WO2008063772A3 - Resolvin d series and protectin d1 mitigate acute kidney injury - Google Patents

Resolvin d series and protectin d1 mitigate acute kidney injury Download PDF

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Publication number
WO2008063772A3
WO2008063772A3 PCT/US2007/080960 US2007080960W WO2008063772A3 WO 2008063772 A3 WO2008063772 A3 WO 2008063772A3 US 2007080960 W US2007080960 W US 2007080960W WO 2008063772 A3 WO2008063772 A3 WO 2008063772A3
Authority
WO
WIPO (PCT)
Prior art keywords
resolvin
protectin
series
kidney injury
acute kidney
Prior art date
Application number
PCT/US2007/080960
Other languages
French (fr)
Other versions
WO2008063772A2 (en
WO2008063772A9 (en
Inventor
Jeremy S Duffield
Song Hong
Charles N Serhan
Joseph V Boneventre
Original Assignee
Brigham & Womens Hospital
Jeremy S Duffield
Song Hong
Charles N Serhan
Joseph V Boneventre
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham & Womens Hospital, Jeremy S Duffield, Song Hong, Charles N Serhan, Joseph V Boneventre filed Critical Brigham & Womens Hospital
Publication of WO2008063772A2 publication Critical patent/WO2008063772A2/en
Publication of WO2008063772A9 publication Critical patent/WO2008063772A9/en
Publication of WO2008063772A3 publication Critical patent/WO2008063772A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The use of DHA (docosahexaenoic acid) analogs termed 'resolvins' to treat and, more importantly, to prevent kidney injury is disclosed.
PCT/US2007/080960 2006-10-13 2007-10-10 Resolvin d series and protectin d1 mitigate acute kidney injury WO2008063772A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82940706P 2006-10-13 2006-10-13
US60/829,407 2006-10-13

Publications (3)

Publication Number Publication Date
WO2008063772A2 WO2008063772A2 (en) 2008-05-29
WO2008063772A9 WO2008063772A9 (en) 2008-08-07
WO2008063772A3 true WO2008063772A3 (en) 2008-10-23

Family

ID=39319620

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/080960 WO2008063772A2 (en) 2006-10-13 2007-10-10 Resolvin d series and protectin d1 mitigate acute kidney injury

Country Status (1)

Country Link
WO (1) WO2008063772A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013095755A (en) * 2011-11-02 2013-05-20 Kyowa Hakko Kirin Co Ltd Cationic lipid
CN103601649A (en) * 2013-10-28 2014-02-26 史克勇 Novel compound
CN103588671A (en) * 2013-10-28 2014-02-19 史克勇 Medicine for treating cancer pain
CN103588669A (en) * 2013-10-28 2014-02-19 史克勇 Compound having activity of releasing cancer pain
CN104016879B (en) * 2014-05-30 2016-02-24 西安交通大学 Dibenzoyl amine compound with anti-tumor activity and its preparation method and application

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018751A1 (en) * 1996-10-30 1998-05-07 Scotia Holdings Plc Presentation of bioactives
WO2003105776A2 (en) * 2002-06-17 2003-12-24 Resolvyx Pharmaceuticals ANALOGUES OF LIPID MEDIATORS DERIVED FROM OMEGA-3 PUFAs AND METHODS OF USE
WO2004014835A2 (en) * 2002-08-12 2004-02-19 Brigham And Women's Hospital Resolvins: biotemplates for therapeutic interventions
WO2005089744A2 (en) * 2004-03-17 2005-09-29 The Brigham And Women's Hospital, Inc. Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma
WO2006117664A1 (en) * 2005-05-04 2006-11-09 Pronova Biopharma Norge As New dha derivatives and their use as medicaments

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018751A1 (en) * 1996-10-30 1998-05-07 Scotia Holdings Plc Presentation of bioactives
WO2003105776A2 (en) * 2002-06-17 2003-12-24 Resolvyx Pharmaceuticals ANALOGUES OF LIPID MEDIATORS DERIVED FROM OMEGA-3 PUFAs AND METHODS OF USE
WO2004014835A2 (en) * 2002-08-12 2004-02-19 Brigham And Women's Hospital Resolvins: biotemplates for therapeutic interventions
WO2005089744A2 (en) * 2004-03-17 2005-09-29 The Brigham And Women's Hospital, Inc. Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma
WO2006117664A1 (en) * 2005-05-04 2006-11-09 Pronova Biopharma Norge As New dha derivatives and their use as medicaments

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BLAKE P G ET AL: "CD59 PROTECTIN IS EXTENSIVELY EXPRESSED ON TUBULAR EPITHELIUM AND VASCULAR ENDOTHELIUM OF NORMAL AND DISEASED HUMAN KIDNEY", CLINICAL AND INVESTIGATIVE MEDICINE, vol. 15, no. 4 SUPPL, 1992, & ANNUAL MEETING OF THE CANADIAN SOCIETY FOR CLINICAL INVESTIGATION AND THE ROYAL COLLEGE OF PHYSICIAN, pages A90, XP008092395, ISSN: 0147-958X *
BONVENTRE JOSEPH V: "Pathophysiology of acute kidney injury: roles of potential inhibitors of inflammation.", CONTRIBUTIONS TO NEPHROLOGY 2007, vol. 156, 2007, pages 39 - 46, XP008092396, ISSN: 0302-5144 *
DUFFIELD JEREMY S ET AL: "Resolvin D series and Protectin D1 mitigate acute kidney injury", JOURNAL OF IMMUNOLOGY, vol. 177, no. 9, November 2006 (2006-11-01), pages 5902 - 5911, XP008092386, ISSN: 0022-1767 *

Also Published As

Publication number Publication date
WO2008063772A2 (en) 2008-05-29
WO2008063772A9 (en) 2008-08-07

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