WO2008085969A2 - Packaging for products to be decontaminated by radiation - Google Patents
Packaging for products to be decontaminated by radiation Download PDFInfo
- Publication number
- WO2008085969A2 WO2008085969A2 PCT/US2008/000255 US2008000255W WO2008085969A2 WO 2008085969 A2 WO2008085969 A2 WO 2008085969A2 US 2008000255 W US2008000255 W US 2008000255W WO 2008085969 A2 WO2008085969 A2 WO 2008085969A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- packaging
- tub
- layer
- peripheral outline
- cover sheet
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
- B65D77/22—Details
- B65D77/24—Inserts or accessories added or incorporated during filling of containers
- B65D77/26—Elements or devices for locating or protecting articles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
- A61B50/20—Holders specially adapted for surgical or diagnostic appliances or instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
- A61B50/30—Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/087—Particle radiation, e.g. electron-beam, alpha or beta radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/26—Accessories or devices or components used for biocidal treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
- B65D77/22—Details
- B65D77/24—Inserts or accessories added or incorporated during filling of containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
- A61B2050/005—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers with a lid or cover
- A61B2050/0065—Peelable cover
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/10—Apparatus features
- A61L2202/18—Aseptic storing means
- A61L2202/181—Flexible packaging means, e.g. permeable membranes, paper
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/24—Medical instruments, e.g. endoscopes, catheters, sharps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/008—Racks for supporting syringes or needles
Definitions
- the invention relates to a packaging for products that is to be decontaminated by radiation.
- the conditions of sterility in which certain stages of the handling or transportation of products or instruments intended for medical use are to be performed are extremely strict, particularly in the pharmaceutical industry. It is, therefore, extremely important to produce packaging compatible with such requirements.
- the expression "selectively impervious material” is to be understood as meaning that the material is designed, in terms of structure, to control any exchange between the inside of the packaging and its external environment.
- the packaging is impervious to contamination by micro-organisms, bacteria and/or a biologically active material likely to come into contact with the packaging while it is being handled, while at the same time remaining permeable to a sterilization or decontamination by radiation or gas, for example of the ETO (ethylene oxide) type.
- the expression "screen against electron radiation” is to be understood as being a screen capable of reflecting and/or partially or completely absorbing the kinetic energy of the electrons from an electron beam, and therefore of slowing or even preventing these electrons from passing through the screen.
- Packagings for products that are or may be sterilized comprising a tub sealed with a cover sheet made of a selectively impervious material are known.
- a sterilization gas for example of the ethylene oxide type, enters the tub through the sheet of selectively impervious material.
- the tub containing the sterilized products is then placed in a protective bag so that the tub can be transported.
- a tub or packaging may contain syringes intended to be filled with a drug in a sterile room or controlled-environment room.
- the packaging prefferably placed beforehand in a protective bag which has a window closed with a material that is permeable to the sterilization gas, and for the sterilization to be subsequently performed on the closed bag.
- the protective bag needs to be opened.
- the packaging which may then be contaminated, needs to be decontaminated before it is taken, for example, into a sterile room.
- Such decontamination can be achieved using multidirectional irradiation by an electron beam developing enough energy that when it has passed through the cover sheet, it delivers a dose of irradiation of, for example, 25 kGy.
- the selectively impervious material has been decontaminated throughout its thickness, particularly the sealed zone, at the interface between the tub and the material.
- the combination of the density and thickness of the packaging is such that it stops these electrons .
- This type of decontamination is not, however, suitable for every type of product transported in the packaging. This is because the electron beam passing through the sheet of selectively impervious material carries the risk of altering or adversely affecting the material of which the syringes or products placed in the tub are made, for example glass.
- the electron beam can also generate ozone from the oxygen in the air contained in the tub.
- the generated ozone carries the risk of polluting the atmosphere and of adversely affecting the active products used to fill the syringes and/or, for example, the rubber components present in the tub such as the caps on the needles mounted on the syringes.
- some packaging have been proposed, that include a screen against electron radiation.
- Document WO02/40064 discloses a packaging comprising a tub sealed with a cover sheet made of a selectively impervious material, the packaging containing syringe bodies.
- the packaging disclosed in WO02/40064 also comprises a screen against electron radiation, with the screen located inside the tub.
- One embodiment of the present invention aims at satisfying this need by providing a packaging for products so that an electron beam can be used to carry out biological decontamination of this packaging at any time during the different handling steps of the packaging, with the packaging also being very easy to manipulate.
- the present invention relates to a packaging for products that is to be decontaminated by radiation, the packaging comprising at least one tub having an opening and a peripheral zone defined about the opening, one cover sheet made of a selectively impervious material and fixed to . the peripheral zone of the tub so as to seal the opening imperviously, at least one screen against electron radiation dimensioned to substantially cover the products, characterized in that the screen is placed on top of the cover sheet, outside of the tub.
- the packaging of the invention is easy to manufacture and to handle. Moreover, the packaging of the invention can be easily decontaminated, at any time of its use, without any risk for the products contained inside the packaging.
- said screen comprises at least two layers, a first layer and a second layer, of material fixed on the cover sheet.
- the two layers have similar shapes and dimensions. [0017] In another embodiment of the invention, one of the two layers has its shape and/or dimension different from the shape and/or dimension of the other layer. [0018] In an embodiment of the invention, the first layer has a first peripheral outline, the second layer has a second peripheral outline, the cover sheet has a third peripheral outline, the first layer being fixed to the second layer along at least part of the first peripheral outline, the second layer being fixed to the cover sheet along at least part of the second peripheral outline and the cover sheet being fixed to the tub along the third peripheral outline, two of the first, second and third peripheral outlines being different.
- said first peripheral outline is comprised in the area defined by the second peripheral outline which is itself comprised in the area defined by the third peripheral outline.
- the packaging comprises an additional filter located above the products inside said tub.
- the screen is attached to the cover sheet by bonding or welding.
- the screen may comprise at least one layer of a material made of filaments of polymer bound together by heat and pressure.
- the polymer is a high density polyethylene.
- the products are medical devices. BRIEF DESCRIPTION OF THE DRAWINGS
- Figure 1 is cross section view of a packaging according to an embodiment of the invention
- Figure 2 is a perspective view of the packaging of figure 1
- Figure 3 is a schematic partial cross section view of a second embodiment of the packaging of the invention
- Figure 4 is a schematic partial cross section view of a third embodiment of the packaging of the invention
- Figure 5 is a schematic partial cross section view of a fourth embodiment of the packaging of the invention .
- Figure 1 shows a packaging 1 of the invention comprising a tub 2 and a cover sheet 3.
- the tub 2 may be made out of plastics material.
- the tub 2 has an opening 4 and a peripheral zone 5 defined about the opening 4.
- the cover sheet 3 is fixed to the peripheral zone 5 of the tub 2 so as to seal the opening 4 imperviously.
- the cover sheet 3 is made of a selectively impervious material.
- the selectively impervious material may be a material made of filaments of a high density polyethylene bound together by heat and pressure, such as the product sold by the Company Du Pont under the trademark "TYVEK®".
- the packaging 1 comprises products, under the form of medical devices such as syringe bodies 6 in the example shown, that are sterilized or to be sterilized.
- the syringe bodies 6 are received in holes designed on a plate 7, the plate 7 being placed inside the tub 2, bearing on a rim 2a provided on the inner wall of the tub 2.
- a screen 8 against the electron radiation is placed on top of the cover sheet 3, outside of the tub 2, and is placed a screen 8 against the electron radiation.
- the screen 8 is dimensioned to substantially cover the syringe bodies 6 and may be made of one layer of filaments of a high density polyethylene bound together by heat and pressure, such as the product sold by the Company Du Pont under the trademark "TYVEK®".
- the screen 8 against electron radiation defines a peripheral outline 9.
- the screen 8 against electron radiation may be attached to the cover sheet 3, for example along all or part of the peripheral outline 9, by bonding or welding.
- the packaging 1 is thus very easy to manufacture and to manipulate during the different steps of its use.
- the peripheral outline 9 of the screen has a shape different from the one of the peripheral zone 5 of the tub 2.
- Figures 3 and 4 are schematic partial cross section views of alternative embodiments of the invention: on these figures, for sake of simplicity, the products such as the syringes bodies 6 in figures 1 and 2 have not been represented.
- the screen 8 comprises two layers, a first layer 10 and a second layer 11, of material fixed on the cover sheet 3.
- the material may be made of filaments of a high density polyethylene bound together by heat and pressure.
- the two layers (10, 11) have similar shapes and dimensions.
- the the two layers of material may be attached one to the other, for example by means of gluing, bonding or welding, preferably along part of all their respective peripheral outlines.
- the first layer 10 has a first peripheral outline 10a
- the second layer 11 has a second peripheral outline 11a
- the cover sheet 3 has a third peripheral outline 3a.
- the first layer 10 is fixed to the second layer 11 along the first peripheral outline 10a
- the second layer 11 is fixed to the cover sheet 3 along the second peripheral outline 11a
- the cover sheet 3 is fixed to the tub 2 along the third peripheral outline 3a.
- the first and second peripheral outline (10a, lla) are similar with each other and different from the third peripheral outline 3a.
- Figure 4 shows a variant of the packaging 1 of figure 3 in which the first layer 10 has a shape and dimensions different from the second layer 11. The references designating the same elements as in figure 3 have been preserved.
- the packaging 1 of the invention further comprises an additional filter 12 located above the syringe bodies 6 inside the tub 2.
- This additional filter 12 may be a screen against electron radiation.
- the additional filter 12 may be made of one layer of filaments of a high density polyethylene bound together by heat and pressure, such as the product sold by the Company Du Pont under the trademark "TYVEK®".
- the packaging of the invention may be efficiently decontaminated by being submitted to electron beam without altering the integrity of the products it contains.
- the products contained in the packaging of the invention are not affected by the electron radiation applied on the packaging, in particular towards the cover sheet during decontamination of the packaging.
- the packaging of the invention is particularly easy to handle and to manipulate. Indeed, the screen can be attached to the cover sheet before the use of the cover sheet to seal the tub opening.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mechanical Engineering (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Packages (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Wrappers (AREA)
- Closures For Containers (AREA)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT08705523T ATE510565T1 (en) | 2007-01-09 | 2008-01-08 | PACKAGING FOR PRODUCTS THAT ARE DECONTAMINATED BY RADIATION |
CN2008800048751A CN101610794B (en) | 2007-01-09 | 2008-01-08 | Packaging for products to be decontaminated by radiation |
BRPI0806513A BRPI0806513B8 (en) | 2007-01-09 | 2008-01-08 | packaging for products to be decontaminated by radiation |
EP08705523A EP2129405B1 (en) | 2007-01-09 | 2008-01-08 | Packaging for products to be decontaminated by radiation |
JP2009545581A JP5331708B2 (en) | 2007-01-09 | 2008-01-08 | Package for products decontaminated by radiation |
MX2009007398A MX2009007398A (en) | 2007-01-09 | 2008-01-08 | Packaging for products to be decontaminated by radiation. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR07/00120 | 2007-01-09 | ||
FR0700120A FR2911072B1 (en) | 2007-01-09 | 2007-01-09 | PACKAGING FOR PRODUCTS WHICH MUST BE DECONTAMINATED BY RADIATION |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008085969A2 true WO2008085969A2 (en) | 2008-07-17 |
WO2008085969A3 WO2008085969A3 (en) | 2008-12-18 |
Family
ID=38458230
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/000255 WO2008085969A2 (en) | 2007-01-09 | 2008-01-08 | Packaging for products to be decontaminated by radiation |
Country Status (10)
Country | Link |
---|---|
US (1) | US20080173563A1 (en) |
EP (1) | EP2129405B1 (en) |
JP (1) | JP5331708B2 (en) |
CN (1) | CN101610794B (en) |
AT (1) | ATE510565T1 (en) |
BR (1) | BRPI0806513B8 (en) |
ES (1) | ES2365952T3 (en) |
FR (1) | FR2911072B1 (en) |
MX (1) | MX2009007398A (en) |
WO (1) | WO2008085969A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1393082B1 (en) * | 2009-01-27 | 2012-04-11 | Semafra S A | PACKAGING STRUCTURE OF CONTAINERS FOR PHARMACEUTICAL USE |
EP2514684A1 (en) | 2011-04-20 | 2012-10-24 | Becton Dickinson France | Packaging for medical containers |
IN2014DN07800A (en) | 2012-02-20 | 2015-05-15 | Terumo Corp | |
ITVI20120215A1 (en) * | 2012-08-30 | 2014-03-01 | Fedegari Autoclavi | STRUCTURE FOR PACKAGING COMPONENTS FOR PHARMACEUTICAL CONTAINERS |
CN102897414A (en) * | 2012-10-31 | 2013-01-30 | 山东威高集团医用高分子制品股份有限公司 | Honeycomb type packaging pre-filling and sealing penicillin bottle |
WO2019093351A1 (en) * | 2017-11-10 | 2019-05-16 | テルモ株式会社 | Medical-device packaging body and production method therefor |
EP3763415B1 (en) * | 2018-03-07 | 2022-03-30 | FUJIFILM Corporation | Method of manufacturing percutaneous absorption sheet |
JPWO2021009890A1 (en) * | 2019-07-18 | 2021-09-13 | 株式会社大協精工 | Medical equipment container |
CN216402234U (en) * | 2020-01-10 | 2022-04-29 | 肖特瑞士股份公司 | Separating layer and transport system for the transport of secondary packages of pharmaceutical products |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1235347A (en) * | 1967-12-20 | 1971-06-09 | Jintan Terumo Company Ltd | A method of enclosing an article in a container |
DE3623568A1 (en) * | 1985-08-27 | 1987-03-12 | Sengewald Karl H | Gas sterilizable packaging |
US5009654A (en) * | 1989-03-10 | 1991-04-23 | Baxter International Inc. | Sterile product and method for sterilizing and assembling such product |
US5342673A (en) * | 1993-02-23 | 1994-08-30 | W. L. Gore & Associates, Inc. | Sterilizable packaging material |
US6203755B1 (en) * | 1994-03-04 | 2001-03-20 | St. Jude Medical, Inc. | Electron beam sterilization of biological tissues |
JP3623007B2 (en) * | 1995-04-05 | 2005-02-23 | テルモ株式会社 | Artificial organ and sterilization method thereof |
US6228324B1 (en) * | 1997-11-28 | 2001-05-08 | Seikagaku Corporation | Sterilizing method for medical sterilization packaging and injection pack |
EP2253549B1 (en) * | 1998-03-13 | 2015-03-04 | Becton Dickinson and Company | Method for manufacturing, filling and packaging medical containers |
FR2816924B1 (en) * | 2000-11-20 | 2003-02-14 | Becton Dickinson France | PACKAGING FOR STERILE PRODUCTS |
US6629602B1 (en) * | 2000-11-20 | 2003-10-07 | Becton, Dickinson And Company | Clear medical packaging |
FR2816925B1 (en) * | 2000-11-20 | 2003-02-14 | Becton Dickinson France | PACKAGING FOR PRODUCTS TO BE STERILIZED USING A HIGH TEMPERATURE STERILIZING FLUID |
FR2838721B1 (en) * | 2002-04-22 | 2004-12-03 | Becton Dickinson France | PACKAGE FOR USE IN CONVEYING OR STERILIZING OBJECTS |
US7329240B2 (en) * | 2003-01-02 | 2008-02-12 | Meridian Medical Technologies, Inc. | Protective packaging for medicament dispenser |
-
2007
- 2007-01-09 FR FR0700120A patent/FR2911072B1/en active Active
-
2008
- 2008-01-08 JP JP2009545581A patent/JP5331708B2/en active Active
- 2008-01-08 AT AT08705523T patent/ATE510565T1/en not_active IP Right Cessation
- 2008-01-08 EP EP08705523A patent/EP2129405B1/en active Active
- 2008-01-08 BR BRPI0806513A patent/BRPI0806513B8/en active IP Right Grant
- 2008-01-08 MX MX2009007398A patent/MX2009007398A/en active IP Right Grant
- 2008-01-08 CN CN2008800048751A patent/CN101610794B/en active Active
- 2008-01-08 US US12/008,024 patent/US20080173563A1/en not_active Abandoned
- 2008-01-08 WO PCT/US2008/000255 patent/WO2008085969A2/en active Search and Examination
- 2008-01-08 ES ES08705523T patent/ES2365952T3/en active Active
Non-Patent Citations (1)
Title |
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None |
Also Published As
Publication number | Publication date |
---|---|
ATE510565T1 (en) | 2011-06-15 |
EP2129405A2 (en) | 2009-12-09 |
BRPI0806513A2 (en) | 2011-09-13 |
FR2911072B1 (en) | 2010-10-22 |
WO2008085969A3 (en) | 2008-12-18 |
BRPI0806513B8 (en) | 2021-06-22 |
US20080173563A1 (en) | 2008-07-24 |
JP2010515634A (en) | 2010-05-13 |
JP5331708B2 (en) | 2013-10-30 |
CN101610794A (en) | 2009-12-23 |
BRPI0806513B1 (en) | 2018-07-17 |
MX2009007398A (en) | 2009-08-20 |
CN101610794B (en) | 2013-06-12 |
FR2911072A1 (en) | 2008-07-11 |
EP2129405B1 (en) | 2011-05-25 |
ES2365952T3 (en) | 2011-10-13 |
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