WO2008072229A3 - Methods for dermal filling using microneedles - Google Patents

Methods for dermal filling using microneedles Download PDF

Info

Publication number
WO2008072229A3
WO2008072229A3 PCT/IL2007/001527 IL2007001527W WO2008072229A3 WO 2008072229 A3 WO2008072229 A3 WO 2008072229A3 IL 2007001527 W IL2007001527 W IL 2007001527W WO 2008072229 A3 WO2008072229 A3 WO 2008072229A3
Authority
WO
WIPO (PCT)
Prior art keywords
skin
filling
dermal
filler
microneedles
Prior art date
Application number
PCT/IL2007/001527
Other languages
French (fr)
Other versions
WO2008072229A2 (en
Inventor
Yotam Levin
Yotam Almagor
Gilad Lavi
Yehoshua Yeshurun
Lior Wolloch
Original Assignee
Nanopass Technologies Ltd
Yotam Levin
Yotam Almagor
Gilad Lavi
Yehoshua Yeshurun
Lior Wolloch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanopass Technologies Ltd, Yotam Levin, Yotam Almagor, Gilad Lavi, Yehoshua Yeshurun, Lior Wolloch filed Critical Nanopass Technologies Ltd
Publication of WO2008072229A2 publication Critical patent/WO2008072229A2/en
Publication of WO2008072229A3 publication Critical patent/WO2008072229A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

A device and method for dermal filling using microneedles is disclosed. A microneedle device including at least two hollow microneedles arranged in at least one row, the row defining a treatment vector of the device, is used to intradermally inject a dermal filler composition into the skin of a subject along a pre-defined line in the skin where dermal filling, cosmetic repair or augmentation of tissue is desired. The device and method reduces or eliminates pain, and provides a safer, more effective administration method. The method also enables reduction in the required number of treatments (and re-treatments) due to an improved stability of the filler in these shallower depths within the skin; smoother contours due to a more even distribution of the filler within the skin; easier application for curved wrinkle lines (as opposed to hypodermic needles that are long and straight); and filling of very fine lines and wrinkles which are not accessible with regular needles.
PCT/IL2007/001527 2006-12-12 2007-12-11 Methods for dermal filling using microneedles WO2008072229A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86956406P 2006-12-12 2006-12-12
US60/869,564 2006-12-12

Publications (2)

Publication Number Publication Date
WO2008072229A2 WO2008072229A2 (en) 2008-06-19
WO2008072229A3 true WO2008072229A3 (en) 2009-05-07

Family

ID=39512175

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2007/001527 WO2008072229A2 (en) 2006-12-12 2007-12-11 Methods for dermal filling using microneedles

Country Status (1)

Country Link
WO (1) WO2008072229A2 (en)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8455459B2 (en) 2007-08-02 2013-06-04 Medicis Pharmaceutical Corporation Method of applying an injectable filler
US10420880B2 (en) 2007-10-02 2019-09-24 West Pharma. Services IL, Ltd. Key for securing components of a drug delivery system during assembly and/or transport and methods of using same
US9656019B2 (en) 2007-10-02 2017-05-23 Medimop Medical Projects Ltd. Apparatuses for securing components of a drug delivery system during transport and methods of using same
EP2195052B1 (en) 2007-10-02 2019-09-04 Medimop Medical Projects Ltd. External drug pump
US9345836B2 (en) 2007-10-02 2016-05-24 Medimop Medical Projects Ltd. Disengagement resistant telescoping assembly and unidirectional method of assembly for such
US7967795B1 (en) 2010-01-19 2011-06-28 Lamodel Ltd. Cartridge interface assembly with driving plunger
JP5584202B2 (en) 2008-05-21 2014-09-03 セラジェクト， インコーポレイテッド Method for manufacturing solid solution punch patch and use thereof
US9393369B2 (en) 2008-09-15 2016-07-19 Medimop Medical Projects Ltd. Stabilized pen injector
AU2009322463B2 (en) 2008-12-02 2015-10-08 Allergan, Inc. Injection device
US10071198B2 (en) 2012-11-02 2018-09-11 West Pharma. Servicees IL, Ltd. Adhesive structure for medical device
US8157769B2 (en) 2009-09-15 2012-04-17 Medimop Medical Projects Ltd. Cartridge insertion assembly for drug delivery system
US10071196B2 (en) 2012-05-15 2018-09-11 West Pharma. Services IL, Ltd. Method for selectively powering a battery-operated drug-delivery device and device therefor
US8348898B2 (en) 2010-01-19 2013-01-08 Medimop Medical Projects Ltd. Automatic needle for drug pump
FR2958042A1 (en) * 2010-03-26 2011-09-30 Oreal Process for carrying in-vitro evaluation of filling product e.g. collagen, applied on surface of skin of e.g. face of patient, involves measuring physical, chemical or biological parameters of in-vitro dermis or in-vitro skin
WO2011141907A1 (en) 2010-05-10 2011-11-17 Medimop Medical Projects Ltd. Low volume accurate injector
USD702834S1 (en) 2011-03-22 2014-04-15 Medimop Medical Projects Ltd. Cartridge for use in injection device
JP2014534864A (en) * 2011-10-28 2014-12-25 プレサージュ バイオサイエンシズ，インコーポレイテッド Drug delivery method
US9072827B2 (en) 2012-03-26 2015-07-07 Medimop Medical Projects Ltd. Fail safe point protector for needle safety flap
JP2015533522A (en) * 2012-08-08 2015-11-26 プレサージュ バイオサイエンシズ，インコーポレイテッド Extrusion methods and devices for drug delivery
US10894062B2 (en) 2012-08-10 2021-01-19 Aquavit Pharmaceuticals, Inc. Vitamin supplement compositions for injection
US10980865B2 (en) * 2012-08-10 2021-04-20 Aquavit Pharmaceuticals, Inc. Direct application system and method for the delivery of bioactive compositions and formulations
WO2015020982A2 (en) * 2013-08-04 2015-02-12 Aquavit Pharmaceuticals, Inc. Direct application system and method for the delivery of bioactive compositions and formulations
WO2014041531A1 (en) 2012-09-13 2014-03-20 Amir Avraham Delivery devices and methods for skin augmentation
EP2716324A1 (en) * 2012-10-04 2014-04-09 Sanofi-Aventis Deutschland GmbH Microneedle arrangement and adapter
US9421323B2 (en) 2013-01-03 2016-08-23 Medimop Medical Projects Ltd. Door and doorstop for portable one use drug delivery apparatus
WO2014171968A1 (en) * 2013-04-15 2014-10-23 Ruiz Melanie Filler manipulator apparatus
US9011164B2 (en) 2013-04-30 2015-04-21 Medimop Medical Projects Ltd. Clip contact for easy installation of printed circuit board PCB
US20140350516A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Mechanical syringe accessory
US20140350518A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Syringe extrusion accessory
US10029048B2 (en) 2014-05-13 2018-07-24 Allergan, Inc. High force injection devices
US10226585B2 (en) 2014-10-01 2019-03-12 Allergan, Inc. Devices for injection and dosing
JP2018507771A (en) 2015-03-10 2018-03-22 アラーガン ファーマシューティカルズ ホールディングス （アイルランド） アンリミテッド カンパニー Multi needle injector
US10293120B2 (en) 2015-04-10 2019-05-21 West Pharma. Services IL, Ltd. Redundant injection device status indication
US10149943B2 (en) 2015-05-29 2018-12-11 West Pharma. Services IL, Ltd. Linear rotation stabilizer for a telescoping syringe stopper driverdriving assembly
EP4252798A3 (en) 2015-06-04 2023-10-25 Medimop Medical Projects Ltd. Cartridge insertion for drug delivery device
US10576207B2 (en) 2015-10-09 2020-03-03 West Pharma. Services IL, Ltd. Angled syringe patch injector
US9987432B2 (en) 2015-09-22 2018-06-05 West Pharma. Services IL, Ltd. Rotation resistant friction adapter for plunger driver of drug delivery device
CN108430536B (en) 2015-10-09 2022-04-08 西医药服务以色列分公司 Method of filling a custom syringe
WO2017078532A1 (en) 2015-11-05 2017-05-11 Tsk Laboratory Europe B.V. Method for connecting two objects using a polymer composition and a system, for use in a cosmetic procedure
JP6513297B2 (en) 2016-01-21 2019-05-22 ウェスト ファーマ サービシーズ イスラエル リミテッド Automatic injector, receiving frame and method of connecting cartridge in automatic injector
US11311674B2 (en) 2016-01-21 2022-04-26 West Pharma. Services IL, Ltd. Medicament delivery device comprising a visual indicator
WO2017127215A1 (en) 2016-01-21 2017-07-27 Medimop Medical Projects Ltd. Needle insertion and retraction mechanism
WO2017161076A1 (en) 2016-03-16 2017-09-21 Medimop Medical Projects Ltd. Staged telescopic screw assembly having different visual indicators
WO2017176476A1 (en) 2016-04-08 2017-10-12 Allergan, Inc. Aspiration and injection device
JP6957525B2 (en) 2016-06-02 2021-11-02 ウェスト ファーマ サービシーズ イスラエル リミテッド Needle evacuation by 3 positions
US11338090B2 (en) 2016-08-01 2022-05-24 West Pharma. Services IL, Ltd. Anti-rotation cartridge pin
JP7059251B2 (en) 2016-08-01 2022-04-25 ウェスト ファーマ サービシーズ イスラエル リミテッド A spring that prevents the door from closing halfway
USD867582S1 (en) 2017-03-24 2019-11-19 Allergan, Inc. Syringe device
US20180289467A1 (en) * 2017-04-05 2018-10-11 Ernesto Andrade Dispensing device, kit, and method for tissue augmentation
WO2018222521A1 (en) 2017-05-30 2018-12-06 West Pharma. Services IL, Ltd. Modular drive train for wearable injector
US11857767B2 (en) 2017-12-22 2024-01-02 West Pharma. Services IL, Ltd. Injector usable with different dimension cartridges
BR112020013872A2 (en) * 2018-01-07 2020-12-01 Avraham Amir high-load microneedles and skin augmentation compositions
CN109011035A (en) * 2018-08-22 2018-12-18 平荧 Minimally invasive autologous tissue's filling device
EP3856323A1 (en) * 2018-09-24 2021-08-04 L'oreal Device comprising microneedles for cosmetic fillers delivery
CN112618098A (en) * 2020-12-17 2021-04-09 金磊 Filler injection method capable of resetting facial soft tissues
CN117813128A (en) * 2021-01-22 2024-04-02 索伦托药业有限公司 Device for delivering coronavirus vaccine by microlitres-grade lymph
US11717660B2 (en) 2021-07-29 2023-08-08 Nanopass Technologies Ltd. Silicon microneedle structure and production method
KR20230067127A (en) 2021-11-09 2023-05-16 코스메드 파마소티컬 씨오 쩜 엘티디 Microneedle for a cosmetic product

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6565532B1 (en) * 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6565532B1 (en) * 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup

Also Published As

Publication number Publication date
WO2008072229A2 (en) 2008-06-19

Similar Documents

Publication Publication Date Title
WO2008072229A3 (en) Methods for dermal filling using microneedles
Chandrashekar et al. Alopecia areata—successful outcome with microneedling and triamcinolone acetonide
CN104470578B (en) Spray nozzle device and minimal invasive injection unit including the spray nozzle device
WO2008001377A2 (en) Needleless injections for administering compositions to the skin
WO2010017556A8 (en) Method and apparatus for fractional deformation and treatment of cutaneous and subcutaneous tissue
KR20160124015A (en) Apparatus for skin tattoo
TN2016000147A1 (en) Compositions for body reconstruction and body-shaping.
WO2013190567A3 (en) Composition and method for an intradermal hair growth solution
CN204910480U (en) Super micropin piece external member of injectable
KR101596419B1 (en) multi needle device for skin beauty and medical treatment with medicine distribution tool
JP2019528111A (en) Non-invasive transport method
WO2008014046A3 (en) Laser treatment of tissue
CN205494570U (en) Skin shallow layer pressurization injection device
CN205127022U (en) Needle is filled in injection plastic
WO2017180279A8 (en) Assistive device for subcutaneous injections or implants
CN105727438A (en) Spiral micro-needle wrinkle removal device and wrinkle removal method
KR20120002241U (en) Operating needle cartridge for gradating of eyebrow
KR101321521B1 (en) The embo-absence with embo-pin
JP3163359U (en) Blow needle
KR20190137252A (en) Grip for syringe
EP3549575A1 (en) Non-therapeutic method, uses of a substance that stimulates or generates an increase in volume
JP5315534B2 (en) Surgical instrument
CN107485781A (en) A kind of artificial stereo eyebrow tattooing method
CN203710558U (en) Laser device for subcutaneous interventional rhytidectomy
US20220395455A1 (en) Methods and processes for enhancing the aesthetic appearance of a face

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07849555

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: COMMUNICATION PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A) SENT 26.08.2009.

122 Ep: pct application non-entry in european phase

Ref document number: 07849555

Country of ref document: EP

Kind code of ref document: A2