WO2008084067A3 - Pharmaceutically active dihydrobenzofurane-substituted benzimidazole derivatives - Google Patents

Pharmaceutically active dihydrobenzofurane-substituted benzimidazole derivatives Download PDF

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Publication number
WO2008084067A3
WO2008084067A3 PCT/EP2008/050212 EP2008050212W WO2008084067A3 WO 2008084067 A3 WO2008084067 A3 WO 2008084067A3 EP 2008050212 W EP2008050212 W EP 2008050212W WO 2008084067 A3 WO2008084067 A3 WO 2008084067A3
Authority
WO
WIPO (PCT)
Prior art keywords
dihydrobenzofurane
pharmaceutically active
benzimidazole derivatives
substituted benzimidazole
substituted
Prior art date
Application number
PCT/EP2008/050212
Other languages
French (fr)
Other versions
WO2008084067A2 (en
Inventor
Christof Brehm
Peter Jan Zimmermann
Saskia Zemolka
Andreas Palmer
Wilm Buhr
Stefan Postius
Wolfgang-Alexander Simon
Michael Herrmann
Original Assignee
Nycomed Gmbh
Christof Brehm
Peter Jan Zimmermann
Saskia Zemolka
Andreas Palmer
Wilm Buhr
Stefan Postius
Wolfgang-Alexander Simon
Michael Herrmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Gmbh, Christof Brehm, Peter Jan Zimmermann, Saskia Zemolka, Andreas Palmer, Wilm Buhr, Stefan Postius, Wolfgang-Alexander Simon, Michael Herrmann filed Critical Nycomed Gmbh
Publication of WO2008084067A2 publication Critical patent/WO2008084067A2/en
Publication of WO2008084067A3 publication Critical patent/WO2008084067A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides compounds of the formula (1), in which the substituents and symbols are as defined in the description. The compounds inhibit the secretion of gastric acid.
PCT/EP2008/050212 2007-01-12 2008-01-10 Pharmaceutically active dihydrobenzofurane-substituted benzimidazole derivatives WO2008084067A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07100441.0 2007-01-12
EP07100441 2007-01-12

Publications (2)

Publication Number Publication Date
WO2008084067A2 WO2008084067A2 (en) 2008-07-17
WO2008084067A3 true WO2008084067A3 (en) 2008-09-04

Family

ID=37876885

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/050212 WO2008084067A2 (en) 2007-01-12 2008-01-10 Pharmaceutically active dihydrobenzofurane-substituted benzimidazole derivatives

Country Status (1)

Country Link
WO (1) WO2008084067A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102470126A (en) 2009-07-09 2012-05-23 拉夸里亚创药株式会社 Acid pump antagonist for treatment of diseases associated with abnormal gastrointestinal movement

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004054984A1 (en) * 2002-12-13 2004-07-01 Altana Pharma Ag 4-substituted benzimidazoles and their use as inhibitors of gastric secretion
WO2006134460A1 (en) * 2005-06-14 2006-12-21 Pfizer Japan Inc. Chromane substituted benzimidazole derivatives as acid pump antagonists

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004054984A1 (en) * 2002-12-13 2004-07-01 Altana Pharma Ag 4-substituted benzimidazoles and their use as inhibitors of gastric secretion
WO2006134460A1 (en) * 2005-06-14 2006-12-21 Pfizer Japan Inc. Chromane substituted benzimidazole derivatives as acid pump antagonists

Also Published As

Publication number Publication date
WO2008084067A2 (en) 2008-07-17

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