WO2008074797A1 - Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors - Google Patents
Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors Download PDFInfo
- Publication number
- WO2008074797A1 WO2008074797A1 PCT/EP2007/064130 EP2007064130W WO2008074797A1 WO 2008074797 A1 WO2008074797 A1 WO 2008074797A1 EP 2007064130 W EP2007064130 W EP 2007064130W WO 2008074797 A1 WO2008074797 A1 WO 2008074797A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- disorder
- pain
- stereoisomers
- chromen
- group
- Prior art date
Links
- 0 **(C(CC1)C2)C1CC2OO Chemical compound **(C(CC1)C2)C1CC2OO 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- Cycloalkoxy means O-cycloalkyl, wherein cycloalkyl is as defined above.
- the labelled compounds of the invention may be useful as diagnostic tools, radio tracers, or monitoring agents in various diagnostic methods, and for in vivo receptor imaging.
- the labelled compound of the invention preferably contains at least one radionuclide as a label. Positron emitting radionuclides are all candidates for usage. In the context of this invention the radionuclide is preferably selected from 2 H (deuterium), 3 H (tritium), 11 C, 13 C, 14 C, 131 1, 125 1, 123 I, and 18 F.
- compositions suitable for vaginal administration may be presented as pessaries, tampons, creams, gels, pastes, foams or sprays containing in addition to the active ingredient such carriers as are known in the art to be appropriate.
- Liquid preparations include solutions, suspensions, and emulsions, for example, water or water-propylene glycol solutions.
- parenteral injection liquid preparations can be formulated as solutions in aqueous polyethylene glycol solution.
- test values are given as IC 50 (the concentration ( ⁇ M) of the test substance which inhibits the specific binding of 3 H-DA, 3 H-NA, or 3 H-5-HT by 50%).
- IC 50 the concentration ( ⁇ M) of the test substance which inhibits the specific binding of 3 H-DA, 3 H-NA, or 3 H-5-HT by 50%.
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Child & Adolescent Psychology (AREA)
- Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Claims
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07857757A EP2121677B1 (en) | 2006-12-20 | 2007-12-18 | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
PL07857757T PL2121677T3 (en) | 2006-12-20 | 2007-12-18 | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
NZ577071A NZ577071A (en) | 2006-12-20 | 2007-12-18 | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
CA002673315A CA2673315A1 (en) | 2006-12-20 | 2007-12-18 | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
MX2009006213A MX2009006213A (en) | 2006-12-20 | 2007-12-18 | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors. |
AU2007336290A AU2007336290A1 (en) | 2006-12-20 | 2007-12-18 | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
CN2007800472000A CN101563344B (en) | 2006-12-20 | 2007-12-18 | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
AT07857757T ATE486868T1 (en) | 2006-12-20 | 2007-12-18 | NOVEL CHROME-2-ON DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER REUPPOST INHIBITORS |
DE602007010356T DE602007010356D1 (en) | 2006-12-20 | 2007-12-18 | NEW CHROMENE-2-ON DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RECOVERY INHIBITORS |
US12/520,236 US8263617B2 (en) | 2006-12-20 | 2007-12-18 | Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
DK07857757.4T DK2121677T3 (en) | 2006-12-20 | 2007-12-18 | Novel Chromium-2-One Derivatives and Their Use of Monoamine Neurotransmitter Reuptake Inhibitors |
BRPI0719578-8A BRPI0719578A2 (en) | 2006-12-20 | 2007-12-18 | COMPOUND, PHARMACEUTICAL COMPOSITION, USE OF THE COMPOUND, AND METHOD FOR TREATMENT, PREVENTION OR RELIEF OF A DISEASE OR DISORDER OR CONDITION OF A LIVE BODY |
JP2009542030A JP2010513391A (en) | 2006-12-20 | 2007-12-18 | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter reuptake inhibitors |
IL198762A IL198762A0 (en) | 2006-12-20 | 2009-05-14 | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
NO20092719A NO20092719L (en) | 2006-12-20 | 2009-07-17 | New chromene-2-one derivatives and their use as monoamine neurotransmitter reuptake inhibitors |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87580606P | 2006-12-20 | 2006-12-20 | |
DKPA200601678 | 2006-12-20 | ||
DKPA200601678 | 2006-12-20 | ||
US60/875,806 | 2006-12-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008074797A1 true WO2008074797A1 (en) | 2008-06-26 |
Family
ID=39284195
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2007/064130 WO2008074797A1 (en) | 2006-12-20 | 2007-12-18 | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Country Status (10)
Country | Link |
---|---|
US (1) | US8263617B2 (en) |
EP (1) | EP2121677B1 (en) |
JP (1) | JP2010513391A (en) |
AU (1) | AU2007336290A1 (en) |
CA (1) | CA2673315A1 (en) |
IL (1) | IL198762A0 (en) |
MX (1) | MX2009006213A (en) |
NO (1) | NO20092719L (en) |
PL (1) | PL2121677T3 (en) |
WO (1) | WO2008074797A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010130620A1 (en) | 2009-05-15 | 2010-11-18 | Neurosearch A/S | Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
US7994323B2 (en) | 2007-05-09 | 2011-08-09 | Neurosearch A/S | Chromen-2-one derivatives |
US8153797B2 (en) | 2006-02-17 | 2012-04-10 | Neurosearch A/S | Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011092061A1 (en) | 2010-01-29 | 2011-08-04 | Neurosearch A/S | Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006035034A1 (en) * | 2004-09-30 | 2006-04-06 | Neurosearch A/S | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
WO2006064031A1 (en) * | 2004-12-17 | 2006-06-22 | Neurosearch A/S | Enantiomers of 3-heteroaryl-8h-8-azabicyclo(3.2.1)oct-2-ene and their use as monoamine neurotransmitter re-uptake inhibitors |
WO2007093604A1 (en) * | 2006-02-17 | 2007-08-23 | Neurosearch A/S | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000500739A (en) | 1995-10-13 | 2000-01-25 | アグレボ・ユー・ケイ・リミテツド | Heterocyclic fungicides |
US5916914A (en) | 1997-08-08 | 1999-06-29 | Warner-Lambert Company | Compounds and method of treating psychosis and schizophrenia |
WO1999065492A1 (en) | 1998-06-19 | 1999-12-23 | Eli Lilly And Company | Inhibition of serotonin reuptake |
EP1534703A2 (en) * | 2002-06-12 | 2005-06-01 | Abbott Laboratories | Antagonists of melanin concentrating hormone receptor |
MX2007002384A (en) * | 2004-09-30 | 2007-05-11 | Neurosearch As | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors. |
WO2008074798A1 (en) | 2006-12-20 | 2008-06-26 | Neurosearch A/S | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
US20110207722A1 (en) * | 2008-08-21 | 2011-08-25 | Neurosearch A/S | Treatment of anxiety disorders |
-
2007
- 2007-12-18 JP JP2009542030A patent/JP2010513391A/en not_active Abandoned
- 2007-12-18 EP EP07857757A patent/EP2121677B1/en not_active Not-in-force
- 2007-12-18 CA CA002673315A patent/CA2673315A1/en not_active Abandoned
- 2007-12-18 AU AU2007336290A patent/AU2007336290A1/en not_active Abandoned
- 2007-12-18 WO PCT/EP2007/064130 patent/WO2008074797A1/en active Application Filing
- 2007-12-18 US US12/520,236 patent/US8263617B2/en not_active Expired - Fee Related
- 2007-12-18 PL PL07857757T patent/PL2121677T3/en unknown
- 2007-12-18 MX MX2009006213A patent/MX2009006213A/en active IP Right Grant
-
2009
- 2009-05-14 IL IL198762A patent/IL198762A0/en unknown
- 2009-07-17 NO NO20092719A patent/NO20092719L/en not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006035034A1 (en) * | 2004-09-30 | 2006-04-06 | Neurosearch A/S | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
WO2006064031A1 (en) * | 2004-12-17 | 2006-06-22 | Neurosearch A/S | Enantiomers of 3-heteroaryl-8h-8-azabicyclo(3.2.1)oct-2-ene and their use as monoamine neurotransmitter re-uptake inhibitors |
WO2007093604A1 (en) * | 2006-02-17 | 2007-08-23 | Neurosearch A/S | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8153797B2 (en) | 2006-02-17 | 2012-04-10 | Neurosearch A/S | Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
US7994323B2 (en) | 2007-05-09 | 2011-08-09 | Neurosearch A/S | Chromen-2-one derivatives |
WO2010130620A1 (en) | 2009-05-15 | 2010-11-18 | Neurosearch A/S | Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
CN102428083A (en) * | 2009-05-15 | 2012-04-25 | 神经研究公司 | Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
US8697721B2 (en) | 2009-05-15 | 2014-04-15 | Aniona Aps | Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Also Published As
Publication number | Publication date |
---|---|
EP2121677A1 (en) | 2009-11-25 |
IL198762A0 (en) | 2010-02-17 |
PL2121677T3 (en) | 2011-04-29 |
NO20092719L (en) | 2009-07-17 |
US20100029711A1 (en) | 2010-02-04 |
CA2673315A1 (en) | 2008-06-26 |
US8263617B2 (en) | 2012-09-11 |
MX2009006213A (en) | 2010-06-30 |
AU2007336290A1 (en) | 2008-06-26 |
JP2010513391A (en) | 2010-04-30 |
EP2121677B1 (en) | 2010-11-03 |
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