-03 | California Institute Of Technology | Compositions and methods for screening T cells with antigens for specific populations |
EP3112853A1 (en) | 2015-07-03 | 2017-01-04 | Memscap S.A. | Apparatus for an atomic clock |
WO2020065478A1 (en) * | 2018-09-24 | 2020-04-02 | Ecole Polytechnique Federale De Lausanne (Epfl) | Miniaturized mr device comprising a cell culture micro-chamber and method for manufacturing such a device |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5981297A (en) * | 1997-02-05 | 1999-11-09 | The United States Of America As Represented By The Secretary Of The Navy | Biosensor using magnetically-detected label |
WO2003054523A2 (en) * | 2001-12-21 | 2003-07-03 | Koninklijke Philips Electronics N.V. | Sensor and method for measuring the areal density of magnetic nanoparticles on a micro-array |
US20030143598A1 (en) * | 2001-11-09 | 2003-07-31 | Viswanadham Garimella | Bioconjugate-nanoparticle probes |
WO2005073695A1 (en) * | 2004-01-26 | 2005-08-11 | Koninklijke Philips Electronics N.V. | Method and device for on-chip magnetic resonance spectroscopy |
-
2007
- 2007-06-27 WO PCT/US2007/072297 patent/WO2008091364A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5981297A (en) * | 1997-02-05 | 1999-11-09 | The United States Of America As Represented By The Secretary Of The Navy | Biosensor using magnetically-detected label |
US20030143598A1 (en) * | 2001-11-09 | 2003-07-31 | Viswanadham Garimella | Bioconjugate-nanoparticle probes |
WO2003054523A2 (en) * | 2001-12-21 | 2003-07-03 | Koninklijke Philips Electronics N.V. | Sensor and method for measuring the areal density of magnetic nanoparticles on a micro-array |
WO2005073695A1 (en) * | 2004-01-26 | 2005-08-11 | Koninklijke Philips Electronics N.V. | Method and device for on-chip magnetic resonance spectroscopy |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104535601A (en) * | 2014-12-19 | 2015-04-22 | 上海师范大学 | Dual-mode sensor for detecting Cd<2+> based on magnetic nanoparticles and preparation method of dual-mode sensor |
CN104535601B (en) * | 2014-12-19 | 2017-01-11 | 上海师范大学 | Dual-mode sensor for detecting Cd2+ based on magnetic nanoparticles and preparation method of dual-mode sensor |
Also Published As
Publication number | Publication date |
---|---|
WO2008091364A2 (en) | 2008-07-31 |
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