WO2008087862A1 - Agent against periodontal disease - Google Patents

Agent against periodontal disease Download PDF

Info

Publication number
WO2008087862A1
WO2008087862A1 PCT/JP2008/000039 JP2008000039W WO2008087862A1 WO 2008087862 A1 WO2008087862 A1 WO 2008087862A1 JP 2008000039 W JP2008000039 W JP 2008000039W WO 2008087862 A1 WO2008087862 A1 WO 2008087862A1
Authority
WO
WIPO (PCT)
Prior art keywords
periodontal
drink
food
drug
tissue
Prior art date
Application number
PCT/JP2008/000039
Other languages
French (fr)
Japanese (ja)
Inventor
Toshikazu Shiba
Kazuki Endo
Original Assignee
Regenetiss Inc.
Yamasa Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regenetiss Inc., Yamasa Corporation filed Critical Regenetiss Inc.
Publication of WO2008087862A1 publication Critical patent/WO2008087862A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/13—Nucleic acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)

Abstract

It is intended to provide a drug or a food or a drink which contains a highly safe compound originating in a natural material as the active ingredient, promotes the blood flow in the periodontal tissue and induces basic fibroblast growth factor in the periodontal tissue or the alveolar bone to thereby exert the function of regenerating the periodontal tissue or the alveolar bone having been broken or reduced by periodontal disease. A drug or a food or a drink which contains, as the active ingredient, an adenine-based nucleic acid compound such as adenosine or AMP is provided. The above-described drug, food or drink promotes the blood flow topically in the periodontal tissue, and induces and produces basic fibroblast growth factor that is capable of strongly inducing the regeneration of the tissue per se. Thus, the drug, food or drink can artificially induce and promote the regeneration of the periodontal tissue having been lost as the periodontal disease proceeds, which makes it usable as a preventive or a remedy for periodontal disease.
PCT/JP2008/000039 2007-01-18 2008-01-17 Agent against periodontal disease WO2008087862A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-009350 2007-01-18
JP2007009350 2007-01-18
JP2007-212212 2007-08-16
JP2007212212 2007-08-16

Publications (1)

Publication Number Publication Date
WO2008087862A1 true WO2008087862A1 (en) 2008-07-24

Family

ID=39635867

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/000039 WO2008087862A1 (en) 2007-01-18 2008-01-17 Agent against periodontal disease

Country Status (1)

Country Link
WO (1) WO2008087862A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010007651A1 (en) * 2008-07-15 2010-01-21 リジェンティス株式会社 Composition having anti-periodontal disease effect

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61171423A (en) * 1985-01-24 1986-08-02 Advance Res & Dev Co Ltd Drug for alleviating dental caries and periodontosis
JPH0446124A (en) * 1990-06-13 1992-02-17 Advance Co Ltd Antiulcer agent
JPH0717876A (en) * 1992-02-27 1995-01-20 Kaken Pharmaceut Co Ltd Agent for treatment of periodental disease
WO1995005840A1 (en) * 1993-08-25 1995-03-02 Kaken Pharmaceutical Co., Ltd. Periodontal disease remedy
JPH11124322A (en) * 1997-10-22 1999-05-11 Lion Corp Composition for oral cavity
WO2006129393A1 (en) * 2005-06-02 2006-12-07 Japan Science And Technology Agency Composition for treating periodontal disease

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61171423A (en) * 1985-01-24 1986-08-02 Advance Res & Dev Co Ltd Drug for alleviating dental caries and periodontosis
JPH0446124A (en) * 1990-06-13 1992-02-17 Advance Co Ltd Antiulcer agent
JPH0717876A (en) * 1992-02-27 1995-01-20 Kaken Pharmaceut Co Ltd Agent for treatment of periodental disease
WO1995005840A1 (en) * 1993-08-25 1995-03-02 Kaken Pharmaceutical Co., Ltd. Periodontal disease remedy
JPH11124322A (en) * 1997-10-22 1999-05-11 Lion Corp Composition for oral cavity
WO2006129393A1 (en) * 2005-06-02 2006-12-07 Japan Science And Technology Agency Composition for treating periodontal disease

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS [online] WANG Y. ET AL.: "Adenosine promotes bFGF protein and bFGF mRNA expression in human umbilical vein endothelial cells in vitro", Database accession no. (2006:327993) *
DATABASE CAPLUS [online] YAMAMOTO T. ET AL.: "Intramyocardial delivery of basic fibroblast growth factor-impregnated gelatin hydrogel microspheres enhances collateral circulation to infarcted canine myocardium", Database accession no. (2001:360738) *
JAPANESE CIRCULATION JOURNAL, vol. 65, no. 5, 2001, pages 439 - 444 *
ZHONGGUOBINGLI SHENGLI ZAZHI, vol. 21, no. 5, 2005, pages 882 - 885 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010007651A1 (en) * 2008-07-15 2010-01-21 リジェンティス株式会社 Composition having anti-periodontal disease effect

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