WO2008068680A3 - Fluidic cell manipulator - Google Patents

Fluidic cell manipulator Download PDF

Info

Publication number
WO2008068680A3
WO2008068680A3 PCT/IB2007/054841 IB2007054841W WO2008068680A3 WO 2008068680 A3 WO2008068680 A3 WO 2008068680A3 IB 2007054841 W IB2007054841 W IB 2007054841W WO 2008068680 A3 WO2008068680 A3 WO 2008068680A3
Authority
WO
WIPO (PCT)
Prior art keywords
particle
manipulating
laminar flow
fluidic cell
shear force
Prior art date
Application number
PCT/IB2007/054841
Other languages
French (fr)
Other versions
WO2008068680A2 (en
Inventor
Dam Dirkjan B Van
Hoog Thomas J De
Judith M Rensen
Simone I E Vulto
Original Assignee
Koninkl Philips Electronics Nv
Dam Dirkjan B Van
Hoog Thomas J De
Judith M Rensen
Simone I E Vulto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninkl Philips Electronics Nv, Dam Dirkjan B Van, Hoog Thomas J De, Judith M Rensen, Simone I E Vulto filed Critical Koninkl Philips Electronics Nv
Priority to JP2009538840A priority Critical patent/JP2010510803A/en
Priority to BRPI0719508-7A priority patent/BRPI0719508A2/en
Publication of WO2008068680A2 publication Critical patent/WO2008068680A2/en
Publication of WO2008068680A3 publication Critical patent/WO2008068680A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/282—Magnetic plugs and dipsticks with associated accumulation indicator, e.g. Hall sensor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/02—Separators
    • B03C5/022—Non-uniform field separators
    • B03C5/026—Non-uniform field separators using open-gradient differential dielectric separation, i.e. using electrodes of special shapes for non-uniform field creation, e.g. Fluid Integrated Circuit [FIC]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G01N2015/1415—Control of particle position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Microscoopes, Condenser (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A system (100) is described for individually manipulating, e.g. orienting, a particle (104) in a fluid (106). The manipulating system (100) comprises a particle trapping system (111) allowing trapping of the particle (111) in a fluid channel (102) and a controller for controlling shear force gradients on the particle. Shear force gradients on the particle are 5 controlled by positioning a particle off center in the fluid channel (102) in a laminar flow or by controlling the laminar flow itself. The laminar flow thereby is generated using a flow generator (108). The system (100) for manipulating may be used in a particle characterization system or may be used for performing actions on the particle (104) under predetermined orientations.
PCT/IB2007/054841 2006-12-01 2007-11-29 Fluidic cell manipulator WO2008068680A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2009538840A JP2010510803A (en) 2006-12-01 2007-11-29 Fluid cell manipulation device
BRPI0719508-7A BRPI0719508A2 (en) 2006-12-01 2007-11-29 SYSTEM FOR INDIVIDUALLY HANDLING A PARTICLE IN A FLUID, CHARACTERIZATION SYSTEM FOR CHARACTERIZING A PARTICLE, METHODS FOR INDIVIDUALLY HANDLING A PARTICLE, AND FOR CHARACTERIZING A PARTICULAR IN A FLUID PRODUCT CONTROL, LEGAL DATA STORAGE MACHINE AND TRANSMISSION OF COMPUTER PROGRAM PRODUCTS.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125224 2006-12-01
EP06125224.3 2006-12-01

Publications (2)

Publication Number Publication Date
WO2008068680A2 WO2008068680A2 (en) 2008-06-12
WO2008068680A3 true WO2008068680A3 (en) 2008-08-14

Family

ID=39358129

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/054841 WO2008068680A2 (en) 2006-12-01 2007-11-29 Fluidic cell manipulator

Country Status (4)

Country Link
JP (1) JP2010510803A (en)
CN (1) CN101548172A (en)
BR (1) BRPI0719508A2 (en)
WO (1) WO2008068680A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI127992B (en) * 2014-08-29 2019-07-15 Svanbaeck Sami Method and system for determining dissolution properties of matter
WO2016098011A1 (en) * 2014-12-16 2016-06-23 Celldynamics I.S.R.L. Device for real time analysis of particles suspended in a fluid and method for the analysis of said particles
CN104765165B (en) * 2015-04-20 2018-08-07 三峡大学 A kind of method and device that the quick light of microballoon suspends
CN105068237B (en) * 2015-07-21 2022-11-18 大连理工大学 Method for generating tunable non-gradient optical force on chalcogenide metal multilayer core-shell surface by oblique incident light
CN105116536A (en) * 2015-07-21 2015-12-02 大连理工大学 Method for producing tunable non-gradient optical force on surface of liquid crystal material/metal multilayer nuclear-shell based on linearly-polarized non-planar light
CN111965050B (en) * 2020-08-19 2022-06-07 天津大学 Method for testing shearing force of colloidal particle microfluid
CN113647904A (en) * 2021-07-12 2021-11-16 中国科学院深圳先进技术研究院 Rotation control module, method and system

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000000293A1 (en) * 1998-06-26 2000-01-06 Evotec Biosystems Ag Electrode arrangement for generating functional field barriers in microsystems
WO2004091795A2 (en) * 2003-04-10 2004-10-28 U.S. Genomics, Inc. Manipulation of polymers in a microchannel

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000000293A1 (en) * 1998-06-26 2000-01-06 Evotec Biosystems Ag Electrode arrangement for generating functional field barriers in microsystems
WO2004091795A2 (en) * 2003-04-10 2004-10-28 U.S. Genomics, Inc. Manipulation of polymers in a microchannel

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ERIKSSON E ET AL: "A microfluidic system in combination with optical tweezers for analyzing rapid and reversible cytological alterations in single cells upon environmental changes", LAB ON A CHIP, vol. 7, no. 1, January 2007 (2007-01-01), pages 71 - 76, XP002480712, ISSN: 1473-0197 *
SHELBY J P ET AL: "Direct manipulation and observation of the rotational motion of single optically trapped microparticles and biological cells in microvortices", ANALYTICAL CHEMISTRY, vol. 76, no. 9, 1 May 2004 (2004-05-01), pages 2492 - 2497, XP001196748, ISSN: 0003-2700 *
SONI G V ET AL: "Development of an optical tweezer combined with micromanipulation for DNA and protein nanobioscience", CURRENT SCIENCE, vol. 83, no. 12, 25 December 2002 (2002-12-25), pages 1464 - 1470, XP002480711, ISSN: 0011-3891 *
WANG W ET AL: "Optical trapping and fluorescence detection in laminar flow streams", APPLIED PHYSICS LETTERS, vol. 67, no. 8, 21 August 1995 (1995-08-21), pages 1057 - 1059, XP000520274, ISSN: 0003-6951 *

Also Published As

Publication number Publication date
WO2008068680A2 (en) 2008-06-12
CN101548172A (en) 2009-09-30
JP2010510803A (en) 2010-04-08
BRPI0719508A2 (en) 2013-12-31

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