WO2008086043A3 - Procédés et compositions permettant l'évaluation et le traitement de l'asthme - Google Patents

Procédés et compositions permettant l'évaluation et le traitement de l'asthme Download PDF

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Publication number
WO2008086043A3
WO2008086043A3 PCT/US2008/000453 US2008000453W WO2008086043A3 WO 2008086043 A3 WO2008086043 A3 WO 2008086043A3 US 2008000453 W US2008000453 W US 2008000453W WO 2008086043 A3 WO2008086043 A3 WO 2008086043A3
Authority
WO
WIPO (PCT)
Prior art keywords
asthma
treatment
methods
assessment
compositions
Prior art date
Application number
PCT/US2008/000453
Other languages
English (en)
Other versions
WO2008086043A2 (fr
Inventor
Frederick Immermann
Andrew Hill
Padmalatha Reddy
Michael Burczynski
Douglas Miller
Karl Nocka
Stan Wolf
Michael Bowman
Andrew Dorner
I-Ming Wang
Original Assignee
Wyeth Corp
Toole Margot O
Frederick Immermann
Andrew Hill
Padmalatha Reddy
Michael Burczynski
Douglas Miller
Karl Nocka
Stan Wolf
Michael Bowman
Andrew Dorner
I-Ming Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp, Toole Margot O, Frederick Immermann, Andrew Hill, Padmalatha Reddy, Michael Burczynski, Douglas Miller, Karl Nocka, Stan Wolf, Michael Bowman, Andrew Dorner, I-Ming Wang filed Critical Wyeth Corp
Publication of WO2008086043A2 publication Critical patent/WO2008086043A2/fr
Publication of WO2008086043A3 publication Critical patent/WO2008086043A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

La présente invention concerne des procédés et des compositions permettant l'évaluation et le traitement de l'asthme et d'autres maladies inflammatoires, en particulier celles véhiculées par l'interleukine-13 (IL-13). La présente invention concerne également des réseaux comprenant des marqueurs pour l'asthme ainsi que la réactivité à l'IL-13. Les marqueurs de la présente invention peuvent être utilisés dans des procédés pour diagnostiquer l'asthme ou une affection véhiculée par l'IL-13 chez un patient, pour évaluer l'efficacité d'agents thérapeutiques potentiels, pour identifier ou évaluer les agents pouvant moduler les niveaux d'expression des marqueurs, et pour sélectionner un traitement pour un patient souffrant d'asthme ou d'une affection véhiculée par l'IL-13.
PCT/US2008/000453 2007-01-10 2008-01-10 Procédés et compositions permettant l'évaluation et le traitement de l'asthme WO2008086043A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87999407P 2007-01-10 2007-01-10
US60/879,994 2007-01-10

Publications (2)

Publication Number Publication Date
WO2008086043A2 WO2008086043A2 (fr) 2008-07-17
WO2008086043A3 true WO2008086043A3 (fr) 2008-11-06

Family

ID=39393813

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/000453 WO2008086043A2 (fr) 2007-01-10 2008-01-10 Procédés et compositions permettant l'évaluation et le traitement de l'asthme

Country Status (2)

Country Link
US (1) US20080226645A1 (fr)
WO (1) WO2008086043A2 (fr)

Families Citing this family (17)

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US20100113299A1 (en) * 2008-10-14 2010-05-06 Von Hoff Daniel D Gene and gene expressed protein targets depicting biomarker patterns and signature sets by tumor type
US8768629B2 (en) * 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors
MX2008014608A (es) * 2006-05-18 2009-03-31 Molecular Profiling Inst Inc Sistema y metodo para determinar la intervencion medica individualizada para un estado de enfermedad.
WO2009114532A2 (fr) 2008-03-10 2009-09-17 National Jewish Health Marqueurs permettant de diagnostiquer une inflammation pulmonaire et procédés associés
US8756190B2 (en) * 2008-03-20 2014-06-17 Ebs Technologies Gmbh Apparatus and a method for automatic treatment adjustment after nervous system dysfunction
GB0904214D0 (en) 2009-03-11 2009-04-22 Ucb Pharma Sa Biological products
WO2011014308A1 (fr) 2009-06-12 2011-02-03 Consolidated Research, Inc. Système et procédé pour tester une hypothèse de traitement médical
US20150099643A1 (en) * 2011-05-02 2015-04-09 Rheinische Friedrich-Wilhelms-Universitat Bonn Blood-based gene expression signatures in lung cancer
WO2012158866A2 (fr) 2011-05-19 2012-11-22 The Johns Hopkins University Traitement de troubles auto-immunitaires et d'infections au moyen d'antagonistes de l'activité sgk1
US10081838B2 (en) * 2012-05-03 2018-09-25 Qiagen Sciences, Llc Gene expression signature for IL-6/STAT3 signaling pathway and use thereof
DK2931920T3 (en) * 2012-12-14 2018-06-14 Univ Newcastle BIOMARKERS FOR INFLAMMATORY ASTMPHENotypes AND TREATMENT RESPONSE
TWI648274B (zh) 2013-02-15 2019-01-21 英商葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之雜環醯胺類 （二）
EP3060685B1 (fr) * 2013-10-23 2019-05-01 F. Hoffmann-La Roche AG Méthode de prédiction de la réponse d'un patient asthmatique au traitement
TR201810635T4 (tr) 2014-02-12 2018-08-27 Hoffmann La Roche Anti-jagged1 antikorları ve kullanım yöntemleri.
US10126295B2 (en) 2014-03-21 2018-11-13 National Jewish Health Method for treating pulmonary exacerbation and disease progression in subjects having cystic fibrosis
US10436799B2 (en) 2015-10-09 2019-10-08 National Jewish Health Methods for diagnosing and treating subjects for pulmonary exacerbation
CN106755309A (zh) * 2016-11-18 2017-05-31 北京致成生物医学科技有限公司 分子标记物在制备胰腺癌预后评估产品中的应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010023241A1 (en) * 1998-02-04 2001-09-20 Sliwkowski Mark X. Use of heregulin as a growth factor
US20020115626A1 (en) * 2000-05-25 2002-08-22 Luca Rastelli Method of detecting inflammatory lung disorders
WO2003008640A2 (fr) * 2001-07-16 2003-01-30 Novartis Ag Gene associe a une maladie
US20030099979A1 (en) * 2001-08-07 2003-05-29 Genox Research, Inc. Method of testing for bronchial asthma
WO2003073990A2 (fr) * 2002-03-01 2003-09-12 Children's Hospital Medical Center Traitement de l'asthme ou des allergies
US20040043021A1 (en) * 2001-10-11 2004-03-04 Tim Keith Nucleotide and amino acid sequences relating to respiratory diseases and obesity

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JP3944996B2 (ja) * 1998-03-05 2007-07-18 株式会社日立製作所 Ｄｎａプローブアレー
US6647341B1 (en) * 1999-04-09 2003-11-11 Whitehead Institute For Biomedical Research Methods for classifying samples and ascertaining previously unknown classes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010023241A1 (en) * 1998-02-04 2001-09-20 Sliwkowski Mark X. Use of heregulin as a growth factor
US20020115626A1 (en) * 2000-05-25 2002-08-22 Luca Rastelli Method of detecting inflammatory lung disorders
WO2003008640A2 (fr) * 2001-07-16 2003-01-30 Novartis Ag Gene associe a une maladie
US20030099979A1 (en) * 2001-08-07 2003-05-29 Genox Research, Inc. Method of testing for bronchial asthma
US20040043021A1 (en) * 2001-10-11 2004-03-04 Tim Keith Nucleotide and amino acid sequences relating to respiratory diseases and obesity
WO2003073990A2 (fr) * 2002-03-01 2003-09-12 Children's Hospital Medical Center Traitement de l'asthme ou des allergies

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Affimetrix GeneChip Human Genome U133 Array Set HG-U133A", GEO,, 1 January 1900 (1900-01-01), XP002254749 *
VERMEER PAOLA D ET AL: "Segregation of receptor and ligand regulates activation of epithelial growth factor receptor.", NATURE (LONDON), vol. 422, no. 6929, 20 March 2003 (2003-03-20), pages 322 - 326, XP002481233, ISSN: 0028-0836 *

Also Published As

Publication number Publication date
WO2008086043A2 (fr) 2008-07-17
US20080226645A1 (en) 2008-09-18

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