WO2008073851A3 - Remotely triggered release from heatable surfaces - Google Patents

Remotely triggered release from heatable surfaces Download PDF

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Publication number
WO2008073851A3
WO2008073851A3 PCT/US2007/086863 US2007086863W WO2008073851A3 WO 2008073851 A3 WO2008073851 A3 WO 2008073851A3 US 2007086863 W US2007086863 W US 2007086863W WO 2008073851 A3 WO2008073851 A3 WO 2008073851A3
Authority
WO
WIPO (PCT)
Prior art keywords
thermally
responsive linker
triggered release
remotely triggered
delivered
Prior art date
Application number
PCT/US2007/086863
Other languages
French (fr)
Other versions
WO2008073851A2 (en
Inventor
Austin M Derfus
Maltzahn Geoffrey Von
Sangeeta N Bhatia
Original Assignee
Massachusetts Inst Technology
Univ California San Diego
Austin M Derfus
Maltzahn Geoffrey Von
Sangeeta N Bhatia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, Univ California San Diego, Austin M Derfus, Maltzahn Geoffrey Von, Sangeeta N Bhatia filed Critical Massachusetts Inst Technology
Priority to AU2007333220A priority Critical patent/AU2007333220A1/en
Priority to EP07869056A priority patent/EP2117595A2/en
Priority to CA002671806A priority patent/CA2671806A1/en
Priority to PCT/US2007/086863 priority patent/WO2008073851A2/en
Publication of WO2008073851A2 publication Critical patent/WO2008073851A2/en
Publication of WO2008073851A3 publication Critical patent/WO2008073851A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0089—Particulate, powder, adsorbate, bead, sphere
    • A61K49/0091—Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
    • A61K49/0093—Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

A conjugate includes (i) a heatable surface, wherein the heatable surface heats in response to an external stimulus; (ii) at least one agent to be delivered; and (iii) at least one thermally-responsive linker. A first end of the thermally-responsive linker is associated with the heatable surface. A second end of the thermally-responsive linker is associated with the agent to be delivered. The thermally-responsive linker is disrupted at a trigger temperature. The agent to be delivered is released from the conjugate when the thermally-responsive linker is heated to the trigger temperature or to temperature higher than the trigger temperature.
PCT/US2007/086863 2006-12-08 2007-12-07 Remotely triggered release from heatable surfaces WO2008073851A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2007333220A AU2007333220A1 (en) 2006-12-08 2007-12-07 Remotely triggered release from heatable surfaces
EP07869056A EP2117595A2 (en) 2006-12-08 2007-12-07 Remotely triggered release from heatable surfaces
CA002671806A CA2671806A1 (en) 2006-12-08 2007-12-07 Remotely triggered release from heatable surfaces
PCT/US2007/086863 WO2008073851A2 (en) 2006-12-08 2007-12-07 Remotely triggered release from heatable surfaces

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US87389706P 2006-12-08 2006-12-08
US60/873,897 2006-12-08
US96938907P 2007-08-31 2007-08-31
US60/969,389 2007-08-31
PCT/US2007/086863 WO2008073851A2 (en) 2006-12-08 2007-12-07 Remotely triggered release from heatable surfaces

Publications (2)

Publication Number Publication Date
WO2008073851A2 WO2008073851A2 (en) 2008-06-19
WO2008073851A3 true WO2008073851A3 (en) 2009-05-22

Family

ID=40427804

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/086863 WO2008073851A2 (en) 2006-12-08 2007-12-07 Remotely triggered release from heatable surfaces

Country Status (4)

Country Link
EP (1) EP2117595A2 (en)
AU (1) AU2007333220A1 (en)
CA (1) CA2671806A1 (en)
WO (1) WO2008073851A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103649295A (en) * 2011-05-13 2014-03-19 加利福尼亚大学董事会 Photothermal substrates for selective transfection of cells

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011026294A (en) * 2009-06-26 2011-02-10 Canon Inc Compound
EP2490723A1 (en) * 2009-10-19 2012-08-29 University Of Louisville Research Foundation, Inc. Nanoparticles for drug delivery
DE102009058769A1 (en) 2009-12-16 2011-06-22 MagForce Nanotechnologies AG, 10589 Temperature-dependent activation of catalytic nucleic acids for controlled drug release
WO2014049566A2 (en) * 2012-09-28 2014-04-03 Stellenbosch University Nutritional kit
WO2014151888A1 (en) 2013-03-15 2014-09-25 The Regents Of The University Of California High-throughput cargo delivery into live cells using photothermal platforms
US10472651B2 (en) 2014-03-28 2019-11-12 The Regents Of The University Of California Efficient delivery of large cargos into cells on a porous substrate
US11559494B2 (en) 2017-07-14 2023-01-24 The Penn State Research Foundation Compositions and methods for targeted delivery of therapeutic and/or diagnostic species
CN110404084B (en) * 2019-08-21 2020-10-23 青岛大学 DNA photo-thermal fusion-based nano particle, preparation method and application
CN112300410B (en) * 2020-11-05 2022-07-15 云南师范大学 Hydrogel composite material with porous structure and preparation and application thereof

Citations (12)

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Publication number Priority date Publication date Assignee Title
WO2001056546A2 (en) * 2000-02-05 2001-08-09 Florida State University Research Foundation Magnetoliposome composition for targeted treatment of biological tissue
WO2003101486A2 (en) * 2002-06-01 2003-12-11 Magnamedics Gmbh Thermosensitive polymer carriers having a modifiable physical structure for biochemical analysis, diagnosis, and therapy
WO2005042142A2 (en) * 2003-10-28 2005-05-12 Magnamedics Gmbh Thermosensitive, biocompatible polymer carriers with a variable physical structure for treatment, diagnosis and analysis
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WO2007097593A1 (en) * 2006-02-24 2007-08-30 Atgen Co., Ltd. Magnetic nano-composite for contrast agent, intelligent contrast agent, drug delivery agent for simultaneous diagnosis and treatment, and separation agent for target substance
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WO2008036144A2 (en) * 2006-06-23 2008-03-27 Abbott Cardiovascular Systems Inc. Nanoshells on polymers
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Patent Citations (12)

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WO2001056546A2 (en) * 2000-02-05 2001-08-09 Florida State University Research Foundation Magnetoliposome composition for targeted treatment of biological tissue
WO2003101486A2 (en) * 2002-06-01 2003-12-11 Magnamedics Gmbh Thermosensitive polymer carriers having a modifiable physical structure for biochemical analysis, diagnosis, and therapy
US20060025713A1 (en) * 2003-05-12 2006-02-02 Alex Rosengart Magnetic particle-based therapy
WO2005042142A2 (en) * 2003-10-28 2005-05-12 Magnamedics Gmbh Thermosensitive, biocompatible polymer carriers with a variable physical structure for treatment, diagnosis and analysis
WO2005065282A2 (en) * 2003-12-31 2005-07-21 The Regents Of The University Of California Remote magnetically induced treatment of cancer
WO2005109313A2 (en) * 2004-04-29 2005-11-17 The Regents Of The University Of California Enclosing drugs with synthetic oligonucleotides
WO2006108405A2 (en) * 2005-04-12 2006-10-19 Magforce Nanotechnologies Ag Nanoparticle/active ingredient conjugate
WO2007021236A1 (en) * 2005-08-19 2007-02-22 Genovis Ab A nanoparticle suitable for delivery of a biomolecule into or out of a membrane enclosed cell or cell organelle
WO2007097593A1 (en) * 2006-02-24 2007-08-30 Atgen Co., Ltd. Magnetic nano-composite for contrast agent, intelligent contrast agent, drug delivery agent for simultaneous diagnosis and treatment, and separation agent for target substance
WO2007116954A2 (en) * 2006-03-30 2007-10-18 Fujifilm Corporation Inorganic nanoparticle comprising an active substance immobilized on the surface and a polymer
WO2008036144A2 (en) * 2006-06-23 2008-03-27 Abbott Cardiovascular Systems Inc. Nanoshells on polymers
WO2008044963A2 (en) * 2006-10-13 2008-04-17 Aleksandr Mettalinovich Tishin Magnetic carrier and medical preparation for controllable delivery and release of active substances, a method of production and method of treatment using thereof

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103649295A (en) * 2011-05-13 2014-03-19 加利福尼亚大学董事会 Photothermal substrates for selective transfection of cells

Also Published As

Publication number Publication date
AU2007333220A1 (en) 2008-06-19
EP2117595A2 (en) 2009-11-18
WO2008073851A2 (en) 2008-06-19
CA2671806A1 (en) 2008-06-19

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