WO2008081424A2 - Robinet d'arrêt amélioré pour l'administration de médicaments dans l'organisme d'un patient - Google Patents

Robinet d'arrêt amélioré pour l'administration de médicaments dans l'organisme d'un patient Download PDF

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Publication number
WO2008081424A2
WO2008081424A2 PCT/IL2007/001509 IL2007001509W WO2008081424A2 WO 2008081424 A2 WO2008081424 A2 WO 2008081424A2 IL 2007001509 W IL2007001509 W IL 2007001509W WO 2008081424 A2 WO2008081424 A2 WO 2008081424A2
Authority
WO
WIPO (PCT)
Prior art keywords
fluid
stopcock
vial
outer body
conduit
Prior art date
Application number
PCT/IL2007/001509
Other languages
English (en)
Other versions
WO2008081424A3 (fr
Inventor
Ilan Brand
Original Assignee
Plastmed Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plastmed Ltd. filed Critical Plastmed Ltd.
Publication of WO2008081424A2 publication Critical patent/WO2008081424A2/fr
Publication of WO2008081424A3 publication Critical patent/WO2008081424A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/223—Multiway valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2058—Connecting means having multiple connecting ports
    • A61J1/2062—Connecting means having multiple connecting ports with directional valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2082—Filtering means for gas filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M2039/229—Stopcocks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/162—Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube

Definitions

  • the present invention relates to medicament administering apparatus. More particularly, the invention relates to a fluid guiding device and to an improved stopcock for safely administering dangerous medicaments into the patient's body.
  • Hydrophobic filter '• is commonly used in airway management and usually composed of synthetic fibers like polypropylene. Because the fibers are hydrophobic, they do not absorb moisture from air flow. Moisture and particulates (viruses, bacteriums, etc.) are collected on the fiber surfaces or pass through the filter. The relative efficiency of the filter diminishes as particles decrease in size (viruses are smaller than bacterium) and when the filter is subjected to higher volumes of airflow or is used over a prolonged period of time, due to that moisture and particulate are able to migrate through the filter.
  • Stopcock ⁇ is a valve used to restrict or isolate the flow of a liquid or gas through a pipe or conduit.
  • a stopcock is usually used for regulating the flow of intravenous medicaments to be administered into a patient's body.
  • each stopcock is used as a needleless injection port.
  • the doctor can switch (by mistake) the stem of the stopcock to a wrong reservoir, and that can lead to the irreversible damage to the patient.
  • This issue is especially critical when administering dangerous medicaments that are not usually administered directly into the patient's body, but are first mixed with other fluid(s) (e.g., glucose, water) within an infusion bag.
  • other fluid(s) e.g., glucose, water
  • US 3,678,960 discloses a stopcock type of device for selectively interconnecting a plurality of fluid-carrying ducts in a variety of configurations.
  • the device includes a plurality of outstanding ports that selectively communicate with a rotatable central hub provided with a predetermined configuration of annular passageways. This makes possible the selection of any one of the variety of flow configurations depending upon the angular position of the valve with respect to the ports.
  • Another patent, US 5,443,453 presents a stopcock valve useable in conjunction with a fluid delivery set for delivering fluids such as intravenous fluids or enteral fluids from one or more containers to a patient.
  • the valve includes a shear-away interference member, which holds the valve in a closed position prior to use, in order to prevent accidental premature free flow of fluid therethrough.
  • the valve also includes a venting passage for allowing access of sterilization gas into all fluid flow passages of the valve, even when the valve stem is rotated to a closed position.
  • Still another patent, US 5,074,334, discloses a multi- way cock that comprises a housing including a cylinder having a plurality of branch tubes extending from the periphery thereof, and a plug including a barrel adapted to be rotatably fitted in the cylinder and having a corresponding plurality of channels formed therein.
  • the above prior art patents do not teach preventing dangerous medicaments from being directly administered into the patient's body.
  • the present invention relates to a fluid guiding device and to an improved stopcock for safely administering dangerous medicaments that are injected into the patient's body.
  • the fluid guiding device comprises an outer body provided with four openings, and an inner body provided with a first conduit, from which an additional conduit branches, said first conduit lying essentially along the diameter of said outer body, wherein said openings provided in said outer body correspond to the ends of said first and said additional conduits, and wherein the chord between the ends of said first and additional conduits is essentially equal to the chord between two corresponding openings of said outer body, and wherein one opening has an axis that makes an angle of about 90 degrees with the axes of each of the two openings adjacent to it.
  • the stopcock for guiding a fluid comprises ⁇ (a) a fluid guiding device, comprising: (a.l.) an outer body having four openings; (a.2.) an inner body provided with a first conduit, from which an additional conduit branches, said first conduit lying essentially along the diameter of said outer body, wherein said openings provided in said outer body correspond to the ends of said first and said additional conduits, and wherein the chord between the ends of said first and additional conduits is essentially equal to the chord between two corresponding openings of said outer body, and wherein one opening has an axis that makes an angle of about 90 degrees with the axes of each of the two openings adjacent to it; (b) two inlet/outlet ports, independently connected to the first and second openings of said outer body; and (c) a spike or a vial holding member that are independently connected to the third and fourth openings of said outer body.
  • the spike is connected to a fluid- dispensing reservoir.
  • the inlet/outlet port is connected to a pump.
  • the inlet/outlet port is connected to a conduit.
  • the pump is a syringe.
  • a vial is connected to a vial holding member which is filled with the fluid or powder, comprising: (a) a medicament; (b) one or more types of vitamins; and (c) one or more types of food additives.
  • the outer body further comprises a protrusion for restricting rotation of the inner body within said outer body.
  • the inner body further comprises a protrusion for restricting its rotation within the outer body.
  • the pump pumps the fluid from the vial to the fluid-dispensing reservoir and/or from said fluid- dispensing reservoir to said vial, e.g., the fluid is dispensed from the fluid- dispensing reservoir to the conduit.
  • the stopcock allows the fluid to flow from one inlet/outlet port to another.
  • the stopcock allows the fluid to flow from the inlet/outlet port to the vial holding member and/or from said vial holding member to said inlet/outlet port.
  • the stopcock allows the fluid to flow from the spike to the inlet/outlet port and/or from said inlet/outlet port to said spike.
  • the stopcock allows the fluid flow from the spike to the vial holding member and/or from said vial holding member to said spike.
  • the stopcock is further connected to one or more additional stopcocks for administering one or more medicaments, or one or more types of vitamins, or one or more types of food additives, or a combination thereof.
  • the inner body is connected by means of a connector to a computer for controlling its rotation within the outer body by means of said computer.
  • Fig. IA is a top view of a fluid guiding device, according to a preferred embodiment of the present invention.
  • Figs. IB and 1C are schematic illustrations of a system for administering medicaments into the patient's body (e.g. under the skin), according to a preferred embodiment of the present invention.
  • Fig. 2A is a perspective view of a stopcock outer body, according to a preferred embodiment of the present invention.
  • Figs. 2B to 2D are schematic illustrations of a stopcock inner body (stem), according to a preferred embodiment of the present invention
  • Fig. 2E is a perspective view of a vial holder, according to a preferred embodiment of the present invention.
  • Fig. 2F is a cross-sectional perspective view of a stopcock connected to a vial holder, according to a preferred embodiment of the present invention.
  • Fig. 2G is another perspective view of a stopcock outer body, according to another preferred embodiment of the present invention.
  • FIGs. 3A and 3B are schematic illustrations of connecting a vial to a stopcock by means of a vial holder, according to a preferred embodiment of the present invention
  • Fig. 4A is a schematic illustration of connecting a syringe to a stopcock, according to a preferred embodiment of the present invention
  • Fig. 4B is a schematic illustration of connecting an infusion bag to a stopcock, according to a preferred embodiment of the present invention.
  • Fig. 4C is a schematic illustration of connecting a conduit to a stopcock, according to a preferred embodiment of the present invention.
  • Fig. 5 is a schematic illustration of jointly connecting two or more stopcocks, according to a preferred embodiment of the present invention.
  • Fig. 6 is a schematic illustration of connecting two vials to a stopcock, according to another preferred embodiment of the present invention.
  • Figs. 7A and 7B are bottom views of a stem, according to another preferred embodiment of the present invention. Detailed Description of the Preferred Embodiments
  • Fig. IA is a top view of a fluid guiding device, according to a preferred embodiment of the present invention.
  • the fluid guiding device comprises a rotatable inner body (stem) 123 having a first conduit (channel) 232 lying essentially along the diameter of an outer body and an additional conduit 231 that branches from said first conduit; and an outer body 122 that has four openings, wherein said openings correspond to the ends of said conduits.
  • Stem 123 can be rotated within body 122 to allow or isolate (block) the fluid flow within conduits 231 and 232.
  • Chord BA between the ends of said first conduit and said additional conduit, is essentially equal to each one of chords B 1 A' and A' C between openings 221 and 223, and also 223 and 224, respectively, of said outer body.
  • fluid guiding device (and its stem 123) has three fluid guiding states ⁇
  • one opening of outer body 122 has an axis that makes an angle of about 90 degrees with the axes of each of the two openings adjacent to it. It should be noted that when the term “about 90 degrees” is used it refers to the angle between 70 and 110 degrees.
  • outer body 122 has a U-shaped protrusion 210 (Fig. 2A) that prevents stem 123 from being rotated around its axis more than a predefined number of degrees (e.g., 180 degrees), thus preventing a fluid from flowing from opening 223 to opening 222 and vice-versa.
  • a predefined number of degrees e.g. 180 degrees
  • stem 123 from can be rotated around its axis by 360 degrees, enabling a fluid to flow from opening 223 to opening 222 and vice -versa.
  • conduit 231 is substantially perpendicular to conduit 232, then by canceling U-shaped protrusion 210 (Fig. 2A), a fluid can flow from opening 221 to opening 222 and vice -versa.
  • Figs. IB and 1C are schematic illustrations of a system 100 for administering medicaments into the patient's body (e.g. under the skin), according to a preferred embodiment of the present invention.
  • the system comprises : a fluid-dispensing reservoir, such as an intravenous infusion bag 101 containing a fluid to be administered into the patient's body through a conduit 125?" a vial 105 filled with a medicament 107 and connected to a stopcock 115 by means of a vial holding member 119; a pump (e.g., syringe) 110 for pumping medicaments from or to said vial 105 or said infusion bag 101; a stopcock 115 for selectively interconnecting infusion bag 101, vial 105, pump 110 and conduit 125 that is connected to a conventional infusion set (not shown) for administering medicaments into the patient's body; and a conventional infusion set (not shown) connected to stopcock 115 by means of conduit 125.
  • stopcock 115 (and its stem 123) has three fluid guiding states'
  • Stopcock 115 comprises : a rotatable stem (inner body) 123 for allowing or isolating (blocking) the flow of a fluid from or to syringe 110, vial 105, infusion bag 101 and conduit 125; and a body (outer body) 122 having inlet/outlet ports 116 and 117 for connecting conduit 125 and syringe 110, respectively, a spike 118 for connecting infusion bag 101, and vial holding member 119 for connecting vial 105.
  • syringe 110 can be permanently connected to stopcock 115 for preventing possible fluid dripping from inlet/outlet port 117 of said stopcock 115.
  • vial holding member 119 is hermetically connected to vial 105 for preventing dripping of the fluid from said vial 105 and/or from opening 221 (Fig. 2A).
  • administering a medicament into the patient's body can be performed by the following steps :
  • vial 105 contains powder medicament 107.
  • the powder medicament is diluted before administering it to the patient by pumping fluid from infusion bag 101 into syringe 110, and then injecting said fluid into vial 105 by means of said syringe 110.
  • administering powder medicament 107 can be performed by the following steps:
  • Fig. 2A is a perspective view of a stopcock outer body 122, according to a preferred embodiment of the present invention.
  • Body 122 comprises a cylindrical portion 250, inlet/outlet ports 116 and 117 extending from said cylindrical portion 250 for connecting conduit 125 and syringe 110 into corresponding openings 222 and 223 of said inlet/outlet ports,' a spike 118, having an opening 224, for connecting infusion bag 101; and a vial holding member 119 (having opening 221) for connecting vial 105 to said stopcock body 122 by (hermetically) connecting portion 106 (Fig. 2E) of said vial holding member 119 to its another portion 120.
  • body 122 comprises a U-shaped protrusion 210 that prevents stem 123 (Fig. 1C) from being rotated around its axis more than a predefined number of degrees (e.g., 180 degrees), thus preventing medicaments from syringe 110 (Fig. IB) and/or vial 105 (Fig. IB) from being directly administered into the patient's body by restricting and isolating the fluid-flow through stopcock 115.
  • a predefined number of degrees e.g. 180 degrees
  • inlet/outlet ports 116 and 117 can be, for example, 45 degrees
  • angle between vial holding member 119 and inlet/outlet port 116 can be, for example, 90 degrees.
  • the angle between inlet/outlet ports 116 and 117 is 90 degrees.
  • inlet/outlet port 117 and vial holding member 119 is substantially equal to the angle between inlet/outlet port 117 and spike 118 (the angle can be, for example, 135 degrees (or 225 degrees)).
  • Figs. 2B to 2D are schematic illustrations of a stopcock inner body (stem) 123, according to a preferred embodiment of the present invention.
  • Stem 123 restricts and isolates the flow of a fluid from or to syringe 110 (Fig. IB), vial 105 (Fig. IB), infusion bag 101 (Fig. IB) and conduit 125 (Fig. IB).
  • Stem 123 comprises conduits (channels) 231 and 232 for allowing the fluid to flow from opennings 235 and 236 to opening 237, and vice-versa.
  • stem 123 can be rotated around its axis by a predefined number of degrees (e.g., 90 degrees) due to U-shaped protrusion 210 (Fig. 2A) provided within stopcock outer body 122.
  • a predefined number of degrees e.g. 90 degrees
  • medicaments from vial 105 (Fig. IB) and syringe 110 (Fig. IB) cannot be directly administered into the patient's body because there cannot be any physical fluid-flow communication between said vial 105 and conduit 125, or said syringe 110 and conduit 125 (that is further connected to the infusion set).
  • protrusion 215 of said stem is blocked by protrusion 210 of said stopcock body 122, preventing stem 123 from continuing to rotate.
  • Fig. 2E is a perspective view of a portion 106 of vial holding member 119 (Fig. IB), according to a preferred embodiment of the present invention.
  • Portion 106 of vial holding member 119 is hermetically connected to portion 120 (Fig. 2A) of said vial holding member 119 by means of its approximate end 201 for preventing dripping of the fluid.
  • a conventional hydrophobic filter 205 (Fig. 2F) is provided between said approximate end 201 and said portion 120.
  • any other filter can be provided instead or in addition to said hydrophobic filter, such as a hydrophobic filter or the like.
  • Fig. 2F is a cross -sectional perspective view of a stopcock 115 with vial holding member 119, according to a preferred embodiment of the present invention.
  • Stopcock 115 comprises ⁇ a rotatable stem 123 for allowing or blocking the flow of a fluid from or to syringe 110 (Fig. IB), vial 105 (Fig. IB), infusion bag 101 (Fig. IB) and conduit 125 (Fig.
  • an outer body 122 having a cylindrical portion 250, inlet/outlet ports 116 and 117 extending from said cylindrical portion 250 for connecting conduit 125 and syringe 110 into corresponding openings 222 and 223 of said inlet/outlet ports; a spike 118, having an opening 224, for connecting infusion bag 101> * and a vial holding member 119 (having an opening 221) for connecting vial 105 to said stopcock body 122 by (hermetically) connecting portion 106 (Fig. 2E) of said vial holding member 119 to its another portion 120.
  • stem 123 can be rotated around its axis by a predefined number of degrees (e.g., 90 degrees) due to U-shaped protrusion 210 (Fig. 2A) provided within stopcock body 122.
  • a predefined number of degrees e.g. 90 degrees
  • medicaments from vial 105 (Fig. IB) and syringe 110 (Fig. IB) can not be directly administered into the patient's body because there cannot be any physical fluid-flow communication between vial 105, syringe 110 and conduit 125 (that is connected to the infusion set).
  • protrusion 215 (Fig. 2D) of said stem is blocked by means of protrusion 210 of said stopcock body 122, preventing stem 123 from continuing to rotate.
  • a conventional hydrophobic filter 205 (Fig. 2F) is provided between approximate end 201 of portion 106 and portion 120 of vial holding member 119.
  • Hydrophobic filter 205 collects moisture and particulates (viruses, bacteriums, etc.) by means of channel 240.
  • any other filter can be provided instead of or in addition to said hydrophobic filter, such as a hydrophobic filter or the like.
  • Fig. 2G is another perspective view of a stopcock outer body 122, according to another preferred embodiment of the present invention.
  • body 122 does not have U-shaped protrusion 210 (Fig. 2A), thus enabling stem 123 (Fig. 1C) to be rotated around its axis by 360 degrees.
  • syringe 110 (Fig. IB) can be directly connected to conduit 125 (which is, in turn, connected to the infusion set) and the medicament from said syringe 110 can be directly administered into the patient's body through said conduit 125.
  • conduit 231 (Fig. 2C) that branches from conduit 232 (Fig. 2C) is substantially perpendicular to said conduit 232
  • vial 105 (Fig. IB) can be directly connected to conduit 125 (which is, in turn, connected to the infusion set) and medicament 107 (Fig. IB) from said vial 105 can be directly administered into the patient's body through said conduit 125.
  • Figs. 3A and 3B are schematic illustrations of connecting a vial 105 to a stopcock 115 by means of a vial holding member 119, according to a preferred embodiment of the present invention.
  • the upper section 301 of vial 105 is inserted inside portion 106 of said vial holding member 119 and can be held inside it by means of one or more teeth provided on an inner side of said portion 106, or by means of an elastic force of said portion 106.
  • Fig. 4A is a schematic illustration of connecting a syringe 110 to a stopcock 115, according to a preferred embodiment of the present invention.
  • the upper end 401 of syringe 110 is inserted inside opening 223 of inlet/outlet port 117 of stopcock body 122.
  • Fig. 4B is a schematic illustration of connecting an infusion bag to a stopcock, according to a preferred embodiment of the present invention.
  • Spike 118 is inserted inside the bottom end 405 of infusion bag 101, allowing fluid flow through opening 224 (Fig. 2F) of said spike 118.
  • Fig. 4C is a schematic illustration of connecting a conduit 125 to a stopcock 115, according to a preferred embodiment of the present invention.
  • Conduit 125 is inserted inside opening 222 of inlet/outlet port 116 of stopcock body 122.
  • Fig. 5 is a schematic illustration of jointly connecting two or more stopcocks, according to a preferred embodiment of the present invention. If more than one medicament is required to be administered into the patient's body, then two or more stopcocks can be connected one to another in a row. Spike 118(2) of stopcock 115(2) can be connected to inlet/outlet port 116(i) of another stopcock 115(i).
  • Infusion bag 101 Fig.
  • IB can be connected to spike 118(i), and the infusion set can be connected to inlet/outlet port 116(2) by means of conduit 125. Then, two or more medicaments can be mixed in infusion bag 101 by using pump 110 (such as a syringe), and after that, administered into the patient's body.
  • pump 110 such as a syringe
  • administering of two medicaments into the patient's body can be performed by the following steps:
  • vials 110(i) and/or 110(2) can comprise one or more of the following: medicaments; various types of vitamins; various types of food additives; and the like.
  • Fig. 6 is a schematic illustration of connecting two vials 105(i) and 105(2) to a stopcock 115, according to another preferred embodiment of the present invention.
  • Either vial 105(i) or 105(2) can be used instead of infusion bag 101 (Fig. IB), enabling the mixing of medicaments and/or the diluting of powder medicaments.
  • vial 105(i) is filled with medicament 107 ⁇ ) and vial 105(2) is filled with another medicament 107(2).
  • medicament 107(i) can be pumped by means of syringe 110 from vial 105(i) to vial 105(2) for mixing it with medicament 107(2).
  • the mixed solution of both medicaments 107(i) and 107(2) can be administered into the patient's body through a conduit 125 (Fig. IB) connected to inlet/outlet port 116.
  • vial 105(i) can be filled with powder medicaments 107(i) and vial 105(2) can be filled with infusion solution 107(2).
  • Powder medicaments 107(i) can be pumped by means of syringe 110 from vial 105(i) to vial 105(2) for diluting it with said infusion solution 107(2). After that, the diluted medicament is administered into the patient's body through a conduit 125.
  • each inlet/outlet port 116, 117, spike 118 and vial- holding member 119 on stopcock 115 can vary.
  • spike 118 can be provided, for example, instead of inlet/outlet port 116, and vice -versa; or inlet/outlet port 117 can be provided, for example, instead of vial-holding member 119 and vice-versa.
  • each of inlet/outlet ports 116, 117, or spike 118 can be connected to any one of the following: (a) an infusion bag; (b) a syringe (pump); (c) a conduit (further connected to a conventional infusion set for administering medicaments into the patient's body); and the like.
  • vial 105(D and/or vial 105(2) can be replaced upon the need (e.g., if empty) without replacing their corresponding vial-holding members 119(i) and 119(2).
  • Figs. 7A and 7B are bottom views of stem 123, according to another preferred embodiment of the present invention.
  • Channel 232 of said stem 123 comprises a protrusion 233 to be inserted into a slot of a connector (not shown) that is further connected to a computer for automatically rotating said stem 123 within stopcock 115 (Fig. IB).
  • a doctor or nurse is not required to manually set the desirable fluid guiding state of stopcock 115.
  • the doctor enters into the computer the exact location of the stopcock in the space (for example, the stopcock is located vertically, and spike 118 is on the top).
  • the doctor automatically controls rotation of stem 123 by means of a computer (rotating stem 123 from its one fluid guiding state to another), enabling him to administer one or more medicaments into the patient's body.
  • the automatic control of stem 123 position can be especially useful when administering more than one medicament, as shown on Fig. 5.
  • stopcock 115 can have only one possible location in the space (e.g., vertical position with spike 118 is on the top).
  • the connector can be connected to protrusion 233 by one way only.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne un robinet d'arrêt amélioré destiné à administrer de manière sûre des médicaments dangereux qui sont injectés dans l'organisme d'un patient. Ledit robinet d'arrêt comprend un dispositif de guidage de liquide, constitué d'un corps externe doté de quatre ouvertures et d'un corps interne doté d'un premier conduit duquel dérive un conduit supplémentaire. Le premier conduit se situe essentiellement le long du diamètre du corps externe, les ouvertures prévues dans le corps externe correspondant aux extrémités du premier conduit et du conduit supplémentaire. La corde située entre les extrémités du premier conduit et du conduit supplémentaire est essentiellement égale à la corde située entre deux ouvertures correspondantes du corps externe. L'une des ouvertures présente un axe qui forme un angle d'environ 90 degrés avec les axes de chacune des deux ouvertures adjacentes. Le robinet d'arrêt comprend également deux orifices d'admission/de sortie indépendamment reliés à la première et à la deuxième ouverture du corps externe, et un perforateur ou un élément de porte-fiole qui est indépendamment relié à la troisième et à la quatrième ouverture du corps externe.
PCT/IL2007/001509 2007-01-04 2007-12-06 Robinet d'arrêt amélioré pour l'administration de médicaments dans l'organisme d'un patient WO2008081424A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL180565A IL180565A0 (en) 2007-01-04 2007-01-04 An improved stopcock for administering medicaments into the patient's body
IL180565 2007-01-04

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WO2008081424A2 true WO2008081424A2 (fr) 2008-07-10
WO2008081424A3 WO2008081424A3 (fr) 2009-05-07

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WO (1) WO2008081424A2 (fr)

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EP2149389A3 (fr) * 2008-07-28 2010-06-23 Tyco Healthcare Group LP Robinet d'arrêt médical avec fermeture
WO2010140063A3 (fr) * 2009-06-03 2011-02-17 Miijers, Jan, Willem, Marinus Dispositif d'administration de médicaments fluides
EP2446875A1 (fr) * 2010-10-27 2012-05-02 Fresenius Kabi Deutschland GmbH Dispositif de mélange et procédé de reconstruction ou de mélange d'un liquide médical
WO2015019343A1 (fr) * 2013-08-07 2015-02-12 Medimop Medical Projects Ltd Dispositif de transfert de liquide utilisable pour des contenants de liquide pour perfusion
US8979792B2 (en) 2009-11-12 2015-03-17 Medimop Medical Projects Ltd. Inline liquid drug medical devices with linear displaceable sliding flow control member
US8998875B2 (en) 2009-10-01 2015-04-07 Medimop Medical Projects Ltd. Vial assemblage with vial and pre-attached fluid transfer device
EP2351549A4 (fr) * 2008-11-25 2015-06-24 Jms Co Ltd Raccord
USD734868S1 (en) 2012-11-27 2015-07-21 Medimop Medical Projects Ltd. Drug vial adapter with downwardly depending stopper
USD737436S1 (en) 2012-02-13 2015-08-25 Medimop Medical Projects Ltd. Liquid drug reconstitution assembly
US9283324B2 (en) 2012-04-05 2016-03-15 Medimop Medical Projects, Ltd Fluid transfer devices having cartridge port with cartridge ejection arrangement
US9339438B2 (en) 2012-09-13 2016-05-17 Medimop Medical Projects Ltd. Telescopic female drug vial adapter
USD757933S1 (en) 2014-09-11 2016-05-31 Medimop Medical Projects Ltd. Dual vial adapter assemblage
USD765837S1 (en) 2013-08-07 2016-09-06 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
USD767124S1 (en) 2013-08-07 2016-09-20 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
WO2016151170A1 (fr) * 2015-03-20 2016-09-29 Servicio Andaluz De Salud Bague pour prélèvements sanguins
US9795536B2 (en) 2012-08-26 2017-10-24 Medimop Medical Projects, Ltd. Liquid drug transfer devices employing manual rotation for dual flow communication step actuations
USD801522S1 (en) 2015-11-09 2017-10-31 Medimop Medical Projects Ltd. Fluid transfer assembly
US9801786B2 (en) 2013-04-14 2017-10-31 Medimop Medical Projects Ltd. Drug container closure for mounting on open-topped drug container to form drug reconstitution assemblage for use with needleless syringe
US9839580B2 (en) 2012-08-26 2017-12-12 Medimop Medical Projects, Ltd. Liquid drug transfer devices
US9943463B2 (en) 2013-05-10 2018-04-17 West Pharma. Services IL, Ltd. Medical devices including vial adapter with inline dry drug module
USD832430S1 (en) 2016-11-15 2018-10-30 West Pharma. Services IL, Ltd. Dual vial adapter assemblage
US10278897B2 (en) 2015-11-25 2019-05-07 West Pharma. Services IL, Ltd. Dual vial adapter assemblage including drug vial adapter with self-sealing access valve
US10285907B2 (en) 2015-01-05 2019-05-14 West Pharma. Services IL, Ltd. Dual vial adapter assemblages with quick release drug vial adapter for ensuring correct usage
WO2019106642A1 (fr) * 2017-12-03 2019-06-06 West Pharma. Services Il, Ltd Dispositifs de transfert de liquide pourvu d'un adaptateur de flacon télescopique destiné à être utilisé avec un récipient de liquide de perfusion et flacon d'injection discret
US10357429B2 (en) 2015-07-16 2019-07-23 West Pharma. Services IL, Ltd. Liquid drug transfer devices for secure telescopic snap fit on injection vials
US10406072B2 (en) 2013-07-19 2019-09-10 Icu Medical, Inc. Pressure-regulating fluid transfer systems and methods
US10646404B2 (en) 2016-05-24 2020-05-12 West Pharma. Services IL, Ltd. Dual vial adapter assemblages including identical twin vial adapters
US10765604B2 (en) 2016-05-24 2020-09-08 West Pharma. Services IL, Ltd. Drug vial adapter assemblages including vented drug vial adapter and vented liquid vial adapter
US10772797B2 (en) 2016-12-06 2020-09-15 West Pharma. Services IL, Ltd. Liquid drug transfer devices for use with intact discrete injection vial release tool
US10806667B2 (en) 2016-06-06 2020-10-20 West Pharma. Services IL, Ltd. Fluid transfer devices for filling drug pump cartridges with liquid drug contents
US10806671B2 (en) 2016-08-21 2020-10-20 West Pharma. Services IL, Ltd. Syringe assembly
USD903864S1 (en) 2018-06-20 2020-12-01 West Pharma. Services IL, Ltd. Medication mixing apparatus
US10945921B2 (en) 2017-03-29 2021-03-16 West Pharma. Services IL, Ltd. User actuated liquid drug transfer devices for use in ready-to-use (RTU) liquid drug transfer assemblages
USD917693S1 (en) 2018-07-06 2021-04-27 West Pharma. Services IL, Ltd. Medication mixing apparatus
USD923782S1 (en) 2019-01-17 2021-06-29 West Pharma. Services IL, Ltd. Medication mixing apparatus
USD923812S1 (en) 2019-01-16 2021-06-29 West Pharma. Services IL, Ltd. Medication mixing apparatus
USD954253S1 (en) 2019-04-30 2022-06-07 West Pharma. Services IL, Ltd. Liquid transfer device
USD956958S1 (en) 2020-07-13 2022-07-05 West Pharma. Services IL, Ltd. Liquid transfer device
US11642285B2 (en) 2017-09-29 2023-05-09 West Pharma. Services IL, Ltd. Dual vial adapter assemblages including twin vented female vial adapters
US11918542B2 (en) 2019-01-31 2024-03-05 West Pharma. Services IL, Ltd. Liquid transfer device

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US4900322A (en) * 1986-09-22 1990-02-13 Adams James D Blood component pooling valve and kit
US20040082904A1 (en) * 2002-10-23 2004-04-29 Eric Houde Rotary manifold syringe

Cited By (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2149389A3 (fr) * 2008-07-28 2010-06-23 Tyco Healthcare Group LP Robinet d'arrêt médical avec fermeture
EP2351549A4 (fr) * 2008-11-25 2015-06-24 Jms Co Ltd Raccord
WO2010140063A3 (fr) * 2009-06-03 2011-02-17 Miijers, Jan, Willem, Marinus Dispositif d'administration de médicaments fluides
US8998875B2 (en) 2009-10-01 2015-04-07 Medimop Medical Projects Ltd. Vial assemblage with vial and pre-attached fluid transfer device
US9132063B2 (en) 2009-11-12 2015-09-15 Medimop Medical Projects Ltd. Inline liquid drug medical devices with linear displaceable sliding flow control member
US8979792B2 (en) 2009-11-12 2015-03-17 Medimop Medical Projects Ltd. Inline liquid drug medical devices with linear displaceable sliding flow control member
WO2012055594A1 (fr) * 2010-10-27 2012-05-03 Fresenius Kabi Deutschland Gmbh Dispositif de mélange et procédé de reconstruction ou de mélange d'un liquide médical
EP2446875A1 (fr) * 2010-10-27 2012-05-02 Fresenius Kabi Deutschland GmbH Dispositif de mélange et procédé de reconstruction ou de mélange d'un liquide médical
USD737436S1 (en) 2012-02-13 2015-08-25 Medimop Medical Projects Ltd. Liquid drug reconstitution assembly
US9283324B2 (en) 2012-04-05 2016-03-15 Medimop Medical Projects, Ltd Fluid transfer devices having cartridge port with cartridge ejection arrangement
US10299990B2 (en) 2012-08-26 2019-05-28 West Pharma. Services IL, Ltd. Liquid drug transfer devices
US9795536B2 (en) 2012-08-26 2017-10-24 Medimop Medical Projects, Ltd. Liquid drug transfer devices employing manual rotation for dual flow communication step actuations
US9839580B2 (en) 2012-08-26 2017-12-12 Medimop Medical Projects, Ltd. Liquid drug transfer devices
US9339438B2 (en) 2012-09-13 2016-05-17 Medimop Medical Projects Ltd. Telescopic female drug vial adapter
USD734868S1 (en) 2012-11-27 2015-07-21 Medimop Medical Projects Ltd. Drug vial adapter with downwardly depending stopper
US9801786B2 (en) 2013-04-14 2017-10-31 Medimop Medical Projects Ltd. Drug container closure for mounting on open-topped drug container to form drug reconstitution assemblage for use with needleless syringe
US9943463B2 (en) 2013-05-10 2018-04-17 West Pharma. Services IL, Ltd. Medical devices including vial adapter with inline dry drug module
US11504302B2 (en) 2013-07-19 2022-11-22 Icu Medical, Inc. Pressure-regulating fluid transfer systems and methods
US11648181B2 (en) 2013-07-19 2023-05-16 Icu Medical, Inc. Pressure-regulating fluid transfer systems and methods
US10406072B2 (en) 2013-07-19 2019-09-10 Icu Medical, Inc. Pressure-regulating fluid transfer systems and methods
US10688295B2 (en) 2013-08-07 2020-06-23 West Pharma. Services IL, Ltd. Liquid transfer devices for use with infusion liquid containers
GB2533714A (en) * 2013-08-07 2016-06-29 Medimop Medical Projects Ltd Liquid transfer devices for use with infusion liquid containers
KR200486088Y1 (ko) 2013-08-07 2018-04-02 메디모프 메디컬 프로젝트스 리미티드. 주입 액체 용기와 함께 사용하기 위한 액체 전달 장치
USD767124S1 (en) 2013-08-07 2016-09-20 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
USD765837S1 (en) 2013-08-07 2016-09-06 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
GB2533714B (en) * 2013-08-07 2020-04-08 Medimop Medical Projects Ltd Liquid transfer devices for use with infusion liquid containers
KR20160001372U (ko) * 2013-08-07 2016-04-27 메디모프 메디컬 프로젝트스 리미티드. 주입 액체 용기와 함께 사용하기 위한 액체 전달 장치
WO2015019343A1 (fr) * 2013-08-07 2015-02-12 Medimop Medical Projects Ltd Dispositif de transfert de liquide utilisable pour des contenants de liquide pour perfusion
USD757933S1 (en) 2014-09-11 2016-05-31 Medimop Medical Projects Ltd. Dual vial adapter assemblage
US10285907B2 (en) 2015-01-05 2019-05-14 West Pharma. Services IL, Ltd. Dual vial adapter assemblages with quick release drug vial adapter for ensuring correct usage
WO2016151170A1 (fr) * 2015-03-20 2016-09-29 Servicio Andaluz De Salud Bague pour prélèvements sanguins
US10357429B2 (en) 2015-07-16 2019-07-23 West Pharma. Services IL, Ltd. Liquid drug transfer devices for secure telescopic snap fit on injection vials
USD801522S1 (en) 2015-11-09 2017-10-31 Medimop Medical Projects Ltd. Fluid transfer assembly
US10278897B2 (en) 2015-11-25 2019-05-07 West Pharma. Services IL, Ltd. Dual vial adapter assemblage including drug vial adapter with self-sealing access valve
US10646404B2 (en) 2016-05-24 2020-05-12 West Pharma. Services IL, Ltd. Dual vial adapter assemblages including identical twin vial adapters
US10765604B2 (en) 2016-05-24 2020-09-08 West Pharma. Services IL, Ltd. Drug vial adapter assemblages including vented drug vial adapter and vented liquid vial adapter
US10806667B2 (en) 2016-06-06 2020-10-20 West Pharma. Services IL, Ltd. Fluid transfer devices for filling drug pump cartridges with liquid drug contents
US10806671B2 (en) 2016-08-21 2020-10-20 West Pharma. Services IL, Ltd. Syringe assembly
USD832430S1 (en) 2016-11-15 2018-10-30 West Pharma. Services IL, Ltd. Dual vial adapter assemblage
US11786443B2 (en) 2016-12-06 2023-10-17 West Pharma. Services IL, Ltd. Liquid transfer device with integral telescopic vial adapter for use with infusion liquid container and discrete injection vial
US10772797B2 (en) 2016-12-06 2020-09-15 West Pharma. Services IL, Ltd. Liquid drug transfer devices for use with intact discrete injection vial release tool
US10772798B2 (en) 2016-12-06 2020-09-15 West Pharma Services Il, Ltd. Liquid transfer device with integral telescopic vial adapter for use with infusion liquid container and discrete injection vial
US10945921B2 (en) 2017-03-29 2021-03-16 West Pharma. Services IL, Ltd. User actuated liquid drug transfer devices for use in ready-to-use (RTU) liquid drug transfer assemblages
US11642285B2 (en) 2017-09-29 2023-05-09 West Pharma. Services IL, Ltd. Dual vial adapter assemblages including twin vented female vial adapters
JP2021505247A (ja) * 2017-12-03 2021-02-18 ウェスト ファーマ サービシーズ イスラエル リミテッド 注入液容器および別の注入瓶と共に使用される望遠鏡式瓶アダプターを備えた輸液装置
US11027062B2 (en) 2017-12-03 2021-06-08 West Pharma. Services IL, Ltd. Liquid transfer device with telescopic vial adapter for use with infusion liquid container and discrete injection vial
WO2019106642A1 (fr) * 2017-12-03 2019-06-06 West Pharma. Services Il, Ltd Dispositifs de transfert de liquide pourvu d'un adaptateur de flacon télescopique destiné à être utilisé avec un récipient de liquide de perfusion et flacon d'injection discret
EP3988074A1 (fr) * 2017-12-03 2022-04-27 West Pharma. Services IL, Ltd Dispositif de transfert de liquide avec adaptateur de flacon télescopique destiné à être utilisé avec un récipient de liquide de perfusion et un flacon d'injection discret
USD903864S1 (en) 2018-06-20 2020-12-01 West Pharma. Services IL, Ltd. Medication mixing apparatus
USD917693S1 (en) 2018-07-06 2021-04-27 West Pharma. Services IL, Ltd. Medication mixing apparatus
USD923812S1 (en) 2019-01-16 2021-06-29 West Pharma. Services IL, Ltd. Medication mixing apparatus
USD923782S1 (en) 2019-01-17 2021-06-29 West Pharma. Services IL, Ltd. Medication mixing apparatus
US11918542B2 (en) 2019-01-31 2024-03-05 West Pharma. Services IL, Ltd. Liquid transfer device
US11484470B2 (en) 2019-04-30 2022-11-01 West Pharma. Services IL, Ltd. Liquid transfer device with dual lumen IV spike
USD954253S1 (en) 2019-04-30 2022-06-07 West Pharma. Services IL, Ltd. Liquid transfer device
US11786442B2 (en) 2019-04-30 2023-10-17 West Pharma. Services IL, Ltd. Liquid transfer device with dual lumen IV spike
USD956958S1 (en) 2020-07-13 2022-07-05 West Pharma. Services IL, Ltd. Liquid transfer device

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