WO2008075978A3 - An extract - Google Patents

An extract Download PDF

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Publication number
WO2008075978A3
WO2008075978A3 PCT/NZ2007/000370 NZ2007000370W WO2008075978A3 WO 2008075978 A3 WO2008075978 A3 WO 2008075978A3 NZ 2007000370 W NZ2007000370 W NZ 2007000370W WO 2008075978 A3 WO2008075978 A3 WO 2008075978A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
extract
arachidonoylethanolamide
acylethanolamine
palmitoylethanolamide
Prior art date
Application number
PCT/NZ2007/000370
Other languages
French (fr)
Other versions
WO2008075978A2 (en
Inventor
Charles Edward Williams
Andrew John Sansom
Original Assignee
Seperex Nutritionals Ltd
Charles Edward Williams
Andrew John Sansom
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seperex Nutritionals Ltd, Charles Edward Williams, Andrew John Sansom filed Critical Seperex Nutritionals Ltd
Priority to CN200780051038XA priority Critical patent/CN101641089B/en
Priority to CA2710054A priority patent/CA2710054C/en
Priority to DE112007003136T priority patent/DE112007003136T5/en
Priority to GB0911796A priority patent/GB2458599B/en
Priority to KR1020097014697A priority patent/KR20090103918A/en
Publication of WO2008075978A2 publication Critical patent/WO2008075978A2/en
Publication of WO2008075978A3 publication Critical patent/WO2008075978A3/en
Priority to HK10103288.3A priority patent/HK1136218A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Edible Oils And Fats (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to compositions that include an oil extract rich in fatty acid amide compounds including N-acylethanolamine (NAE) compounds such as N-palmitoylethanolamide (PEA) and N-arachidonoylethanolamide (AEA). The composition may be derived from marine materials including mussel meat.
PCT/NZ2007/000370 2006-12-20 2007-12-18 An extract WO2008075978A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN200780051038XA CN101641089B (en) 2006-12-20 2007-12-18 An extract
CA2710054A CA2710054C (en) 2006-12-20 2007-12-18 Oil extract from a bivalve mollusc that is rich in n-acylethanolamides
DE112007003136T DE112007003136T5 (en) 2006-12-20 2007-12-18 An extract
GB0911796A GB2458599B (en) 2006-12-20 2007-12-18 Oil extract from a bivalve mollusc that is rich in N-acylethanolamides
KR1020097014697A KR20090103918A (en) 2006-12-20 2007-12-18 An extract
HK10103288.3A HK1136218A1 (en) 2006-12-20 2010-03-30 Oil extract from a bivalve mollusc that is rich in n-acylethanolamides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NZ552238 2006-12-20
NZ552238A NZ552238A (en) 2006-12-20 2006-12-20 An extract

Publications (2)

Publication Number Publication Date
WO2008075978A2 WO2008075978A2 (en) 2008-06-26
WO2008075978A3 true WO2008075978A3 (en) 2008-07-31

Family

ID=39536841

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NZ2007/000370 WO2008075978A2 (en) 2006-12-20 2007-12-18 An extract

Country Status (9)

Country Link
KR (1) KR20090103918A (en)
CN (2) CN103638003A (en)
CA (1) CA2710054C (en)
DE (1) DE112007003136T5 (en)
GB (1) GB2458599B (en)
HK (1) HK1136218A1 (en)
NZ (1) NZ552238A (en)
TW (1) TWI405568B (en)
WO (1) WO2008075978A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101181194B1 (en) 2006-10-18 2012-09-18 화이자 프로덕츠 인코포레이티드 Biaryl ether urea compounds
NZ552238A (en) 2006-12-20 2009-07-31 Seperex Nutritionals Ltd An extract
CN102014868B (en) * 2008-04-28 2014-11-12 莫尼科贾夫西尔瓦诺21控股股份公司 Pharmaceutical formulation containing palmitoyl ethanolamide and stearoyl ethanolamide
NZ575985A (en) * 2009-03-31 2010-04-30 Bomac Research Ltd Medicament Uptake
GB0909643D0 (en) * 2009-06-04 2009-07-22 Avexxin As Glomerulonephritis treatment
ITPD20090360A1 (en) * 2009-12-01 2011-06-02 Vermont Italia Srl COMPOSITION FOR TOPICAL USE
WO2011097344A1 (en) * 2010-02-04 2011-08-11 Monell Chemical Senses Center Compounds and methods for enhancing salty taste
GB201014633D0 (en) 2010-09-02 2010-10-13 Avexxin As Rheumatoid arthritis treatment
PT2444078T (en) * 2010-10-04 2017-11-15 Epitech Group S P A Use of amides of mono and dicarboxylic acids in the treatment of renal diseases
FR2965478B1 (en) * 2010-10-05 2015-04-24 Oreal USE OF ANANDAMIDE TO CONTROL SKIN DROUGHT
WO2012070905A2 (en) * 2010-11-26 2012-05-31 Kim Young-Moon Mollusk extract for preventing or treating rare and intractable diseases of the human body
CN103113253A (en) * 2013-01-28 2013-05-22 国家海洋局第三海洋研究所 Alcohol amine derivative of unsaturated fatty acid and preparation method and application thereof
ITMI20130354A1 (en) 2013-03-08 2014-09-09 Again Life Italia Srl MIXTURE OF FATTY ACIDS (F.A.G. FATTY ACIDS GROUP) FOR USE IN THE TREATMENT OF INFLAMMATORY DISEASES.
CA2914760A1 (en) * 2013-06-07 2014-12-11 Loma Linda University Dietary omega-3 fatty acid derived glycerophospholipids to treat neuropathic pain
GB201409363D0 (en) 2014-05-27 2014-07-09 Avexxin As Skin cancer treatment
DK3177281T3 (en) * 2014-08-08 2024-03-11 Ali Res S R L MIXTURE OF FATTY ACIDS AND PALMITOYLET THANOLAMIDE FOR USE IN THE TREATMENT OF INFLAMMATORY AND ALLERGIC PATHOLOGIES
US10966937B2 (en) * 2015-05-04 2021-04-06 Cytometix, Inc. Compositions and methods for delivery of polyunsaturated fatty acid derivatives and analogs
GB201604316D0 (en) 2016-03-14 2016-04-27 Avexxin As Combination therapy
CN109789111B (en) 2016-09-21 2021-11-16 埃维克辛公司 Pharmaceutical composition
TW201828961A (en) * 2016-12-20 2018-08-16 紐西蘭商聖福德有限公司 Bioactive mussel compositions and/or extracts
AU2017380471B2 (en) * 2016-12-23 2023-12-21 Mm Health Ltd Topical formulation comprising green lipped mussel and honey
WO2024124172A1 (en) * 2022-12-09 2024-06-13 The Trustees Of The University Of Pennsylvania Compositions and methods for stimulating and/or enhancing exercise motivation and/or physical performance

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4801453A (en) 1984-05-01 1989-01-31 James M. Broadbent Stabilized mussel extract
NZ328489A (en) 1994-07-22 1999-06-29 Mcfarlane Lab New Zealand Ltd Extraction of glycogen from green lipped mussels and use as an anti-inflammatory agent
NZ270754A (en) 1995-03-20 1997-08-22 Mcfarlane Lab Nz Ltd Mussel/fish oil mixture; finely ground, freeze-dried green-lipped mussel (perna canaliculus) suspended in fish oil; encapsulated mixture with anti-inflammatory activity
AUPN531195A0 (en) 1995-09-11 1995-10-05 J.W. Broadbent Nominees Pty. Ltd. Lipid extract having anti-inflamatory activity
NZ314867A (en) 1997-05-21 1999-04-29 Mcfarlane Lab New Zealand Ltd Glucosamine and mussel extract compositions for use as anti-inflammatories
NZ329018A (en) 1998-12-22 2000-04-28 Ind Res Ltd Extracting glycogen from Green Shell Mussels and the use of the glycogen as a food supplement or additive or in the treatment of inflammatory diseases such as arthritis.
US6596303B1 (en) 1999-03-22 2003-07-22 Mars Incorporated Pet food for maintenance of joint health and alleviation of arthritic symptoms in companion animals
CN1304988A (en) * 2000-06-09 2001-07-25 山东绿叶制药股份有限公司 Mussel oil and its preparing process and application
NZ510407A (en) 2001-03-08 2004-05-28 Healtheries Of New Zealand Ltd Mussel extract derivative with anti-inflammatory activity
NZ552238A (en) 2006-12-20 2009-07-31 Seperex Nutritionals Ltd An extract

Non-Patent Citations (8)

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Title
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JAGGAR S. ET AL., PAIN, vol. 76, 1998, pages 189 - 199, XP002902321 *
KUEHL F.A. ET AL., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 79, 1957, pages 5577 - 5578 *
LAMBERT D.M. ET AL., CURRENT MEDICINAL CHEMISTRY, vol. 9, 2002, pages 663 - 674, XP009000869 *
LO VERME J., MOLECULAR PHARMACOLOGY, vol. 67, no. 1, 2005, pages 15 - 19 *
MATIAS I. ET AL., JOURNAL OF NEUROCHEMISTRY, vol. 93, 2005, pages 1141 - 1156 *
MURPHY K.J. ET AL., ASIAN PACIFIC JOURNAL OF CLINICAL NUTRITION, vol. 12, no. 1, 2003, pages 50 - 60 *
SEPE N. ET AL., BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1389, 1998, pages 101 - 111 *

Also Published As

Publication number Publication date
CN103638003A (en) 2014-03-19
GB2458599A (en) 2009-09-30
CA2710054A1 (en) 2008-06-26
CN101641089B (en) 2013-06-12
HK1136218A1 (en) 2010-06-25
CN101641089A (en) 2010-02-03
TWI405568B (en) 2013-08-21
GB0911796D0 (en) 2009-08-19
WO2008075978A2 (en) 2008-06-26
GB2458599B (en) 2011-03-23
TW200833318A (en) 2008-08-16
DE112007003136T5 (en) 2009-11-19
KR20090103918A (en) 2009-10-01
CA2710054C (en) 2012-11-20
NZ552238A (en) 2009-07-31

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