WO2008071766A3 - Spiro-indene substituted imidazonaphythyridine and pyranoimidazopyridine derivatives as inhibitors of gastric acid secretion - Google Patents

Spiro-indene substituted imidazonaphythyridine and pyranoimidazopyridine derivatives as inhibitors of gastric acid secretion Download PDF

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Publication number
WO2008071766A3
WO2008071766A3 PCT/EP2007/063889 EP2007063889W WO2008071766A3 WO 2008071766 A3 WO2008071766 A3 WO 2008071766A3 EP 2007063889 W EP2007063889 W EP 2007063889W WO 2008071766 A3 WO2008071766 A3 WO 2008071766A3
Authority
WO
WIPO (PCT)
Prior art keywords
pyranoimidazopyridine
imidazonaphythyridine
spiro
inhibitors
derivatives
Prior art date
Application number
PCT/EP2007/063889
Other languages
French (fr)
Other versions
WO2008071766A2 (en
Inventor
Andreas Palmer
Peter Jan Zimmermann
Wilm Buhr
Christof Brehm
Joerg Senn-Bilfinger
Wolfgang-Alexander Simon
Stefan Postius
Wolfgang Kromer
Original Assignee
Nycomed Gmbh
Andreas Palmer
Peter Jan Zimmermann
Wilm Buhr
Christof Brehm
Joerg Senn-Bilfinger
Wolfgang-Alexander Simon
Stefan Postius
Wolfgang Kromer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Gmbh, Andreas Palmer, Peter Jan Zimmermann, Wilm Buhr, Christof Brehm, Joerg Senn-Bilfinger, Wolfgang-Alexander Simon, Stefan Postius, Wolfgang Kromer filed Critical Nycomed Gmbh
Publication of WO2008071766A2 publication Critical patent/WO2008071766A2/en
Publication of WO2008071766A3 publication Critical patent/WO2008071766A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Abstract

The invention provides compounds of the formula (1), in which the substituents and symbols are as defined in the description. The compounds inhibit the secretion of gastric acid.
PCT/EP2007/063889 2006-12-14 2007-12-13 Spiro-indene substituted imidazonaphythyridine and pyranoimidazopyridine derivatives as inhibitors of gastric acid secretion WO2008071766A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06126083.2 2006-12-14
EP06126083 2006-12-14

Publications (2)

Publication Number Publication Date
WO2008071766A2 WO2008071766A2 (en) 2008-06-19
WO2008071766A3 true WO2008071766A3 (en) 2008-08-28

Family

ID=37762613

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/063889 WO2008071766A2 (en) 2006-12-14 2007-12-13 Spiro-indene substituted imidazonaphythyridine and pyranoimidazopyridine derivatives as inhibitors of gastric acid secretion

Country Status (1)

Country Link
WO (1) WO2008071766A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011004882A1 (en) 2009-07-09 2011-01-13 ラクオリア創薬株式会社 Acid pump antagonist for treatment of diseases associated with abnormal gastrointestinal movement

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003014123A1 (en) * 2001-08-10 2003-02-20 Altana Pharma Ag Tricyclic imidazopyridines
WO2004046144A1 (en) * 2002-11-19 2004-06-03 Altana Pharma Ag 8-substituted imidazopyridines
WO2005090358A2 (en) * 2004-03-17 2005-09-29 Altana Pharma Ag 7h-8,9-dihydro-pyrano (2,3-c) imidazo (1,2a) pyridine derivatives and their use as gastric acid secretion inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003014123A1 (en) * 2001-08-10 2003-02-20 Altana Pharma Ag Tricyclic imidazopyridines
WO2004046144A1 (en) * 2002-11-19 2004-06-03 Altana Pharma Ag 8-substituted imidazopyridines
WO2005090358A2 (en) * 2004-03-17 2005-09-29 Altana Pharma Ag 7h-8,9-dihydro-pyrano (2,3-c) imidazo (1,2a) pyridine derivatives and their use as gastric acid secretion inhibitors

Also Published As

Publication number Publication date
WO2008071766A2 (en) 2008-06-19

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