WO2008062480A3 - An improved process for the preparation of rimonabant - Google Patents
An improved process for the preparation of rimonabant Download PDFInfo
- Publication number
- WO2008062480A3 WO2008062480A3 PCT/IN2007/000546 IN2007000546W WO2008062480A3 WO 2008062480 A3 WO2008062480 A3 WO 2008062480A3 IN 2007000546 W IN2007000546 W IN 2007000546W WO 2008062480 A3 WO2008062480 A3 WO 2008062480A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- rimonabant
- relates
- present
- preparation
- reaction conditions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Abstract
The present invention relates to an industrially advantageous, eco-friendly process for the re aration of rimonabant of formula-(I), staring from l-(4-chlorophenyl)-propan-l-one in high yields and high purity by using mild reaction conditions and avoiding use of toxic and expensive reagents, as well as stringent reaction conditions. The present invention relates to an isolated impurity of rimonabant, referred to as 'Bis impurity' and removal thereof.1 The present invention also relates to novel crystalline form-Ill of rimonabant and processes for its preparation and conversion to form-I of rimonabant.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2531DE2006 | 2006-11-24 | ||
IN2530/DEL/2006 | 2006-11-24 | ||
IN2531/DEL/2006 | 2006-11-24 | ||
IN2530DE2006 | 2006-11-24 | ||
IN2434DE2007 | 2007-11-21 | ||
IN2434/DEL/2007 | 2007-11-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008062480A2 WO2008062480A2 (en) | 2008-05-29 |
WO2008062480A3 true WO2008062480A3 (en) | 2009-10-22 |
Family
ID=39430185
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2007/000546 WO2008062480A2 (en) | 2006-11-24 | 2007-11-23 | An improved process for the preparation of rimonabant |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008062480A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009153804A1 (en) * | 2008-06-16 | 2009-12-23 | Cadila Healthcare Limited | Process for preparing form i of rimonabant |
CN102206182B (en) * | 2011-04-11 | 2013-03-13 | 中国药科大学 | Method for synthesizing Rimonabant hydrochloride |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5624941A (en) * | 1992-06-23 | 1997-04-29 | Sanofi | Pyrazole derivatives, method of preparing them and pharmaceutical compositions in which they are present |
WO2007146890A2 (en) * | 2006-06-09 | 2007-12-21 | Auspex Pharmaceuticals, Inc. | Preparation and utility of substituted pyrazole compounds with cannabinoid receptor activity |
WO2008032330A2 (en) * | 2006-09-11 | 2008-03-20 | Hetero Drugs Limited | Improved process for rimonabant |
WO2008044153A2 (en) * | 2006-08-29 | 2008-04-17 | Medichem, S.A. | Improved method for synthesizing rimonabant |
WO2008060771A2 (en) * | 2006-10-02 | 2008-05-22 | National Health Research Institutes | Pyrazole compounds |
-
2007
- 2007-11-23 WO PCT/IN2007/000546 patent/WO2008062480A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5624941A (en) * | 1992-06-23 | 1997-04-29 | Sanofi | Pyrazole derivatives, method of preparing them and pharmaceutical compositions in which they are present |
WO2007146890A2 (en) * | 2006-06-09 | 2007-12-21 | Auspex Pharmaceuticals, Inc. | Preparation and utility of substituted pyrazole compounds with cannabinoid receptor activity |
WO2008044153A2 (en) * | 2006-08-29 | 2008-04-17 | Medichem, S.A. | Improved method for synthesizing rimonabant |
WO2008032330A2 (en) * | 2006-09-11 | 2008-03-20 | Hetero Drugs Limited | Improved process for rimonabant |
WO2008060771A2 (en) * | 2006-10-02 | 2008-05-22 | National Health Research Institutes | Pyrazole compounds |
Non-Patent Citations (1)
Title |
---|
M KRISHNAMURTHY ET AL.: "Synthesis, biological evaluation, and structural studies on N1 ani C5 substituted cycloalkyl analogues of the pyrazole class of CB1 and CB2 ligands", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 12, no. 2, 2004, pages 393 - 404, XP009159956, DOI: doi:10.1016/j.bmc.2003.10.045 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008062480A2 (en) | 2008-05-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2007026971A3 (en) | Process for preparing benzazepine compounds or salts thereof | |
WO2009102155A3 (en) | Process for preparation of 2-methyl-2´-phenylpropionic acid derivatives and novel intermediate compounds | |
MX2009005664A (en) | Crystalline d-isoglutamyl-d-tryptophan and the mono ammonium salt of d-isoglutamyl- d-tryptophan. | |
EP1686131A3 (en) | Process for preparation of penam derivatives | |
CA2585802A1 (en) | Industrial process for the preparation of 17-hydroxy-6.beta.,7.beta.;15.beta.,16.beta.-bismethylene-3-oxo-17.alpha.pregn-4-ene-21-carboxylic acid.gamma.-lactone and key-intermediates for this process | |
WO2006061855A3 (en) | Salts assisted selective extraction of 6-acetyl-4.1', 6' trichlorogalactosucrose and 4, 1 ', 6' trichlorogalactosucrose from aqueous reaction mixture | |
CA2773012A1 (en) | Process for the preparation of lenalidomide | |
IL188716A0 (en) | Method for preparing 4??-amino-4'-dimethyl-4- | |
WO2008062480A3 (en) | An improved process for the preparation of rimonabant | |
WO2004080959A3 (en) | Process for the preparation of dexmethylphenidate hydrochloride | |
WO2011107843A3 (en) | Process for the preparation of atazanavir sulfate substantially free of diastereomers | |
EP1460065A4 (en) | Processes for production of cyclic diamine compounds or salts thereof | |
WO2005080329A3 (en) | Process for manufacture of racemic carvedilol | |
WO2007039914A3 (en) | Novel polymorphs of telithromycin | |
WO2003093262A3 (en) | Processes for preparing losartan and losartan potassium | |
WO2008059513A3 (en) | Compounds suitable as modulators of hdl | |
MX2008000011A (en) | Processes for preparing pyrazole-o-glycoside derivatives and novel intermediates of said processes. | |
TW200740763A (en) | A method for preparing 5-hydroxy-1-alkyl pyrazole derivatives | |
WO2007070238A3 (en) | Processes for the preparation of modafinil and analogs thereof | |
WO2006035960A3 (en) | Process for production of 2-chloro-4-nitroimidazole | |
MXPA05013604A (en) | Process for preparing acylsulfamoylbenzamides. | |
WO2008015005A3 (en) | Polymorphic forms of ziprasidone sulfates | |
WO2007049302A3 (en) | An improved process for the preparation of pure venlafaxine | |
WO2007015257A3 (en) | A process for the preparation of gemcitabine using novel intermediates | |
WO2006134219A3 (en) | Atipamezhole hydrochloride crystallization method |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 07827608 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 07827608 Country of ref document: EP Kind code of ref document: A2 |