WO2008088917A3 - Methods of using pyridinium and thiazolium compounds as reagents, diagnostic compounds and therapeutic agents - Google Patents

Methods of using pyridinium and thiazolium compounds as reagents, diagnostic compounds and therapeutic agents Download PDF

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Publication number
WO2008088917A3
WO2008088917A3 PCT/US2008/000794 US2008000794W WO2008088917A3 WO 2008088917 A3 WO2008088917 A3 WO 2008088917A3 US 2008000794 W US2008000794 W US 2008000794W WO 2008088917 A3 WO2008088917 A3 WO 2008088917A3
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WO
WIPO (PCT)
Prior art keywords
compounds
pyridinium
reagents
methods
therapeutic agents
Prior art date
Application number
PCT/US2008/000794
Other languages
French (fr)
Other versions
WO2008088917A2 (en
Inventor
Richard B Klein
Jeffrey L Selph
John J Partridge
Original Assignee
Mycosol Inc
Richard B Klein
Jeffrey L Selph
John J Partridge
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mycosol Inc, Richard B Klein, Jeffrey L Selph, John J Partridge filed Critical Mycosol Inc
Publication of WO2008088917A2 publication Critical patent/WO2008088917A2/en
Publication of WO2008088917A3 publication Critical patent/WO2008088917A3/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G01N33/56988—HIV or HTLV
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders

Abstract

Methods of using pyridinium and thiazolium compounds, homologs, analogs and derivatives thereof as reagents, diagnostic tools and therapeutic agents are provided.
PCT/US2008/000794 2007-01-19 2008-01-22 Methods of using pyridinium and thiazolium compounds as reagents, diagnostic compounds and therapeutic agents WO2008088917A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88134807P 2007-01-19 2007-01-19
US60/881,348 2007-01-19

Publications (2)

Publication Number Publication Date
WO2008088917A2 WO2008088917A2 (en) 2008-07-24
WO2008088917A3 true WO2008088917A3 (en) 2008-09-18

Family

ID=39636610

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/000794 WO2008088917A2 (en) 2007-01-19 2008-01-22 Methods of using pyridinium and thiazolium compounds as reagents, diagnostic compounds and therapeutic agents

Country Status (1)

Country Link
WO (1) WO2008088917A2 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6335446B1 (en) * 1998-10-05 2002-01-01 Oxford Glycosciences (Uk) Ltd. Quinolinium- and pyridinium-based fluorescent dye compounds
US20020028464A1 (en) * 2000-02-29 2002-03-07 Ko Nakamura Pyrrolopyridinium derivatives
WO2002094998A2 (en) * 2001-05-21 2002-11-28 Aclara Biosciences, Inc. Analyzing phosphorylated proteins
US20040224984A1 (en) * 2003-03-03 2004-11-11 Selph Jeffrey L. Methods of treating inflammations and infections with pyridinium salts
WO2005049091A2 (en) * 2003-11-13 2005-06-02 Elan Pharma International Ltd. Antibody-targeted nanoparticulate active agent delivery
WO2006065942A2 (en) * 2004-12-17 2006-06-22 Mycosol, Inc. Thiazolium compounds and uses thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6335446B1 (en) * 1998-10-05 2002-01-01 Oxford Glycosciences (Uk) Ltd. Quinolinium- and pyridinium-based fluorescent dye compounds
US20020028464A1 (en) * 2000-02-29 2002-03-07 Ko Nakamura Pyrrolopyridinium derivatives
WO2002094998A2 (en) * 2001-05-21 2002-11-28 Aclara Biosciences, Inc. Analyzing phosphorylated proteins
US20040224984A1 (en) * 2003-03-03 2004-11-11 Selph Jeffrey L. Methods of treating inflammations and infections with pyridinium salts
WO2005049091A2 (en) * 2003-11-13 2005-06-02 Elan Pharma International Ltd. Antibody-targeted nanoparticulate active agent delivery
WO2006065942A2 (en) * 2004-12-17 2006-06-22 Mycosol, Inc. Thiazolium compounds and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PRIVAT: "Oligonucleotide-conjugated thiazole orage probes as "Light-up" probes for messenger ribonucleic acid molecules in living cells", PHOTOCHEMISTRY AND PHOTOBIOLOGY, October 2001 (2001-10-01) *

Also Published As

Publication number Publication date
WO2008088917A2 (en) 2008-07-24

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