WO2008083090A3 - Heteropolynucleotide duplexes with purine-purine base pairing - Google Patents

Heteropolynucleotide duplexes with purine-purine base pairing Download PDF

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Publication number
WO2008083090A3
WO2008083090A3 PCT/US2007/088617 US2007088617W WO2008083090A3 WO 2008083090 A3 WO2008083090 A3 WO 2008083090A3 US 2007088617 W US2007088617 W US 2007088617W WO 2008083090 A3 WO2008083090 A3 WO 2008083090A3
Authority
WO
WIPO (PCT)
Prior art keywords
purine
heteropolynucleotide
duplexes
base pairing
nucleobase
Prior art date
Application number
PCT/US2007/088617
Other languages
French (fr)
Other versions
WO2008083090A2 (en
Inventor
Thomas R Battersby
Maria Albalos
Michel Friesenhahn
Edward Brooks
Original Assignee
Siemens Healthcare Diagnostics
Thomas R Battersby
Maria Albalos
Michel Friesenhahn
Edward Brooks
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Healthcare Diagnostics, Thomas R Battersby, Maria Albalos, Michel Friesenhahn, Edward Brooks filed Critical Siemens Healthcare Diagnostics
Priority to EP07869787A priority Critical patent/EP2097436B1/en
Priority to AT07869787T priority patent/ATE543828T1/en
Priority to US12/521,012 priority patent/US8399194B2/en
Publication of WO2008083090A2 publication Critical patent/WO2008083090A2/en
Publication of WO2008083090A3 publication Critical patent/WO2008083090A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to stable anti-parallel heteropolynucleotide duplexes, comprising a plurality of complementary purine -purine nucleobase dyads, wherein the nucleobase is coupled to a pentose sugar backbone. The present invention further relates to methods of hybridizing two heteropolynucleotide molecules to form such purine-purine nucleobase dyads, as well as kits and solid supports comprising such purine-purine nucleobase dyads.
PCT/US2007/088617 2006-12-26 2007-12-21 Heteropolynucleotide duplexes with purine-purine base pairing WO2008083090A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP07869787A EP2097436B1 (en) 2006-12-26 2007-12-21 Heteropolynucleotide duplexes with purine-purine base pairing
AT07869787T ATE543828T1 (en) 2006-12-26 2007-12-21 HETEROPOLYNUCLEOTIDE DUPLEXES WITH PURINE-PURINE PAIRING
US12/521,012 US8399194B2 (en) 2006-12-26 2007-12-21 Heteropolynucleotide duplexes with purine—purine base pairing

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87189106P 2006-12-26 2006-12-26
US60/871,891 2006-12-26

Publications (2)

Publication Number Publication Date
WO2008083090A2 WO2008083090A2 (en) 2008-07-10
WO2008083090A3 true WO2008083090A3 (en) 2009-01-29

Family

ID=39589183

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/088617 WO2008083090A2 (en) 2006-12-26 2007-12-21 Heteropolynucleotide duplexes with purine-purine base pairing

Country Status (4)

Country Link
US (1) US8399194B2 (en)
EP (1) EP2097436B1 (en)
AT (1) ATE543828T1 (en)
WO (1) WO2008083090A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9870649B1 (en) 2015-08-28 2018-01-16 State Farm Mutual Automobile Insurance Company Shared vehicle usage, monitoring and feedback
CN110964816A (en) * 2019-11-20 2020-04-07 深圳市鲲鹏未来科技有限公司 Solution containing blood-stable nanoparticles, preparation method thereof and detection method of miRNA marker

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3529478A1 (en) 1985-08-16 1987-02-19 Boehringer Mannheim Gmbh 7-DESAZA-2'DESOXYGUANOSINE NUCLEOTIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE FOR NUCLEIC ACID SEQUENCING
DE3924424A1 (en) 1989-07-24 1991-01-31 Boehringer Mannheim Gmbh NUCLEOSIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICINAL PRODUCT AND THEIR USE IN THE SEQUENCING OF NUCLEIC ACID
DE4140463A1 (en) 1991-12-09 1993-06-17 Boehringer Mannheim Gmbh 2'-DESOXY-ISOGUANOSINE, THE ISOSTERAL ANALOGS AND THE APPLICATION THEREOF
WO2001016149A2 (en) 1999-08-30 2001-03-08 Roche Diagnostics Gmbh 2-azapurine compounds and their use
WO2006009581A1 (en) 2004-06-17 2006-01-26 Medtronic, Inc. Novel lead retention means
PL1856257T3 (en) 2005-03-05 2012-03-30 Seegene Inc Processes using dual specificity oligonucleotide and dual specificity oligonucleotide

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ARNEZ AND SEITZ: "DNA Made of Purines Only", CHEMISTRY AND BIOLOGY, vol. 14, May 2007 (2007-05-01), pages 467 - 469, XP022087038 *
EVERTSZ ET AL.: "Paralellel-stranded duplex DNA containing blocks of trans purine-purine and purine-pyrimidine base pairs", NUCLEIC ACIDS RESEARCH, vol. 22, no. 16, 1994, pages 3293 - 3303, XP008109873 *
GROEBKE ET AL.: "Why Pentose- and not Hexose-Nucleic Acids? Purine-Purine Pairing in homo-DNA: Guaninem Isoguanine, 2,6-Diaminopurine, and Xanthine", HELVETICA CHIMCA ACTA, vol. 81, 1998, pages 375 - 474, XP008109845 *

Also Published As

Publication number Publication date
US20100190972A1 (en) 2010-07-29
EP2097436A4 (en) 2010-07-14
EP2097436B1 (en) 2012-02-01
US8399194B2 (en) 2013-03-19
ATE543828T1 (en) 2012-02-15
WO2008083090A2 (en) 2008-07-10
EP2097436A2 (en) 2009-09-09

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