WO2008088301A3 - Inhibiteurs de l'activité de l'adna - Google Patents

Inhibiteurs de l'activité de l'adna Download PDF

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Publication number
WO2008088301A3
WO2008088301A3 PCT/US2006/016252 US2006016252W WO2008088301A3 WO 2008088301 A3 WO2008088301 A3 WO 2008088301A3 US 2006016252 W US2006016252 W US 2006016252W WO 2008088301 A3 WO2008088301 A3 WO 2008088301A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitors
dnaa
dsodn
dnaa activity
activity
Prior art date
Application number
PCT/US2006/016252
Other languages
English (en)
Other versions
WO2008088301A2 (fr
Inventor
Leslie M Mcevoy
Original Assignee
Corgentech Inc
Leslie M Mcevoy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corgentech Inc, Leslie M Mcevoy filed Critical Corgentech Inc
Publication of WO2008088301A2 publication Critical patent/WO2008088301A2/fr
Publication of WO2008088301A3 publication Critical patent/WO2008088301A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/13—Decoys

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne une molécule d'oligodésoxynucléotide double brin (dsODN) apte à une liaison spécifique à un ADNa bactérien, ledit dsODN inhibant la liaison de l'ADNa à son site de liaison naturel dans le chromosome d'une bactérie.
PCT/US2006/016252 2005-04-26 2006-04-26 Inhibiteurs de l'activité de l'adna WO2008088301A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67529405P 2005-04-26 2005-04-26
US60/675,294 2005-04-26

Publications (2)

Publication Number Publication Date
WO2008088301A2 WO2008088301A2 (fr) 2008-07-24
WO2008088301A3 true WO2008088301A3 (fr) 2009-04-23

Family

ID=39636489

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/016252 WO2008088301A2 (fr) 2005-04-26 2006-04-26 Inhibiteurs de l'activité de l'adna

Country Status (1)

Country Link
WO (1) WO2008088301A2 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030175283A1 (en) * 2000-03-28 2003-09-18 Council Of Scientific And Industrial Research Novel formulation comprising thymol useful in the treatment of drug resistant bacterial infections
US20040096452A1 (en) * 1996-05-01 2004-05-20 Denney Dan W. Vaccines for treatment of lymphoma and leukemia
US20050042623A1 (en) * 2002-10-30 2005-02-24 Dana Ault-Riche Systems for capture and analysis of biological particles and methods using the systems
WO2005035547A2 (fr) * 2003-10-06 2005-04-21 Corgentech, Inc. Molecules leurres oligonucleotidiques e2f

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040096452A1 (en) * 1996-05-01 2004-05-20 Denney Dan W. Vaccines for treatment of lymphoma and leukemia
US20030175283A1 (en) * 2000-03-28 2003-09-18 Council Of Scientific And Industrial Research Novel formulation comprising thymol useful in the treatment of drug resistant bacterial infections
US20050042623A1 (en) * 2002-10-30 2005-02-24 Dana Ault-Riche Systems for capture and analysis of biological particles and methods using the systems
WO2005035547A2 (fr) * 2003-10-06 2005-04-21 Corgentech, Inc. Molecules leurres oligonucleotidiques e2f

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GLINKOWSKA ET AL.: "The Mechanism of Regulation of Bacteriophage LambdapR Promoter Activity by Escherichia coli DnaA Protein", JBC., vol. 278, pages 22250 - 22256 *

Also Published As

Publication number Publication date
WO2008088301A2 (fr) 2008-07-24

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