WO2008089487A3 - Carboxyethylpyrrole compounds and methods of their production - Google Patents

Carboxyethylpyrrole compounds and methods of their production Download PDF

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Publication number
WO2008089487A3
WO2008089487A3 PCT/US2008/051689 US2008051689W WO2008089487A3 WO 2008089487 A3 WO2008089487 A3 WO 2008089487A3 US 2008051689 W US2008051689 W US 2008051689W WO 2008089487 A3 WO2008089487 A3 WO 2008089487A3
Authority
WO
WIPO (PCT)
Prior art keywords
cep
linker
methods
masked
carboxyethylpyrrole
Prior art date
Application number
PCT/US2008/051689
Other languages
French (fr)
Other versions
WO2008089487A2 (en
Inventor
Robert G Salomon
John W Crabb
Keeve Daryl Jaffe
Liang Lu
Xiaorong Gu
Jaewoo Choi
Original Assignee
Cleveland Clinic Foundation
Robert G Salomon
John W Crabb
Keeve Daryl Jaffe
Liang Lu
Xiaorong Gu
Jaewoo Choi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cleveland Clinic Foundation, Robert G Salomon, John W Crabb, Keeve Daryl Jaffe, Liang Lu, Xiaorong Gu, Jaewoo Choi filed Critical Cleveland Clinic Foundation
Priority to PCT/US2008/051689 priority Critical patent/WO2008089487A2/en
Publication of WO2008089487A2 publication Critical patent/WO2008089487A2/en
Publication of WO2008089487A3 publication Critical patent/WO2008089487A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials

Abstract

The present invention involves methods of anchoring carboxyethylpyrrole (CEP) haptens to carriers via various linkers. Provided herein are 9-fluorenylmethyl (Fm) masked-CEP-linker acids and Fm masked-CEP-linker esters that are useful for the preparation of CEP-linker- carrier derivatives. Also provided are methods of preparing said Fm masked-CEP-linker acids, Fm masked-CEP-linker esters and CEP-linker-carrier derivatives.
PCT/US2008/051689 2007-01-19 2008-01-22 Carboxyethylpyrrole compounds and methods of their production WO2008089487A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/US2008/051689 WO2008089487A2 (en) 2007-01-19 2008-01-22 Carboxyethylpyrrole compounds and methods of their production

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88125207P 2007-01-19 2007-01-19
US60/881,252 2007-01-19
PCT/US2008/051689 WO2008089487A2 (en) 2007-01-19 2008-01-22 Carboxyethylpyrrole compounds and methods of their production

Publications (2)

Publication Number Publication Date
WO2008089487A2 WO2008089487A2 (en) 2008-07-24
WO2008089487A3 true WO2008089487A3 (en) 2008-09-18

Family

ID=40445199

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/051689 WO2008089487A2 (en) 2007-01-19 2008-01-22 Carboxyethylpyrrole compounds and methods of their production

Country Status (1)

Country Link
WO (1) WO2008089487A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050014954A1 (en) * 2001-11-22 2005-01-20 Reinhold Ohrlein Pyrrole synthesis
US20050222129A1 (en) * 2004-03-31 2005-10-06 Carruthers Nicholas I Non-imidazole heterocyclic compounds
US20060240092A1 (en) * 2005-04-01 2006-10-26 Kurt Breitenkamp Polymeric micelles for drug delivery

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050014954A1 (en) * 2001-11-22 2005-01-20 Reinhold Ohrlein Pyrrole synthesis
US20050222129A1 (en) * 2004-03-31 2005-10-06 Carruthers Nicholas I Non-imidazole heterocyclic compounds
US20060240092A1 (en) * 2005-04-01 2006-10-26 Kurt Breitenkamp Polymeric micelles for drug delivery

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ELMORE: "Peptide Synthesis "from" Amino Acids, Peptides and Proteins", THE ROYAL SOCIETY OF CHEMISTRY, vol. 32, no. 3, 29 October 2001 (2001-10-29) *
GU ET AL.: "Carboxyethylpyrrole Protein Adducts and Autoantibodies, Biomarkers for Age-related Macular Degeneration", JBC, vol. 278, no. 43, 15 August 2003 (2003-08-15), XP002462360 *

Also Published As

Publication number Publication date
WO2008089487A2 (en) 2008-07-24

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