WO2008060540A3 - Procédés d'identification de compositions qui modulent la protéine tyrosine kinase, ptp-bl - Google Patents

Procédés d'identification de compositions qui modulent la protéine tyrosine kinase, ptp-bl Download PDF

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Publication number
WO2008060540A3
WO2008060540A3 PCT/US2007/023845 US2007023845W WO2008060540A3 WO 2008060540 A3 WO2008060540 A3 WO 2008060540A3 US 2007023845 W US2007023845 W US 2007023845W WO 2008060540 A3 WO2008060540 A3 WO 2008060540A3
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WO
WIPO (PCT)
Prior art keywords
ptp
methods
tyrosine phosphatase
modulate
protein tyrosine
Prior art date
Application number
PCT/US2007/023845
Other languages
English (en)
Other versions
WO2008060540A2 (fr
Inventor
Michael J Grusby
Original Assignee
Harvard College
Michael J Grusby
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Michael J Grusby filed Critical Harvard College
Publication of WO2008060540A2 publication Critical patent/WO2008060540A2/fr
Publication of WO2008060540A3 publication Critical patent/WO2008060540A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne, au moins partiellement, la découverte que la tyrosine phosphatase, du type PTP-Basophile (PTP-BL), interagit physiquement avec de multiples protéines STAT, par exemple, STAT4, STAT1 et/ou STAT6. L'invention concerne également, au moins partiellement, la génération d'animaux non humains déficients en Ptp-bt1-. En conséquence, l'invention met en oeuvre des procédés pour identifier des modulateurs de l'interaction des polypeptides STAT et des polypeptides PTP-BL ainsi que des animaux non humains déficients en Ptp-bt1- et des cellules dérivés de ces polypeptides et leurs procédés d'utilisation.
PCT/US2007/023845 2006-11-13 2007-11-13 Procédés d'identification de compositions qui modulent la protéine tyrosine kinase, ptp-bl WO2008060540A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US85861506P 2006-11-13 2006-11-13
US60/858,615 2006-11-13
US90049307P 2007-02-09 2007-02-09
US60/900,493 2007-02-09
US90122707P 2007-02-13 2007-02-13
US60/901,227 2007-02-13

Publications (2)

Publication Number Publication Date
WO2008060540A2 WO2008060540A2 (fr) 2008-05-22
WO2008060540A3 true WO2008060540A3 (fr) 2008-10-16

Family

ID=39313222

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/023845 WO2008060540A2 (fr) 2006-11-13 2007-11-13 Procédés d'identification de compositions qui modulent la protéine tyrosine kinase, ptp-bl

Country Status (1)

Country Link
WO (1) WO2008060540A2 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002042489A1 (fr) * 2000-11-27 2002-05-30 The Hospital For Sick Children Methodes faisant intervenir la proteine tyrosine phosphatase de lymphocyte t
WO2002096412A1 (fr) * 2001-05-31 2002-12-05 The Cleveland Clinic Foundation Inhibiteurs de ptpase et leur methode d'utilisation
US20040033979A1 (en) * 1999-04-12 2004-02-19 Dean Nicholas M. Antisense modulation of Fas mediated signaling
US20040224337A1 (en) * 2003-03-04 2004-11-11 Erik Foehr Use of biomolecular targets in the treatment and visualization of tumors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040033979A1 (en) * 1999-04-12 2004-02-19 Dean Nicholas M. Antisense modulation of Fas mediated signaling
WO2002042489A1 (fr) * 2000-11-27 2002-05-30 The Hospital For Sick Children Methodes faisant intervenir la proteine tyrosine phosphatase de lymphocyte t
WO2002096412A1 (fr) * 2001-05-31 2002-12-05 The Cleveland Clinic Foundation Inhibiteurs de ptpase et leur methode d'utilisation
US20040224337A1 (en) * 2003-03-04 2004-11-11 Erik Foehr Use of biomolecular targets in the treatment and visualization of tumors

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HAQUE S J ET AL: "Roles of protein-tyrosine phosphatases in Stat1 alpha-mediated cell signaling.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 27 OCT 1995, vol. 270, no. 43, 27 October 1995 (1995-10-27), pages 25709 - 25714, XP002489749, ISSN: 0021-9258 *
NAKAHIRA MASAKIYO ET AL: "Regulation of signal transducer and activator of transcription signaling by the tyrosine phosphatase PTP-BL", IMMUNITY, vol. 26, no. 2, February 2007 (2007-02-01), pages 163 - 176, XP002489752, ISSN: 1074-7613 *
SATO ET AL: "Nuclear retention of STAT3 through the coiled-coil domain regulates its activity", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 336, no. 2, 21 October 2005 (2005-10-21), pages 617 - 624, XP005165755, ISSN: 0006-291X *
WURSTER ANDREA L ET AL: "Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis.", MOLECULAR AND CELLULAR BIOLOGY JAN 2002, vol. 22, no. 1, January 2002 (2002-01-01), pages 117 - 126, XP002489750, ISSN: 0270-7306 *
ZHU WEI ET AL: "Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 27 SEP 2002, vol. 277, no. 39, 27 September 2002 (2002-09-27), pages 35787 - 35790, XP002489751, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2008060540A2 (fr) 2008-05-22

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